IE35505L - Heterocyclic thiourea derivatives. - Google Patents

Heterocyclic thiourea derivatives.

Info

Publication number
IE35505L
IE35505L IE710714A IE71471A IE35505L IE 35505 L IE35505 L IE 35505L IE 710714 A IE710714 A IE 710714A IE 71471 A IE71471 A IE 71471A IE 35505 L IE35505 L IE 35505L
Authority
IE
Ireland
Prior art keywords
imidazolyl
formula
lower alkyl
alkyl
thiourea derivatives
Prior art date
Application number
IE710714A
Other versions
IE35505B1 (en
Original Assignee
Smith Kline French Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline French Lab filed Critical Smith Kline French Lab
Publication of IE35505L publication Critical patent/IE35505L/en
Publication of IE35505B1 publication Critical patent/IE35505B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/68—Halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Tires In General (AREA)

Abstract

N-(heterocyclyl)-alkyl-thioureas-selective antihistamines. The compns contain thio-ureas of formula (I): in which A is a divalent radical completing an unsatd. 5- or 6-membered heterocyclic ring, e.g. imidazole pyridine, thiazole or 1,2,4-triazole, X is H, lower alkyl, halogen or lower alkylthio, n is 3-6, and R is H lower alkyl, opt. substd. aryl or aralkyl (excluding benzyl), in combination with a pharmaceutical diluent or carrier. Cpds. of formula (I) in which R = CH3, n = 4, and A completes a 4(5)-imidazolyl, 4-bromo-5-imidazolyl or 2-thiazolyl ring are new. (I) inhibit certain effects of histamine, e.g. stimulation of gastric secretion. [FR2100822A1]
IE714/71A 1970-06-25 1971-06-03 Thiourea derivatives IE35505B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB3083470 1970-06-25
GB4900770 1970-10-15
GB291871 1971-01-22

Publications (2)

Publication Number Publication Date
IE35505L true IE35505L (en) 1971-12-25
IE35505B1 IE35505B1 (en) 1976-03-03

Family

ID=27254147

Family Applications (1)

Application Number Title Priority Date Filing Date
IE714/71A IE35505B1 (en) 1970-06-25 1971-06-03 Thiourea derivatives

Country Status (13)

Country Link
JP (1) JPS5738583B1 (en)
BE (1) BE768474A (en)
CA (1) CA938556A (en)
CH (1) CH551409A (en)
DE (1) DE2131625A1 (en)
ES (1) ES392628A2 (en)
FR (1) FR2100822A1 (en)
HK (1) HK55076A (en)
IE (1) IE35505B1 (en)
IL (1) IL36980A (en)
KE (1) KE2624A (en)
NL (1) NL7108585A (en)
PH (1) PH11791A (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1565647A (en) * 1975-07-31 1980-04-23 Smith Kline French Lab Pharmacologically active compounds 4-substituted-imidazole-5-methanols
DE3107599C2 (en) * 1981-02-27 1982-12-16 Ludwig Heumann & Co GmbH, 8500 Nürnberg N-cyano-N'-methyl-N "- {2 - [(5-methylthio-imidazol-4-yl) -methylthio] -ethyl} -guanidine, process for its preparation and medicaments containing this compound
USRE37303E1 (en) * 1992-01-10 2001-07-31 Institut National Del La Sante Et De La Recherche Medicale Imidazole compounds and their therapeutic applications
FR2686084B1 (en) * 1992-01-10 1995-12-22 Bioprojet Soc Civ NEW IMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATIONS.
NL9302045A (en) * 1993-08-27 1995-03-16 Vrije Universiteit New imidazole derivative with agonistic or antagonistic activity on the histamine H3 receptor
WO1995006037A1 (en) * 1993-08-27 1995-03-02 Vrije Universiteit New imidazole derivatives having agonistic or antagonistic activity on the histamine h3 receptor

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE758145A (en) * 1969-10-29 1971-04-28 Smith Kline French Lab ISO-THIO-UREES AND DERIVATIVES

Also Published As

Publication number Publication date
FR2100822A1 (en) 1972-03-24
PH11791A (en) 1978-07-05
NL7108585A (en) 1971-12-28
CA938556A (en) 1973-12-18
CH551409A (en) 1974-07-15
BE768474A (en) 1971-12-14
FR2100822B1 (en) 1974-11-15
IE35505B1 (en) 1976-03-03
ES392628A2 (en) 1975-07-16
IL36980A0 (en) 1971-08-25
IL36980A (en) 1978-07-31
KE2624A (en) 1976-05-28
HK55076A (en) 1976-09-17
DE2131625A1 (en) 1971-12-30
JPS5738583B1 (en) 1982-08-16

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