FR2100822A1 - N-heterocyclyl)-alkyl-thioureas-selective antihistamines - Google Patents
N-heterocyclyl)-alkyl-thioureas-selective antihistaminesInfo
- Publication number
- FR2100822A1 FR2100822A1 FR7122512A FR7122512A FR2100822A1 FR 2100822 A1 FR2100822 A1 FR 2100822A1 FR 7122512 A FR7122512 A FR 7122512A FR 7122512 A FR7122512 A FR 7122512A FR 2100822 A1 FR2100822 A1 FR 2100822A1
- Authority
- FR
- France
- Prior art keywords
- alkyl
- thioureas
- heterocyclyl
- imidazolyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940125715 antihistaminic agent Drugs 0.000 title abstract 2
- 239000000739 antihistaminic agent Substances 0.000 title abstract 2
- -1 4-bromo-5-imidazolyl Chemical group 0.000 abstract 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- SBPIDKODQVLBGV-UHFFFAOYSA-N 1h-imidazole;pyridine Chemical compound C1=CNC=N1.C1=CC=NC=C1 SBPIDKODQVLBGV-UHFFFAOYSA-N 0.000 abstract 1
- NSPMIYGKQJPBQR-UHFFFAOYSA-N 4H-1,2,4-triazole Chemical compound C=1N=CNN=1 NSPMIYGKQJPBQR-UHFFFAOYSA-N 0.000 abstract 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229960001340 histamine Drugs 0.000 abstract 1
- 239000008024 pharmaceutical diluent Substances 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
- 150000003585 thioureas Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/68—Halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Tires In General (AREA)
- Pyridine Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3083470 | 1970-06-25 | ||
| GB4900770 | 1970-10-15 | ||
| GB291871 | 1971-01-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2100822A1 true FR2100822A1 (en) | 1972-03-24 |
| FR2100822B1 FR2100822B1 (OSRAM) | 1974-11-15 |
Family
ID=27254147
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7122512A Granted FR2100822A1 (en) | 1970-06-25 | 1971-06-21 | N-heterocyclyl)-alkyl-thioureas-selective antihistamines |
Country Status (13)
| Country | Link |
|---|---|
| JP (1) | JPS5738583B1 (OSRAM) |
| BE (1) | BE768474A (OSRAM) |
| CA (1) | CA938556A (OSRAM) |
| CH (1) | CH551409A (OSRAM) |
| DE (1) | DE2131625A1 (OSRAM) |
| ES (1) | ES392628A2 (OSRAM) |
| FR (1) | FR2100822A1 (OSRAM) |
| HK (1) | HK55076A (OSRAM) |
| IE (1) | IE35505B1 (OSRAM) |
| IL (1) | IL36980A (OSRAM) |
| KE (1) | KE2624A (OSRAM) |
| NL (1) | NL7108585A (OSRAM) |
| PH (1) | PH11791A (OSRAM) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2319341A1 (fr) * | 1975-07-31 | 1977-02-25 | Smith Kline French Lab | Nouvelles guanidines ou thiourees, leur procede de preparation et leur application |
| FR2500828A1 (fr) * | 1981-02-27 | 1982-09-03 | Heumann Ludwig & Co Gmbh | Derives de 4-(5)-alkylmercaptoimidazole, procede de preparation de ceux-ci et medicaments les contenant |
| FR2686084A1 (fr) * | 1992-01-10 | 1993-07-16 | Bioprojet Soc Civ | Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques. |
| USRE37303E1 (en) * | 1992-01-10 | 2001-07-31 | Institut National Del La Sante Et De La Recherche Medicale | Imidazole compounds and their therapeutic applications |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995006037A1 (en) * | 1993-08-27 | 1995-03-02 | Vrije Universiteit | New imidazole derivatives having agonistic or antagonistic activity on the histamine h3 receptor |
| NL9302045A (nl) * | 1993-08-27 | 1995-03-16 | Vrije Universiteit | Nieuwe imidazoolafgeleide met agonistische of antagonistische activiteit op de histamine H3-receptor. |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2052692A1 (de) * | 1969-10-29 | 1971-05-06 | Smith Kline and French Laboratories Ltd , Welwyn Garden City, Hertford (Großbritannien) | Isothioharnstoffverbmdungen, ihre Salze mit Sauren, Verfahren zu ihrer Her stellung und ihre Verwendung zur Her stellung von Arzneimitteln |
-
1971
- 1971-06-01 CA CA114497A patent/CA938556A/en not_active Expired
- 1971-06-03 IE IE714/71A patent/IE35505B1/xx unknown
- 1971-06-03 IL IL36980A patent/IL36980A/xx unknown
- 1971-06-04 PH PH12587A patent/PH11791A/en unknown
- 1971-06-14 BE BE768474A patent/BE768474A/xx not_active IP Right Cessation
- 1971-06-21 FR FR7122512A patent/FR2100822A1/fr active Granted
- 1971-06-22 NL NL7108585A patent/NL7108585A/xx not_active Application Discontinuation
- 1971-06-24 CH CH928871A patent/CH551409A/fr not_active IP Right Cessation
- 1971-06-25 DE DE19712131625 patent/DE2131625A1/de not_active Withdrawn
- 1971-06-25 JP JP4675871A patent/JPS5738583B1/ja active Pending
- 1971-06-25 ES ES392628A patent/ES392628A2/es not_active Expired
-
1976
- 1976-05-18 KE KE2624*UA patent/KE2624A/xx unknown
- 1976-09-08 HK HK550/76*UA patent/HK55076A/xx unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2052692A1 (de) * | 1969-10-29 | 1971-05-06 | Smith Kline and French Laboratories Ltd , Welwyn Garden City, Hertford (Großbritannien) | Isothioharnstoffverbmdungen, ihre Salze mit Sauren, Verfahren zu ihrer Her stellung und ihre Verwendung zur Her stellung von Arzneimitteln |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2319341A1 (fr) * | 1975-07-31 | 1977-02-25 | Smith Kline French Lab | Nouvelles guanidines ou thiourees, leur procede de preparation et leur application |
| FR2500828A1 (fr) * | 1981-02-27 | 1982-09-03 | Heumann Ludwig & Co Gmbh | Derives de 4-(5)-alkylmercaptoimidazole, procede de preparation de ceux-ci et medicaments les contenant |
| FR2686084A1 (fr) * | 1992-01-10 | 1993-07-16 | Bioprojet Soc Civ | Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques. |
| WO1993014070A3 (fr) * | 1992-01-10 | 1993-08-19 | Inst Nat Sante Rech Med | Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques |
| US5559113A (en) * | 1992-01-10 | 1996-09-24 | Institut National De La Sante Et De La Recherche Medicale | Imidazole compounds and their therapeutic applications |
| US5708171A (en) * | 1992-01-10 | 1998-01-13 | Institut National De La Sante Et De La Recherche Medicale | Imidazole derivatives for pharmaceutical use |
| USRE37303E1 (en) * | 1992-01-10 | 2001-07-31 | Institut National Del La Sante Et De La Recherche Medicale | Imidazole compounds and their therapeutic applications |
Also Published As
| Publication number | Publication date |
|---|---|
| KE2624A (en) | 1976-05-28 |
| CH551409A (fr) | 1974-07-15 |
| NL7108585A (OSRAM) | 1971-12-28 |
| CA938556A (en) | 1973-12-18 |
| IE35505L (en) | 1971-12-25 |
| ES392628A2 (es) | 1975-07-16 |
| HK55076A (en) | 1976-09-17 |
| IE35505B1 (en) | 1976-03-03 |
| PH11791A (en) | 1978-07-05 |
| IL36980A0 (en) | 1971-08-25 |
| BE768474A (fr) | 1971-12-14 |
| JPS5738583B1 (OSRAM) | 1982-08-16 |
| DE2131625A1 (de) | 1971-12-30 |
| FR2100822B1 (OSRAM) | 1974-11-15 |
| IL36980A (en) | 1978-07-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |