FR2201885A1 - 4-Aryl carbonyl methyl pyrimidine oxime carbamates - prepd. by treatment of the oxime with an isocyanate, used as sedatives, analgesics, vasodilators, diuretics - Google Patents

4-Aryl carbonyl methyl pyrimidine oxime carbamates - prepd. by treatment of the oxime with an isocyanate, used as sedatives, analgesics, vasodilators, diuretics

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Publication number
FR2201885A1
FR2201885A1 FR7235860A FR7235860A FR2201885A1 FR 2201885 A1 FR2201885 A1 FR 2201885A1 FR 7235860 A FR7235860 A FR 7235860A FR 7235860 A FR7235860 A FR 7235860A FR 2201885 A1 FR2201885 A1 FR 2201885A1
Authority
FR
France
Prior art keywords
oxime
prepd
sedatives
vasodilators
diuretics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7235860A
Other languages
French (fr)
Other versions
FR2201885B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delalande SA filed Critical Delalande SA
Priority to FR7235860A priority Critical patent/FR2201885A1/en
Publication of FR2201885A1 publication Critical patent/FR2201885A1/en
Application granted granted Critical
Publication of FR2201885B1 publication Critical patent/FR2201885B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Title cpds. of formula (I): (where X=N-CONHR; R=1-3C alkyl, opt. unsatd. (chloro) phenyl or methoxyphenyl; and R1 = H or Cl) are prepd. by reacting a cpd. of formula (II) (I; X = O) with an excess of NH2OH in the presence of methanol, and then reacting the prod. (III) (I; X = N-OH) with O=C=N-R in the presence of chloroform. (I) may be administered orally (25-250 mg, 1-5 times daily) or rectally (25-250 mg, 1-2 times daily).
FR7235860A 1972-10-10 1972-10-10 4-Aryl carbonyl methyl pyrimidine oxime carbamates - prepd. by treatment of the oxime with an isocyanate, used as sedatives, analgesics, vasodilators, diuretics Granted FR2201885A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7235860A FR2201885A1 (en) 1972-10-10 1972-10-10 4-Aryl carbonyl methyl pyrimidine oxime carbamates - prepd. by treatment of the oxime with an isocyanate, used as sedatives, analgesics, vasodilators, diuretics

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7235860A FR2201885A1 (en) 1972-10-10 1972-10-10 4-Aryl carbonyl methyl pyrimidine oxime carbamates - prepd. by treatment of the oxime with an isocyanate, used as sedatives, analgesics, vasodilators, diuretics

Publications (2)

Publication Number Publication Date
FR2201885A1 true FR2201885A1 (en) 1974-05-03
FR2201885B1 FR2201885B1 (en) 1975-10-31

Family

ID=9105427

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7235860A Granted FR2201885A1 (en) 1972-10-10 1972-10-10 4-Aryl carbonyl methyl pyrimidine oxime carbamates - prepd. by treatment of the oxime with an isocyanate, used as sedatives, analgesics, vasodilators, diuretics

Country Status (1)

Country Link
FR (1) FR2201885A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0470805A1 (en) * 1990-08-08 1992-02-12 American Home Products Corporation Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents
EP1103553A2 (en) * 1999-11-23 2001-05-30 Pfizer Products Inc. Substituted heterocyclic derivatives

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2077856A1 (en) * 1970-02-19 1971-11-05 Delalande Sa 4-phenylcarbonylmethyl pyrimidines - with analgesic antiinflammatory,hypotensive and spasmolytic activity

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2077856A1 (en) * 1970-02-19 1971-11-05 Delalande Sa 4-phenylcarbonylmethyl pyrimidines - with analgesic antiinflammatory,hypotensive and spasmolytic activity

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0470805A1 (en) * 1990-08-08 1992-02-12 American Home Products Corporation Oxime-carbamates and oxime-carbonates as bronchodilators and anti-inflammatory agents
EP1103553A2 (en) * 1999-11-23 2001-05-30 Pfizer Products Inc. Substituted heterocyclic derivatives
EP1103553A3 (en) * 1999-11-23 2001-08-01 Pfizer Products Inc. Substituted heterocyclic derivatives

Also Published As

Publication number Publication date
FR2201885B1 (en) 1975-10-31

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