FI961737A - Leimatut kemotaktiset peptidit infektio- tai tulehduskohtien kuvaamiseksi - Google Patents
Leimatut kemotaktiset peptidit infektio- tai tulehduskohtien kuvaamiseksi Download PDFInfo
- Publication number
- FI961737A FI961737A FI961737A FI961737A FI961737A FI 961737 A FI961737 A FI 961737A FI 961737 A FI961737 A FI 961737A FI 961737 A FI961737 A FI 961737A FI 961737 A FI961737 A FI 961737A
- Authority
- FI
- Finland
- Prior art keywords
- inflammation
- infection
- chemotactic peptides
- labeled chemotactic
- sites
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/140,000 US5792444A (en) | 1989-05-09 | 1993-10-22 | Labeled chemotactic peptides to image focal sites of infection or inflammation |
PCT/US1994/012279 WO1995011045A1 (en) | 1993-10-22 | 1994-10-24 | Labeled chemotactic peptides to image focal sites of infection or inflammation |
Publications (2)
Publication Number | Publication Date |
---|---|
FI961737A0 FI961737A0 (fi) | 1996-04-22 |
FI961737A true FI961737A (fi) | 1996-06-20 |
Family
ID=22489276
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI961737A FI961737A (fi) | 1993-10-22 | 1996-04-22 | Leimatut kemotaktiset peptidit infektio- tai tulehduskohtien kuvaamiseksi |
Country Status (17)
Country | Link |
---|---|
US (1) | US5792444A (zh) |
EP (1) | EP0732944A4 (zh) |
JP (1) | JPH09504526A (zh) |
KR (1) | KR100355424B1 (zh) |
CN (1) | CN1077439C (zh) |
AU (1) | AU699273B2 (zh) |
BR (1) | BR9407879A (zh) |
CA (1) | CA2173972A1 (zh) |
FI (1) | FI961737A (zh) |
HU (1) | HUT75056A (zh) |
IL (2) | IL111336A0 (zh) |
NO (1) | NO961532L (zh) |
NZ (2) | NZ329594A (zh) |
PL (1) | PL177585B1 (zh) |
TW (1) | TW472149B (zh) |
WO (1) | WO1995011045A1 (zh) |
ZA (1) | ZA948300B (zh) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5985240A (en) * | 1989-08-09 | 1999-11-16 | Rhomed Incorporated | Peptide radiopharmaceutical applications |
US5443816A (en) * | 1990-08-08 | 1995-08-22 | Rhomed Incorporated | Peptide-metal ion pharmaceutical preparation and method |
US5744120A (en) * | 1993-03-30 | 1998-04-28 | The Dupont Merick Pharmaceutical Company | Ternary radiopharmaceutical complexes |
ZA955642B (en) * | 1994-07-07 | 1997-05-06 | Ortho Pharma Corp | Lyophilized imaging agent formulation |
US6713605B1 (en) * | 1996-04-10 | 2004-03-30 | Kansas State University Research Foundation | Synthetic peptides that inhibit leukocyte superoxide anion production and/or attract leukocytes |
AR008290A1 (es) * | 1996-08-15 | 1999-12-29 | Smithkline Beecham Corp | Nuevos compuestos que contienen guanidina utiles como antagonistas de los receptores de il-8, composiciones farmaceuticas que los contienenprocedimiento para la preparacion de dichos compuestos y procedimiento para la preparacion de intermediarios. |
AU9307498A (en) | 1997-09-08 | 1999-03-29 | General Hospital Corporation, The | Imaging agents for early detection and monitoring of cardiovascular plaque |
US7060251B1 (en) | 1997-09-08 | 2006-06-13 | The General Hospital Corporation | Imaging agents for early detection and monitoring of cardiovascular plaque |
CA2359573C (en) | 1999-01-19 | 2010-04-20 | Biostream, Inc. | Conjugates of colony stimulating factors for targeting and imaging infection and inflammation |
WO2000046183A1 (en) | 1999-02-08 | 2000-08-10 | Checkpoint Genetics, Inc. | N-substituted amino acids, antioxidant pharmaceutical compositions containing same and methods using same |
US6358697B2 (en) | 1999-04-21 | 2002-03-19 | Children's Hospital Medical Center | Intracellular pharmaceutical targeting |
DE60036382D1 (de) * | 1999-06-21 | 2007-10-25 | Nihon Mediphysics Co Ltd | Verfahren zur verabreichung von arzneimitteln mit bindungsaffinität zum plasmaprotein und verwendung der zusammensetzung in dem verfahren |
US6685914B1 (en) * | 1999-09-13 | 2004-02-03 | Bristol-Myers Squibb Pharma Company | Macrocyclic chelants for metallopharmaceuticals |
EP1283728A2 (en) * | 2000-05-23 | 2003-02-19 | Amersham Health AS | Contrast agents |
NZ538869A (en) * | 2002-09-27 | 2006-09-29 | Nihon Mediphysics Co Ltd | Compound binding to leukocytes and medicinal composition containing the compound in labeled state as the active ingredient |
US20040225214A1 (en) * | 2003-05-07 | 2004-11-11 | General Electric Company | Method of high-throughput quantitative pet for small animal imaging using a large-bore pet scanner for the assessment of pet tracer performance |
US6987270B2 (en) * | 2003-05-07 | 2006-01-17 | General Electric Company | Method to account for event losses due to positron range in positron emission tomography and assay of positron-emitting isotopes |
US7317104B2 (en) | 2003-06-13 | 2008-01-08 | Bristol-Myers Squibb Pharma Company | Chelants and macrocyclic metal complex radiopharmaceuticals thereof |
US7319149B2 (en) * | 2003-06-13 | 2008-01-15 | Bristol-Myers Squibb Pharma Company | Chelants and macrocyclic metal complex radiopharmaceuticals thereof |
TWI332404B (en) | 2004-03-25 | 2010-11-01 | Nihon Mediphysics Co Ltd | Medicinal composition containing peptide improved in water solubility and metal labeling efficacy thereof and medicinal formulation containing metal labeled peptide |
US8115373B2 (en) | 2005-07-06 | 2012-02-14 | Rochester Institute Of Technology | Self-regenerating particulate trap systems for emissions and methods thereof |
JP5994971B2 (ja) | 2011-03-30 | 2016-09-21 | 日本メジフィジックス株式会社 | 炎症部位集積性化合物、核医学画像診断剤及び標識前駆体 |
WO2015031871A1 (en) * | 2013-08-30 | 2015-03-05 | St. Jude Children's Research Hospital | Substituted urea depsipeptide analogs as activators of the clpp endopeptidase |
US10100090B2 (en) | 2015-03-04 | 2018-10-16 | St. Jude Children's Research Hospital | Substituted urea depsipeptide analogs as activators of the CLPP endopeptidase |
US10570179B2 (en) | 2016-09-02 | 2020-02-25 | St. Jude Children's Research Hospital | Substituted urea depsipeptide analogs as activators of the CLPP endopeptidase |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4315906A (en) * | 1979-05-21 | 1982-02-16 | New England Nuclear Corporation | Cold insoluble globulin, its purification and use |
US4360509A (en) * | 1979-12-19 | 1982-11-23 | Byk-Mallinckrodt Cil B.V. | Vivo radioassay process |
US4348375A (en) * | 1979-12-31 | 1982-09-07 | Byk-Mallinckrodt Cil B.V. | Radioassay process and compositions useful therein |
US4444744A (en) * | 1980-03-03 | 1984-04-24 | Goldenberg Milton David | Tumor localization and therapy with labeled antibodies to cell surface antigens |
US4421735A (en) * | 1980-04-17 | 1983-12-20 | The Massachusetts General Hospital | Radiolabeled diagnostic compositions and method for making the same |
FI82379C (fi) * | 1981-10-27 | 1991-03-11 | Univ California | Radioaktivt maerkta monoklonala antikroppar samt en komposition innehaollande dessa och anvaendbar som diagnostiskt radiofarmaseutiskt medel. |
US4427660A (en) * | 1982-03-03 | 1984-01-24 | Research Corporation | Formyl-methionyl chemotatic peptide antibiotic conjugates useful in treating infections |
US4472509A (en) * | 1982-06-07 | 1984-09-18 | Gansow Otto A | Metal chelate conjugated monoclonal antibodies |
US4741900A (en) * | 1982-11-16 | 1988-05-03 | Cytogen Corporation | Antibody-metal ion complexes |
US4707353A (en) * | 1982-12-08 | 1987-11-17 | Mallinckrodt, Inc. | Radiographic imaging agents |
US4636380A (en) * | 1984-04-23 | 1987-01-13 | Wong Dennis W | Novel physiologic chemical method of labeling protein substances with the radionuclides of indium |
US4672028A (en) * | 1984-05-23 | 1987-06-09 | Icn Micromedic Systems, Inc. | Compositions and method for simultaneous multiple array of analytes using radioisotope chelate labels |
US4639365A (en) * | 1984-10-18 | 1987-01-27 | The Board Of Regents, The University Of Texas System | Gadolinium chelates as NMR contrast agents |
AU597032B2 (en) * | 1986-01-16 | 1990-05-24 | General Hospital Corporation, The | Method for the diagnosis and treatment of inflammation |
US4926869A (en) * | 1986-01-16 | 1990-05-22 | The General Hospital Corporation | Method for the diagnosis and treatment of inflammation |
DK172629B1 (da) * | 1986-02-14 | 1999-03-22 | Nihon Mediphysics Co Ltd | Reaktive højmolekylære forbindelser med mindst én fri aminogruppe, højmolekylære forbindelser kombineret med et fysiologisk |
US4915933A (en) * | 1986-06-26 | 1990-04-10 | The University Of New Mexico | Mixed complexes as shift and contrast reagents in NMR imaging and spectroscopy |
PT85537B (pt) * | 1986-08-18 | 1990-06-29 | Univ Texas | Processo para a preparacao de um sistema de administracao farmaceutica contendo peptidos apresentando quimiotaxia |
FI80801C (fi) * | 1987-01-14 | 1990-07-10 | Innofarm Oy | Konjugat av en monoklonal antikropp och anvaendning. eller ett fragment daerav och ett kelaterande aemne, dess framstaellning |
US5094950A (en) * | 1988-06-07 | 1992-03-10 | Nihon Medi-Physics Co., Ltd. | Diethylenetriamine pentaacetic acid derivatives |
IL93432A (en) * | 1989-02-24 | 1994-02-27 | Johnson Mathey Inc | Hydrazines and hydrazides, their conjugates with macromolecules, and such conjugates labeled with metallic ions |
US5376356A (en) * | 1989-03-14 | 1994-12-27 | Neorx Corporation | Imaging tissue sites of inflammation |
US4986979A (en) * | 1989-03-14 | 1991-01-22 | Neorx Corporation | Imaging tissue sites of inflammation |
NZ233601A (en) * | 1989-05-09 | 1997-06-24 | Gen Hospital Corp | N-terminal acylated peptides having an initial sequence met (or nle) -leu-phe and having a detectable label bound through dtpa or edta to a c-terminal lys or pu residue |
US5759515A (en) * | 1989-08-09 | 1998-06-02 | Rhomed Incorporated | Polyvalent peptide pharmaceutical applications |
US5443815A (en) * | 1991-11-27 | 1995-08-22 | Diatech, Inc. | Technetium-99m labeled peptides for imaging |
WO1993023085A1 (en) * | 1992-05-21 | 1993-11-25 | Diatech, Inc. | TECHNETIUM-99m LABELED PEPTIDES FOR THROMBUS IMAGING |
ATE188387T1 (de) * | 1991-02-08 | 2000-01-15 | Diatide Inc | Technetium-99m markierte polypeptide zur bildformung |
US5965107A (en) * | 1992-03-13 | 1999-10-12 | Diatide, Inc. | Technetium-99m labeled peptides for imaging |
US5225180A (en) * | 1991-09-10 | 1993-07-06 | Diatech, Inc. | Technetium-99m labeled somatostatin-derived peptides for imaging |
DK0629133T3 (da) * | 1992-01-03 | 2001-04-02 | Rhomed Inc | Farmaceutisk anvendelse af peptidmetalioner |
JPH07504902A (ja) * | 1992-03-13 | 1995-06-01 | ダイアタイド・インコーポレイテッド | 炎症造影用のテクネチウム−99m標識ペプチド |
US5508020A (en) * | 1992-06-05 | 1996-04-16 | Diatech, Inc. | Technetium-99M labeled peptides for imaging |
-
1993
- 1993-10-22 US US08/140,000 patent/US5792444A/en not_active Expired - Lifetime
-
1994
- 1994-10-19 IL IL11133694A patent/IL111336A0/xx unknown
- 1994-10-21 ZA ZA948300A patent/ZA948300B/xx unknown
- 1994-10-24 KR KR1019960702063A patent/KR100355424B1/ko not_active IP Right Cessation
- 1994-10-24 AU AU81261/94A patent/AU699273B2/en not_active Ceased
- 1994-10-24 PL PL94314109A patent/PL177585B1/pl not_active IP Right Cessation
- 1994-10-24 NZ NZ329594A patent/NZ329594A/en unknown
- 1994-10-24 WO PCT/US1994/012279 patent/WO1995011045A1/en not_active Application Discontinuation
- 1994-10-24 BR BR9407879A patent/BR9407879A/pt not_active Application Discontinuation
- 1994-10-24 HU HU9601044A patent/HUT75056A/hu unknown
- 1994-10-24 CN CN94194352A patent/CN1077439C/zh not_active Expired - Fee Related
- 1994-10-24 JP JP7512257A patent/JPH09504526A/ja not_active Ceased
- 1994-10-24 CA CA002173972A patent/CA2173972A1/en not_active Abandoned
- 1994-10-24 NZ NZ275964A patent/NZ275964A/en unknown
- 1994-10-24 EP EP95900435A patent/EP0732944A4/en not_active Withdrawn
-
1995
- 1995-03-31 TW TW084103229A patent/TW472149B/zh not_active IP Right Cessation
-
1996
- 1996-04-18 NO NO961532A patent/NO961532L/no unknown
- 1996-04-22 FI FI961737A patent/FI961737A/fi not_active IP Right Cessation
-
2000
- 2000-07-02 IL IL13712900A patent/IL137129A0/xx unknown
Also Published As
Publication number | Publication date |
---|---|
BR9407879A (pt) | 1996-10-29 |
PL177585B1 (pl) | 1999-12-31 |
EP0732944A4 (en) | 2000-06-07 |
HUT75056A (en) | 1997-03-28 |
US5792444A (en) | 1998-08-11 |
AU699273B2 (en) | 1998-11-26 |
CN1077439C (zh) | 2002-01-09 |
JPH09504526A (ja) | 1997-05-06 |
AU8126194A (en) | 1995-05-08 |
NZ275964A (en) | 1998-04-27 |
CA2173972A1 (en) | 1995-04-27 |
CN1141002A (zh) | 1997-01-22 |
NO961532D0 (no) | 1996-04-18 |
NO961532L (no) | 1996-06-21 |
NZ329594A (en) | 2000-07-28 |
HU9601044D0 (en) | 1996-06-28 |
IL137129A0 (en) | 2001-07-24 |
FI961737A0 (fi) | 1996-04-22 |
PL314109A1 (en) | 1996-08-19 |
ZA948300B (en) | 1995-06-22 |
KR960705592A (ko) | 1996-11-08 |
KR100355424B1 (ko) | 2003-02-17 |
IL111336A0 (en) | 1994-12-29 |
TW472149B (en) | 2002-01-11 |
EP0732944A1 (en) | 1996-09-25 |
WO1995011045A1 (en) | 1995-04-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MA | Patent expired |