GB2014141B - 8 -ethyl and 8 -methyl 4,5a-epoxymorphinan -6- one compounds - Google Patents

8 -ethyl and 8 -methyl 4,5a-epoxymorphinan -6- one compounds

Info

Publication number
GB2014141B
GB2014141B GB7904029A GB7904029A GB2014141B GB 2014141 B GB2014141 B GB 2014141B GB 7904029 A GB7904029 A GB 7904029A GB 7904029 A GB7904029 A GB 7904029A GB 2014141 B GB2014141 B GB 2014141B
Authority
GB
United Kingdom
Prior art keywords
epoxymorphinan
ethyl
methyl
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB7904029A
Other versions
GB2014141A (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Miles Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miles Laboratories Inc filed Critical Miles Laboratories Inc
Publication of GB2014141A publication Critical patent/GB2014141A/en
Application granted granted Critical
Publication of GB2014141B publication Critical patent/GB2014141B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
GB7904029A 1978-02-10 1979-02-06 8 -ethyl and 8 -methyl 4,5a-epoxymorphinan -6- one compounds Expired GB2014141B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87664078A 1978-02-10 1978-02-10
US91193978A 1978-06-02 1978-06-02

Publications (2)

Publication Number Publication Date
GB2014141A GB2014141A (en) 1979-08-22
GB2014141B true GB2014141B (en) 1982-09-15

Family

ID=27128411

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7904029A Expired GB2014141B (en) 1978-02-10 1979-02-06 8 -ethyl and 8 -methyl 4,5a-epoxymorphinan -6- one compounds

Country Status (7)

Country Link
JP (1) JPS54117499A (en)
AU (1) AU507873B2 (en)
CA (1) CA1106369A (en)
DE (1) DE2900918A1 (en)
FR (1) FR2424277A1 (en)
GB (1) GB2014141B (en)
IL (1) IL56222A (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4272541A (en) * 1978-06-02 1981-06-09 Miles Laboratories, Inc. 7,8 and 7-8 Substituted 4,5α-epoxymorphinan-6-one compounds, and methods of treating pain and drug dependence with them
US4259329A (en) * 1979-10-17 1981-03-31 Miles Laboratories, Inc. 17-Cyclobutylmethyl-3-hydroxy-β-methyl-6-methylene morphinane, and methods of treating pain with them
US4275205A (en) * 1980-05-05 1981-06-23 Miles Laboratories, Inc. 7,7-Ditosyloxymethyl-4,5α-epoxy-morphinan-6-ols
EP0103636B1 (en) * 1982-03-16 1990-09-12 Rockefeller University Use of opium antagonists for the manufacture of medicaments for controlling gastrointestinal dysmotility
JPH0174251U (en) * 1987-11-02 1989-05-19
JPH043470U (en) * 1990-04-24 1992-01-13
US5194637A (en) * 1991-08-22 1993-03-16 Syracuse University Method and apparatus for synthesis of highly isomerically pure stereoisomers of glycidol derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1355143A (en) * 1963-04-05 1964-03-13 Shionogi & Co Morphinan derivatives and manufacturing process

Also Published As

Publication number Publication date
JPS54117499A (en) 1979-09-12
GB2014141A (en) 1979-08-22
AU507873B2 (en) 1980-02-28
AU4409079A (en) 1979-08-16
FR2424277B1 (en) 1982-03-12
FR2424277A1 (en) 1979-11-23
DE2900918A1 (en) 1979-08-16
CA1106369A (en) 1981-08-04
IL56222A (en) 1981-11-30
IL56222A0 (en) 1979-03-12
JPS5757476B2 (en) 1982-12-04

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee