ES468133A1 - N-(2,3-dihydro-9-ergolen-8-ylmethyl) ureas - Google Patents
N-(2,3-dihydro-9-ergolen-8-ylmethyl) ureasInfo
- Publication number
- ES468133A1 ES468133A1 ES468133A ES468133A ES468133A1 ES 468133 A1 ES468133 A1 ES 468133A1 ES 468133 A ES468133 A ES 468133A ES 468133 A ES468133 A ES 468133A ES 468133 A1 ES468133 A1 ES 468133A1
- Authority
- ES
- Spain
- Prior art keywords
- ergolen
- ureas
- ylmethyl
- dihydro
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
A description is given of the preparation of ergolene derivatives with an action lowering blood pressure and the formula I < IMAGE > in which R1 and R2 are each hydrogen or an alkyl group with 1 to 4 carbon atoms, or else together form an alkylidene chain with a maximum of 5 carbon atoms, and their salts with acids. Corresponding compounds unsaturated in position 2,3 are reduced selectively in position 2,3 and the resulting compounds of the formula I are converted where appropriate into their acid addition salts.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH381477A CH628049A5 (en) | 1977-03-25 | 1977-03-25 | Process for the preparation of ergolene derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES468133A1 true ES468133A1 (en) | 1980-06-16 |
Family
ID=4264035
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES468133A Expired ES468133A1 (en) | 1977-03-25 | 1978-03-22 | N-(2,3-dihydro-9-ergolen-8-ylmethyl) ureas |
Country Status (20)
| Country | Link |
|---|---|
| JP (1) | JPS53119898A (en) |
| AT (1) | AT366685B (en) |
| AU (1) | AU520738B2 (en) |
| BE (1) | BE865267A (en) |
| CA (1) | CA1105009A (en) |
| CH (1) | CH628049A5 (en) |
| DE (1) | DE2810774A1 (en) |
| DK (1) | DK147072C (en) |
| ES (1) | ES468133A1 (en) |
| FI (1) | FI66375C (en) |
| GB (1) | GB1596210A (en) |
| IE (1) | IE46688B1 (en) |
| IL (1) | IL54342A (en) |
| IT (1) | IT1104183B (en) |
| NL (1) | NL7803031A (en) |
| NZ (1) | NZ186775A (en) |
| PT (1) | PT67816A (en) |
| SE (1) | SE7803040L (en) |
| SU (1) | SU1053755A3 (en) |
| ZA (1) | ZA781714B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3205169A1 (en) * | 1981-02-24 | 1982-10-14 | Sandoz-Patent-GmbH, 7850 Lörrach | NEW ERGOL DERIVATIVES, THEIR PRODUCTION AND THEIR PHARMACEUTICAL COMPOSITIONS |
| DE3411981A1 (en) * | 1984-03-28 | 1985-10-10 | Schering AG, Berlin und Bergkamen, 1000 Berlin | METHOD FOR PRODUCING 2.3-DIHYDROERGOLINES |
| GB2173189B (en) * | 1985-02-21 | 1988-04-27 | Maruko Pharmaceutical Co | Ergoline derivatives and salts thereof and pharmaceutical compositions thereof |
| US4798834A (en) * | 1987-08-31 | 1989-01-17 | Eli Lilly And Company | Optionally substituted (3β-9,10-didehydro-2,3-dihydro ergoline as serotonergic function enhancement |
-
1977
- 1977-03-25 CH CH381477A patent/CH628049A5/en not_active IP Right Cessation
-
1978
- 1978-03-13 DE DE19782810774 patent/DE2810774A1/en not_active Withdrawn
- 1978-03-16 FI FI780835A patent/FI66375C/en not_active IP Right Cessation
- 1978-03-16 SE SE7803040A patent/SE7803040L/en unknown
- 1978-03-16 DK DK119778A patent/DK147072C/en not_active IP Right Cessation
- 1978-03-21 GB GB11112/78A patent/GB1596210A/en not_active Expired
- 1978-03-21 NL NL7803031A patent/NL7803031A/en not_active Application Discontinuation
- 1978-03-22 ES ES468133A patent/ES468133A1/en not_active Expired
- 1978-03-23 IT IT48557/78A patent/IT1104183B/en active
- 1978-03-23 IL IL54342A patent/IL54342A/en unknown
- 1978-03-23 IE IE580/78A patent/IE46688B1/en unknown
- 1978-03-23 AU AU34483/78A patent/AU520738B2/en not_active Expired
- 1978-03-23 AT AT0207078A patent/AT366685B/en not_active IP Right Cessation
- 1978-03-23 BE BE186239A patent/BE865267A/en not_active IP Right Cessation
- 1978-03-23 CA CA299,678A patent/CA1105009A/en not_active Expired
- 1978-03-23 ZA ZA00781714A patent/ZA781714B/en unknown
- 1978-03-23 NZ NZ186775A patent/NZ186775A/en unknown
- 1978-03-23 PT PT67816A patent/PT67816A/en unknown
- 1978-03-24 SU SU782595601A patent/SU1053755A3/en active
- 1978-03-24 JP JP3316578A patent/JPS53119898A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| NZ186775A (en) | 1980-12-19 |
| DK119778A (en) | 1978-09-26 |
| DK147072C (en) | 1984-09-10 |
| IL54342A (en) | 1981-02-27 |
| DE2810774A1 (en) | 1978-10-05 |
| SE7803040L (en) | 1978-09-26 |
| ATA207078A (en) | 1981-09-15 |
| PT67816A (en) | 1978-04-01 |
| IL54342A0 (en) | 1978-06-15 |
| AT366685B (en) | 1982-04-26 |
| IT1104183B (en) | 1985-10-21 |
| DK147072B (en) | 1984-04-02 |
| NL7803031A (en) | 1978-09-27 |
| AU3448378A (en) | 1979-09-27 |
| IE780580L (en) | 1978-09-25 |
| FI780835A (en) | 1978-09-26 |
| FI66375C (en) | 1984-10-10 |
| GB1596210A (en) | 1981-08-19 |
| SU1053755A3 (en) | 1983-11-07 |
| AU520738B2 (en) | 1982-02-25 |
| FI66375B (en) | 1984-06-29 |
| IE46688B1 (en) | 1983-08-24 |
| ZA781714B (en) | 1979-11-28 |
| CA1105009A (en) | 1981-07-14 |
| BE865267A (en) | 1978-09-25 |
| JPS53119898A (en) | 1978-10-19 |
| CH628049A5 (en) | 1982-02-15 |
| IT7848557A0 (en) | 1978-03-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES433145A1 (en) | 4-Ureido-2-acyl phenoxypropanolamine | |
| ES456725A1 (en) | 4,5-Dichloroimidazole-2-carboxylic acid derivatives | |
| ES405983A1 (en) | N-fluoroalkylated phenylethylamine | |
| IE41440L (en) | Thiatetracyclines | |
| ES441591A1 (en) | 11-Aminoalkyl-pyridobenzodiazepinones and salts thereof | |
| ES474543A1 (en) | Propionic acid derivatives | |
| ES481551A1 (en) | Bis(aryloxy-alcanecarboxylic compounds, their preparation and their therapeutic use. | |
| ES468133A1 (en) | N-(2,3-dihydro-9-ergolen-8-ylmethyl) ureas | |
| IE42337L (en) | Pyrimidinylthionophosphonic acid esters--insecticides. | |
| AU3624089A (en) | Analgesic phenothiazine derivatives | |
| ES478643A1 (en) | Therapeutically useful N-phenylaniline derivatives | |
| AU1669288A (en) | Antidiabetic composition comprising 7-thiaprostaglandin e1 or its derivative | |
| ES8401761A1 (en) | 1-(3,4,5-Trimethoxycinnamoyl)-4-aminocarbonylethyl-substituted piperazine derivatives and a process for the preparation thereof. | |
| GB2001062A (en) | Preparation of Pyridinecarboxylic acid piperazides | |
| ES467237A1 (en) | Derivatives of cyclopropane | |
| AU6306886A (en) | Alkylcarboxamides of pyridylalkylamines, their preparation and their use in human and veterinary medicine | |
| US4027030A (en) | Certain thiazole-carboxamides and their pharmaceutical utility | |
| ES430900A1 (en) | Substituted indanones | |
| ES430420A1 (en) | Phenylpropanolamines | |
| ES449446A1 (en) | 1-Oxo-1H-6-piperidinopyrimido{8 1,2-a{9 quinoline-2-carboxylic acids and esters | |
| ES467519A1 (en) | Furoyl- and thenoyl-aryloxyalkyl carboxylic acid derivatives, their preparation and their use in therapy | |
| ES432562A1 (en) | O,S-Dialkyl-O-(2-cyanophenyl)-thionothiolphosphoric acid esters and insecticidal and acaricidal compositions and method | |
| GB1500973A (en) | Piperidine derivatives | |
| ES443309A1 (en) | O-Alkyl-N-subustituted-S-halophenoxymethyl-dithiophosphoric acid ester-amides | |
| ES462982A1 (en) | 8-azoprostanoic acid derivatives |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19990503 |