FR2077856A1 - 4-phenylcarbonylmethyl pyrimidines - with analgesic antiinflammatory,hypotensive and spasmolytic activity - Google Patents

4-phenylcarbonylmethyl pyrimidines - with analgesic antiinflammatory,hypotensive and spasmolytic activity

Info

Publication number
FR2077856A1
FR2077856A1 FR7005886A FR7005886A FR2077856A1 FR 2077856 A1 FR2077856 A1 FR 2077856A1 FR 7005886 A FR7005886 A FR 7005886A FR 7005886 A FR7005886 A FR 7005886A FR 2077856 A1 FR2077856 A1 FR 2077856A1
Authority
FR
France
Prior art keywords
hypotensive
phenylcarbonylmethyl
pyrimidines
spasmolytic activity
analgesic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7005886A
Other languages
French (fr)
Other versions
FR2077856B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delalande SA filed Critical Delalande SA
Priority to FR7005886A priority Critical patent/FR2077856A1/en
Publication of FR2077856A1 publication Critical patent/FR2077856A1/en
Application granted granted Critical
Publication of FR2077856B1 publication Critical patent/FR2077856B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Abstract

Cpds. are of formula (I): (where R1, R2, R3 = H, halogen or 1-5C alkoxy). The cpds. have analgesic, anti-inflammatory, hypotensive and spasmolytic activity, and are prepd. by 4-methylpyrimidine with an ester of the appropriate benzoic acid in presence of sodamide. Oral LD50 in mice is 400-600 mg/kg. The clinical analgesic, anti-inflammatory dose is 10-250 mg/kg orally.
FR7005886A 1970-02-19 1970-02-19 4-phenylcarbonylmethyl pyrimidines - with analgesic antiinflammatory,hypotensive and spasmolytic activity Granted FR2077856A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7005886A FR2077856A1 (en) 1970-02-19 1970-02-19 4-phenylcarbonylmethyl pyrimidines - with analgesic antiinflammatory,hypotensive and spasmolytic activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7005886A FR2077856A1 (en) 1970-02-19 1970-02-19 4-phenylcarbonylmethyl pyrimidines - with analgesic antiinflammatory,hypotensive and spasmolytic activity

Publications (2)

Publication Number Publication Date
FR2077856A1 true FR2077856A1 (en) 1971-11-05
FR2077856B1 FR2077856B1 (en) 1973-03-16

Family

ID=9050904

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7005886A Granted FR2077856A1 (en) 1970-02-19 1970-02-19 4-phenylcarbonylmethyl pyrimidines - with analgesic antiinflammatory,hypotensive and spasmolytic activity

Country Status (1)

Country Link
FR (1) FR2077856A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2201885A1 (en) * 1972-10-10 1974-05-03 Delalande Sa 4-Aryl carbonyl methyl pyrimidine oxime carbamates - prepd. by treatment of the oxime with an isocyanate, used as sedatives, analgesics, vasodilators, diuretics
FR2207918A1 (en) * 1972-11-03 1974-06-21 Sandoz Sa Naphthoquinone pigments and dispersion dyes - contg. s-triazinyl or pyrimidyl gps., for colouring polymers and synthetic fibres

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2487391A (en) * 1948-03-11 1949-11-08 American Cyanamid Co 2-phenacylpyrimidines and method of preparing the same

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2487391A (en) * 1948-03-11 1949-11-08 American Cyanamid Co 2-phenacylpyrimidines and method of preparing the same

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2201885A1 (en) * 1972-10-10 1974-05-03 Delalande Sa 4-Aryl carbonyl methyl pyrimidine oxime carbamates - prepd. by treatment of the oxime with an isocyanate, used as sedatives, analgesics, vasodilators, diuretics
FR2207918A1 (en) * 1972-11-03 1974-06-21 Sandoz Sa Naphthoquinone pigments and dispersion dyes - contg. s-triazinyl or pyrimidyl gps., for colouring polymers and synthetic fibres

Also Published As

Publication number Publication date
FR2077856B1 (en) 1973-03-16

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