FR2100822A1 - N-heterocyclyl)-alkyl-thioureas-selective antihistamines - Google Patents

N-heterocyclyl)-alkyl-thioureas-selective antihistamines

Info

Publication number
FR2100822A1
FR2100822A1 FR7122512A FR7122512A FR2100822A1 FR 2100822 A1 FR2100822 A1 FR 2100822A1 FR 7122512 A FR7122512 A FR 7122512A FR 7122512 A FR7122512 A FR 7122512A FR 2100822 A1 FR2100822 A1 FR 2100822A1
Authority
FR
France
Prior art keywords
alkyl
thioureas
heterocyclyl
imidazolyl
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7122512A
Other languages
English (en)
Other versions
FR2100822B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
GlaxoSmithKline LLC
Original Assignee
Smith Kline and French Laboratories Ltd
GlaxoSmithKline LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline and French Laboratories Ltd, GlaxoSmithKline LLC filed Critical Smith Kline and French Laboratories Ltd
Publication of FR2100822A1 publication Critical patent/FR2100822A1/fr
Application granted granted Critical
Publication of FR2100822B1 publication Critical patent/FR2100822B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/68—Halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
FR7122512A 1970-06-25 1971-06-21 N-heterocyclyl)-alkyl-thioureas-selective antihistamines Granted FR2100822A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB3083470 1970-06-25
GB4900770 1970-10-15
GB291871 1971-01-22

Publications (2)

Publication Number Publication Date
FR2100822A1 true FR2100822A1 (en) 1972-03-24
FR2100822B1 FR2100822B1 (fr) 1974-11-15

Family

ID=27254147

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7122512A Granted FR2100822A1 (en) 1970-06-25 1971-06-21 N-heterocyclyl)-alkyl-thioureas-selective antihistamines

Country Status (13)

Country Link
JP (1) JPS5738583B1 (fr)
BE (1) BE768474A (fr)
CA (1) CA938556A (fr)
CH (1) CH551409A (fr)
DE (1) DE2131625A1 (fr)
ES (1) ES392628A2 (fr)
FR (1) FR2100822A1 (fr)
HK (1) HK55076A (fr)
IE (1) IE35505B1 (fr)
IL (1) IL36980A (fr)
KE (1) KE2624A (fr)
NL (1) NL7108585A (fr)
PH (1) PH11791A (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2319341A1 (fr) * 1975-07-31 1977-02-25 Smith Kline French Lab Nouvelles guanidines ou thiourees, leur procede de preparation et leur application
FR2500828A1 (fr) * 1981-02-27 1982-09-03 Heumann Ludwig & Co Gmbh Derives de 4-(5)-alkylmercaptoimidazole, procede de preparation de ceux-ci et medicaments les contenant
FR2686084A1 (fr) * 1992-01-10 1993-07-16 Bioprojet Soc Civ Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques.
USRE37303E1 (en) * 1992-01-10 2001-07-31 Institut National Del La Sante Et De La Recherche Medicale Imidazole compounds and their therapeutic applications

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL9302045A (nl) * 1993-08-27 1995-03-16 Vrije Universiteit Nieuwe imidazoolafgeleide met agonistische of antagonistische activiteit op de histamine H3-receptor.
AU7823894A (en) * 1993-08-27 1995-03-21 Vrije Universiteit New imidazole derivatives having agonistic or antagonistic activity on the histamine h3 receptor

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2052692A1 (de) * 1969-10-29 1971-05-06 Smith Kline and French Laboratories Ltd , Welwyn Garden City, Hertford (Großbritannien) Isothioharnstoffverbmdungen, ihre Salze mit Sauren, Verfahren zu ihrer Her stellung und ihre Verwendung zur Her stellung von Arzneimitteln

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2052692A1 (de) * 1969-10-29 1971-05-06 Smith Kline and French Laboratories Ltd , Welwyn Garden City, Hertford (Großbritannien) Isothioharnstoffverbmdungen, ihre Salze mit Sauren, Verfahren zu ihrer Her stellung und ihre Verwendung zur Her stellung von Arzneimitteln

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2319341A1 (fr) * 1975-07-31 1977-02-25 Smith Kline French Lab Nouvelles guanidines ou thiourees, leur procede de preparation et leur application
FR2500828A1 (fr) * 1981-02-27 1982-09-03 Heumann Ludwig & Co Gmbh Derives de 4-(5)-alkylmercaptoimidazole, procede de preparation de ceux-ci et medicaments les contenant
FR2686084A1 (fr) * 1992-01-10 1993-07-16 Bioprojet Soc Civ Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques.
WO1993014070A2 (fr) * 1992-01-10 1993-07-22 Institut National De La Sante Et De La Recherche Medicale Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques
WO1993014070A3 (fr) * 1992-01-10 1993-08-19 Inst Nat Sante Rech Med Nouveaux derives de l'imidazole, leur preparation et leurs applications therapeutiques
US5559113A (en) * 1992-01-10 1996-09-24 Institut National De La Sante Et De La Recherche Medicale Imidazole compounds and their therapeutic applications
US5708171A (en) * 1992-01-10 1998-01-13 Institut National De La Sante Et De La Recherche Medicale Imidazole derivatives for pharmaceutical use
USRE37303E1 (en) * 1992-01-10 2001-07-31 Institut National Del La Sante Et De La Recherche Medicale Imidazole compounds and their therapeutic applications

Also Published As

Publication number Publication date
CA938556A (en) 1973-12-18
CH551409A (fr) 1974-07-15
IL36980A (en) 1978-07-31
BE768474A (fr) 1971-12-14
FR2100822B1 (fr) 1974-11-15
HK55076A (en) 1976-09-17
JPS5738583B1 (fr) 1982-08-16
IL36980A0 (en) 1971-08-25
NL7108585A (fr) 1971-12-28
ES392628A2 (es) 1975-07-16
IE35505L (en) 1971-12-25
DE2131625A1 (de) 1971-12-30
IE35505B1 (en) 1976-03-03
KE2624A (en) 1976-05-28
PH11791A (en) 1978-07-05

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