FR2150853A1 - 5,7-dimorpholino-pyrimido (4,5-d) pyrimidine derivs - diuretics - Google Patents

5,7-dimorpholino-pyrimido (4,5-d) pyrimidine derivs - diuretics

Info

Publication number
FR2150853A1
FR2150853A1 FR7230249A FR7230249A FR2150853A1 FR 2150853 A1 FR2150853 A1 FR 2150853A1 FR 7230249 A FR7230249 A FR 7230249A FR 7230249 A FR7230249 A FR 7230249A FR 2150853 A1 FR2150853 A1 FR 2150853A1
Authority
FR
France
Prior art keywords
dimorpholino
pyrimido
diuretics
pyrimidine derivs
derivs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7230249A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of FR2150853A1 publication Critical patent/FR2150853A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

The novel title cpds. of formula: (where R1, R2, R3 and R4 are independently H or lower alkyl), are prepd. by condensing 2-phenyl-5,7-dihalopyrimido-/4,5-d/pyrimidines (also claimed as new) with opt. substd. morpholines. They have low toxicity, and may be administered orally or parenterally in daily doses of 50-300 mg.
FR7230249A 1971-08-28 1972-08-24 5,7-dimorpholino-pyrimido (4,5-d) pyrimidine derivs - diuretics Withdrawn FR2150853A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6610371A JPS4832899A (en) 1971-08-28 1971-08-28

Publications (1)

Publication Number Publication Date
FR2150853A1 true FR2150853A1 (en) 1973-04-13

Family

ID=13306201

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7230249A Withdrawn FR2150853A1 (en) 1971-08-28 1972-08-24 5,7-dimorpholino-pyrimido (4,5-d) pyrimidine derivs - diuretics

Country Status (6)

Country Link
JP (1) JPS4832899A (en)
AU (1) AU4579072A (en)
BE (1) BE787950A (en)
DE (1) DE2242162A1 (en)
FR (1) FR2150853A1 (en)
NL (1) NL7211728A (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60226882A (en) * 1984-04-24 1985-11-12 Nippon Zoki Pharmaceut Co Ltd Novel pyrimidopyrimidine derivative
ES2648388T3 (en) 2006-08-23 2018-01-02 Kudos Pharmaceuticals Limited Derivatives of 2-methylmorpholin pyrido-, pyrazo- and pyrimido-pyrimidine as mTOR inhibitors
PE20090695A1 (en) * 2007-04-13 2009-06-27 Schering Corp PYRIMIDINDIONE DERIVATIVES AS AGONISTS OF THE NICOTINIC ACID RECEPTOR

Also Published As

Publication number Publication date
JPS4832899A (en) 1973-05-02
DE2242162A1 (en) 1973-03-08
BE787950A (en) 1972-12-18
AU4579072A (en) 1974-02-28
NL7211728A (en) 1973-03-02

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Legal Events

Date Code Title Description
ST Notification of lapse