NO965080L - Antisens oligonukleotidmodulering av genekspresjon - Google Patents

Antisens oligonukleotidmodulering av genekspresjon

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Publication number
NO965080L
NO965080L NO965080A NO965080A NO965080L NO 965080 L NO965080 L NO 965080L NO 965080 A NO965080 A NO 965080A NO 965080 A NO965080 A NO 965080A NO 965080 L NO965080 L NO 965080L
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NO
Norway
Prior art keywords
oligonucleotides
gene expression
raf
inhibiting
expression
Prior art date
Application number
NO965080A
Other languages
English (en)
Other versions
NO965080D0 (no
Inventor
Brett P Monia
Russell T Boggs
Original Assignee
Isis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc
Publication of NO965080D0 publication Critical patent/NO965080D0/no
Publication of NO965080L publication Critical patent/NO965080L/no

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3517—Marker; Tag

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  • Health & Medical Sciences (AREA)
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  • Oncology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Oligonukleotider som blir målsøkt til nukleinsyrer kodende for human raf og som har evne til å inhibere raf ekspresjon er beskrevet. Oligonukleotidene blir målsøkt til mRNA kodende for human c-raf eller human a-raf. Oligonukleotidene kan ha kjemiske modifikasjoner ved en eller flere posisjoner og kan være chimeriske oligonukleotider. Fremgangsmåte for inhibering av ekspresjonen av human raf ved anvendelse av Oligonukleotidene er også beskrevet. Det er videre beskrevet fremgangsmåter for inhibering av hyperproliferasjonen til celler og fremgangsmåter for behandling av unormale proliferative tilstander ved anvendelse av ovennevnte oligonukleotider.
NO965080A 1994-05-31 1996-11-28 Antisens oligonukleotidmodulering av genekspresjon NO965080L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/250,856 US5563255A (en) 1994-05-31 1994-05-31 Antisense oligonucleotide modulation of raf gene expression
PCT/US1995/007111 WO1995032987A1 (en) 1994-05-31 1995-05-31 ANTISENSE OLIGONUCLEOTIDE MODULATION OF raf GENE EXPRESSION

Publications (2)

Publication Number Publication Date
NO965080D0 NO965080D0 (no) 1996-11-28
NO965080L true NO965080L (no) 1996-11-28

Family

ID=22949424

Family Applications (1)

Application Number Title Priority Date Filing Date
NO965080A NO965080L (no) 1994-05-31 1996-11-28 Antisens oligonukleotidmodulering av genekspresjon

Country Status (12)

Country Link
US (4) US5563255A (no)
EP (1) EP0763052B1 (no)
JP (2) JP3231779B2 (no)
AT (1) ATE280772T1 (no)
AU (1) AU689267B2 (no)
CA (1) CA2191795C (no)
DE (1) DE69533697T2 (no)
FI (1) FI964792A (no)
HU (1) HUT76675A (no)
IL (1) IL113804A (no)
NO (1) NO965080L (no)
WO (1) WO1995032987A1 (no)

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US20140187601A1 (en) 2014-07-03
DE69533697D1 (de) 2004-12-02
EP0763052A1 (en) 1997-03-19
US5563255A (en) 1996-10-08
JPH09507502A (ja) 1997-07-29
HUT76675A (en) 1997-10-28
AU2698295A (en) 1995-12-21
IL113804A0 (en) 1995-08-31
HU9603277D0 (en) 1997-01-28
ATE280772T1 (de) 2004-11-15
US20120149755A1 (en) 2012-06-14
WO1995032987A1 (en) 1995-12-07
JP3121599B2 (ja) 2001-01-09
AU689267B2 (en) 1998-03-26
US20130079387A1 (en) 2013-03-28
FI964792A0 (fi) 1996-11-29
JP2000152797A (ja) 2000-06-06
CA2191795A1 (en) 1995-12-07
EP0763052A4 (en) 1998-10-14
JP3231779B2 (ja) 2001-11-26
DE69533697T2 (de) 2006-02-09
FI964792A (fi) 1996-11-29
CA2191795C (en) 2003-06-10
EP0763052B1 (en) 2004-10-27

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