NL7703682A - Antiinflammatory, analgesic alclofenac lysine salt - with improved bio-availability and suitable for admin. by injection - Google Patents
Antiinflammatory, analgesic alclofenac lysine salt - with improved bio-availability and suitable for admin. by injectionInfo
- Publication number
- NL7703682A NL7703682A NL7703682A NL7703682A NL7703682A NL 7703682 A NL7703682 A NL 7703682A NL 7703682 A NL7703682 A NL 7703682A NL 7703682 A NL7703682 A NL 7703682A NL 7703682 A NL7703682 A NL 7703682A
- Authority
- NL
- Netherlands
- Prior art keywords
- alclofenac
- analgesic
- lysine salt
- lysine
- injection
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
New lysine salt is lysine 4-allyloxy-3-chlorophenylacetate of formula (I): (I) is the lysine salt of the known anti-inflammatory agent and analgesic alclofenac. It has the advantage of solubility in water and biological fluids, and is particularly suitable for administration by intravenous or intramuscular injection. Its anti-inflammatory, analgesic and anti-pyretic activity is as good as or better than that of alcofenac itself, and absorption after oral or rectal administration is better than with alclofenac. In an example, (I) is prepd. by mixing a soln. of alclofenac (226.6g) in 25% EtOH (1200 ml) with a soln. of lysine (146g) in CO2-satd. water, leaving 24 hrs. at room temp., evaporating to small volume, and leaving 72 hrs. in an ice-bath to crystallise.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL7703682A NL7703682A (en) | 1977-04-05 | 1977-04-05 | Antiinflammatory, analgesic alclofenac lysine salt - with improved bio-availability and suitable for admin. by injection |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL7703682A NL7703682A (en) | 1977-04-05 | 1977-04-05 | Antiinflammatory, analgesic alclofenac lysine salt - with improved bio-availability and suitable for admin. by injection |
Publications (1)
Publication Number | Publication Date |
---|---|
NL7703682A true NL7703682A (en) | 1978-10-09 |
Family
ID=19828304
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NL7703682A NL7703682A (en) | 1977-04-05 | 1977-04-05 | Antiinflammatory, analgesic alclofenac lysine salt - with improved bio-availability and suitable for admin. by injection |
Country Status (1)
Country | Link |
---|---|
NL (1) | NL7703682A (en) |
-
1977
- 1977-04-05 NL NL7703682A patent/NL7703682A/en not_active Application Discontinuation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
BV | The patent application has lapsed |