NL7703682A - Antiinflammatory, analgesic alclofenac lysine salt - with improved bio-availability and suitable for admin. by injection - Google Patents

Antiinflammatory, analgesic alclofenac lysine salt - with improved bio-availability and suitable for admin. by injection

Info

Publication number
NL7703682A
NL7703682A NL7703682A NL7703682A NL7703682A NL 7703682 A NL7703682 A NL 7703682A NL 7703682 A NL7703682 A NL 7703682A NL 7703682 A NL7703682 A NL 7703682A NL 7703682 A NL7703682 A NL 7703682A
Authority
NL
Netherlands
Prior art keywords
alclofenac
analgesic
lysine salt
lysine
injection
Prior art date
Application number
NL7703682A
Other languages
Dutch (nl)
Original Assignee
Biochefarm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biochefarm filed Critical Biochefarm
Priority to NL7703682A priority Critical patent/NL7703682A/en
Publication of NL7703682A publication Critical patent/NL7703682A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

New lysine salt is lysine 4-allyloxy-3-chlorophenylacetate of formula (I): (I) is the lysine salt of the known anti-inflammatory agent and analgesic alclofenac. It has the advantage of solubility in water and biological fluids, and is particularly suitable for administration by intravenous or intramuscular injection. Its anti-inflammatory, analgesic and anti-pyretic activity is as good as or better than that of alcofenac itself, and absorption after oral or rectal administration is better than with alclofenac. In an example, (I) is prepd. by mixing a soln. of alclofenac (226.6g) in 25% EtOH (1200 ml) with a soln. of lysine (146g) in CO2-satd. water, leaving 24 hrs. at room temp., evaporating to small volume, and leaving 72 hrs. in an ice-bath to crystallise.
NL7703682A 1977-04-05 1977-04-05 Antiinflammatory, analgesic alclofenac lysine salt - with improved bio-availability and suitable for admin. by injection NL7703682A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NL7703682A NL7703682A (en) 1977-04-05 1977-04-05 Antiinflammatory, analgesic alclofenac lysine salt - with improved bio-availability and suitable for admin. by injection

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL7703682A NL7703682A (en) 1977-04-05 1977-04-05 Antiinflammatory, analgesic alclofenac lysine salt - with improved bio-availability and suitable for admin. by injection

Publications (1)

Publication Number Publication Date
NL7703682A true NL7703682A (en) 1978-10-09

Family

ID=19828304

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7703682A NL7703682A (en) 1977-04-05 1977-04-05 Antiinflammatory, analgesic alclofenac lysine salt - with improved bio-availability and suitable for admin. by injection

Country Status (1)

Country Link
NL (1) NL7703682A (en)

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Legal Events

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BV The patent application has lapsed