FR2081508A2 - - Google Patents
Info
- Publication number
- FR2081508A2 FR2081508A2 FR7104195A FR7104195A FR2081508A2 FR 2081508 A2 FR2081508 A2 FR 2081508A2 FR 7104195 A FR7104195 A FR 7104195A FR 7104195 A FR7104195 A FR 7104195A FR 2081508 A2 FR2081508 A2 FR 2081508A2
- Authority
- FR
- France
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB697870A GB1309692A (en) | 1970-02-13 | 1970-02-13 | N-substituted lactams |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2081508A2 true FR2081508A2 (fr) | 1971-12-03 |
FR2081508B2 FR2081508B2 (fr) | 1975-06-06 |
Family
ID=9824325
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7104195A Expired FR2081508B2 (fr) | 1970-02-13 | 1971-02-08 |
Country Status (15)
Country | Link |
---|---|
JP (2) | JPS535301B1 (fr) |
BE (1) | BE762728R (fr) |
CH (1) | CH530395A (fr) |
CS (2) | CS167911B2 (fr) |
DE (1) | DE2106418C2 (fr) |
DK (1) | DK137451B (fr) |
ES (1) | ES388135A2 (fr) |
FI (1) | FI54916C (fr) |
FR (1) | FR2081508B2 (fr) |
GB (1) | GB1309692A (fr) |
MY (1) | MY7400072A (fr) |
NL (1) | NL168830C (fr) |
SU (2) | SU508186A3 (fr) |
YU (2) | YU34876B (fr) |
ZA (1) | ZA71877B (fr) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2320741A1 (fr) * | 1975-08-13 | 1977-03-11 | Isf Spa | Derives pyrrolidiniques et leur application pharmacologique |
EP0005689A1 (fr) * | 1978-05-08 | 1979-11-28 | U C B, S.A. | Nouveaux acides lactame-N-acétiques et leurs amides, leurs procédés de préparation et compositions thérapeutiques |
FR2458544A1 (fr) * | 1979-06-13 | 1981-01-02 | Nattermann A & Cie | Nouveaux amides d'acide pyrrolidin-(2)-on-(1)-ylalcoyl-carboxylique, leur procede de preparation et leur application comme medicaments |
EP0162036A1 (fr) * | 1984-05-15 | 1985-11-21 | U C B, S.A. | (S)-alpha-éthyl-2-oxo-1-pyrrolidineacétamide |
EP0165919A1 (fr) * | 1984-05-15 | 1985-12-27 | U C B, S.A. | (R)-alpha-éthyl-2-oxo-1-pyrrolidineacétamide |
US4929272A (en) * | 1986-09-12 | 1990-05-29 | Ciba-Geigy Corporation | N-phenyl-maleimides and N-phenyl-succinimides and their use in a herbicidal and/or plant growth regulating action |
EP3533862A4 (fr) * | 2016-12-05 | 2019-09-04 | Changxing Pharmaceutical Co. Ltd. | Methylocystis et utilisation associée dans la résolution sélective et la préparation d'acétate de (s)-alpha-éthyl-2-oxo-1-pyrrolidine |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1583871A (en) * | 1976-10-19 | 1981-02-04 | Ucb Sa | Anti-aggregants |
BE864269A (fr) * | 1977-03-03 | 1978-06-16 | Parke Davis & Co | Nouveaux n-(aminoalkyl substitue)-2-oxo-1-pyrrolidine-acetamides et procedes pour les produire |
FR2515179A1 (fr) * | 1981-07-24 | 1983-04-29 | Hoffmann La Roche | Derives de pyrrolidine, leur procede de preparation, les intermediaires pour leur synthese et leur application therapeutique |
EP0089900B1 (fr) * | 1982-03-24 | 1985-12-27 | Prodes S.A. | N-((2-oxo-1-pyrrolidinyl)acétyl)pipérazines, procédés pour leur préparation et leurs sels, ainsi que leur utilisation dans des préparations pharmaceutiques |
DE3420193A1 (de) * | 1984-05-30 | 1985-12-05 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue substituierte pyrrolidinone, verfahren zu ihrer herstellung und arzneimittel |
GB8827389D0 (en) * | 1988-11-23 | 1988-12-29 | Ucb Sa | Process for preparation of(s)alpha-ethyl-2-oxo-1-pyrrolidineacetamide |
AR020115A1 (es) * | 1998-08-06 | 2002-04-10 | Daiichi Seiyaku Co | Agente terapeutico o preventivo para epilepsias rebeldes y uso del compuesto para la produccion de los mismos |
GB0004297D0 (en) * | 2000-02-23 | 2000-04-12 | Ucb Sa | 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses |
US6686477B2 (en) | 2000-09-29 | 2004-02-03 | Eastman Chemical Company | Highly enantiomerically pure lactam-substituted propanoic acid derivatives and methods of making and using same |
WO2002094787A1 (fr) | 2001-05-23 | 2002-11-28 | Ucb, S.A. | Derives d'acide alcanoique 2-oxo-piperidinyl- et 2-oxo-azepanyle destines au traitement de l'epilepsie et d'autres troubles neurologiques |
IL160045A0 (en) | 2001-08-10 | 2004-06-20 | Ucb Sa | Oxopyrrolidine compounds, preparation of said compounds and their use in the manufacturing of levetiracetam and analogues |
MXPA04002714A (es) * | 2001-10-08 | 2004-07-05 | Ucb Sa | Uso de derivados de 2-oxo-1-pirrolidina para el tratamiento de trastornos del movimiento y de la discinesia. |
US7132552B2 (en) | 2003-02-03 | 2006-11-07 | Teva Pharmaceutical Industries, Ltd. | Process for producing levetiracetam |
ES2214147B1 (es) | 2003-02-28 | 2005-10-01 | Farma-Lepori S.A. | Procedimiento de obtencion de un agente antiepileptico. |
US7531673B2 (en) | 2004-02-18 | 2009-05-12 | Dr. Reddy's Laboratories Limited | Preparation of amino acid amides |
CA2488325C (fr) | 2004-11-22 | 2010-08-24 | Apotex Pharmachem Inc. | Methode de synthese amelioree du (s)-alpha-ethyl-2-oxo-1-pyrrolidine-acetamide et du (r)-alpha-ethyl-2-oxo-1-pyrroldine-acetamide |
US20080146819A1 (en) * | 2005-03-10 | 2008-06-19 | Rubamin Limited | Process for Preparing Levetiracetam |
CA2610042C (fr) | 2005-06-01 | 2013-04-23 | Ucb Pharma, S.A. | Derives de 2-oxo-1-pyrrolidine, procedes pour leur preparation et leur utilisation |
EP2147911A1 (fr) | 2008-07-24 | 2010-01-27 | ZaCh System S.p.A. | Procédé de préparation de lévétiracetam |
EP3260118B1 (fr) | 2008-10-16 | 2021-03-24 | The Johns Hopkins University | Procédés et compositions pour améliorer la fonction cognitive |
US8785661B2 (en) | 2009-05-13 | 2014-07-22 | Nektar Therapeutics | Oligome-containing pyrrolidine compounds |
US7939676B2 (en) | 2009-09-17 | 2011-05-10 | Zach System S.P.A. | Process for the preparation of levetiracetam |
EP2533645B1 (fr) | 2010-02-09 | 2016-07-27 | The Johns Hopkins University | Procédés et compositions pour améliorer la fonction cognitive |
WO2014078568A1 (fr) | 2012-11-14 | 2014-05-22 | The Johns Hopkins University | Méthodes et compositions pour le traitement de la schizophrénie |
AU2014228512A1 (en) | 2013-03-15 | 2015-10-01 | Agenebio, Inc. | Methods and compositions for improving cognitive function |
EP2968237A4 (fr) | 2013-03-15 | 2016-08-31 | Univ Johns Hopkins | Procédés et compositions pour améliorer la fonction cognitive |
SI3431106T1 (sl) | 2014-01-21 | 2021-03-31 | Janssen Pharmaceutica Nv | Kombinacije, ki vsebujejo pozitivne alosterične modulatorje metabotropnega glutamatergičnega receptorja podtipa 2 in njihova uporaba |
DK3096790T3 (da) | 2014-01-21 | 2019-10-07 | Janssen Pharmaceutica Nv | Kombinationer omfattende positive allosteriske modulatorer eller orthosteriske agonister af metabotrop glutamaterg subtype 2-receptor og anvendelse af disse |
CN104059010A (zh) * | 2014-06-12 | 2014-09-24 | 浙江华海药业股份有限公司 | 一种制备2-(2-氧代吡咯烷-1-基)-丁酸酯的方法 |
RU2663899C1 (ru) * | 2017-07-19 | 2018-08-13 | Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" | Способ получения 1-карбамоилметил-4-фенил-2-пирролидона |
US11384050B1 (en) | 2021-02-03 | 2022-07-12 | Vitaworks Ip, Llc | Method for preparing levetiracetam and intermediates thereof |
WO2024039886A1 (fr) | 2022-08-19 | 2024-02-22 | Agenebio, Inc. | Dérivés de benzoazépine, compositions et méthodes de traitement de déficience cognitive |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1039113A (en) * | 1964-08-06 | 1966-08-17 | Ucb Sa | New n-substituted lactams |
-
1970
- 1970-02-13 GB GB697870A patent/GB1309692A/en not_active Expired
-
1971
- 1971-02-08 FR FR7104195A patent/FR2081508B2/fr not_active Expired
- 1971-02-09 NL NLAANVRAGE7101697,A patent/NL168830C/xx not_active IP Right Cessation
- 1971-02-10 CS CS987A patent/CS167911B2/cs unknown
- 1971-02-10 FI FI383/71A patent/FI54916C/fi active
- 1971-02-10 DK DK59571AA patent/DK137451B/da not_active IP Right Cessation
- 1971-02-10 ES ES388135A patent/ES388135A2/es not_active Expired
- 1971-02-10 YU YU306/71A patent/YU34876B/xx unknown
- 1971-02-10 BE BE762728A patent/BE762728R/fr active
- 1971-02-11 ZA ZA710877A patent/ZA71877B/xx unknown
- 1971-02-11 CH CH200171A patent/CH530395A/fr not_active IP Right Cessation
- 1971-02-11 DE DE2106418A patent/DE2106418C2/de not_active Expired
- 1971-02-12 JP JP612471A patent/JPS535301B1/ja active Pending
- 1971-02-12 SU SU1893858A patent/SU508186A3/ru active
- 1971-02-12 SU SU1621307A patent/SU508185A3/ru active
- 1971-12-10 CS CS140674A patent/CS167912B2/cs unknown
-
1974
- 1974-12-31 MY MY197472A patent/MY7400072A/xx unknown
-
1977
- 1977-11-07 JP JP13335277A patent/JPS53130656A/ja active Granted
-
1978
- 1978-06-19 YU YU01445/78A patent/YU144578A/xx unknown
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2320741A1 (fr) * | 1975-08-13 | 1977-03-11 | Isf Spa | Derives pyrrolidiniques et leur application pharmacologique |
EP0005689A1 (fr) * | 1978-05-08 | 1979-11-28 | U C B, S.A. | Nouveaux acides lactame-N-acétiques et leurs amides, leurs procédés de préparation et compositions thérapeutiques |
FR2425433A1 (fr) * | 1978-05-08 | 1979-12-07 | Ucb Sa | Nouveaux acides lactame-n-acetiques et leurs amides, leurs procedes de preparation et compositions therapeutiques |
FR2458544A1 (fr) * | 1979-06-13 | 1981-01-02 | Nattermann A & Cie | Nouveaux amides d'acide pyrrolidin-(2)-on-(1)-ylalcoyl-carboxylique, leur procede de preparation et leur application comme medicaments |
EP0162036A1 (fr) * | 1984-05-15 | 1985-11-21 | U C B, S.A. | (S)-alpha-éthyl-2-oxo-1-pyrrolidineacétamide |
EP0165919A1 (fr) * | 1984-05-15 | 1985-12-27 | U C B, S.A. | (R)-alpha-éthyl-2-oxo-1-pyrrolidineacétamide |
US4696942A (en) * | 1984-05-15 | 1987-09-29 | Ucb Societe Anonyme | Treatment of memory impairment using (R)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide |
US4696943A (en) * | 1984-05-15 | 1987-09-29 | U C B Societe Anonyme | (S)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide |
US4837223A (en) * | 1984-05-15 | 1989-06-06 | Ucb Societe Anonyme | (S)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide compositions |
US4837224A (en) * | 1984-05-15 | 1989-06-06 | Ucb Societe Anonyme | (R)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide compositions |
US4929272A (en) * | 1986-09-12 | 1990-05-29 | Ciba-Geigy Corporation | N-phenyl-maleimides and N-phenyl-succinimides and their use in a herbicidal and/or plant growth regulating action |
EP3533862A4 (fr) * | 2016-12-05 | 2019-09-04 | Changxing Pharmaceutical Co. Ltd. | Methylocystis et utilisation associée dans la résolution sélective et la préparation d'acétate de (s)-alpha-éthyl-2-oxo-1-pyrrolidine |
Also Published As
Publication number | Publication date |
---|---|
DE2106418C2 (de) | 1983-12-22 |
FR2081508B2 (fr) | 1975-06-06 |
JPS53130656A (en) | 1978-11-14 |
YU34876B (en) | 1980-04-30 |
NL168830C (nl) | 1982-05-17 |
GB1309692A (en) | 1973-03-14 |
CS167911B2 (fr) | 1976-05-28 |
YU144578A (en) | 1982-10-31 |
ES388135A2 (es) | 1973-05-01 |
CS167912B2 (fr) | 1976-05-28 |
MY7400072A (en) | 1974-12-31 |
FI54916B (fi) | 1978-12-29 |
DE2106418A1 (de) | 1971-08-19 |
DK137451C (fr) | 1978-07-24 |
SU508186A3 (ru) | 1976-03-25 |
CH530395A (fr) | 1972-11-15 |
FI54916C (fi) | 1979-04-10 |
SU508185A3 (ru) | 1976-03-25 |
BE762728R (fr) | 1971-08-10 |
NL7101697A (fr) | 1971-08-17 |
JPS5420491B2 (fr) | 1979-07-23 |
JPS535301B1 (fr) | 1978-02-25 |
DK137451B (da) | 1978-03-06 |
ZA71877B (en) | 1971-10-27 |
NL168830B (nl) | 1981-12-16 |
YU30671A (en) | 1979-10-31 |