FR2139740A1 - 1-amino-3-methyl-3-phenoxy-2-butanols - inhibitors of platelet stickiness for treatment of thrombosis - Google Patents

1-amino-3-methyl-3-phenoxy-2-butanols - inhibitors of platelet stickiness for treatment of thrombosis

Info

Publication number
FR2139740A1
FR2139740A1 FR7120094A FR7120094A FR2139740A1 FR 2139740 A1 FR2139740 A1 FR 2139740A1 FR 7120094 A FR7120094 A FR 7120094A FR 7120094 A FR7120094 A FR 7120094A FR 2139740 A1 FR2139740 A1 FR 2139740A1
Authority
FR
France
Prior art keywords
butanols
thrombosis
phenoxy
inhibitors
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7120094A
Other languages
French (fr)
Other versions
FR2139740B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to FR7120094A priority Critical patent/FR2139740A1/en
Publication of FR2139740A1 publication Critical patent/FR2139740A1/en
Application granted granted Critical
Publication of FR2139740B1 publication Critical patent/FR2139740B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cpds. are of formula:- and their acid-addition salts; R1 = H, Cl, Br, I, trihalomethyl, alkyl (1-4C) alkoxy alkyl (1-4C); R2 = H, alkyl (1-6C); R3 = alkyl (1-6C) dialkylamino (alkyls have 1-4C), opt. substd. phenyl, cycloalkyl (3-7C); or R2 + R3 + the attached N-atom form an opt. substd. heterocyclic ring, opt. contng. another heteroatom. They are prepd. from cpds. of formula:- which are converted to an epoxy cpd. and reacted with an amine: R3R2NH.
FR7120094A 1971-06-03 1971-06-03 1-amino-3-methyl-3-phenoxy-2-butanols - inhibitors of platelet stickiness for treatment of thrombosis Granted FR2139740A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7120094A FR2139740A1 (en) 1971-06-03 1971-06-03 1-amino-3-methyl-3-phenoxy-2-butanols - inhibitors of platelet stickiness for treatment of thrombosis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7120094A FR2139740A1 (en) 1971-06-03 1971-06-03 1-amino-3-methyl-3-phenoxy-2-butanols - inhibitors of platelet stickiness for treatment of thrombosis

Publications (2)

Publication Number Publication Date
FR2139740A1 true FR2139740A1 (en) 1973-01-12
FR2139740B1 FR2139740B1 (en) 1974-08-30

Family

ID=9078042

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7120094A Granted FR2139740A1 (en) 1971-06-03 1971-06-03 1-amino-3-methyl-3-phenoxy-2-butanols - inhibitors of platelet stickiness for treatment of thrombosis

Country Status (1)

Country Link
FR (1) FR2139740A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0082461A2 (en) * 1981-12-23 1983-06-29 Beiersdorf Aktiengesellschaft Substituted phenoxyalkanol amines and phenoxyalkanol-cycloalkyl amines, process for their preparation, pharmaceutical compositions containing them and intermediates
CN104066725A (en) * 2011-11-25 2014-09-24 拜耳知识产权有限责任公司 Novel heterocyclic alkanol-derivatives

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0082461A2 (en) * 1981-12-23 1983-06-29 Beiersdorf Aktiengesellschaft Substituted phenoxyalkanol amines and phenoxyalkanol-cycloalkyl amines, process for their preparation, pharmaceutical compositions containing them and intermediates
EP0082461A3 (en) * 1981-12-23 1983-09-28 Beiersdorf Aktiengesellschaft Substituted phenoxyalkanol amines and phenoxyalkanol-cycloalkyl amines, process for their preparation, pharmaceutical compositions containing them and intermediates
US4864061A (en) * 1981-12-23 1989-09-05 Beiersdorf Aktiengesellschaft Substituted phenoxyalkanolamines and phenoxyalkanol-cycloalkylamines, and intermediate products
US4871775A (en) * 1981-12-23 1989-10-03 Beiersdorf Ag Substituted phenoxyalkanolamies and phenoxyalkanol-cycloalkylamines in pharmaceutical formulations and use thereof
CN104066725A (en) * 2011-11-25 2014-09-24 拜耳知识产权有限责任公司 Novel heterocyclic alkanol-derivatives

Also Published As

Publication number Publication date
FR2139740B1 (en) 1974-08-30

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Legal Events

Date Code Title Description
ST Notification of lapse