FI961628A0 - Indolijohdannaisia NMDA-antagonisteina - Google Patents

Indolijohdannaisia NMDA-antagonisteina

Info

Publication number
FI961628A0
FI961628A0 FI961628A FI961628A FI961628A0 FI 961628 A0 FI961628 A0 FI 961628A0 FI 961628 A FI961628 A FI 961628A FI 961628 A FI961628 A FI 961628A FI 961628 A0 FI961628 A0 FI 961628A0
Authority
FI
Finland
Prior art keywords
indole derivatives
nmda antagonists
nmda
antagonists
indole
Prior art date
Application number
FI961628A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI961628A (fi
Inventor
Alfredo Cugola
Fabio Romano Di
Giorgio Pentas-Suglia
Original Assignee
Glaxo Wellcome Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Wellcome Spa filed Critical Glaxo Wellcome Spa
Publication of FI961628A0 publication Critical patent/FI961628A0/fi
Publication of FI961628A publication Critical patent/FI961628A/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI961628A 1993-10-14 1996-04-12 Indolijohdannaisia NMDA-antagonisteina FI961628A (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939321221A GB9321221D0 (en) 1993-10-14 1993-10-14 Heterocyclic compounds
PCT/EP1994/003359 WO1995010517A1 (en) 1993-10-14 1994-10-12 Indole derivatives as nmda antagonists

Publications (2)

Publication Number Publication Date
FI961628A0 true FI961628A0 (fi) 1996-04-12
FI961628A FI961628A (fi) 1996-04-12

Family

ID=10743550

Family Applications (1)

Application Number Title Priority Date Filing Date
FI961628A FI961628A (fi) 1993-10-14 1996-04-12 Indolijohdannaisia NMDA-antagonisteina

Country Status (27)

Country Link
US (3) US5760059A (ja)
EP (1) EP0723541A1 (ja)
JP (1) JPH09503770A (ja)
CN (1) CN1070490C (ja)
AP (1) AP574A (ja)
AU (1) AU681194B2 (ja)
BG (1) BG61839B1 (ja)
CA (1) CA2171449A1 (ja)
CO (1) CO4290355A1 (ja)
CZ (1) CZ92396A3 (ja)
FI (1) FI961628A (ja)
GB (1) GB9321221D0 (ja)
HU (1) HU219710B (ja)
IL (1) IL111294A (ja)
IS (1) IS4219A (ja)
MY (1) MY112411A (ja)
NO (1) NO309861B1 (ja)
NZ (1) NZ274179A (ja)
OA (1) OA10578A (ja)
PE (1) PE21995A1 (ja)
PL (1) PL179568B1 (ja)
RU (1) RU2144535C1 (ja)
SG (1) SG49013A1 (ja)
SK (1) SK44996A3 (ja)
TW (1) TW283144B (ja)
WO (1) WO1995010517A1 (ja)
ZA (1) ZA947948B (ja)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9321221D0 (en) * 1993-10-14 1993-12-01 Glaxo Spa Heterocyclic compounds
GB9704498D0 (en) * 1997-03-05 1997-04-23 Glaxo Wellcome Spa Chemical compound
GB9704499D0 (en) * 1997-03-05 1997-04-23 Glaxo Wellcome Spa Method of manufacture
JP2002540098A (ja) 1999-03-23 2002-11-26 住友製薬株式会社 三環性インドール−2−カルボン酸化合物
DE10153346A1 (de) 2001-10-29 2004-04-22 Grünenthal GmbH Substituierte Indole
US20030162825A1 (en) * 2001-11-09 2003-08-28 Sepracor Inc. D-amino acid oxidase inhibitors for learning and memory
ZA200605383B (en) 2003-12-29 2008-06-25 Sepracor Inc Pyrrole and pyrazole daao inhibitors
WO2007006003A2 (en) 2005-07-06 2007-01-11 Sepracor Inc. Combinations of eszopiclone and trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-n-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders
RU2430913C2 (ru) 2006-01-06 2011-10-10 Сепракор Инк. Циклоалкиламины в качестве ингибиторов повторного поглощения моноамина
WO2007081542A2 (en) * 2006-01-06 2007-07-19 Sepracor Inc. Tetralone-based monoamine reuptake inhibitors
DK2013835T3 (en) 2006-03-31 2015-12-14 Sunovion Pharmaceuticals Inc Preparation of chiral amides and AMINES
US7579370B2 (en) * 2006-06-30 2009-08-25 Sepracor Inc. Fused heterocycles
US7884124B2 (en) * 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US20080082066A1 (en) * 2006-10-02 2008-04-03 Weyerhaeuser Co. Crosslinked carboxyalkyl cellulose fibers having non-permanent and temporary crosslinks
CA2676432A1 (en) * 2007-01-18 2008-07-24 Sepracor, Inc. Inhibitors of d-amino acid oxidase
US7902252B2 (en) * 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
BRPI0811639A2 (pt) 2007-05-31 2014-09-30 Sepracor Inc Cicloaquilaminas fenil substituídas como inibidores da recaptação de monoamina
US20100120740A1 (en) * 2008-08-07 2010-05-13 Sepracor Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
US20110319463A1 (en) * 2009-03-10 2011-12-29 Saten Pharamaceuticals Co., Ltd. Preventive or therapeutic agents for optic nerve disorders comprising 4,6-dichloro-1h-indole-2-carboxylic acid derivatives or salts thereof as active ingredients
WO2011017634A2 (en) * 2009-08-07 2011-02-10 Sepracore Inc. Prodrugs of fused heterocyclic inhibitors of d-amino acid oxidase
EP2763676B1 (en) 2011-10-03 2019-12-25 The University of Utah Research Foundation Application of 5-ht6 receptor antagonists for the alleviation of cognitive deficits of down syndrome
IL248567B (en) 2014-04-30 2022-08-01 Univ Nat Taiwan Use of compounds known as d-amino acid oxidase inhibitors
IL265108B2 (en) 2016-09-14 2024-03-01 Yufeng Jane Tseng Novel mutated benzimidazoles as D-amino acid oxidase (DAAO) inhibitors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5256673A (en) * 1983-11-25 1993-10-26 Merck Patent Gesellschaft Mit Beschrankter Haftung Indole-3-yl-A-tetrahydropyridyl or piperidyl compounds
US4960786A (en) * 1989-04-24 1990-10-02 Merrell Dow Pharmaceuticals Inc. Excitatory amino acid antagonists
DE4101686A1 (de) * 1991-01-22 1992-07-23 Merck Patent Gmbh Indolderivate
US5284862A (en) * 1991-03-18 1994-02-08 Warner-Lambert Company Derivatives of 2-carboxyindoles having pharmaceutical activity
US5145845A (en) * 1991-05-14 1992-09-08 Warner-Lambert Co. Substituted 2-carboxylindoles having pharmaceutical activity
EP0545478A1 (en) * 1991-12-03 1993-06-09 MERCK SHARP & DOHME LTD. Heterocyclic compounds as tachykinin antagonists
GB9208492D0 (en) * 1992-04-16 1992-06-03 Glaxo Spa Heterocyclic compounds
EP0915090A1 (en) * 1992-09-10 1999-05-12 Eli Lilly And Company Compounds useful as hypoglycemic agents and for treating Alzheimer's disease
DE4333254A1 (de) * 1993-09-30 1995-04-06 Merck Patent Gmbh Piperidine und Piperazine
GB9321221D0 (en) * 1993-10-14 1993-12-01 Glaxo Spa Heterocyclic compounds

Also Published As

Publication number Publication date
HU219710B (hu) 2001-06-28
US5962496A (en) 1999-10-05
TW283144B (ja) 1996-08-11
SG49013A1 (en) 1998-05-18
CN1133042A (zh) 1996-10-09
US5760059A (en) 1998-06-02
JPH09503770A (ja) 1997-04-15
ZA947948B (en) 1995-05-23
AU681194B2 (en) 1997-08-21
WO1995010517A1 (en) 1995-04-20
HU9600969D0 (en) 1996-06-28
NO309861B1 (no) 2001-04-09
NO961475L (no) 1996-04-12
AP9400685A0 (en) 1994-10-31
CN1070490C (zh) 2001-09-05
MY112411A (en) 2001-06-30
US6100289A (en) 2000-08-08
PL179568B1 (pl) 2000-09-29
RU2144535C1 (ru) 2000-01-20
NO961475D0 (no) 1996-04-12
OA10578A (en) 2002-06-07
IL111294A (en) 1998-12-06
CA2171449A1 (en) 1995-04-20
BG61839B1 (bg) 1998-07-31
GB9321221D0 (en) 1993-12-01
CZ92396A3 (en) 1996-08-14
FI961628A (fi) 1996-04-12
BG100511A (en) 1996-11-29
HUT76065A (en) 1997-06-30
IL111294A0 (en) 1994-12-29
NZ274179A (en) 1998-01-26
CO4290355A1 (es) 1996-04-17
EP0723541A1 (en) 1996-07-31
SK44996A3 (en) 1997-01-08
AU7813394A (en) 1995-05-04
IS4219A (is) 1995-04-15
AP574A (en) 1997-01-30
PE21995A1 (es) 1995-08-14
PL313969A1 (en) 1996-08-05

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