FR2308367B1 - - Google Patents

Info

Publication number
FR2308367B1
FR2308367B1 FR7610958A FR7610958A FR2308367B1 FR 2308367 B1 FR2308367 B1 FR 2308367B1 FR 7610958 A FR7610958 A FR 7610958A FR 7610958 A FR7610958 A FR 7610958A FR 2308367 B1 FR2308367 B1 FR 2308367B1
Authority
FR
France
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR7610958A
Other languages
French (fr)
Other versions
FR2308367A1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of FR2308367A1 publication Critical patent/FR2308367A1/fr
Application granted granted Critical
Publication of FR2308367B1 publication Critical patent/FR2308367B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR7610958A 1975-04-21 1976-04-14 Piperazinyl pyrazines Granted FR2308367A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57005275A 1975-04-21 1975-04-21

Publications (2)

Publication Number Publication Date
FR2308367A1 FR2308367A1 (fr) 1976-11-19
FR2308367B1 true FR2308367B1 (enExample) 1979-09-21

Family

ID=24277994

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7610958A Granted FR2308367A1 (fr) 1975-04-21 1976-04-14 Piperazinyl pyrazines

Country Status (36)

Country Link
JP (1) JPS51136688A (enExample)
AR (1) AR210349A1 (enExample)
AT (1) AT353795B (enExample)
AU (1) AU496854B2 (enExample)
BE (1) BE840904A (enExample)
BG (1) BG34185A3 (enExample)
CA (1) CA1059128A (enExample)
CH (1) CH619462A5 (enExample)
CS (1) CS195726B2 (enExample)
CY (1) CY1090A (enExample)
DD (1) DD124599A5 (enExample)
DE (1) DE2617205C3 (enExample)
DK (1) DK143899C (enExample)
EG (1) EG12387A (enExample)
ES (4) ES447150A1 (enExample)
FI (1) FI62666C (enExample)
FR (1) FR2308367A1 (enExample)
GB (1) GB1492528A (enExample)
GR (1) GR59900B (enExample)
HK (1) HK60380A (enExample)
HU (1) HU172684B (enExample)
IE (1) IE42979B1 (enExample)
IL (1) IL49391A (enExample)
KE (1) KE3088A (enExample)
LU (1) LU74795A1 (enExample)
MY (1) MY8100225A (enExample)
NL (1) NL167692C (enExample)
NO (1) NO146599C (enExample)
PH (1) PH12274A (enExample)
PL (1) PL99664B1 (enExample)
PT (1) PT65027B (enExample)
RO (1) RO73278A (enExample)
SE (1) SE421695B (enExample)
SU (1) SU638260A3 (enExample)
YU (1) YU100676A (enExample)
ZA (1) ZA762320B (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4091098A (en) * 1977-04-25 1978-05-23 Merck & Co., Inc. 3-(1-PIPERAZINYL)-1,2,4-BENZOTRIAZINES AND N-oxides
US4163849A (en) 1978-03-17 1979-08-07 Merck & Co., Inc. Piperazinylpyrazines
US4252816A (en) * 1979-12-03 1981-02-24 Merck & Co., Inc. Tetrahydro-1H-1,4-diazepino(1,7-a)benzimidazoles useful as analgesic agents
US4339579A (en) 1980-12-29 1982-07-13 American Home Products Corporation 2,6-Bis-(pyrrolopyrazinyl)pyrazines
EP0094498A3 (en) * 1982-05-06 1985-04-03 American Cyanamid Company Antiatherosclerotic 1-piperazine derivatives
US4547505A (en) * 1983-03-25 1985-10-15 Degussa Aktiengesellschaft N-Phenyl-N-'-cycloalkylalkanoylpiperazine useful as analgetics and process for its production
US4788290A (en) * 1987-12-11 1988-11-29 American Home Products Corporation Serotonergic pyrazine derivatives
EP0580465A1 (fr) * 1992-06-25 1994-01-26 Sanofi Nouvelle utilisation thérapeutique d'hétérocyclyl-pipérazines comme 5-HT3 agonistes et nouveaux dérivés
KR100607838B1 (ko) 1997-10-27 2006-08-04 뉴로서치 에이/에스 니코틴 작용성 아세틸콜린 수용체상의 콜린 작용성 리간드로서의 호모피페라진 유도체 및 이를 포함하는 약제학적 조성물
EP1175416B1 (en) 1999-04-26 2003-07-16 Neurosearch A/S Heteroaryl diazacycloalkanes, their preparation and use
ATE307121T1 (de) * 2000-02-16 2005-11-15 Neurogen Corp Substituierte arylpyrazine
US6825198B2 (en) * 2001-06-21 2004-11-30 Pfizer Inc 5-HT receptor ligands and uses thereof
DK1534391T3 (da) 2002-07-19 2007-06-11 Biovitrum Ab Nye piperazinyl-pyrazinonderivater til behandling af 5-HT2A-recptor-relaterede forstyrrelser
SE0202287D0 (sv) * 2002-07-19 2002-07-19 Biovitrum Ab New compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2606906A (en) * 1948-10-14 1952-08-12 American Cyanamid Co 1-(2-pyridyl) piperazine and process of preparing same

Also Published As

Publication number Publication date
NO146599B (no) 1982-07-26
CS195726B2 (en) 1980-02-29
DE2617205B2 (de) 1980-05-08
DD124599A5 (enExample) 1977-03-02
ZA762320B (en) 1977-11-30
NL167692B (nl) 1981-08-17
SE421695B (sv) 1982-01-25
MY8100225A (en) 1981-12-31
ES459406A1 (es) 1978-08-16
YU100676A (en) 1982-08-31
BE840904A (fr) 1976-08-16
JPS51136688A (en) 1976-11-26
RO73278A (ro) 1982-09-09
AT353795B (de) 1979-12-10
AU496854B2 (en) 1978-11-02
LU74795A1 (enExample) 1977-02-07
SU638260A3 (ru) 1978-12-15
ES459405A1 (es) 1978-08-16
SE7604093L (sv) 1976-10-22
NO761207L (enExample) 1976-10-22
AU1296676A (en) 1977-10-20
ATA288376A (de) 1979-05-15
FR2308367A1 (fr) 1976-11-19
ES447150A1 (es) 1977-09-16
FI62666C (fi) 1983-02-10
PH12274A (en) 1978-12-12
NL167692C (nl) 1982-01-18
CA1059128A (en) 1979-07-24
PT65027A (en) 1976-05-01
HU172684B (hu) 1978-11-28
DE2617205C3 (de) 1981-01-29
DE2617205A1 (de) 1976-10-28
NO146599C (no) 1982-11-03
BG34185A3 (bg) 1983-07-15
JPS5522475B2 (enExample) 1980-06-17
IL49391A (en) 1979-09-30
PL99664B1 (pl) 1978-07-31
NL7603800A (nl) 1976-10-25
DK143899B (da) 1981-10-26
IE42979L (en) 1976-10-21
GR59900B (en) 1978-03-16
FI760978A7 (enExample) 1976-10-22
EG12387A (en) 1978-12-31
CY1090A (en) 1980-12-27
HK60380A (en) 1980-11-07
IL49391A0 (en) 1976-06-30
DK164476A (da) 1976-10-22
FI62666B (fi) 1982-10-29
KE3088A (en) 1980-11-07
AR210349A1 (es) 1977-07-29
CH619462A5 (en) 1980-09-30
IE42979B1 (en) 1980-11-19
DK143899C (da) 1982-04-13
GB1492528A (en) 1977-11-23
ES459407A1 (es) 1978-08-16
PT65027B (en) 1978-04-03

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Legal Events

Date Code Title Description
ST Notification of lapse