KR960705592A - 감염 또는 염증의 병소부위를 영상화하기 위한 표지된 주화성 펩티드(labeled chemotactic peptides to image focal sites of infection or inflammation) - Google Patents

감염 또는 염증의 병소부위를 영상화하기 위한 표지된 주화성 펩티드(labeled chemotactic peptides to image focal sites of infection or inflammation)

Info

Publication number
KR960705592A
KR960705592A KR1019960702063A KR19960702063A KR960705592A KR 960705592 A KR960705592 A KR 960705592A KR 1019960702063 A KR1019960702063 A KR 1019960702063A KR 19960702063 A KR19960702063 A KR 19960702063A KR 960705592 A KR960705592 A KR 960705592A
Authority
KR
South Korea
Prior art keywords
inflammation
infection
image focal
chemotactic peptides
focal sites
Prior art date
Application number
KR1019960702063A
Other languages
English (en)
Other versions
KR100355424B1 (ko
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of KR960705592A publication Critical patent/KR960705592A/ko
Application granted granted Critical
Publication of KR100355424B1 publication Critical patent/KR100355424B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
KR1019960702063A 1993-10-22 1994-10-24 감염또는염증의병소부위를영상화하기위한표지된주화성펩티드 KR100355424B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/140000 1993-10-22
US08/140,000 US5792444A (en) 1989-05-09 1993-10-22 Labeled chemotactic peptides to image focal sites of infection or inflammation

Publications (2)

Publication Number Publication Date
KR960705592A true KR960705592A (ko) 1996-11-08
KR100355424B1 KR100355424B1 (ko) 2003-02-17

Family

ID=22489276

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019960702063A KR100355424B1 (ko) 1993-10-22 1994-10-24 감염또는염증의병소부위를영상화하기위한표지된주화성펩티드

Country Status (17)

Country Link
US (1) US5792444A (ko)
EP (1) EP0732944A4 (ko)
JP (1) JPH09504526A (ko)
KR (1) KR100355424B1 (ko)
CN (1) CN1077439C (ko)
AU (1) AU699273B2 (ko)
BR (1) BR9407879A (ko)
CA (1) CA2173972A1 (ko)
FI (1) FI961737A (ko)
HU (1) HUT75056A (ko)
IL (2) IL111336A0 (ko)
NO (1) NO961532L (ko)
NZ (2) NZ275964A (ko)
PL (1) PL177585B1 (ko)
TW (1) TW472149B (ko)
WO (1) WO1995011045A1 (ko)
ZA (1) ZA948300B (ko)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5985240A (en) * 1989-08-09 1999-11-16 Rhomed Incorporated Peptide radiopharmaceutical applications
US5443816A (en) * 1990-08-08 1995-08-22 Rhomed Incorporated Peptide-metal ion pharmaceutical preparation and method
US5744120A (en) * 1993-03-30 1998-04-28 The Dupont Merick Pharmaceutical Company Ternary radiopharmaceutical complexes
ZA955642B (en) * 1994-07-07 1997-05-06 Ortho Pharma Corp Lyophilized imaging agent formulation
US6713605B1 (en) * 1996-04-10 2004-03-30 Kansas State University Research Foundation Synthetic peptides that inhibit leukocyte superoxide anion production and/or attract leukocytes
AR008290A1 (es) * 1996-08-15 1999-12-29 Smithkline Beecham Corp Nuevos compuestos que contienen guanidina utiles como antagonistas de los receptores de il-8, composiciones farmaceuticas que los contienenprocedimiento para la preparacion de dichos compuestos y procedimiento para la preparacion de intermediarios.
US7060251B1 (en) 1997-09-08 2006-06-13 The General Hospital Corporation Imaging agents for early detection and monitoring of cardiovascular plaque
EP1011738A1 (en) 1997-09-08 2000-06-28 The General Hospital Corporation Imaging agents for early detection of cardiovascular plaque
ATE420665T1 (de) 1999-01-19 2009-01-15 Molecular Insight Pharm Inc Konjugate des granulozyten-kolonie stimulierenden faktors zur gezielten bildgebung von infektionen und entzündungen
US6346547B1 (en) 1999-02-08 2002-02-12 Checkpoint, Genetics, Inc. N-substituted amino acids, antioxidant pharmaceutical compositions containing n-substituted amino acids and methods for preventing cardiovascular diseases and/or preventing and/or treating antioxidant responsive diseases therewith
US6358697B2 (en) 1999-04-21 2002-03-19 Children's Hospital Medical Center Intracellular pharmaceutical targeting
WO2000078352A1 (fr) * 1999-06-21 2000-12-28 Nihon Medi-Physics Co., Ltd. Procede d'administration de medicaments possedant une affinite de liaison aux proteines plasmatiques et preparation utilisee pour la mise en oeuvre dudit procede
US6685914B1 (en) * 1999-09-13 2004-02-03 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
EP1283728A2 (en) * 2000-05-23 2003-02-19 Amersham Health AS Contrast agents
ATE382632T1 (de) 2002-09-27 2008-01-15 Nihon Mediphysics Co Ltd An leukozyten bindende verbindung und diese verbindung im markierten zustand als wirkstoff enthaltende medizinische zusammensetzung
US20040225214A1 (en) * 2003-05-07 2004-11-11 General Electric Company Method of high-throughput quantitative pet for small animal imaging using a large-bore pet scanner for the assessment of pet tracer performance
US6987270B2 (en) * 2003-05-07 2006-01-17 General Electric Company Method to account for event losses due to positron range in positron emission tomography and assay of positron-emitting isotopes
US7317104B2 (en) 2003-06-13 2008-01-08 Bristol-Myers Squibb Pharma Company Chelants and macrocyclic metal complex radiopharmaceuticals thereof
US7319149B2 (en) * 2003-06-13 2008-01-15 Bristol-Myers Squibb Pharma Company Chelants and macrocyclic metal complex radiopharmaceuticals thereof
TWI332404B (en) 2004-03-25 2010-11-01 Nihon Mediphysics Co Ltd Medicinal composition containing peptide improved in water solubility and metal labeling efficacy thereof and medicinal formulation containing metal labeled peptide
US8115373B2 (en) 2005-07-06 2012-02-14 Rochester Institute Of Technology Self-regenerating particulate trap systems for emissions and methods thereof
CA2772767C (en) 2011-03-30 2019-02-26 Kyoto University Compound accumulating in inflammatory site, diagnostic agent containing the compound in labeled state and its precursor compound for labeling
US9879050B2 (en) 2013-08-30 2018-01-30 St. Jude Children's Research Hospital Substituted urea depsipeptide analogs as activators of the CLPP endopeptidase
US10100090B2 (en) 2015-03-04 2018-10-16 St. Jude Children's Research Hospital Substituted urea depsipeptide analogs as activators of the CLPP endopeptidase
EP3506922B1 (en) 2016-09-02 2024-05-08 St. Jude Children's Research Hospital Substituted urea depsipeptide analogs as activators of the clpp endopeptidase

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4315906A (en) * 1979-05-21 1982-02-16 New England Nuclear Corporation Cold insoluble globulin, its purification and use
US4360509A (en) * 1979-12-19 1982-11-23 Byk-Mallinckrodt Cil B.V. Vivo radioassay process
US4348375A (en) * 1979-12-31 1982-09-07 Byk-Mallinckrodt Cil B.V. Radioassay process and compositions useful therein
US4444744A (en) * 1980-03-03 1984-04-24 Goldenberg Milton David Tumor localization and therapy with labeled antibodies to cell surface antigens
US4421735A (en) * 1980-04-17 1983-12-20 The Massachusetts General Hospital Radiolabeled diagnostic compositions and method for making the same
AT392004B (de) * 1981-10-27 1991-01-10 Hybritech Inc Verfahren zur herstellung eines monoklonalen antikoerpers gegen tumor-assoziiertes antigen und dessen verwendung
US4427660A (en) * 1982-03-03 1984-01-24 Research Corporation Formyl-methionyl chemotatic peptide antibiotic conjugates useful in treating infections
US4472509A (en) * 1982-06-07 1984-09-18 Gansow Otto A Metal chelate conjugated monoclonal antibodies
US4741900A (en) * 1982-11-16 1988-05-03 Cytogen Corporation Antibody-metal ion complexes
US4707353A (en) * 1982-12-08 1987-11-17 Mallinckrodt, Inc. Radiographic imaging agents
US4636380A (en) * 1984-04-23 1987-01-13 Wong Dennis W Novel physiologic chemical method of labeling protein substances with the radionuclides of indium
US4672028A (en) * 1984-05-23 1987-06-09 Icn Micromedic Systems, Inc. Compositions and method for simultaneous multiple array of analytes using radioisotope chelate labels
US4639365A (en) * 1984-10-18 1987-01-27 The Board Of Regents, The University Of Texas System Gadolinium chelates as NMR contrast agents
US4926869A (en) * 1986-01-16 1990-05-22 The General Hospital Corporation Method for the diagnosis and treatment of inflammation
AU597032B2 (en) * 1986-01-16 1990-05-24 General Hospital Corporation, The Method for the diagnosis and treatment of inflammation
AU593611B2 (en) * 1986-02-14 1990-02-15 Nihon Medi-Physics Co., Ltd. High molecular compounds having amino groups, and their utilization
US4915933A (en) * 1986-06-26 1990-04-10 The University Of New Mexico Mixed complexes as shift and contrast reagents in NMR imaging and spectroscopy
EP0256989A1 (en) * 1986-08-18 1988-02-24 Board Of Regents, The University Of Texas System Pharmaceutical administration systems containing chemotactic peptides
FI80801C (fi) * 1987-01-14 1990-07-10 Innofarm Oy Konjugat av en monoklonal antikropp och anvaendning. eller ett fragment daerav och ett kelaterande aemne, dess framstaellning
US5094950A (en) * 1988-06-07 1992-03-10 Nihon Medi-Physics Co., Ltd. Diethylenetriamine pentaacetic acid derivatives
IL93432A (en) * 1989-02-24 1994-02-27 Johnson Mathey Inc Hydrazines and hydrazides, their conjugates with macromolecules, and such conjugates labeled with metallic ions
US4986979A (en) * 1989-03-14 1991-01-22 Neorx Corporation Imaging tissue sites of inflammation
US5376356A (en) * 1989-03-14 1994-12-27 Neorx Corporation Imaging tissue sites of inflammation
NZ314680A (en) * 1989-05-09 2000-08-25 Ortho Pharma Corp Treating localised infection or inflammation with a therapeutically conjugated chemotactic peptide
US5759515A (en) * 1989-08-09 1998-06-02 Rhomed Incorporated Polyvalent peptide pharmaceutical applications
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
US5965107A (en) * 1992-03-13 1999-10-12 Diatide, Inc. Technetium-99m labeled peptides for imaging
JP2774378B2 (ja) * 1991-02-08 1998-07-09 ダイアテク，インコーポレイテッド 映像用テクネチウム−９９ｍ標識化ポリペプチド
US5225180A (en) * 1991-09-10 1993-07-06 Diatech, Inc. Technetium-99m labeled somatostatin-derived peptides for imaging
CA2127284C (en) * 1992-01-03 2002-02-05 Buck A. Rhodes Protein- and peptide-metal ion pharmaceutical applications
WO1993017719A1 (en) * 1992-03-13 1993-09-16 Diatech, Inc. TECHNETIUM-99m LABELED PEPTIDES FOR IMAGING INFLAMMATION
US5508020A (en) * 1992-06-05 1996-04-16 Diatech, Inc. Technetium-99M labeled peptides for imaging
DK0641222T3 (da) * 1992-05-21 2000-12-11 Diatide Inc Peptider mærket med technetium-99m til trombeafbildning

Also Published As

Publication number Publication date
NZ275964A (en) 1998-04-27
PL177585B1 (pl) 1999-12-31
IL137129A0 (en) 2001-07-24
CN1077439C (zh) 2002-01-09
EP0732944A4 (en) 2000-06-07
BR9407879A (pt) 1996-10-29
ZA948300B (en) 1995-06-22
CA2173972A1 (en) 1995-04-27
WO1995011045A1 (en) 1995-04-27
US5792444A (en) 1998-08-11
PL314109A1 (en) 1996-08-19
FI961737A0 (fi) 1996-04-22
HU9601044D0 (en) 1996-06-28
NO961532L (no) 1996-06-21
AU8126194A (en) 1995-05-08
KR100355424B1 (ko) 2003-02-17
AU699273B2 (en) 1998-11-26
NZ329594A (en) 2000-07-28
IL111336A0 (en) 1994-12-29
NO961532D0 (no) 1996-04-18
JPH09504526A (ja) 1997-05-06
TW472149B (en) 2002-01-11
FI961737A (fi) 1996-06-20
EP0732944A1 (en) 1996-09-25
HUT75056A (en) 1997-03-28
CN1141002A (zh) 1997-01-22

Similar Documents

Publication Publication Date Title
KR960705592A (ko) 감염 또는 염증의 병소부위를 영상화하기 위한 표지된 주화성 펩티드(labeled chemotactic peptides to image focal sites of infection or inflammation)
DE69428491T2 (de) Bildlinse
DE69410467T2 (de) Silizium-bildelektrode
DE69428642D1 (de) Zoomlinsenmechanismus
DE69405225D1 (de) Bildzusammensetzungssystem
DE59306082D1 (de) Endoskopobjektiv
BR9405802A (pt) Composição de éster epoxídico
DE69306645D1 (de) Zoomlinsenanordnung
DE69433988D1 (de) Bilderzeugung
DE69419663D1 (de) Multitasking-Prozessorarchitektur
DE69302946T2 (de) Weitwinkel-Zoomobjektiv
DE69423020D1 (de) Optischer Abtaster und Entfernungsmesser
DE69416439D1 (de) Optisches Bildaufnahmesystem
DE728203T1 (de) Zu innerem bild eines virenprotein ahnliche peptide
KR950001931U (ko) 고체 촬상소자 카메라의 초점 조절 장치
DE69406967D1 (de) Bildverstärker
DE9404993U1 (de) Balg
DE69421044T2 (de) Kompaktes optisches Linsensystem
ITBO930238A1 (it) Unita' di misura e conversione.
DE69402367T2 (de) Bildverstärkerröhre
KR940024682U (ko) 자바라형 튜브 보트
KR950002495U (ko) 영상관측장치의 구조
KR930022546U (ko) Fbt 의 포커스 유니트
ES1015497Y (es) Chancleta de playa
KR940025688U (ko) 이미지 스캐너의 고체촬상소자 보호장치

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20050722

Year of fee payment: 4

LAPS Lapse due to unpaid annual fee