FR2034999A1 - Nouvelles 6-phenyl-4h-s-triazolo-(4,3-a)(1,4)-benzodiazepines douees d'activite pharmacologique et leur procede de preparation - Google Patents

Nouvelles 6-phenyl-4h-s-triazolo-(4,3-a)(1,4)-benzodiazepines douees d'activite pharmacologique et leur procede de preparation

Info

Publication number
FR2034999A1
FR2034999A1 FR7009329A FR7009329A FR2034999A1 FR 2034999 A1 FR2034999 A1 FR 2034999A1 FR 7009329 A FR7009329 A FR 7009329A FR 7009329 A FR7009329 A FR 7009329A FR 2034999 A1 FR2034999 A1 FR 2034999A1
Authority
FR
France
Prior art keywords
benzodiazepines
triazolo
news
phenyl
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7009329A
Other languages
English (en)
French (fr)
Other versions
FR2034999B1 (enExample
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27123060&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR2034999(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of FR2034999A1 publication Critical patent/FR2034999A1/fr
Application granted granted Critical
Publication of FR2034999B1 publication Critical patent/FR2034999B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/20—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Fodder In General (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
FR7009329A 1969-03-17 1970-03-16 Nouvelles 6-phenyl-4h-s-triazolo-(4,3-a)(1,4)-benzodiazepines douees d'activite pharmacologique et leur procede de preparation Granted FR2034999A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80793369A 1969-03-17 1969-03-17
US04/872,394 US3987052A (en) 1969-03-17 1969-10-29 6-Phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines

Publications (2)

Publication Number Publication Date
FR2034999A1 true FR2034999A1 (fr) 1970-12-18
FR2034999B1 FR2034999B1 (enExample) 1973-07-13

Family

ID=27123060

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7009329A Granted FR2034999A1 (fr) 1969-03-17 1970-03-16 Nouvelles 6-phenyl-4h-s-triazolo-(4,3-a)(1,4)-benzodiazepines douees d'activite pharmacologique et leur procede de preparation

Country Status (18)

Country Link
US (1) US3987052A (enExample)
JP (1) JPS4940239B1 (enExample)
AU (2) AU491139B2 (enExample)
BE (1) BE747493A (enExample)
BR (1) BR7017488D0 (enExample)
CH (1) CH535788A (enExample)
DE (1) DE2012190C3 (enExample)
ES (1) ES376689A1 (enExample)
FR (1) FR2034999A1 (enExample)
GB (1) GB1291631A (enExample)
HK (1) HK61677A (enExample)
IL (1) IL33859A (enExample)
NL (2) NL172510C (enExample)
OA (1) OA03446A (enExample)
PH (1) PH9329A (enExample)
PL (1) PL80541B1 (enExample)
SE (1) SE387641B (enExample)
YU (1) YU35139B (enExample)

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2085748A1 (enExample) * 1970-03-27 1971-12-31 Takeda Chemical Industries Ltd
FR2128552A2 (en) * 1972-03-02 1972-10-20 Upjohn Co S-triazolo (4,3-a) (1,4) benzodiazepines - as anxiolytic agents, muscle relaxants
FR2128551A2 (fr) * 1969-03-17 1972-10-20 Upjohn Co Nouvelles 6-(2,6-difluorophenyl)-triazolobenzodiazepines et leur procede de preparation
FR2128553A2 (en) * 1971-03-03 1972-10-20 Upjohn Co S-triazolo (4,3-a) (1,4) benzodiazepines - as sedatives, hypnotics, tranquillisers, muscle relaxants
FR2128550A2 (en) * 1971-03-03 1972-10-20 Upjohn Co S-triazolo (4,3-a) (1,4) benzodiazepines - as hypnotics, sedatives, tranquillisers, muscle-relaxants
FR2132767A1 (enExample) * 1971-04-08 1972-11-24 Ciba Geigy Ag
FR2134625A1 (enExample) * 1971-04-28 1972-12-08 Upjohn Co
FR2134585A1 (enExample) * 1971-04-28 1972-12-08 Upjohn Co
FR2137685A1 (enExample) * 1971-05-10 1972-12-29 Upjohn Co
FR2137714A1 (enExample) * 1971-05-11 1972-12-29 Upjohn Co
FR2154496A1 (enExample) * 1971-09-13 1973-05-11 Upjohn Co
FR2154475A1 (enExample) * 1971-09-08 1973-05-11 Upjohn Co
FR2154494A1 (enExample) * 1971-09-13 1973-05-11 Upjohn Co
FR2158413A1 (enExample) * 1971-11-02 1973-06-15 Upjohn Co
FR2207722A1 (enExample) * 1972-11-28 1974-06-21 Ciba Geigy Ag
FR2212144A1 (enExample) * 1972-12-29 1974-07-26 Ciba Geigy Ag

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE758921A (fr) * 1969-11-15 1971-04-16 Takeda Chemical Industries Ltd Derives de benzodiazepine
BE759099A (fr) * 1969-11-18 1971-04-30 Takeda Chemical Industries Ltd Procede de fabrication de composes heterocycliques
DE2156472A1 (de) * 1970-11-23 1972-05-31 Ciba-Geigy Ag, Basel (Schweiz) Verfahren zur Herstellung von neuen Diazepinderivaten
CH544764A (de) * 1971-01-21 1974-01-15 Ciba Geigy Ag Verfahren zur Herstellung von neuen Triazolo-benzodiazepinderivaten
US3709898A (en) * 1971-02-09 1973-01-09 Upjohn Co Process for the production of triazolobenzodiazepines and intermediates
DE2164778C2 (de) * 1971-03-03 1984-07-05 The Upjohn Co., Kalamazoo, Mich. 6-(o-Chlorphenyl)-1-methyl-4H-s-triazolo[4,3-a][1,4]-benzodiazepin und dieses enthaltende pharmazeutische Präparat
US4000289A (en) * 1971-07-08 1976-12-28 The Upjohn Company Animal feed and process
BE787251A (fr) * 1971-08-04 1973-02-05 Upjohn Co Nouvelles benzodiazepines et leur preparation
US3870793A (en) * 1971-08-09 1975-03-11 Upjohn Co Animal feed and process
US3714178A (en) * 1971-09-30 1973-01-30 Upjohn Co 6,7-DIHYDRO-7-ALKYL-5H-1,2,4-TRIAZOLO[4,3-d][1,4]BENZODIAZEPINES AND THEIR PRODUCTION
FI53821C (fi) * 1971-11-15 1978-08-10 Ciba Geigy Ag Foerfarande foer framstaellning av farmakologiskt vaerdefull 6-fenyl-8-klor-4h-s-triazolo(4 3-a)(1 4)bensodiazepin-1-metanol
US4978753A (en) * 1973-01-15 1990-12-18 The Upjohn Company 7-phenylpyrimido[1,2-alpha][1,4]benzodiazepin-3(5H)-ones
US4082761A (en) * 1973-09-04 1978-04-04 The Upjohn Company Triazolo[4,3-a][1,4]benzodiazepinium quaternary salts
US4169150A (en) * 1975-11-12 1979-09-25 Teijin Limited Benzodiazepine derivatives and pharmaceutical compositions containing said derivatives
US4431589A (en) * 1980-12-11 1984-02-14 Lilly House Benzodiazepine compounds and their use as pharmaceuticals
US4375473A (en) * 1982-01-04 1983-03-01 The Upjohn Company Method
US4455307A (en) * 1982-01-04 1984-06-19 The Upjohn Company Antihypertensive use of triazolobenzodiazepines
US4481208A (en) * 1983-06-06 1984-11-06 The Upjohn Company Treatment of panic disorders with estazolam
US4508726A (en) * 1982-09-16 1985-04-02 The Upjohn Company Treatment of panic disorders with alprazolam
DE3332830A1 (de) * 1982-09-16 1984-03-22 The Upjohn Co., 49001 Kalamazoo, Mich. Verwendung von benzodiazepinen zur bekaempfung oder bei der behandlung von panikzustaenden
US4689413A (en) * 1983-03-17 1987-08-25 The Upjohn Company Triazolo-benzodiazepine-1-ethanamines as diuretics
US4514407A (en) * 1983-03-17 1985-04-30 The Upjohn Company 1-Ethanamine-triazolo-benzodiazepines as diuretics
US4474699A (en) * 1983-05-25 1984-10-02 The Upjohn Company Preparing 1-aminomethyl-6-substituted-4H-s-triazolo[4,3-a][1,4]benzodiazepines in improved procedures
US4588721A (en) * 1983-09-12 1986-05-13 The Upjohn Company Treatment of negative symptoms of schizophrenia
US4547499A (en) * 1984-05-10 1985-10-15 The Upjohn Company 2,4-Dihydro-2(omega-aminoalkyl)-1H-[1,2,4]triazolo[3,4-c]benzoxazin-1-one anti-allergy drug compounds, compositions and use
US4634703A (en) * 1985-10-25 1987-01-06 Bristol-Myers Company Method for alleviation of panic disorders
US4959361A (en) * 1987-12-18 1990-09-25 Hoffmann-La Roche Inc. Triazolo(4,3-A)(1,4)benzodiazepines and thieno (3,2-F)(1,2,4)triazolo(4,3-A)(1,4)diazepine compounds which have useful activity as platelet activating factor (PAF) antagonists
US5334592A (en) * 1988-04-27 1994-08-02 Schering Corporation Certain PAF antagonist antihistamine combinations and methods
US4856303A (en) * 1988-07-21 1989-08-15 Whirlpool Corporation Agitator thrust spacer for automatic washer
US5225198A (en) * 1991-08-27 1993-07-06 Cygnus Therapeutic Systems Transdermal administration of short or intermediate half-life benzodiazepines
US5900250A (en) * 1992-05-13 1999-05-04 Alza Corporation Monoglyceride/lactate ester permeation enhancer for oxybutnin
EP0721349A1 (en) * 1993-09-29 1996-07-17 Alza Corporation Monoglyceride/lactate ester permeation enhancer for oxybutynin
DE69910795T2 (de) 1998-06-09 2004-06-17 Takeda Chemical Industries, Ltd. Pharmazeutische kombination mit einer trizyclischen verbindung und mindestens einer von zolpidem, zopiclone und brotizolam, zur behandlung oder verhinderung von schlafstörungen
JP2005503425A (ja) 2001-05-24 2005-02-03 アレックザ モレキュラー デリヴァリー コーポレイション 所定の吸入ルートによる薬剤エステルの送出
US7766013B2 (en) 2001-06-05 2010-08-03 Alexza Pharmaceuticals, Inc. Aerosol generating method and device
US7585493B2 (en) 2001-05-24 2009-09-08 Alexza Pharmaceuticals, Inc. Thin-film drug delivery article and method of use
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US7458374B2 (en) 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
US7090830B2 (en) 2001-05-24 2006-08-15 Alexza Pharmaceuticals, Inc. Drug condensation aerosols and kits
US20040105818A1 (en) 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
US7913688B2 (en) 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
US20040234699A1 (en) 2003-05-21 2004-11-25 Alexza Molecular Delivery Corporation Methods of controlling uniformity of substrate temperature and self-contained heating unit and drug-supply unit employing same
BRPI0414802A (pt) * 2003-09-26 2006-11-14 Alza Corp formas de dosagem osmóticas para liberação controlada de alprazolam
US20050163843A1 (en) * 2003-12-31 2005-07-28 Garth Boehm Alprazolam formulations
US7540286B2 (en) 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
EP2246086A3 (en) 2004-08-12 2012-11-21 Alexza Pharmaceuticals, Inc. Aerosol drug delivery device incorporating percussively activated heating unit
WO2007010369A2 (en) * 2005-07-22 2007-01-25 Emcure Pharmaceuticals Limited Sustained release formulation of alprazolam
US20070087055A1 (en) * 2005-10-14 2007-04-19 David Jan Directly compressible extended release alprazolam formulation
US20070218135A1 (en) * 2006-03-14 2007-09-20 Glenmark Pharmaceuticals Limited Sustained release matrix pharmaceutical composition
EP2121088B1 (en) 2007-03-09 2016-07-13 Alexza Pharmaceuticals, Inc. Heating unit for use in a drug delivery device
US8530463B2 (en) * 2007-05-07 2013-09-10 Hale Biopharma Ventures Llc Multimodal particulate formulations
US8106189B2 (en) * 2007-10-03 2012-01-31 Centaur Chemicals Pvt Ltd Process for preparation of triazol-benzodiazepine derivatives
EP2087893B1 (en) 2008-02-05 2013-02-13 Laboratorios Bagó S.A. Compositions comprising alprazolam for treating primary insomnia and insomnia associated with anxiety states and processes for preparing them
JP5613657B2 (ja) 2008-03-28 2014-10-29 ヘイル バイオファーマ ベンチャーズ，エルエルシー ベンゾジアゼピン組成物の投与
US10289671B2 (en) * 2008-05-07 2019-05-14 Microsoft Technology Licensing, Llc Graphically displaying selected data sources within a grid
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DK3415139T3 (da) 2011-06-14 2022-06-20 Neurelis Inc Administration af benzodiazepin
JP7139323B2 (ja) 2016-11-01 2022-09-20 エフ．ホフマン－ラ ロシュ アーゲー Ｃｎｓ関連疾患を処置するための１，３－ジヒドロ－１，４－ベンゾジアゼピン－２－チオン
CN110267662A (zh) 2016-12-09 2019-09-20 艾利斯达医药品公司 治疗癫痫的方法
US12214118B2 (en) 2018-02-02 2025-02-04 Alexza Pharmaceuticals, Inc. Electrical condensation aerosol device
CN109748922B (zh) * 2019-01-15 2020-04-14 山东安信制药有限公司 一种阿普唑仑i晶型的制备方法
WO2021198124A1 (en) * 2020-03-31 2021-10-07 F. Hoffmann-La Roche Ag Benzodiazepine derivatives as gaba a gamma1 pams
EP3901155A1 (en) * 2020-04-20 2021-10-27 F. Hoffmann-La Roche AG New benzodiazepine derivatives as gaba a gamma1 pam
US12599611B2 (en) 2021-06-10 2026-04-14 Neurelis, Inc. Methods and compositions for treating seizure disorders in pediatric patients
AR127157A1 (es) 2021-09-29 2023-12-27 Hoffmann La Roche NUEVOS DERIVADOS DE BENZODIAZEPINA COMO MODULADORES ALOSTÉRICOS POSITIVOS DE GABAA g1
IL311377A (en) 2021-10-06 2024-05-01 Hoffmann La Roche Benzodiazepine derivatives as positive allosteric modulators of the GABA A GAMMA 1 receptor

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BE706803A (enExample) * 1966-11-23 1968-05-21

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US2891862A (en) * 1956-11-06 1959-06-23 Eastman Kodak Co Stabilized photographic silver halide emulsions
NL295083A (enExample) * 1962-07-10

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Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2128551A2 (fr) * 1969-03-17 1972-10-20 Upjohn Co Nouvelles 6-(2,6-difluorophenyl)-triazolobenzodiazepines et leur procede de preparation
FR2085748A1 (enExample) * 1970-03-27 1971-12-31 Takeda Chemical Industries Ltd
FR2128553A2 (en) * 1971-03-03 1972-10-20 Upjohn Co S-triazolo (4,3-a) (1,4) benzodiazepines - as sedatives, hypnotics, tranquillisers, muscle relaxants
FR2128550A2 (en) * 1971-03-03 1972-10-20 Upjohn Co S-triazolo (4,3-a) (1,4) benzodiazepines - as hypnotics, sedatives, tranquillisers, muscle-relaxants
FR2132767A1 (enExample) * 1971-04-08 1972-11-24 Ciba Geigy Ag
FR2134585A1 (enExample) * 1971-04-28 1972-12-08 Upjohn Co
FR2134625A1 (enExample) * 1971-04-28 1972-12-08 Upjohn Co
FR2137685A1 (enExample) * 1971-05-10 1972-12-29 Upjohn Co
FR2137714A1 (enExample) * 1971-05-11 1972-12-29 Upjohn Co
FR2154475A1 (enExample) * 1971-09-08 1973-05-11 Upjohn Co
FR2154496A1 (enExample) * 1971-09-13 1973-05-11 Upjohn Co
FR2154494A1 (enExample) * 1971-09-13 1973-05-11 Upjohn Co
FR2158413A1 (enExample) * 1971-11-02 1973-06-15 Upjohn Co
FR2128552A2 (en) * 1972-03-02 1972-10-20 Upjohn Co S-triazolo (4,3-a) (1,4) benzodiazepines - as anxiolytic agents, muscle relaxants
FR2207722A1 (enExample) * 1972-11-28 1974-06-21 Ciba Geigy Ag
FR2212144A1 (enExample) * 1972-12-29 1974-07-26 Ciba Geigy Ag

Also Published As

Publication number Publication date
AU8550075A (en) 1975-12-18
IL33859A0 (en) 1970-04-20
YU35139B (en) 1980-09-25
NL172510B (nl) 1983-04-18
JPS4940239B1 (enExample) 1974-10-31
US3987052A (en) 1976-10-19
IL33859A (en) 1973-01-30
DE2012190C3 (de) 1980-11-13
YU34570A (en) 1979-04-30
BR7017488D0 (pt) 1973-02-13
AU8549975A (en) 1975-12-18
NL170857C (nl) 1983-01-03
PH9329A (en) 1975-09-23
AU490626B2 (en) 1975-12-18
HK61677A (en) 1977-12-23
DE2012190B2 (de) 1980-03-06
OA03446A (fr) 1971-03-30
AU491139B2 (en) 1975-12-18
FR2034999B1 (enExample) 1973-07-13
NL172510C (nl) 1983-09-16
DE2012190A1 (de) 1970-09-24
NL7003750A (nl) 1970-09-21
PL80541B1 (pl) 1975-08-30
NL8100081A (nl) 1981-04-29
NL170857B (nl) 1982-08-02
CH535788A (de) 1973-04-15
ES376689A1 (es) 1972-05-01
BE747493A (fr) 1970-09-17
GB1291631A (en) 1972-10-04
SE387641B (sv) 1976-09-13

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