FI964792A - raf-geenin ilmentymisen muuttaminen antisense-oligonukleotideillä - Google Patents
raf-geenin ilmentymisen muuttaminen antisense-oligonukleotideillä Download PDFInfo
- Publication number
- FI964792A FI964792A FI964792A FI964792A FI964792A FI 964792 A FI964792 A FI 964792A FI 964792 A FI964792 A FI 964792A FI 964792 A FI964792 A FI 964792A FI 964792 A FI964792 A FI 964792A
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- Prior art keywords
- oligonucleotides
- raf
- altering
- gene expression
- antisense oligonucleotides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
- C12N2310/3341—5-Methylcytosine
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/341—Gapmers, i.e. of the type ===---===
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3517—Marker; Tag
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Oncology (AREA)
- Virology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/250,856 US5563255A (en) | 1994-05-31 | 1994-05-31 | Antisense oligonucleotide modulation of raf gene expression |
PCT/US1995/007111 WO1995032987A1 (en) | 1994-05-31 | 1995-05-31 | ANTISENSE OLIGONUCLEOTIDE MODULATION OF raf GENE EXPRESSION |
Publications (2)
Publication Number | Publication Date |
---|---|
FI964792A0 FI964792A0 (fi) | 1996-11-29 |
FI964792A true FI964792A (fi) | 1996-11-29 |
Family
ID=22949424
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI964792A FI964792A (fi) | 1994-05-31 | 1996-11-29 | raf-geenin ilmentymisen muuttaminen antisense-oligonukleotideillä |
Country Status (12)
Country | Link |
---|---|
US (4) | US5563255A (fi) |
EP (1) | EP0763052B1 (fi) |
JP (2) | JP3231779B2 (fi) |
AT (1) | ATE280772T1 (fi) |
AU (1) | AU689267B2 (fi) |
CA (1) | CA2191795C (fi) |
DE (1) | DE69533697T2 (fi) |
FI (1) | FI964792A (fi) |
HU (1) | HUT76675A (fi) |
IL (1) | IL113804A (fi) |
NO (1) | NO965080L (fi) |
WO (1) | WO1995032987A1 (fi) |
Families Citing this family (101)
Publication number | Priority date | Publication date | Assignee | Title |
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US5981731A (en) * | 1994-05-31 | 1999-11-09 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide modulation of B-raf gene expression |
US6090626A (en) * | 1994-05-31 | 2000-07-18 | Isis Pharmaceuticals Inc. | Antisense oligonucleotide modulation of raf gene expression |
US6410518B1 (en) * | 1994-05-31 | 2002-06-25 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide inhibition of raf gene expression |
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KR100211178B1 (ko) * | 1994-05-31 | 1999-07-15 | 파샬 비. 린네 | 라프유전자 발현의 안티센스 올리고뉴클레오티드 조절 |
US6358932B1 (en) * | 1994-05-31 | 2002-03-19 | Isis Pharmaceticals, Inc. | Antisense oligonucleotide inhibition of raf gene expression |
US6608035B1 (en) * | 1994-10-25 | 2003-08-19 | Hybridon, Inc. | Method of down-regulating gene expression |
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-
1994
- 1994-05-31 US US08/250,856 patent/US5563255A/en not_active Expired - Lifetime
-
1995
- 1995-05-21 IL IL11380495A patent/IL113804A/xx not_active IP Right Cessation
- 1995-05-31 HU HU9603277A patent/HUT76675A/hu unknown
- 1995-05-31 AU AU26982/95A patent/AU689267B2/en not_active Expired - Fee Related
- 1995-05-31 WO PCT/US1995/007111 patent/WO1995032987A1/en active IP Right Grant
- 1995-05-31 AT AT95922217T patent/ATE280772T1/de not_active IP Right Cessation
- 1995-05-31 EP EP95922217A patent/EP0763052B1/en not_active Expired - Lifetime
- 1995-05-31 JP JP50125796A patent/JP3231779B2/ja not_active Expired - Lifetime
- 1995-05-31 DE DE69533697T patent/DE69533697T2/de not_active Expired - Lifetime
- 1995-05-31 CA CA002191795A patent/CA2191795C/en not_active Expired - Lifetime
-
1996
- 1996-11-28 NO NO965080A patent/NO965080L/no not_active Application Discontinuation
- 1996-11-29 FI FI964792A patent/FI964792A/fi unknown
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2000
- 2000-01-18 JP JP2000008654A patent/JP3121599B2/ja not_active Expired - Fee Related
-
2011
- 2011-07-18 US US13/185,406 patent/US20120149755A1/en not_active Abandoned
-
2012
- 2012-11-15 US US13/678,432 patent/US20130079387A1/en not_active Abandoned
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2013
- 2013-07-31 US US13/956,213 patent/US20140187601A1/en not_active Abandoned
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FI964792A0 (fi) | 1996-11-29 |
JP2000152797A (ja) | 2000-06-06 |
US20130079387A1 (en) | 2013-03-28 |
EP0763052B1 (en) | 2004-10-27 |
CA2191795A1 (en) | 1995-12-07 |
JP3231779B2 (ja) | 2001-11-26 |
US20120149755A1 (en) | 2012-06-14 |
US5563255A (en) | 1996-10-08 |
NO965080D0 (no) | 1996-11-28 |
JPH09507502A (ja) | 1997-07-29 |
US20140187601A1 (en) | 2014-07-03 |
ATE280772T1 (de) | 2004-11-15 |
CA2191795C (en) | 2003-06-10 |
JP3121599B2 (ja) | 2001-01-09 |
EP0763052A4 (en) | 1998-10-14 |
HU9603277D0 (en) | 1997-01-28 |
IL113804A (en) | 2000-12-06 |
AU2698295A (en) | 1995-12-21 |
IL113804A0 (en) | 1995-08-31 |
DE69533697D1 (de) | 2004-12-02 |
EP0763052A1 (en) | 1997-03-19 |
HUT76675A (en) | 1997-10-28 |
WO1995032987A1 (en) | 1995-12-07 |
AU689267B2 (en) | 1998-03-26 |
DE69533697T2 (de) | 2006-02-09 |
NO965080L (no) | 1996-11-28 |
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