FI96682B - (2R,4S)-2-klormetyl-4-klor-1-sulfonylpyrrolidin-mellanprodukter, deras framställning och deras användning - Google Patents
(2R,4S)-2-klormetyl-4-klor-1-sulfonylpyrrolidin-mellanprodukter, deras framställning och deras användning Download PDFInfo
- Publication number
- FI96682B FI96682B FI902334A FI902334A FI96682B FI 96682 B FI96682 B FI 96682B FI 902334 A FI902334 A FI 902334A FI 902334 A FI902334 A FI 902334A FI 96682 B FI96682 B FI 96682B
- Authority
- FI
- Finland
- Prior art keywords
- compound
- formula
- preparation
- reaction
- hydroxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Claims (8)
1. Förening, som har formeln s /<S) \ (IX) ( CH,C1 SO2R2 10 där R2 är fenyl, som är substituerad med C^-C^-alkyl.
2. Förening enligt patentkrav 1, känne-t e c k n a d därav, att R2 Sr p-tolyl.
3. Förfarande för framställning av en förening, som 15 har formeln V-, /(s) \ (IX) (. iiau.uiCH^Cl 20 <R> S02 R2 där R2 är fenyl, som är substituerad med Cj^-Cj-alkyl, kännetecknat därav, att en förening, som har . . 25 formeln I · 1 • · « ·* ·* HO : %_ *:./ /(r) \ / \mmuCH20H (X)
30 I . .·. so2r2 1 · · •M • ♦ · där R2 är ovan definierad, uppvärms med tosylklorid i pyri-din. 35 4. Förfarande enligt patentkrav 3, känne tecknat därav, att R2 är p-tolyl. 96682
5. Användning av en förening med formeln (IX) för framställning av en förening med formeln (IA) eller ett syraadditionssalt därav, »Λ v>«R) i Ri 10 där Rx är väte eller C1-C6-alkyl, Y är väte eller S02R2, och R2 är fenyl, som är substituerad med C1-C6-alkyl, eller ett syraadditionssalt därav, kännetecknat därav, att (a) en förening med formeln (IX) C1\_. /iin C Jlii**u1CH2Cl (IX) \n/(r»
20 I SO2R2 där R2 är ovan definierad, omsätts med en Cj-C^-alkylamin eller ammoniak, varvid bildas en förening med formeln IA, där Y är S02R2 och Rx och R2 är ovan definierade, och om sä 25 önskas, • ♦ · S ·1 b) reduceras eller hydrolyseras en förening med * » ·.1·? formeln IA, där Y är S02R2, varvid bildas en förening med : 1 i formeln IA, där Y är väte. * ft 4 • · « • · · « · · • · · • » » •ft# • ft 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI932911A FI94532C (sv) | 1989-05-11 | 1993-06-23 | 2,5-diazabicyklo/2,2,1/heptanderivat |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35042389A | 1989-05-11 | 1989-05-11 | |
| US35042389 | 1989-05-11 | ||
| US07/423,063 US5036153A (en) | 1989-05-11 | 1989-10-18 | Preparation of 2,5-diazabicyclo[2.2.1]heptanes and intermediates |
| US42306389 | 1989-10-18 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI902334A0 FI902334A0 (sv) | 1990-05-10 |
| FI96682B true FI96682B (sv) | 1996-04-30 |
| FI96682C FI96682C (sv) | 1996-08-12 |
Family
ID=26996610
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI902334A FI96682C (sv) | 1989-05-11 | 1990-05-10 | (2R,4S)-2-klormetyl-4-klor-1-sulfonylpyrrolidin-mellanprodukter, deras framställning och deras användning |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5036153A (sv) |
| EP (1) | EP0397351B1 (sv) |
| JP (1) | JPH035482A (sv) |
| KR (1) | KR920003560B1 (sv) |
| CN (1) | CN1025852C (sv) |
| AT (1) | ATE108795T1 (sv) |
| AU (1) | AU637099B2 (sv) |
| CA (1) | CA2016343C (sv) |
| CZ (1) | CZ279947B6 (sv) |
| DE (1) | DE69010761T2 (sv) |
| DK (1) | DK0397351T3 (sv) |
| ES (1) | ES2056381T3 (sv) |
| FI (1) | FI96682C (sv) |
| HU (1) | HU206718B (sv) |
| IE (1) | IE64185B1 (sv) |
| IL (1) | IL94303A (sv) |
| NO (1) | NO902072L (sv) |
| NZ (1) | NZ233624A (sv) |
| PT (1) | PT93986B (sv) |
| RU (1) | RU2024524C1 (sv) |
| YU (1) | YU48131B (sv) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5196548A (en) * | 1989-05-11 | 1993-03-23 | Pfizer Inc. | Preparation of diazabicyclic Intermediates |
| US5128483A (en) * | 1989-07-19 | 1992-07-07 | American Cyanamid Company | Dibromovinyl and acetylene-1-pyrrolidinecarboxylic acid intermediates |
| US5254696A (en) * | 1990-09-13 | 1993-10-19 | Bayer Aktiengesellschaft | N-acylpyrrolidine derivatives |
| DE4029054A1 (de) * | 1990-09-13 | 1992-03-19 | Bayer Ag | N-acylpyrrolidin-derivate |
| AT403803B (de) | 1996-04-19 | 1998-05-25 | Sanochemia Ltd | Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln |
| US6589978B2 (en) * | 2000-06-30 | 2003-07-08 | Hoffman-La Roche Inc. | 1-sulfonyl pyrrolidine derivatives |
| JP4827154B2 (ja) * | 2001-07-25 | 2011-11-30 | 株式会社オーイズミ | 遊技装置 |
| TW200303742A (en) * | 2001-11-21 | 2003-09-16 | Novartis Ag | Organic compounds |
| JP4631262B2 (ja) * | 2003-10-07 | 2011-02-16 | 東レ・ファインケミカル株式会社 | （シス）−４−ヒドロキシプロリン誘導体の製造方法 |
| JP2007244428A (ja) * | 2006-03-13 | 2007-09-27 | Olympia:Kk | メダル貸出機 |
| JP4771416B2 (ja) * | 2006-03-22 | 2011-09-14 | サミー株式会社 | 遊技機 |
| CN102180824B (zh) * | 2011-02-18 | 2012-11-14 | 华东理工大学 | 吡咯衍生物的制备方法 |
| CN103755710B (zh) * | 2014-01-14 | 2015-08-12 | 昆明理工大学 | 一类2,5-二氮杂双环庚烷类化合物及其应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3083208A (en) * | 1961-05-11 | 1963-03-26 | Mead Johnson & Co | 1-acyl and 1-carbalkoxy-3-pyrrolidinols |
| NL124628C (sv) * | 1963-02-05 | |||
| US3459768A (en) * | 1966-05-24 | 1969-08-05 | Richardson Merrell Inc | Pyrrolidine-2,2-dimethanols and methods of preparing the same |
| US3947445A (en) * | 1974-05-09 | 1976-03-30 | Stanford Research Institute | Diazabicyclooctanes and diazabicycloheptanes |
| US3905979A (en) * | 1974-05-09 | 1975-09-16 | Stanford Research Inst | Diazabicyclooctanes and diazabicycloheptanes |
| HU184960B (en) * | 1981-07-20 | 1984-11-28 | Richter Gedeon Vegyeszet | Process for preparing new derivatives of 3,7-diazabicyclo/3.3.1/ nonane |
| US4539411A (en) * | 1982-02-05 | 1985-09-03 | Hoffmann-La Roche Inc. | Rhodium complexes of chiral phosphines |
| JPS60190760A (ja) * | 1984-03-09 | 1985-09-28 | Mitsubishi Chem Ind Ltd | ピロリジン誘導体及びその製造法 |
| US4571396A (en) * | 1984-04-16 | 1986-02-18 | Warner-Lambert Company | Antibacterial agents |
| IN166416B (sv) * | 1985-09-18 | 1990-05-05 | Pfizer | |
| JPS63162672A (ja) * | 1986-12-25 | 1988-07-06 | Ono Pharmaceut Co Ltd | 新規なプロリナ−ル誘導体、それらの製造方法およびそれらを含有する抗健忘症剤 |
| US4923879A (en) * | 1987-07-31 | 1990-05-08 | Warner-Lambert Company | 1,8-Naphthyridines and their use as antibacterial agents |
| GB8800694D0 (en) * | 1988-01-13 | 1988-02-10 | Pfizer Ltd | Antiarrhythmic agents |
-
1989
- 1989-10-18 US US07/423,063 patent/US5036153A/en not_active Expired - Lifetime
-
1990
- 1990-04-25 DK DK90304442.8T patent/DK0397351T3/da active
- 1990-04-25 AT AT90304442T patent/ATE108795T1/de not_active IP Right Cessation
- 1990-04-25 EP EP90304442A patent/EP0397351B1/en not_active Expired - Lifetime
- 1990-04-25 DE DE69010761T patent/DE69010761T2/de not_active Expired - Fee Related
- 1990-04-25 ES ES90304442T patent/ES2056381T3/es not_active Expired - Lifetime
- 1990-05-06 IL IL9430390A patent/IL94303A/en not_active IP Right Cessation
- 1990-05-08 CZ CS902279A patent/CZ279947B6/cs not_active IP Right Cessation
- 1990-05-09 PT PT93986A patent/PT93986B/pt not_active IP Right Cessation
- 1990-05-09 NZ NZ233624A patent/NZ233624A/en unknown
- 1990-05-09 CA CA002016343A patent/CA2016343C/en not_active Expired - Lifetime
- 1990-05-10 IE IE168990A patent/IE64185B1/en not_active IP Right Cessation
- 1990-05-10 KR KR1019900006578A patent/KR920003560B1/ko not_active IP Right Cessation
- 1990-05-10 CN CN90102798A patent/CN1025852C/zh not_active Expired - Lifetime
- 1990-05-10 HU HU902994A patent/HU206718B/hu not_active IP Right Cessation
- 1990-05-10 YU YU91390A patent/YU48131B/sh unknown
- 1990-05-10 FI FI902334A patent/FI96682C/sv active IP Right Grant
- 1990-05-10 AU AU54908/90A patent/AU637099B2/en not_active Ceased
- 1990-05-10 RU SU904743987A patent/RU2024524C1/ru not_active IP Right Cessation
- 1990-05-10 NO NO90902072A patent/NO902072L/no unknown
- 1990-05-11 JP JP2122831A patent/JPH035482A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI96682B (sv) | (2R,4S)-2-klormetyl-4-klor-1-sulfonylpyrrolidin-mellanprodukter, deras framställning och deras användning | |
| FI109295B (sv) | Asymmetriskt förfarande för framställning av florfenikol, tiamfenikol, kloramfenikol och oxazolinderivat | |
| DK1620396T3 (en) | A process for preparing N-substituted 2-cyanopyrrolidines | |
| CZ288652B6 (cs) | Způsob přípravy derivátů kyseliny gama-merkaptokarboxylové | |
| US20080009637A1 (en) | Preparation of N-protected-3-pyrrolidine-lactam substituted phosphonium salts | |
| Albanese et al. | Synthesis of N-sulfonyl aziridines through regioselective opening of epoxides under solid-liquid PTC conditions | |
| CA2263268A1 (en) | Process for the preparation of 3-amino-2-hydroxy-1-propyl ethers | |
| FI94532B (sv) | 2,5-diazabicyklo/2,2,1/heptanderivat | |
| US5196548A (en) | Preparation of diazabicyclic Intermediates | |
| US6388079B1 (en) | Process for preparing pergolide | |
| US20030153771A1 (en) | Large scale synthesis of optically pure aziridines | |
| FI113859B (sv) | Nya förfaranden för framställning av (S)-4-amino-hepta-5,6-diensyra och dess mellanprodukter samt nya mellanprodukter | |
| EP1282601B1 (en) | Process and intermediates for the preparation of 1-(9h-carbazol-4-yloxy)-3-[2-(2-methoxy-phenoxy)-ethylamino]-propan-2-ol, carvedilol or acid addition salt thereof | |
| EP1426356B1 (en) | Intermediate compounds for the preparation of mirtazapine and the production methods thereof | |
| US5142066A (en) | Stereoselective process for the preparation of 2-amino-ethanol derivatives having a central analgesic activity and intermidiates thereof | |
| FI93547B (sv) | Förfarande för framställning av optiskt aktiva 2-alkyl-2,5-diazabicyklo/2,2,1/heptaner | |
| PL164450B1 (pl) | Sposób wytwarzania pochodnych /2S,5S-diazablcyklo[2.2.1] heptanu PL | |
| NO158020B (no) | Fremgangsmaate for fremstilling av optisk rent s-3-morfolino-4-(3'-tertbutylamino-2'-hydroxypropoxy)-1,2,5-thiadiazol | |
| KR20030059724A (ko) | 이미다졸 유도체의 제조방법 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Patent granted |
Owner name: PFIZER INC. |
|
| BB | Publication of examined application | ||
| FG | Patent granted |
Owner name: PFIZER INC. |