FR2102221A1 - 4-amino-(2-(5-nitro-2-furyl) vinyl)-quinazolines - antimicrobial gastrointestinal sterilisation agents - Google Patents

4-amino-(2-(5-nitro-2-furyl) vinyl)-quinazolines - antimicrobial gastrointestinal sterilisation agents

Info

Publication number
FR2102221A1
FR2102221A1 FR7129610A FR7129610A FR2102221A1 FR 2102221 A1 FR2102221 A1 FR 2102221A1 FR 7129610 A FR7129610 A FR 7129610A FR 7129610 A FR7129610 A FR 7129610A FR 2102221 A1 FR2102221 A1 FR 2102221A1
Authority
FR
France
Prior art keywords
lower alkyl
nitro
antimicrobial
quinazolines
furyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7129610A
Other languages
French (fr)
Other versions
FR2102221B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of FR2102221A1 publication Critical patent/FR2102221A1/en
Application granted granted Critical
Publication of FR2102221B1 publication Critical patent/FR2102221B1/fr
Granted legal-status Critical Current

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  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cpds. of general formula (I) : (where R is H, halogen or nitro; R1 and R2 are each H, lower alkyl (max. 7C) or hydroxy-lower alkyl, or form together with N a 5-7 membered monocyclic, heterocyclic ring system (max. 18 atoms, excepting H) opt. substd. with one or two lower alkyl, lower alkoxy, hydroxy-6ower alkyl or alkanoyloxy-lower alkyl). (I) have antimicrobial activity and may be used against mammalian infections caused by e.g. T. vaginalis, T. foetus, Staph. aureus, Salm. schottmuelleri, E. coli, etc. (I) do not adsorb well int the gastro-intestinal tract and may therefore be used as G.I-sterilising agents or against infections of the G.I.-tract.
FR7129610A 1970-08-12 1971-08-12 4-amino-(2-(5-nitro-2-furyl) vinyl)-quinazolines - antimicrobial gastrointestinal sterilisation agents Granted FR2102221A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6332770A 1970-08-12 1970-08-12

Publications (2)

Publication Number Publication Date
FR2102221A1 true FR2102221A1 (en) 1972-04-07
FR2102221B1 FR2102221B1 (en) 1975-02-07

Family

ID=22048454

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7129610A Granted FR2102221A1 (en) 1970-08-12 1971-08-12 4-amino-(2-(5-nitro-2-furyl) vinyl)-quinazolines - antimicrobial gastrointestinal sterilisation agents

Country Status (3)

Country Link
CH (1) CH529781A (en)
DE (1) DE2140280A1 (en)
FR (1) FR2102221A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0579496A1 (en) * 1992-07-15 1994-01-19 Ono Pharmaceutical Co., Ltd. 4-Aminoquinazoline derivatives, and their use as medicine

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU763345A1 (en) * 1977-09-09 1980-09-15 Ордена Трудового Красного Знамени Институт Органического Синтеза Ан Латвийской Сср Substituted amides of 2-/2'(5"-nitrofuryl-2")-vinyl-and 4-(5"-nitrofuryl-2")-1,3-butadienyl/-quinoline-4-carboxylic acidsor their water-soluble salts possessing antiblastic activity
US7220751B2 (en) * 2000-11-02 2007-05-22 Nippon Shinyaku Co., Ltd. Quinazoline derivatives and drugs
US7829566B2 (en) 2001-09-17 2010-11-09 Werner Mederski 4-amino-quinazolines
WO2005014585A1 (en) 2003-08-08 2005-02-17 Ulysses Pharmaceutical Products Inc. Halogenated quinazolinyl nitrofurans as antibacterial agents
WO2006032138A1 (en) * 2004-09-23 2006-03-30 Ulysses Pharmaceutical Products Inc. Carbo- and hetero-cyclic antibiotics and use thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0579496A1 (en) * 1992-07-15 1994-01-19 Ono Pharmaceutical Co., Ltd. 4-Aminoquinazoline derivatives, and their use as medicine
US5436233A (en) * 1992-07-15 1995-07-25 Ono Pharmaceutical Co., Ltd. 4-aminoquinazoline derivatives

Also Published As

Publication number Publication date
FR2102221B1 (en) 1975-02-07
DE2140280A1 (en) 1972-02-17
CH529781A (en) 1972-10-31

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