FR2356630A1 - Procede de purification de peptides de haut poids moleculaire - Google Patents

Procede de purification de peptides de haut poids moleculaire

Info

Publication number
FR2356630A1
FR2356630A1 FR7720310A FR7720310A FR2356630A1 FR 2356630 A1 FR2356630 A1 FR 2356630A1 FR 7720310 A FR7720310 A FR 7720310A FR 7720310 A FR7720310 A FR 7720310A FR 2356630 A1 FR2356630 A1 FR 2356630A1
Authority
FR
France
Prior art keywords
purification
molecular weight
high molecular
weight peptides
ion exchangers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7720310A
Other languages
English (en)
Other versions
FR2356630B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of FR2356630A1 publication Critical patent/FR2356630A1/fr
Application granted granted Critical
Publication of FR2356630B1 publication Critical patent/FR2356630B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
    • A23K10/32—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms from hydrolysates of wood or straw
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C07K14/625—Extraction from natural sources
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/854—Glands

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Physiology (AREA)
  • Animal Husbandry (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention a pour objet un procédé de purification de peptides de haut poids moléculaire ayant une tendance à s'associer, par chromatographie sur échangeurs d'ions dans des solvants aqueux tamponnés, sur des échangeurs d'ions acides ou basiques, caractérisé en ce que l'on dissout des détergents non ioniques dans les solvants tamponnés.
FR7720310A 1976-07-01 1977-07-01 Procede de purification de peptides de haut poids moleculaire Granted FR2356630A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2629568A DE2629568C3 (de) 1976-07-01 1976-07-01 Verfahren zur Reinigung von Insulin, seinen Analogen und Derivaten

Publications (2)

Publication Number Publication Date
FR2356630A1 true FR2356630A1 (fr) 1978-01-27
FR2356630B1 FR2356630B1 (fr) 1983-10-07

Family

ID=5981950

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7720310A Granted FR2356630A1 (fr) 1976-07-01 1977-07-01 Procede de purification de peptides de haut poids moleculaire

Country Status (22)

Country Link
US (1) US4129560A (fr)
JP (1) JPS535101A (fr)
AT (1) AT352922B (fr)
AU (1) AU509110B2 (fr)
BE (1) BE856385A (fr)
CA (1) CA1086308A (fr)
CH (1) CH626051A5 (fr)
DE (1) DE2629568C3 (fr)
DK (1) DK149201C (fr)
ES (1) ES460099A1 (fr)
FI (1) FI61490C (fr)
FR (1) FR2356630A1 (fr)
GB (1) GB1582056A (fr)
GR (1) GR78333B (fr)
IE (1) IE44766B1 (fr)
IT (1) IT1080658B (fr)
NL (1) NL188804C (fr)
NO (1) NO145692C (fr)
NZ (1) NZ184516A (fr)
PT (1) PT66751B (fr)
SE (1) SE440507B (fr)
ZA (1) ZA773964B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2581647A1 (fr) * 1985-04-12 1986-11-14 Berlin Chemie Veb Procede de purification de l'insuline

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4701521A (en) * 1978-07-17 1987-10-20 The Trustees Of Boston University Method of effecting cellular uptake of molecules
US4783441A (en) * 1979-04-30 1988-11-08 Hoechst Aktiengesellschaft Aqueous protein solutions stable to denaturation
US4292041A (en) * 1979-11-02 1981-09-29 Merck & Co., Inc. Surfactant assay
US4459226A (en) * 1982-02-26 1984-07-10 Eli Lilly And Company Process for recovering insulin
US4839341A (en) * 1984-05-29 1989-06-13 Eli Lilly And Company Stabilized insulin formulations
JPS6230956A (ja) * 1985-07-31 1987-02-09 Sumitomo Chem Co Ltd 合成ペプチド類に含有されるイオン類の分析法
DE3726655A1 (de) * 1987-08-11 1989-02-23 Hoechst Ag Verfahren zur isolierung basischer proteine aus proteingemischen, welche solche basischen proteine enthalten
JPH07119767B2 (ja) * 1989-03-07 1995-12-20 積水化学工業株式会社 梅毒検査用試薬及びその製造法
DE4028120C2 (de) * 1990-09-05 1996-09-19 Hoechst Ag Verfahren zur Reinigung von Insulin und/oder Insulinderivaten
EP0547544B1 (fr) * 1991-12-18 1997-03-12 Hoechst Aktiengesellschaft Procédé de préparation de solutions contenant de l'insuline
US6444788B1 (en) * 1999-03-15 2002-09-03 Novo Nordisk A/S Ion exchange chromatography of GLP-1, analogs and derivatives thereof
US6451987B1 (en) * 1999-03-15 2002-09-17 Novo Nordisk A/S Ion exchange chromatography of proteins and peptides
DE602004023626D1 (de) * 2003-08-21 2009-11-26 Novo Nordisk As Trennung von polypeptiden mit einer racemisierten aminosäure
US20080096800A1 (en) * 2004-03-12 2008-04-24 Biodel, Inc. Rapid mucosal gel or film insulin compositions
US20080085298A1 (en) * 2004-03-12 2008-04-10 Biodel, Inc. Rapid Mucosal Gel or Film Insulin Compositions
US20080090753A1 (en) 2004-03-12 2008-04-17 Biodel, Inc. Rapid Acting Injectable Insulin Compositions
US7713929B2 (en) * 2006-04-12 2010-05-11 Biodel Inc. Rapid acting and long acting insulin combination formulations
US8084420B2 (en) 2005-09-29 2011-12-27 Biodel Inc. Rapid acting and long acting insulin combination formulations
JP2009533471A (ja) 2006-04-12 2009-09-17 バイオデル， インコーポレイテッド 即効型および長時間作用型組合せインスリン製剤
US9060927B2 (en) 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake
KR20140007377A (ko) 2011-02-01 2014-01-17 노보 노르디스크 에이/에스 인슐린의 정제
CN103703015B (zh) * 2011-08-25 2019-07-05 霍夫曼-拉罗奇有限公司 阳离子和阴离子交换层析法
JP6093364B2 (ja) * 2011-09-30 2017-03-08 ジーイー・ヘルスケア・バイオプロセス・アールアンドディ・アクチボラグ 生体分子の精製方法
CN103130868B (zh) * 2013-03-12 2014-09-17 合肥天麦生物科技发展有限公司 一种蛋白质或多肽的纯化方法
WO2016014325A1 (fr) 2014-07-21 2016-01-28 Merck Sharp & Dohme Corp. Procédé de purification de l'inlsuline et d'analogues de l'insuline par chromatographie

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3616235A (en) * 1968-05-16 1971-10-26 Forsch Die Garungsindustrie En Process for precipitating enzymes and enzymatic inactive proteins in solution with synthetic tanning materials
US3607858A (en) * 1970-03-31 1971-09-21 American Cyanamid Co Process for preparing lyophilized human blood proteins such as gamma globulin in the presence of a nonionic surfactant
US3683939A (en) * 1970-05-28 1972-08-15 Wilson Pharm & Chem Corp Proteinaceous cosmetic material for hair conditioning
US3907676A (en) * 1970-07-28 1975-09-23 Novo Terapeutisk Labor As Process for purifying insulin
JPS5328989B2 (fr) * 1974-05-27 1978-08-17
US4076800A (en) * 1975-01-13 1978-02-28 The Procter & Gamble Company Protein-containing detergent compositions for protecting keratinous materials

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CA1973 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2581647A1 (fr) * 1985-04-12 1986-11-14 Berlin Chemie Veb Procede de purification de l'insuline

Also Published As

Publication number Publication date
SE440507B (sv) 1985-08-05
FI61490C (fi) 1982-08-10
NO145692B (no) 1982-02-01
ZA773964B (en) 1978-05-30
NZ184516A (en) 1979-10-25
IE44766L (en) 1978-01-01
CH626051A5 (fr) 1981-10-30
DK293277A (da) 1978-01-02
IE44766B1 (en) 1982-03-24
ATA466377A (de) 1979-03-15
AU2660477A (en) 1979-01-04
GR78333B (fr) 1984-09-26
NO145692C (no) 1982-05-12
NL188804B (nl) 1992-05-06
FR2356630B1 (fr) 1983-10-07
ES460099A1 (es) 1978-05-01
JPS535101A (en) 1978-01-18
FI61490B (fi) 1982-04-30
AU509110B2 (en) 1980-04-17
PT66751A (de) 1977-07-01
BE856385A (fr) 1978-01-02
NL7707037A (nl) 1978-01-03
JPS6126560B2 (fr) 1986-06-20
AT352922B (de) 1979-10-10
IT1080658B (it) 1985-05-16
GB1582056A (en) 1980-12-31
CA1086308A (fr) 1980-09-23
SE7707612L (sv) 1978-01-02
PT66751B (de) 1979-01-22
US4129560A (en) 1978-12-12
DK149201B (da) 1986-03-10
NL188804C (nl) 1992-10-01
DE2629568C3 (de) 1981-09-10
DE2629568B2 (de) 1980-09-04
NO772318L (no) 1978-01-03
DE2629568A1 (de) 1978-01-12
FI772023A (fr) 1978-01-02
DK149201C (da) 1986-08-04

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