FI98067C - Nya alkylendiammoniumdiklavulanataderivat, förfarande för deras framställning samt deras användning för rening av klavulansyra - Google Patents

Nya alkylendiammoniumdiklavulanataderivat, förfarande för deras framställning samt deras användning för rening av klavulansyra

Info

Publication number
FI98067C
FI98067C FI931332A FI931332A FI98067C FI 98067 C FI98067 C FI 98067C FI 931332 A FI931332 A FI 931332A FI 931332 A FI931332 A FI 931332A FI 98067 C FI98067 C FI 98067C
Authority
FI
Finland
Prior art keywords
purification
derivatives
novel
preparation
well
Prior art date
Application number
FI931332A
Other languages
English (en)
Finnish (fi)
Other versions
FI931332A0 (sv
FI931332A (sv
FI98067B (sv
Inventor
Anton Copar
Original Assignee
Lek Tovarna Farmacevtskih
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lek Tovarna Farmacevtskih filed Critical Lek Tovarna Farmacevtskih
Publication of FI931332A0 publication Critical patent/FI931332A0/sv
Publication of FI931332A publication Critical patent/FI931332A/sv
Application granted granted Critical
Publication of FI98067B publication Critical patent/FI98067B/sv
Publication of FI98067C publication Critical patent/FI98067C/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI931332A 1992-03-26 1993-03-25 Nya alkylendiammoniumdiklavulanataderivat, förfarande för deras framställning samt deras användning för rening av klavulansyra FI98067C (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0061992A AT399155B (de) 1992-03-26 1992-03-26 Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung

Publications (4)

Publication Number Publication Date
FI931332A0 FI931332A0 (sv) 1993-03-25
FI931332A FI931332A (sv) 1993-09-27
FI98067B FI98067B (sv) 1996-12-31
FI98067C true FI98067C (sv) 1997-04-10

Family

ID=3495387

Family Applications (1)

Application Number Title Priority Date Filing Date
FI931332A FI98067C (sv) 1992-03-26 1993-03-25 Nya alkylendiammoniumdiklavulanataderivat, förfarande för deras framställning samt deras användning för rening av klavulansyra

Country Status (15)

Country Link
US (2) US5310898A (sv)
EP (1) EP0562583B1 (sv)
JP (1) JP2873143B2 (sv)
KR (1) KR950014004B1 (sv)
AT (1) AT399155B (sv)
AU (1) AU655718B2 (sv)
CA (1) CA2092330C (sv)
DE (1) DE59306148D1 (sv)
DK (1) DK0562583T3 (sv)
ES (1) ES2103394T3 (sv)
FI (1) FI98067C (sv)
HU (1) HU212578B (sv)
LV (1) LV11896B (sv)
SG (1) SG44638A1 (sv)
SI (1) SI9200392A (sv)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT400033B (de) * 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
GB2282810B (en) * 1992-06-11 1997-02-26 Smithkline Beecham Plc Preparation or purification of clavulanic acid
SI9300296B (sl) * 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
SI9200139A (en) * 1992-07-08 1994-03-31 Lek Tovarna Farmacevtskih New inclusion complex of clavulanic acid with hydrophylyc and hydropholyc beta-cyclodextrin derivates for production of them
GB9305565D0 (en) * 1993-03-18 1993-05-05 Smithkline Beecham Plc Novel compounds and processes
US5760218A (en) * 1993-03-26 1998-06-02 Gist-Brocades N.V. Diamine salts of clavulanic acid
HUT69372A (en) * 1993-03-26 1995-09-28 Gist Brocades Nv Diamine salts of clarulanic acid, pharmaceutical compositions containing the same and process for their production
US5741903A (en) * 1993-03-26 1998-04-21 Gist-Brocades N.V. Diamine salts for purification of clavulanic acid
JP2839955B2 (ja) * 1993-03-26 1998-12-24 ギスト ブロカデス ナムローゼ フェンノートシャップ クラブラン酸のジアミン塩
US5821364A (en) * 1993-03-26 1998-10-13 Gist-Brocades N.V. Diamine salts of clavulanic acid
DE4318916A1 (de) * 1993-06-07 1994-12-08 Bayer Ag Cyclobutylazole
SI9400107A (en) * 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB9426261D0 (en) 1994-12-24 1995-02-22 Spurcourt Ltd Clavulanic acid salts
SI9500074A (en) * 1995-03-10 1996-10-31 Lek Tovarna Farmacevtskih Process for preparation of alkani salts of clavulanic acid.
SI9500134B (sl) * 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
SI9500265A1 (en) 1995-08-28 1997-02-28 Lek Tovarna Farmacevtskih Process for purification of the aqueous fermented broth filtrate of streptomyces sp. p 6621 ferm p 2804 by ultrafiltration
AT403375B (de) * 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
US6414142B1 (en) * 1996-06-13 2002-07-02 Smithkline Beecham Corporation Process for preparing potassium clavulanate
DZ2456A1 (fr) * 1997-04-04 2003-01-18 Smithkline Beecham Plc Procédé de préparation de sels de l'acide clavulanique.
EP1095046A1 (en) * 1998-07-16 2001-05-02 Dsm N.V. Improved process for the preparation of salts and esters of clavulanic acid

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1290132A (fr) * 1960-03-31 1962-04-13 Ministerul Ind Petrolului Procédé de valorisation des liqueurs mères de la préparation de la pénicilline
GB1508977A (en) * 1974-04-20 1978-04-26 Beecham Group Ltd Beta-lactam antibiotic from streptomyces clavuligerus
IE41110B1 (en) * 1974-04-20 1979-10-24 Beecham Group Ltd Esters of clavulanic acid
NZ177159A (en) * 1974-04-20 1978-03-06 Beecham Group Ltd Clavulanic acid, salts, esters and preparation thereof from streptomyces clavuligerus: pharmaceutical compositions
GB1508978A (en) * 1975-04-11 1978-04-26 Beecham Group Ltd Esters of clavulanic acid
GB1561395A (en) * 1976-02-26 1980-02-20 Beecham Group Ltd -lactam antibiotic
GB1578739A (en) * 1976-07-23 1980-11-05 Beecham Group Ltd Amine salts of clavulanic acid methods for their preparation and compositions containing them
DE2861607D1 (en) * 1977-11-26 1982-03-11 Beecham Group Plc Derivatives of clavulanic acid and pharmaceutical compositions containing them
JPS55162993A (en) * 1979-06-07 1980-12-18 Sanraku Inc Preparation of culavulanic acid
DE3063683D1 (en) * 1979-08-24 1983-07-14 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
US4454069A (en) * 1979-08-24 1984-06-12 Beecham Group Limited Clavulanic acid salts and their preparation from the tertiary butyl amine salt
ES2010143A6 (es) * 1989-03-01 1989-10-16 Pharma Mar S A Pharmar Un nuevo procedimiento de obtencion del acido z(2r,5r)-3-(2-hiadroxietiliden)-7- oxo-4-oxa-1-azabiciclo(3,2,0) -heptano-2-carboxilico y de sales estares farmaceutiacamente aceptables del mismo,a partir de caldos de fermentacion de streptomyces, sp.
AT400033B (de) * 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
SI9300296B (sl) * 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
GB9305565D0 (en) * 1993-03-18 1993-05-05 Smithkline Beecham Plc Novel compounds and processes
HUT69372A (en) * 1993-03-26 1995-09-28 Gist Brocades Nv Diamine salts of clarulanic acid, pharmaceutical compositions containing the same and process for their production

Also Published As

Publication number Publication date
US5310898A (en) 1994-05-10
AU655718B2 (en) 1995-01-05
SG44638A1 (en) 1997-12-19
JPH0656844A (ja) 1994-03-01
CA2092330C (en) 2002-01-29
EP0562583B1 (de) 1997-04-16
JP2873143B2 (ja) 1999-03-24
HU9300880D0 (en) 1993-06-28
DK0562583T3 (da) 1997-09-29
FI931332A0 (sv) 1993-03-25
KR930019681A (ko) 1993-10-18
ATA61992A (de) 1994-08-15
EP0562583A1 (de) 1993-09-29
LV11896A (lv) 1997-12-20
CA2092330A1 (en) 1993-09-27
FI931332A (sv) 1993-09-27
ES2103394T3 (es) 1997-09-16
AT399155B (de) 1995-03-27
DE59306148D1 (de) 1997-05-22
HU212578B (en) 1996-08-29
SI9200392A (en) 1993-09-30
LV11896B (en) 1998-03-20
HUT64347A (en) 1993-12-28
KR950014004B1 (ko) 1995-11-20
US5859238A (en) 1999-01-12
FI98067B (sv) 1996-12-31
AU3548993A (en) 1993-09-30

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Legal Events

Date Code Title Description
FG Patent granted

Owner name: LEK, TOVARNA FARMACEVTSKIH IN KEMICNIH

BB Publication of examined application