FI97331B - Nya råmaterial för ersättande av ben och ben- eller protesförbindning - Google Patents
Nya råmaterial för ersättande av ben och ben- eller protesförbindning Download PDFInfo
- Publication number
- FI97331B FI97331B FI910600A FI910600A FI97331B FI 97331 B FI97331 B FI 97331B FI 910600 A FI910600 A FI 910600A FI 910600 A FI910600 A FI 910600A FI 97331 B FI97331 B FI 97331B
- Authority
- FI
- Finland
- Prior art keywords
- ceramic
- composition according
- bone
- approx
- resin component
- Prior art date
Links
- 239000002994 raw material Substances 0.000 title claims description 37
- 210000000988 bone and bone Anatomy 0.000 title claims description 32
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 38
- 239000011347 resin Substances 0.000 claims description 35
- 229920005989 resin Polymers 0.000 claims description 35
- 239000000463 material Substances 0.000 claims description 32
- 239000000919 ceramic Substances 0.000 claims description 27
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims description 26
- 239000000203 mixture Substances 0.000 claims description 26
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 20
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims description 15
- 239000002245 particle Substances 0.000 claims description 15
- 235000011187 glycerol Nutrition 0.000 claims description 13
- 229910010293 ceramic material Inorganic materials 0.000 claims description 12
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 12
- 239000001506 calcium phosphate Substances 0.000 claims description 11
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 11
- 239000000843 powder Substances 0.000 claims description 11
- 239000008187 granular material Substances 0.000 claims description 10
- 235000014655 lactic acid Nutrition 0.000 claims description 10
- 239000004310 lactic acid Substances 0.000 claims description 9
- 229920000642 polymer Polymers 0.000 claims description 9
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 8
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 8
- 150000001875 compounds Chemical class 0.000 claims description 7
- 238000009826 distribution Methods 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- 229910052784 alkaline earth metal Inorganic materials 0.000 claims description 4
- 230000036760 body temperature Effects 0.000 claims description 4
- 150000002148 esters Chemical class 0.000 claims description 4
- 235000019731 tricalcium phosphate Nutrition 0.000 claims description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical group [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 3
- 229910052782 aluminium Inorganic materials 0.000 claims description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 3
- 230000000975 bioactive effect Effects 0.000 claims description 3
- 239000003054 catalyst Substances 0.000 claims description 3
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims description 3
- 229940078499 tricalcium phosphate Drugs 0.000 claims description 3
- 239000003513 alkali Substances 0.000 claims description 2
- 150000001342 alkaline earth metals Chemical class 0.000 claims description 2
- 150000003839 salts Chemical group 0.000 claims description 2
- 239000002671 adjuvant Substances 0.000 claims 1
- 230000002902 bimodal effect Effects 0.000 claims 1
- 239000004068 calcium phosphate ceramic Substances 0.000 claims 1
- 150000002763 monocarboxylic acids Chemical class 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 239000007787 solid Substances 0.000 description 12
- 229920000728 polyester Polymers 0.000 description 10
- 239000002131 composite material Substances 0.000 description 9
- 239000012071 phase Substances 0.000 description 9
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 8
- 235000011010 calcium phosphates Nutrition 0.000 description 8
- 238000006243 chemical reaction Methods 0.000 description 8
- 239000003153 chemical reaction reagent Substances 0.000 description 8
- 239000012074 organic phase Substances 0.000 description 8
- 210000001519 tissue Anatomy 0.000 description 8
- 239000001993 wax Substances 0.000 description 7
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 239000002253 acid Substances 0.000 description 6
- 229910000389 calcium phosphate Inorganic materials 0.000 description 6
- 239000000945 filler Substances 0.000 description 6
- 239000002904 solvent Substances 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 5
- 239000007795 chemical reaction product Substances 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 150000007513 acids Chemical class 0.000 description 4
- 239000000316 bone substitute Substances 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 238000011282 treatment Methods 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 229910019142 PO4 Inorganic materials 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 229910052791 calcium Inorganic materials 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
- 238000006731 degradation reaction Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000006384 oligomerization reaction Methods 0.000 description 3
- 239000007858 starting material Substances 0.000 description 3
- 238000001356 surgical procedure Methods 0.000 description 3
- ALRHLSYJTWAHJZ-UHFFFAOYSA-N 3-hydroxypropionic acid Chemical compound OCCC(O)=O ALRHLSYJTWAHJZ-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 238000005520 cutting process Methods 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 229910010272 inorganic material Inorganic materials 0.000 description 2
- 239000011147 inorganic material Substances 0.000 description 2
- 238000004898 kneading Methods 0.000 description 2
- 229910052749 magnesium Inorganic materials 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- 239000000155 melt Substances 0.000 description 2
- 238000006386 neutralization reaction Methods 0.000 description 2
- 239000011368 organic material Substances 0.000 description 2
- 229920000620 organic polymer Polymers 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 235000021317 phosphate Nutrition 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 238000006068 polycondensation reaction Methods 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- BHQCQFFYRZLCQQ-UHFFFAOYSA-N (3alpha,5alpha,7alpha,12alpha)-3,7,12-trihydroxy-cholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 BHQCQFFYRZLCQQ-UHFFFAOYSA-N 0.000 description 1
- DNUYOWCKBJFOGS-UHFFFAOYSA-N 2-[[10-(2,2-dicarboxyethyl)anthracen-9-yl]methyl]propanedioic acid Chemical compound C1=CC=C2C(CC(C(=O)O)C(O)=O)=C(C=CC=C3)C3=C(CC(C(O)=O)C(O)=O)C2=C1 DNUYOWCKBJFOGS-UHFFFAOYSA-N 0.000 description 1
- VHBSECWYEFJRNV-UHFFFAOYSA-N 2-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=CC=C1O.OC(=O)C1=CC=CC=C1O VHBSECWYEFJRNV-UHFFFAOYSA-N 0.000 description 1
- YZWQAUGRNTXWBH-UHFFFAOYSA-N 2-hydroxybenzoic acid 4-methoxybenzoic acid Chemical compound OC(=O)c1ccccc1O.COc1ccc(cc1)C(O)=O YZWQAUGRNTXWBH-UHFFFAOYSA-N 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- SJZRECIVHVDYJC-UHFFFAOYSA-N 4-hydroxybutyric acid Chemical compound OCCCC(O)=O SJZRECIVHVDYJC-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 239000004380 Cholic acid Substances 0.000 description 1
- 208000032170 Congenital Abnormalities Diseases 0.000 description 1
- 102100028203 Cytochrome c oxidase subunit 3 Human genes 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 208000003433 Gingival Pocket Diseases 0.000 description 1
- 101710094396 Hexon protein Proteins 0.000 description 1
- 101000861034 Homo sapiens Cytochrome c oxidase subunit 3 Proteins 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 229920000954 Polyglycolide Polymers 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 150000001370 alpha-amino acid derivatives Chemical class 0.000 description 1
- 235000008206 alpha-amino acids Nutrition 0.000 description 1
- 229910052586 apatite Inorganic materials 0.000 description 1
- 238000013475 authorization Methods 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000008468 bone growth Effects 0.000 description 1
- 230000010072 bone remodeling Effects 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- -1 carboxylic acid carboxylic acids Chemical class 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 description 1
- 235000019416 cholic acid Nutrition 0.000 description 1
- 229960002471 cholic acid Drugs 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 239000007859 condensation product Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000013256 coordination polymer Substances 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- DDWFREDBVAUMFO-UHFFFAOYSA-N diphosphono hydrogen phosphate;hydrate Chemical compound O.OP(O)(=O)OP(O)(=O)OP(O)(O)=O DDWFREDBVAUMFO-UHFFFAOYSA-N 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 230000032050 esterification Effects 0.000 description 1
- 238000005886 esterification reaction Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000002657 fibrous material Substances 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 230000009969 flowable effect Effects 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000010954 inorganic particle Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- IJFXRHURBJZNAO-UHFFFAOYSA-N meta--hydroxybenzoic acid Natural products OC(=O)C1=CC=CC(O)=C1 IJFXRHURBJZNAO-UHFFFAOYSA-N 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- 229920002601 oligoester Polymers 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- 239000011236 particulate material Substances 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920002721 polycyanoacrylate Polymers 0.000 description 1
- 239000004633 polyglycolic acid Substances 0.000 description 1
- 239000004626 polylactic acid Substances 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 238000005245 sintering Methods 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000000967 suction filtration Methods 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000009044 synergistic interaction Effects 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 238000004260 weight control Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L24/0073—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
- A61L24/0084—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix containing fillers of phosphorus-containing inorganic compounds, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/3006—Properties of materials and coating materials
- A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00179—Ceramics or ceramic-like structures
- A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Composite Materials (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Materials Engineering (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Claims (13)
1. Komposition, som lämpar sig för ersättning eller förenande av ben, innehällande ätminstone partiellt resor- 5 berbara benersättnings- och/eller benkompoundrämaterial och hjälpämnen för inbindning av protesmaterial i levande benvävnader, och innehällande som väsentliga komponenter av kroppen fördragbara keramikrämaterial i blandning med av kroppen resorberbara oligomerer och/eller polymerer av 10 lägre hydroxikarbonsyror, speciellt av glykolsyra och/eller mjölksyra (hartskomponent), kännetecknad därav, att hartskomponenten framställs under medanvändning av molekylviktsreglerande koreaktanter ur klassen 1- eller flerfunktionella karbonsyror respektive motsvarande alko-15 holer och praktiskt taget befriats frän fria karboxyl-grupper.
2. Komposition enligt patentkrav 1, känne-t e c k n a d därav, att hartskomponenten framställts under medanvändning av glycerin och/eller glycerinpar- 20 tialestrar med speciellt högre monokarbonsyror - föret-rädesvis med ett C-antal i omrädet C12.i8· ,.
3. Komposition enligt patentkrav 2, känne- tecknad därav, att i hartskomponenten ursprungligen . . föreliggande fria karboxylgrupper omvandlats tili av krop- 25 pen fördragbara saltgrupper, speciellt tili sädana av alkali- och/eller jordalkalimetaller respektive av alumimi-nium, varvid motsvarande kalciumgrupper kan vara speciellt prefererade.
4. Komposition enligt nägot av patentkraven 1-3, ;1:1 30 kännetecknad därav, att rämaterialet innehäl- * ler ätminstone partiellt, företrädesvis övervägande eller • · enbart bioaktiva keramikrämaterial, speciellt ur klassen *···. resorberbara och/eller icke-resorberbara kalciumfosfatke- : ^ ramikmaterial i pulver- och/eller i granulatform. 97331
5. Komposition enligt nägot av patentkraven 1-4, kännetecknad därav, att den innehäller korn-formade keramikrämaterial, vilka speciellt även kan före-ligga som poröst granulat, vilket ätminstone partiellt 5 fyllts och/eller omhöljts med hartskomponenten.
6. Komposition enligt nägot av patentkraven 1-5, kännetecknad därav, att den som bioaktivt keramikrämaterial innehäller trikalciumfosfat och/eller hyd-roxylapatit i osintrad och/eller sintrad form.
7. Komposition enligt nägot av patentkraven 1-6, kännetecknad därav, att den utformats som ko-hesivt, vid rumstemperatur och företrädesvis även vid kroppstemperatur knädbart eller styvt kompoundrämaterial, vilket innehäller hartskomponenten i sluten fas, i vilken 15 det keramiska rämaterialet föreligger dispergerat i företrädesvis homogen fördelning.
8. Komposition enligt nägot av patentkraven 1-6, kännetecknad därav, att den utformats som dis-pergerbart kompoundmaterial, vars enskilda partiklar bil- ,. 20 dats av keramikpartiklar eller partikelagglomerat, vilka ’omhöljts med hartskomponenten och eventuellt indränkts ätminstone partiellt.
9. Komposition enligt nägot av patentkraven 1-8, kännetecknad därav, att den innehäller harts- *.· 25 komponenter med en medelmolekylvikt i omrädet ca. 200 - 10 000 g/mol, speciellt ca. 300 - 5 000 g/mol.
10. Komposition enligt nägot av patentkraven 1-9, kännetecknad därav, att den föreligger som en ; ;1 kohesiv, i värme formbar massa och att keramikrämaterialet • Il .1:1 30 uteslutande föreligger i pulverform och innehäller pulvret i en mängd över ca. 30 vikt-%, företrädesvis i omrädet ca. t · • 40-65 vikt-%, varvid den prefererade partikelstorleken hos pulvret ligger under 100 pm.
11. Komposition enligt nägot av patentkraven 1-9, .... 35 kännetecknad därav, att den som kohesiv massa 97331 innehäller keramikrämaterialen i granulatform - företrädesvis uppgär partikeldiametern hos granulaterna tili ca. 0,1 - 2 mm, speciellt 0,2 - 1 mm, varvid granulathalten ligger företrädesvis i omrädet ca. 20 - 60 vikt-% och spe-5 ciellt i omrädet ca. 25 - 50 vikt-%.
12. Komposition enligt nnnägot av patentkraven 1 - 11, kännetecknad därav, att de keramiska rä-materialen föreligger med ätminstone bimodal storleksför-delning, speciellt som blandning av pulver och granulat, 10 varvid pulverandelen företrädesvis uppgär tili ca. 5-30 vikt-% och granulatandelen tili ca. 15 - 50 vikt-%, i vart fall beräknat pä totalrämaterialet.
13. Komposition enligt nägot av patentkraven 1 - 12, kännetecknad därav, att som hartskom-15 ponent föreligger polymerer av glykolsyra och/eller mjölk- syra, vilka ej innehäller rester av främmande katalysato-rer ur framställningen. I 1 I I I I I I I < 1 ! ’ f | I I I I « r I f i • < I I « I • i • I • t · • · • · · • M I · • « • « • · e ♦ • · • I I » » ' I · • t $ • • · I I *
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3826915 | 1988-08-09 | ||
| DE3826915A DE3826915A1 (de) | 1988-08-09 | 1988-08-09 | Neue werkstoffe fuer den knochenersatz und knochen- bzw. prothesenverbund |
| EP8900893 | 1989-07-31 | ||
| PCT/EP1989/000893 WO1990001342A1 (de) | 1988-08-09 | 1989-07-31 | Neue werkstoffe für den knochenersatz und knochen- bzw. prothesenverbund |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI910600A0 FI910600A0 (sv) | 1991-02-07 |
| FI97331B true FI97331B (sv) | 1996-08-30 |
| FI97331C FI97331C (sv) | 1996-12-10 |
Family
ID=6360459
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI910600A FI97331C (sv) | 1988-08-09 | 1991-02-07 | Nya råmaterial för ersättande av ben och ben- eller protesförbindning |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5552454A (sv) |
| EP (1) | EP0428554B1 (sv) |
| JP (1) | JP2786495B2 (sv) |
| KR (1) | KR0134223B1 (sv) |
| AU (1) | AU627209B2 (sv) |
| BR (1) | BR8907595A (sv) |
| DE (2) | DE3826915A1 (sv) |
| DK (1) | DK170017B1 (sv) |
| FI (1) | FI97331C (sv) |
| NO (1) | NO178216C (sv) |
| WO (1) | WO1990001342A1 (sv) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4037516A1 (de) * | 1990-11-26 | 1992-05-27 | Henkel Kgaa | Hochfeste und abbaubare werkstoffe und formkoerper fuer die implantation in den menschlichen und tierischen organismus |
| DE4120325A1 (de) * | 1991-06-20 | 1992-12-24 | Merck Patent Gmbh | Implantatwerkstoff |
| DE4226465C2 (de) * | 1991-08-10 | 2003-12-04 | Gunze Kk | Kieferknochen-reproduzierendes Material |
| ES2192623T3 (es) * | 1995-12-18 | 2003-10-16 | Jens Schug | Implante medico. |
| DE19610715C1 (de) * | 1996-03-19 | 1997-06-26 | Axel Kirsch | Verfahren zum Herstellen eines Knochenersatzmaterials |
| DE19614421C2 (de) * | 1996-04-12 | 1999-12-16 | Biovision Gmbh | Verfahren zur Herstellung eines biodegradierbaren Knochenersatz- und Implantatwerkstoffes und biodegradierbarer Knochenersatz- und Implantatwerkstoff |
| JPH1033657A (ja) * | 1996-07-23 | 1998-02-10 | Dainippon Ink & Chem Inc | 生体内分解性材料及びその製造方法 |
| US5977204A (en) * | 1997-04-11 | 1999-11-02 | Osteobiologics, Inc. | Biodegradable implant material comprising bioactive ceramic |
| US7524335B2 (en) * | 1997-05-30 | 2009-04-28 | Smith & Nephew, Inc. | Fiber-reinforced, porous, biodegradable implant device |
| FI972890A7 (sv) * | 1997-07-08 | 1999-01-09 | Bioxid Oy | Ny plastbaserad komposit och dess användning |
| DE19841342A1 (de) * | 1998-09-10 | 2000-04-20 | Merck Patent Gmbh | Neue Reaktivsysteme aus polymerisierbaren Monomeren , die Peroxide und stabilisierten Boralkylverbindungen enthalten |
| KR20010027252A (ko) * | 1999-09-13 | 2001-04-06 | 김정식 | 생체분해성 뼈 접합 기구 및 그의 제조방법 |
| EP1229858B1 (en) * | 1999-11-01 | 2007-05-23 | Osteobiologics, Inc. | Biodegradable polymer/ceramic implant material with bimodal degradation profile |
| KR20010073801A (ko) * | 2000-01-20 | 2001-08-03 | 김현이 | 생체 이식용 복합체 제조 방법 |
| KR100445720B1 (ko) * | 2000-04-19 | 2004-08-25 | 퍼저 파마수티컬 컴퍼니 리미티드 | α-ＴＣＰ/ＨＡＰ 2성분상으로 구성된 시멘트 및 그제조방법 |
| DE10026620A1 (de) * | 2000-05-29 | 2002-03-07 | Gerhard Quelle | Poröse Implantate und Partikel |
| CA2430744C (en) * | 2000-12-08 | 2009-11-10 | Osteotech, Inc. | Implant for orthopedic applications |
| US20020114795A1 (en) | 2000-12-22 | 2002-08-22 | Thorne Kevin J. | Composition and process for bone growth and repair |
| US20020120340A1 (en) * | 2001-02-23 | 2002-08-29 | Metzger Robert G. | Knee joint prosthesis |
| US7497874B1 (en) | 2001-02-23 | 2009-03-03 | Biomet Manufacturing Corp. | Knee joint prosthesis |
| US8740987B2 (en) * | 2001-06-04 | 2014-06-03 | Warsaw Orthopedic, Inc. | Tissue-derived mesh for orthopedic regeneration |
| CN1294885C (zh) * | 2001-06-05 | 2007-01-17 | 江苏阳生生物工程有限公司 | 人体骨组织生物工程支架制品及其制备方法和用途 |
| KR100383433B1 (ko) * | 2001-06-29 | 2003-05-12 | 주식회사 씨엠리서치 | 고강도 뼈 고정용 생분해성 유기 고분자/무기 복합 소재의제조 방법 및 그에 의해 제조된 생분해성 유기고분자/무기 복합 소재 |
| US7211136B2 (en) | 2001-10-24 | 2007-05-01 | Pentron Clinical Technologies, Llc | Dental filling material |
| US7204875B2 (en) | 2001-10-24 | 2007-04-17 | Pentron Clinical Technologies, Llc | Dental filling material |
| US7204874B2 (en) | 2001-10-24 | 2007-04-17 | Pentron Clinical Technologies, Llc | Root canal filling material |
| US7750063B2 (en) | 2001-10-24 | 2010-07-06 | Pentron Clinical Technologies, Llc | Dental filling material |
| US7303817B2 (en) | 2001-10-24 | 2007-12-04 | Weitao Jia | Dental filling material |
| EP1344538A1 (en) | 2002-03-14 | 2003-09-17 | Degradable Solutions AG | Porous biodegradable implant material and method for its fabrication |
| DE20205016U1 (de) * | 2002-03-30 | 2003-08-14 | Mathys Medizinaltechnik Ag, Bettlach | Chirurgisches Implantat |
| IL149562A0 (en) | 2002-05-09 | 2002-11-10 | Prochon Ltd | Fgf variants and methods for use thereof |
| AU2003262660B2 (en) * | 2002-08-12 | 2009-07-16 | Warsaw Orthopedic, Inc. | Synthesis of a bone-polymer composite material |
| WO2004032988A2 (en) * | 2002-10-08 | 2004-04-22 | Osteotech, Inc. | Coupling agents for orthopedic biomaterials |
| WO2004053112A1 (en) * | 2002-12-12 | 2004-06-24 | Osteotech, Inc. | Formable and settable polymer bone composite and method of production thereof |
| US9107751B2 (en) | 2002-12-12 | 2015-08-18 | Warsaw Orthopedic, Inc. | Injectable and moldable bone substitute materials |
| EP1433489A1 (en) * | 2002-12-23 | 2004-06-30 | Degradable Solutions AG | Biodegradable porous bone implant with a barrier membrane sealed thereto |
| JP3831402B2 (ja) * | 2003-02-26 | 2006-10-11 | トライアル株式会社 | 生分解性樹脂及びリン酸カルシウムを含む再生医療用材料及びその製造方法 |
| US7572298B2 (en) * | 2003-03-28 | 2009-08-11 | Ethicon, Inc. | Implantable medical devices and methods for making same |
| US7012106B2 (en) | 2003-03-28 | 2006-03-14 | Ethicon, Inc. | Reinforced implantable medical devices |
| US7067123B2 (en) | 2003-04-29 | 2006-06-27 | Musculoskeletal Transplant Foundation | Glue for cartilage repair |
| US7901457B2 (en) | 2003-05-16 | 2011-03-08 | Musculoskeletal Transplant Foundation | Cartilage allograft plug |
| US7955616B2 (en) * | 2003-09-23 | 2011-06-07 | Orthocon, Inc. | Absorbable implants and methods for their use in hemostasis and in the treatment of osseous defects |
| US8016865B2 (en) | 2003-09-29 | 2011-09-13 | Depuy Mitek, Inc. | Method of performing anterior cruciate ligament reconstruction using biodegradable interference screw |
| US8012210B2 (en) | 2004-01-16 | 2011-09-06 | Warsaw Orthopedic, Inc. | Implant frames for use with settable materials and related methods of use |
| US20060015184A1 (en) * | 2004-01-30 | 2006-01-19 | John Winterbottom | Stacking implants for spinal fusion |
| US8163030B2 (en) * | 2004-05-06 | 2012-04-24 | Degradable Solutions Ag | Biocompatible bone implant compositions and methods for repairing a bone defect |
| US7815826B2 (en) | 2004-05-12 | 2010-10-19 | Massachusetts Institute Of Technology | Manufacturing process, such as three-dimensional printing, including solvent vapor filming and the like |
| DE102004035182B4 (de) * | 2004-07-14 | 2008-05-29 | Innovent E.V. Technologieentwicklung | Implantatmaterial, ein Verfahren zu seiner Herstellung und seine Verwendung |
| US7837740B2 (en) | 2007-01-24 | 2010-11-23 | Musculoskeletal Transplant Foundation | Two piece cancellous construct for cartilage repair |
| US20060233849A1 (en) * | 2005-04-13 | 2006-10-19 | Simon Bruce J | Composite bone graft material |
| US7621963B2 (en) * | 2005-04-13 | 2009-11-24 | Ebi, Llc | Composite bone graft material |
| US7815926B2 (en) | 2005-07-11 | 2010-10-19 | Musculoskeletal Transplant Foundation | Implant for articular cartilage repair |
| WO2007035778A2 (en) | 2005-09-19 | 2007-03-29 | Histogenics Corporation | Cell-support matrix and a method for preparation thereof |
| CA2637606C (en) | 2006-01-19 | 2013-03-19 | Osteotech, Inc. | Porous osteoimplant |
| US7718616B2 (en) * | 2006-12-21 | 2010-05-18 | Zimmer Orthobiologics, Inc. | Bone growth particles and osteoinductive composition thereof |
| US8163028B2 (en) | 2007-01-10 | 2012-04-24 | Biomet Manufacturing Corp. | Knee joint prosthesis system and method for implantation |
| US8187280B2 (en) | 2007-10-10 | 2012-05-29 | Biomet Manufacturing Corp. | Knee joint prosthesis system and method for implantation |
| US8157869B2 (en) | 2007-01-10 | 2012-04-17 | Biomet Manufacturing Corp. | Knee joint prosthesis system and method for implantation |
| US8562616B2 (en) | 2007-10-10 | 2013-10-22 | Biomet Manufacturing, Llc | Knee joint prosthesis system and method for implantation |
| US8328873B2 (en) | 2007-01-10 | 2012-12-11 | Biomet Manufacturing Corp. | Knee joint prosthesis system and method for implantation |
| US8435551B2 (en) | 2007-03-06 | 2013-05-07 | Musculoskeletal Transplant Foundation | Cancellous construct with support ring for repair of osteochondral defects |
| US20090054984A1 (en) | 2007-08-20 | 2009-02-26 | Histogenics Corporation | Method For Use Of A Double-Structured Tissue Implant For Treatment Of Tissue Defects |
| US8685107B2 (en) | 2007-07-03 | 2014-04-01 | Histogenics Corporation | Double-structured tissue implant and a method for preparation and use thereof |
| EP2265220A1 (en) | 2008-03-05 | 2010-12-29 | Musculoskeletal Transplant Foundation | Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles |
| GB0813659D0 (en) * | 2008-07-25 | 2008-09-03 | Smith & Nephew | Fracture putty |
| JP5361427B2 (ja) * | 2009-02-06 | 2013-12-04 | 日本特殊陶業株式会社 | 生体吸収性インプラント及びその製造方法 |
| US8444699B2 (en) * | 2010-02-18 | 2013-05-21 | Biomet Manufacturing Corp. | Method and apparatus for augmenting bone defects |
| CN103313733A (zh) | 2010-11-15 | 2013-09-18 | 捷迈整形外科生物材料有限公司 | 骨空隙填充剂 |
| US10077420B2 (en) | 2014-12-02 | 2018-09-18 | Histogenics Corporation | Cell and tissue culture container |
| JP6842170B2 (ja) * | 2017-09-28 | 2021-03-17 | 国立大学法人 岡山大学 | 生体組織接着剤の製造方法及び生体組織接着剤 |
| GB201910233D0 (en) * | 2019-07-17 | 2019-08-28 | Univ Oxford Innovation Ltd | Scaffold for bone ingrowth |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2362511A (en) * | 1939-11-21 | 1944-11-14 | Du Pont | Modified glycolide resins |
| US3773919A (en) * | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| DE2242867C3 (de) * | 1972-08-31 | 1975-09-25 | Battelle-Institut E.V., 6000 Frankfurt | Verfahren zur Herstellung implantierbarer, keramischer Knochenersatz-, Knochenverbund- oder Prothesenverankerung swerkstoffe |
| US3919773A (en) * | 1973-12-20 | 1975-11-18 | Sybron Corp | Direct moldable implant material |
| US4010196A (en) * | 1975-06-25 | 1977-03-01 | American Home Products Corporation | Linear polyester salts |
| US4011312A (en) * | 1975-06-25 | 1977-03-08 | American Home Products Corporation | Prolonged release drug form for the treatment of bovine mastitis |
| DE2620891C3 (de) * | 1976-05-12 | 1989-06-29 | Battelle-Institut eV, 6000 Frankfurt | Fester, resorbierbarer Knochenersatz-, Knochenverbund- oder Prothesenverankerungswerkstoff |
| US4118470A (en) * | 1976-06-01 | 1978-10-03 | American Cyanamid Company | Normally-solid, bioabsorbable, hydrolyzable, polymeric reaction product |
| FR2364644B1 (fr) * | 1976-09-20 | 1981-02-06 | Inst Nat Sante Rech Med | Nouveau materiau de prothese osseuse et son application |
| JPS5798556A (en) * | 1980-10-20 | 1982-06-18 | American Cyanamid Co | Refomation of polyglycolic acid obtaining variable vital body physical properties |
| DE3229540A1 (de) * | 1982-08-07 | 1984-02-09 | Henkel KGaA, 4000 Düsseldorf | Resorbierbare knochenwachse |
| US4443430A (en) * | 1982-11-16 | 1984-04-17 | Ethicon, Inc. | Synthetic absorbable hemostatic agent |
| DE3716302C2 (de) * | 1987-05-15 | 1996-02-01 | Henkel Kgaa | Verbesserte resorbierbare Knochenwachse und ihre Verwendung |
| US4563489A (en) * | 1984-02-10 | 1986-01-07 | University Of California | Biodegradable organic polymer delivery system for bone morphogenetic protein |
| DE3414924A1 (de) * | 1984-04-19 | 1985-10-31 | Klaus Dr.med. Dr.med.habil. 8000 München Draenert | Beschichtetes verankerungsteil fuer implantate |
| US4636526A (en) * | 1985-02-19 | 1987-01-13 | The Dow Chemical Company | Composites of unsintered calcium phosphates and synthetic biodegradable polymers useful as hard tissue prosthetics |
| US4842604A (en) * | 1985-02-19 | 1989-06-27 | The Dow Chemical Company | Composites of unsintered calcium phosphates and synthetic biodegradable polymers useful as hard tissue prosthetics |
| US4645503A (en) * | 1985-08-27 | 1987-02-24 | Orthomatrix Inc. | Moldable bone-implant material |
| DE3620685A1 (de) * | 1986-06-20 | 1987-12-23 | Henkel Kgaa | Neue mittel zur abdeckung unverletzter und/oder verletzter bereiche menschlicher oder tierischer haut |
| JP2567595B2 (ja) * | 1987-01-23 | 1996-12-25 | 京セラ株式会社 | 骨補綴部材 |
| US4843112A (en) * | 1987-03-12 | 1989-06-27 | The Beth Israel Hospital Association | Bioerodable implant composition |
| JPH01163135A (ja) * | 1987-12-18 | 1989-06-27 | Taki Chem Co Ltd | 徐放性基剤の製造方法 |
| DE3825211A1 (de) * | 1988-07-25 | 1990-02-01 | Henkel Kgaa | Verbesserte koerperresorbierbare knochenwachse (iii) |
-
1988
- 1988-08-09 DE DE3826915A patent/DE3826915A1/de not_active Withdrawn
-
1989
- 1989-07-31 BR BR898907595A patent/BR8907595A/pt not_active Application Discontinuation
- 1989-07-31 EP EP89908425A patent/EP0428554B1/de not_active Expired - Lifetime
- 1989-07-31 AU AU39724/89A patent/AU627209B2/en not_active Ceased
- 1989-07-31 DE DE8989908425T patent/DE58904522D1/de not_active Expired - Lifetime
- 1989-07-31 WO PCT/EP1989/000893 patent/WO1990001342A1/de not_active Ceased
- 1989-07-31 JP JP1507789A patent/JP2786495B2/ja not_active Expired - Fee Related
- 1989-07-31 KR KR1019900700739A patent/KR0134223B1/ko not_active Expired - Fee Related
-
1991
- 1991-01-31 NO NO910375A patent/NO178216C/no unknown
- 1991-02-07 FI FI910600A patent/FI97331C/sv not_active IP Right Cessation
- 1991-02-08 DK DK022191A patent/DK170017B1/da not_active IP Right Cessation
-
1994
- 1994-11-04 US US08/334,633 patent/US5552454A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DK22191A (da) | 1991-02-08 |
| DK170017B1 (da) | 1995-05-01 |
| JP2786495B2 (ja) | 1998-08-13 |
| KR900701334A (ko) | 1990-12-01 |
| WO1990001342A1 (de) | 1990-02-22 |
| EP0428554B1 (de) | 1993-05-26 |
| DK22191D0 (da) | 1991-02-08 |
| NO910375D0 (no) | 1991-01-31 |
| FI97331C (sv) | 1996-12-10 |
| NO178216C (no) | 1996-02-14 |
| FI910600A0 (sv) | 1991-02-07 |
| KR0134223B1 (ko) | 1998-04-18 |
| EP0428554A1 (de) | 1991-05-29 |
| BR8907595A (pt) | 1991-07-02 |
| DE3826915A1 (de) | 1990-02-15 |
| NO178216B (no) | 1995-11-06 |
| DE58904522D1 (de) | 1993-07-01 |
| AU627209B2 (en) | 1992-08-20 |
| AU3972489A (en) | 1990-03-05 |
| NO910375L (no) | 1991-01-31 |
| US5552454A (en) | 1996-09-03 |
| JPH04500013A (ja) | 1992-01-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI97331B (sv) | Nya råmaterial för ersättande av ben och ben- eller protesförbindning | |
| US5308623A (en) | Resorbable bone wax | |
| US5679723A (en) | Hard tissue bone cements and substitutes | |
| AU578135B2 (en) | Medical putty for tissue augmentation | |
| CH632158A5 (de) | Knochenersatz-, knochenverbund- oder prothesenverankerungswerkstoff. | |
| Tang et al. | A fast degradable citrate-based bone scaffold promotes spinal fusion | |
| JPH0663118A (ja) | 生体吸収可能ポリマーマトリックス中に分散した炭酸カルシウム粒子を含む骨補綴物質 | |
| WO1999033766A1 (fr) | Procede de fabrication d'une ceramique apatitique, en particulier pour usage biologique | |
| TW200924804A (en) | A bone and/or dental cement composition and uses thereof | |
| JPWO2006046414A1 (ja) | アパタイト／コラーゲン複合体繊維を含む多孔体の製造方法 | |
| KR102458881B1 (ko) | 콜라겐, 및 폴리카프로락톤을 포함하는 치유성이 개선된 다공성 치주조직 재생용 지지체 및 이의 제조방법 | |
| JPH0345265A (ja) | 医用組成物 | |
| JP2005095639A (ja) | 椎骨および管状骨を再生するためのセラミック中空体を有するインプラント | |
| KR101176793B1 (ko) | 실크 피브로인 가수분해물과 ｐｍｍａ를 함유하는 생체적합성 골 시멘트 조성물 | |
| KR101686343B1 (ko) | 히알루론산-키토산 복합체를 포함하는 생체 흡수성 고분자 복합재, 그의 제조방법 및 이를 포함하는 의료용 이식 재료 | |
| JPH02203861A (ja) | 生体材料 | |
| JP2638619B2 (ja) | 自己硬化型高強度複合生体材料とその製造方法 | |
| JPH0533633B2 (sv) | ||
| US20240293451A1 (en) | Angiogenesis material, bone-regeneration-promoting material, method for producing angiogenesis material, and method for producing bone-regeneration-promoting material | |
| US5236702A (en) | Composition and method for blood coagulation on hard body tissues | |
| CN1272077C (zh) | 骨组织修复填充材料及其制备方法 | |
| KR100445720B1 (ko) | α-ＴＣＰ/ＨＡＰ 2성분상으로 구성된 시멘트 및 그제조방법 | |
| Wu et al. | Wang Z, Liu Y, Zhao X, Fang C, Leung F, Yeung KWK and Wong TM (2022) The Development of a Magnesium-Releasing and Long-Term Mechanically Stable Calcium Phosphate Bone Cement Possessing Osteogenic and Immunomodulation Effects for Promoting Bone Fracture Regeneration | |
| JP2000256115A (ja) | リン酸カルシウムセメント粉体及びリン酸カルシウムセメント組成物 | |
| JPH01101976A (ja) | 骨セメント組成物 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB | Transfer or assigment of application |
Owner name: MERCK PATENT GMBH |
|
| BB | Publication of examined application | ||
| MM | Patent lapsed |