AR127157A1 - NUEVOS DERIVADOS DE BENZODIAZEPINA COMO MODULADORES ALOSTÉRICOS POSITIVOS DE GABAA g1 - Google Patents
NUEVOS DERIVADOS DE BENZODIAZEPINA COMO MODULADORES ALOSTÉRICOS POSITIVOS DE GABAA g1Info
- Publication number
- AR127157A1 AR127157A1 ARP220102592A ARP220102592A AR127157A1 AR 127157 A1 AR127157 A1 AR 127157A1 AR P220102592 A ARP220102592 A AR P220102592A AR P220102592 A ARP220102592 A AR P220102592A AR 127157 A1 AR127157 A1 AR 127157A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- hydrogen
- alkoxy
- halo
- hydroxy
- Prior art date
Links
- 229940053197 benzodiazepine derivative antiepileptics Drugs 0.000 title 1
- 150000001557 benzodiazepines Chemical class 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 20
- 229910052739 hydrogen Inorganic materials 0.000 abstract 8
- 239000001257 hydrogen Substances 0.000 abstract 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 8
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000001153 fluoro group Chemical group F* 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 125000004043 oxo group Chemical group O=* 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- -1 NR8R9C(O)- Chemical group 0.000 abstract 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Reivindicación 1: Un compuesto de fórmula (1) o una sal farmacéuticamente aceptable de este, en donde: W es C-R⁶ o N; X es C-R⁷ o N; R¹ se selecciona de hidrógeno, alquil C₁-C₆, hidroxi-alquil C₁-C₆, halo-alquil C₁-C₆, alcoxi C₁-C₆, alcoxi C₁-C₆-alquil C₁-C₆, ciano, NR⁸R⁹C(O)-, sulfamoílo, alquil C₁-C₆-NH-C(O)-NH-, cicloalquil C₃-C₁₀-NH-C(O)-NH-, alquil C₁-C₆-SO₂-, alquil C₁-C₆-NH-SO₂-, alquil C₁-C₆-C(O)-NH-alquil C₁-C₆-, y un grupo de fórmula (2); R² se selecciona de hidrógeno y alquil C₁-C₆; R³ se selecciona de fluoro y cloro; R⁴ se selecciona de cloro y bromo; R⁵ se selecciona de halógeno, alquil C₁-C₆ y halo-alquil C₁-C₆; R⁶ se selecciona de hidrógeno, alquil C₁-C₆ e hidroxi-alquil C₁-C₆; o R⁶ y R¹, tomados junto con los átomos de carbono a los que están unidos, forman un cicloalquil C₃-C₁₀; R⁷ se selecciona de hidrógeno, fluoro y cloro; R⁸ se selecciona de hidrógeno, alquil C₁-C₆, deuterio-alquil C₁-C₆, halo-alquil C₁-C₆, hidroxi-alquil C₁-C₆, ciano-alquil C₁-C₆, alcoxi C₁-C₆-alquilC₁-C₆, y (alquil C₁-C₆)₂N-; R⁹ se selecciona de hidrógeno, alquil C₁-C₆ y deuterio-alquil C₁-C₆; R¹⁰ se selecciona de hidrógeno, hidroxi, oxo, ciano, halógeno, alquil C₁-C₆, halo-alquil C₁-C₆, alcoxi C₁-C₆, deuterio-alcoxi C₁-C₆, y halo-alcoxi C₁-C₆; R¹¹ se selecciona de hidrógeno y oxo; A se selecciona de un heterocicloalquilo de 3 - 14 miembros y cicloalquil C₃-C₁₀; y L se selecciona de un enlace covalente, carbonilo, O, C(O)NH, NHC(O) y NHC(O)NH.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP21199653 | 2021-09-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR127157A1 true AR127157A1 (es) | 2023-12-27 |
Family
ID=78049169
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP220102592A AR127157A1 (es) | 2021-09-29 | 2022-09-27 | NUEVOS DERIVADOS DE BENZODIAZEPINA COMO MODULADORES ALOSTÉRICOS POSITIVOS DE GABAA g1 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20230136326A1 (es) |
| EP (1) | EP4408848A1 (es) |
| JP (1) | JP2024537773A (es) |
| CN (1) | CN118019742A (es) |
| AR (1) | AR127157A1 (es) |
| TW (1) | TW202322802A (es) |
| WO (1) | WO2023052312A1 (es) |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH562246A5 (es) | 1971-04-08 | 1975-05-30 | Ciba Geigy Ag | |
| BE786530A (fr) | 1971-07-23 | 1973-01-22 | Ciba Geigy | Procede de preparation de nouveaux derives de diazepine et composes obtenus |
| CH551993A (de) | 1971-07-23 | 1974-07-31 | Ciba Geigy Ag | Verfahren zur herstellung von neuen diazepinderivaten. |
| CH569739A5 (en) | 1972-02-07 | 1975-11-28 | Ciba Geigy Ag | 4h-s-triazolo (1,5-a) (1,4) benzodiazepine-2-carboxylic acid amide(s) - CNS inhibitors, anticonvulsants, tranquillizers, etc. |
| CH569018A5 (en) | 1972-02-07 | 1975-11-14 | Ciba Geigy Ag | 4h-s-triazolo (1,5-a) (1,4) benzodiazepine-2-carboxylic acid amide(s) - CNS inhibitors, anticonvulsants, tranquillizers, etc. |
| CH567025A5 (en) | 1972-02-07 | 1975-09-30 | Ciba Geigy Ag | 4h-s-triazolo (1,5-a) (1,4) benzodiazepine-2-carboxylic acid amide(s) - CNS inhibitors, anticonvulsants, tranquillizers, etc. |
| BE795020A (fr) | 1972-02-07 | 1973-08-06 | Ciba Geigy | Procede de preparation de nouvelles diazepines |
| CH574426A5 (en) | 1972-03-20 | 1976-04-15 | Ciba Geigy Ag | Triazole carboxylates prepn - 1-(2-Benzoyl-phenyl)-1H-1, 2,4-triazole-3-carboxylates prepd. by reacting 2-aminobenzophenone diazo salts with dialkyl acylamino malonates |
| CH572057A5 (en) | 1973-01-19 | 1976-01-30 | Ciba Geigy Ag | 6-Phenyl-s-triazolo(1,5-a)(1,4)-benzodiazepine-2-carboxamides - with CNS depressant activity, from corresp. aldehydes |
| AT328458B (de) | 1973-02-06 | 1976-03-25 | Ciba Geigy Ag | Verfahren zur herstellung neuer diazepinderivate sowie deren 5-oxide und saureadditionssalze |
| CH601264A5 (es) | 1974-06-14 | 1978-06-30 | Ciba Geigy Ag | |
| EP4299126A3 (en) * | 2014-06-26 | 2024-04-03 | The Johns Hopkins University | Peripherally restricted gaba positive allosteric modulators for the treatment of irritable bowel syndrome and other ailments of the peripheral nervous system |
-
2022
- 2022-09-27 CN CN202280063987.4A patent/CN118019742A/zh active Pending
- 2022-09-27 EP EP22797320.3A patent/EP4408848A1/en active Pending
- 2022-09-27 JP JP2024519282A patent/JP2024537773A/ja active Pending
- 2022-09-27 AR ARP220102592A patent/AR127157A1/es unknown
- 2022-09-27 WO PCT/EP2022/076738 patent/WO2023052312A1/en active Application Filing
- 2022-09-28 US US17/935,961 patent/US20230136326A1/en active Pending
- 2022-09-28 TW TW111136769A patent/TW202322802A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2024537773A (ja) | 2024-10-16 |
| EP4408848A1 (en) | 2024-08-07 |
| TW202322802A (zh) | 2023-06-16 |
| US20230136326A1 (en) | 2023-05-04 |
| CN118019742A (zh) | 2024-05-10 |
| WO2023052312A1 (en) | 2023-04-06 |
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