FR2235685A1 - 1-Amino alkyl-3,3-diphenyl-2-pyrrolidinones - useful as coronary dilators, anti histamines choleretics etc. - Google Patents
1-Amino alkyl-3,3-diphenyl-2-pyrrolidinones - useful as coronary dilators, anti histamines choleretics etc.Info
- Publication number
- FR2235685A1 FR2235685A1 FR7322419A FR7322419A FR2235685A1 FR 2235685 A1 FR2235685 A1 FR 2235685A1 FR 7322419 A FR7322419 A FR 7322419A FR 7322419 A FR7322419 A FR 7322419A FR 2235685 A1 FR2235685 A1 FR 2235685A1
- Authority
- FR
- France
- Prior art keywords
- diphenyl
- useful
- choleretics
- pyrrolidinones
- coronary dilators
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/267—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
Substd. 3, 3-diphenyl-2-pyrrolidone of formula (I) or its salt: (where X = phenyl; n = 0, 1 or 2; R1 = H or 1-3C alkyl; R2 and R3 = H, alkyl, hydroxyalkyl, or aralkyl or together with the N atom form a heterocycle which may contain another heteroatom), is useful as analgesics, spasmolytics, vasodilators, coronary dilators etc. (I) is prepd. by treatment at 150-240 degrees C of alpha, alpha-diphenyl gamma-butyrolactone with 1.5-3 times the stoichiometric quantity of (II).
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7322419A FR2235685A1 (en) | 1973-06-20 | 1973-06-20 | 1-Amino alkyl-3,3-diphenyl-2-pyrrolidinones - useful as coronary dilators, anti histamines choleretics etc. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7322419A FR2235685A1 (en) | 1973-06-20 | 1973-06-20 | 1-Amino alkyl-3,3-diphenyl-2-pyrrolidinones - useful as coronary dilators, anti histamines choleretics etc. |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2235685A1 true FR2235685A1 (en) | 1975-01-31 |
FR2235685B1 FR2235685B1 (en) | 1976-09-03 |
Family
ID=9121228
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7322419A Granted FR2235685A1 (en) | 1973-06-20 | 1973-06-20 | 1-Amino alkyl-3,3-diphenyl-2-pyrrolidinones - useful as coronary dilators, anti histamines choleretics etc. |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2235685A1 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2333792A1 (en) * | 1975-09-23 | 1977-07-01 | Robins Co Inc A H | 4-HYDROXYMETHYL-2-PYRROLIDINONES AND THEIR PREPARATION PROCESS |
WO1995023135A1 (en) * | 1991-03-07 | 1995-08-31 | Fisons Corporation | Diphenyl-2-piperidinone and -2-pyrrolidinone derivatives having anti-convulsant and neuroprotective activity |
-
1973
- 1973-06-20 FR FR7322419A patent/FR2235685A1/en active Granted
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2333792A1 (en) * | 1975-09-23 | 1977-07-01 | Robins Co Inc A H | 4-HYDROXYMETHYL-2-PYRROLIDINONES AND THEIR PREPARATION PROCESS |
WO1995023135A1 (en) * | 1991-03-07 | 1995-08-31 | Fisons Corporation | Diphenyl-2-piperidinone and -2-pyrrolidinone derivatives having anti-convulsant and neuroprotective activity |
Also Published As
Publication number | Publication date |
---|---|
FR2235685B1 (en) | 1976-09-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
TP | Transmission of property | ||
ST | Notification of lapse |