FR2422658A1 - Composes piperazinyl-benzoheterocycliques, leur preparation et leurs utilisations therapeutiques - Google Patents

Composes piperazinyl-benzoheterocycliques, leur preparation et leurs utilisations therapeutiques

Info

Publication number
FR2422658A1
FR2422658A1 FR7909338A FR7909338A FR2422658A1 FR 2422658 A1 FR2422658 A1 FR 2422658A1 FR 7909338 A FR7909338 A FR 7909338A FR 7909338 A FR7909338 A FR 7909338A FR 2422658 A1 FR2422658 A1 FR 2422658A1
Authority
FR
France
Prior art keywords
piperazinyl
preparation
therapeutic uses
benzoheterocyclic compounds
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7909338A
Other languages
English (en)
French (fr)
Other versions
FR2422658B1 (it
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP53043624A external-priority patent/JPS6034957B2/ja
Priority claimed from JP10738778A external-priority patent/JPS5576875A/ja
Priority claimed from JP53110464A external-priority patent/JPS6037118B2/ja
Priority claimed from JP13715778A external-priority patent/JPS5564588A/ja
Priority claimed from JP53141785A external-priority patent/JPS6037119B2/ja
Priority claimed from JP14273178A external-priority patent/JPS5569583A/ja
Priority claimed from JP53145638A external-priority patent/JPS5951959B2/ja
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of FR2422658A1 publication Critical patent/FR2422658A1/fr
Application granted granted Critical
Publication of FR2422658B1 publication Critical patent/FR2422658B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FR7909338A 1978-04-12 1979-04-12 Composes piperazinyl-benzoheterocycliques, leur preparation et leurs utilisations therapeutiques Granted FR2422658A1 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP53043624A JPS6034957B2 (ja) 1978-04-12 1978-04-12 ペニシラン酸誘導体
JP10738778A JPS5576875A (en) 1978-08-31 1978-08-31 Benzo ij quinolizine-2-carboxylic acid derivative and its preparation
JP53110464A JPS6037118B2 (ja) 1978-09-07 1978-09-07 ペニシラン酸誘導体
JP13715778A JPS5564588A (en) 1978-11-06 1978-11-06 Pyrrolo (3, 2, 1-ij) quinoline-5-carboxylic acid derivative and its preparation
JP53141785A JPS6037119B2 (ja) 1978-11-16 1978-11-16 ペニシラン酸誘導体
JP14273178A JPS5569583A (en) 1978-11-17 1978-11-17 Pyrido 3,2,1-jk carbazole derivative
JP53145638A JPS5951959B2 (ja) 1978-11-24 1978-11-24 ペニシラン酸誘導体

Publications (2)

Publication Number Publication Date
FR2422658A1 true FR2422658A1 (fr) 1979-11-09
FR2422658B1 FR2422658B1 (it) 1981-12-31

Family

ID=27564567

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7909338A Granted FR2422658A1 (fr) 1978-04-12 1979-04-12 Composes piperazinyl-benzoheterocycliques, leur preparation et leurs utilisations therapeutiques

Country Status (8)

Country Link
AU (1) AU529330B2 (it)
CA (1) CA1153374A (it)
CH (1) CH640853A5 (it)
DE (3) DE2953974C2 (it)
FR (1) FR2422658A1 (it)
GB (2) GB2019844B (it)
IT (1) IT1196531B (it)
NL (1) NL180664C (it)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2463771A1 (fr) * 1979-08-22 1981-02-27 Kyorin Seiyaku Kk Procede de preparation de derives d'acide quinoleinecarboxylique et nouveaux produits ainsi obtenus, a activite antibacterienne
FR2493849A1 (fr) * 1980-11-10 1982-05-14 Otsuka Pharma Co Ltd Composes benzoheterocycliques utiles comme medicaments antimicrobiens et procedes de leur preparation
FR2496662A1 (fr) * 1980-12-18 1982-06-25 Otsuka Pharma Co Ltd Procedes pour preparer des composes benzoheterocycliques
EP0203795A2 (en) * 1985-05-24 1986-12-03 Tokyo Tanabe Company Limited Benzo [i,j] quinolizine-2-carboxylic acid derivatives, the salts and their hydrates, pharmaceutical compositions thereof, and process for preparing the same

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5746986A (en) * 1980-09-02 1982-03-17 Dai Ichi Seiyaku Co Ltd Pyrido(1,2,3-de)(1,4)benzoxazine derivative
JPS57176987A (en) * 1981-04-24 1982-10-30 Otsuka Pharmaceut Co Ltd Pyrrolo(3,2,1-ij)quinoline-5-carboxylic acid derivative
PH22140A (en) 1982-06-29 1988-06-01 Daiichi Seiyaku Co Tricyclic compounds
JPS59137482A (ja) * 1983-01-26 1984-08-07 Otsuka Pharmaceut Co Ltd ピロロ〔３，２，１，−ｉｊ〕キノリン−５−カルボン酸誘導体
DE3517709A1 (de) * 1985-01-05 1986-07-10 Bayer Ag Basische zubereitungen von chinoloncarbonsaeuren
KR900014383A (ko) * 1989-03-29 1990-10-23 원본미기재 피롤로퀴놀린 유도체, 이의 제조방법 및 이를 사용한 항균제
DE69102900T3 (de) * 1990-02-14 1998-04-09 Otsuka Pharma Co Ltd Brausemischung, deren Herstellung sowie Verwendung.
US6488961B1 (en) 1996-09-20 2002-12-03 Ethypharm, Inc. Effervescent granules and methods for their preparation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE793524A (fr) * 1971-12-30 1973-06-29 Riker Laboratories Inc Acides benzoquinolizine-carboxyliques et leurs derives
US3985882A (en) * 1972-11-02 1976-10-12 Riker Laboratories, Inc. Substituted benzo[ij]quinolinzine-2-carboxylic acids and derivatives thereof as bactericidal agents

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2463771A1 (fr) * 1979-08-22 1981-02-27 Kyorin Seiyaku Kk Procede de preparation de derives d'acide quinoleinecarboxylique et nouveaux produits ainsi obtenus, a activite antibacterienne
FR2493849A1 (fr) * 1980-11-10 1982-05-14 Otsuka Pharma Co Ltd Composes benzoheterocycliques utiles comme medicaments antimicrobiens et procedes de leur preparation
FR2496662A1 (fr) * 1980-12-18 1982-06-25 Otsuka Pharma Co Ltd Procedes pour preparer des composes benzoheterocycliques
EP0203795A2 (en) * 1985-05-24 1986-12-03 Tokyo Tanabe Company Limited Benzo [i,j] quinolizine-2-carboxylic acid derivatives, the salts and their hydrates, pharmaceutical compositions thereof, and process for preparing the same
EP0203795B1 (en) * 1985-05-24 1992-07-29 Tokyo Tanabe Company Limited Benzo [i,j] quinolizine-2-carboxylic acid derivatives, the salts and their hydrates, pharmaceutical compositions thereof, and process for preparing the same

Also Published As

Publication number Publication date
GB2019844B (en) 1983-01-19
AU529330B2 (en) 1983-06-02
DE2914258C2 (it) 1989-08-03
DE2953974C2 (it) 1992-06-25
NL180664B (nl) 1986-11-03
NL7902905A (nl) 1979-10-16
CH640853A5 (de) 1984-01-31
GB2020279A (en) 1979-11-14
IT1196531B (it) 1988-11-16
FR2422658B1 (it) 1981-12-31
CA1153374A (en) 1983-09-06
DE2953973C2 (it) 1989-02-02
DE2953973A1 (it) 1982-08-26
IT7948690A0 (it) 1979-04-10
GB2019844A (en) 1979-11-07
NL180664C (nl) 1987-04-01
GB2020279B (en) 1983-02-02
DE2914258A1 (de) 1979-10-25
AU4603779A (en) 1979-10-18

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