FR2385397B1 - - Google Patents

Info

Publication number
FR2385397B1
FR2385397B1 FR7820936A FR7820936A FR2385397B1 FR 2385397 B1 FR2385397 B1 FR 2385397B1 FR 7820936 A FR7820936 A FR 7820936A FR 7820936 A FR7820936 A FR 7820936A FR 2385397 B1 FR2385397 B1 FR 2385397B1
Authority
FR
France
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR7820936A
Other versions
FR2385397A1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BIORESEARCH Sas
Original Assignee
BIORESEARCH Sas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BIORESEARCH Sas filed Critical BIORESEARCH Sas
Publication of FR2385397A1 publication Critical patent/FR2385397A1/fr
Application granted granted Critical
Publication of FR2385397B1 publication Critical patent/FR2385397B1/fr
Granted legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D475/00Heterocyclic compounds containing pteridine ring systems
    • C07D475/02Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
FR7820936A 1977-02-22 1978-07-13 Compositions stables d'un sel alcalin ou alcalino-terreux d'acide 5-methyltetrahydrofolique a usage therapeutique Granted FR2385397A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7290/77A GB1572137A (en) 1977-02-22 1977-02-22 Stable compositions for therapeutic use based on d,1-5-methyltetrahydrofolic acid and its salts

Publications (2)

Publication Number Publication Date
FR2385397A1 FR2385397A1 (fr) 1978-10-27
FR2385397B1 true FR2385397B1 (fr) 1981-07-17

Family

ID=9830275

Family Applications (2)

Application Number Title Priority Date Filing Date
FR7804847A Granted FR2381047A1 (fr) 1977-02-22 1978-02-21 Procede de production de l'acide 5-methyltetrahydrofolique- d,1 et de ses sels
FR7820936A Granted FR2385397A1 (fr) 1977-02-22 1978-07-13 Compositions stables d'un sel alcalin ou alcalino-terreux d'acide 5-methyltetrahydrofolique a usage therapeutique

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FR7804847A Granted FR2381047A1 (fr) 1977-02-22 1978-02-21 Procede de production de l'acide 5-methyltetrahydrofolique- d,1 et de ses sels

Country Status (32)

Country Link
JP (1) JPS5831353B2 (fr)
AR (1) AR215162A1 (fr)
AT (1) AT380020B (fr)
AU (1) AU520715B2 (fr)
BE (1) BE863808A (fr)
CA (1) CA1093554A (fr)
CH (1) CH635344A5 (fr)
CZ (1) CZ279815B6 (fr)
DD (1) DD134099A5 (fr)
DE (1) DE2807393A1 (fr)
DK (1) DK144944C (fr)
EG (1) EG13399A (fr)
ES (1) ES467153A1 (fr)
FI (1) FI67082C (fr)
FR (2) FR2381047A1 (fr)
GB (1) GB1572137A (fr)
GR (1) GR71704B (fr)
HU (1) HU179422B (fr)
IE (1) IE46402B1 (fr)
IL (1) IL54052A (fr)
IN (1) IN149574B (fr)
LU (1) LU79067A1 (fr)
MX (1) MX5288E (fr)
NL (1) NL190285C (fr)
NO (1) NO147793C (fr)
NZ (1) NZ186465A (fr)
PL (1) PL118654B1 (fr)
PT (1) PT67656B (fr)
SE (1) SE437028B (fr)
SU (1) SU747427A3 (fr)
YU (1) YU40505B (fr)
ZA (1) ZA78837B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5838285A (ja) * 1981-08-25 1983-03-05 Kanegafuchi Chem Ind Co Ltd 5−メチル−(6rs)−5,6,7,8−テトラヒドロ−l−葉酸のマグネシウム塩またはその遊離酸の製法
GB8621268D0 (en) * 1986-09-03 1986-10-08 Univ Strathclyde Separation of substances
IT1229517B (it) * 1989-01-31 1991-09-03 Bioresearch Spa Impiego di acido 5-metiltetraidrofolico, di acido 5 formiltetraidrofolico, e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato adatte ad essere impiegate nella terapia dei disordini depressivi e composizioni farmaceutiche relative.
IT1229203B (it) * 1989-03-22 1991-07-25 Bioresearch Spa Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
NL8901432A (nl) * 1989-06-06 1991-01-02 Pharmachemie Bv Bij koelkasttemperatuur stabiele waterige folinaatoplossing, alsmede werkwijze ter bereiding daarvan.
CH680731A5 (fr) * 1990-04-12 1992-10-30 Sapec Fine Chemicals
US5217974A (en) * 1991-03-29 1993-06-08 Eli Lilly And Company Method for treating gar-transformylase tumors in mammals and reducing mammalian toxicity
CH683261A5 (it) * 1991-10-10 1994-02-15 Applied Pharma Res Procedimento per la preparazione dell'acido metiltetraidrofolico nella forma (6(R,S)(-))N-5 e separazione del diastereoisomero attivo (6(S)(-))N-5) sotto forma di sali.
CH682665A5 (de) * 1991-10-29 1993-10-29 Sapec Fine Chemicals Verfahren zur Reinigung von rohen Erdalkalimetallsalzen von N(5)-Methyl-5,6,7,8-tetrahydrofolsäure.
US6162914A (en) * 1998-04-24 2000-12-19 Cerbios-Pharma S.A. Process for the reduction of pterins
CH693905A5 (de) * 1999-04-15 2004-04-15 Eprova Ag Stabile kristalline Salze von 5-Methyltetrahydrofolsäure.
CH698729B1 (de) * 2007-05-30 2009-10-15 Cerbios Pharma Sa Stabile, kristalline (6S)-N(5)-Methyl-5, 6,7,8-tetrahydrofolsäure.
CN103214487A (zh) * 2013-04-12 2013-07-24 张家港威胜生物医药有限公司 一种重要医药化工原料(6s)-5-甲基四氢叶酸盐的合成
WO2015193778A1 (fr) 2014-06-16 2015-12-23 Mylan Laboratories Ltd. Forme cristalline de lévoméfolate de calcium

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL80276C (fr) *
GB1293541A (en) * 1969-03-18 1972-10-18 John Alexander Blair Folic acid derivatives
US3856959A (en) * 1972-07-24 1974-12-24 Department Of Health Education Inhibition of leukemia utilizing 5-methyltetrahydrohomofolate
US4148999A (en) * 1977-08-22 1979-04-10 The Government Of The United States Of America Preparation and purification of citrovorum factor
CH649550A5 (en) * 1984-02-09 1985-05-31 Eprova Ag Process for the preparation of alkaline earth metal salts of 5-methyltetrahydrofolic acid

Also Published As

Publication number Publication date
MX5288E (es) 1983-06-06
JPS5831353B2 (ja) 1983-07-05
ZA78837B (en) 1979-09-26
GB1572137A (en) 1980-07-23
FR2381047A1 (fr) 1978-09-15
ES467153A1 (es) 1978-11-16
IL54052A0 (en) 1978-04-30
AU3343078A (en) 1979-08-30
NO780594L (no) 1978-08-23
EG13399A (en) 1981-12-31
CZ112978A3 (en) 1995-02-15
PL204747A1 (pl) 1979-03-12
CZ279815B6 (cs) 1995-07-12
DK144944C (da) 1982-11-29
SE7801973L (sv) 1978-08-23
IN149574B (fr) 1982-01-30
SE437028B (sv) 1985-02-04
AR215162A1 (es) 1979-09-14
FI67082B (fi) 1984-09-28
DE2807393C2 (fr) 1990-06-13
CA1093554A (fr) 1981-01-13
PT67656B (en) 1979-07-19
FI67082C (fi) 1985-01-10
SU747427A3 (ru) 1980-07-23
LU79067A1 (fr) 1978-06-27
NZ186465A (en) 1980-10-08
DK144944B (da) 1982-07-12
BE863808A (fr) 1978-05-29
NL190285C (nl) 1994-01-03
YU37978A (en) 1983-01-21
ATA90378A (de) 1985-08-15
AT380020B (de) 1986-03-25
HU179422B (en) 1982-10-28
DD134099A5 (de) 1979-02-07
GR71704B (fr) 1983-06-21
NO147793C (no) 1983-06-15
FI780565A (fi) 1978-08-23
IL54052A (en) 1981-07-31
AU520715B2 (en) 1982-02-25
NL7801775A (nl) 1978-08-24
PL118654B1 (en) 1981-10-31
DK76578A (da) 1978-08-23
IE46402B1 (en) 1983-06-01
CH635344A5 (en) 1983-03-31
DE2807393A1 (de) 1978-09-07
PT67656A (en) 1978-03-01
FR2381047B1 (fr) 1981-07-24
FR2385397A1 (fr) 1978-10-27
NL190285B (nl) 1993-08-02
NO147793B (no) 1983-03-07
YU40505B (en) 1986-02-28
JPS53124297A (en) 1978-10-30
IE780285L (en) 1978-08-22

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