FI953981A - 2-Bentsyyli-polysykliset guaniinijohdannaiset ja menetelmä niiden valmistamiseksi - Google Patents
2-Bentsyyli-polysykliset guaniinijohdannaiset ja menetelmä niiden valmistamiseksi Download PDFInfo
- Publication number
- FI953981A FI953981A FI953981A FI953981A FI953981A FI 953981 A FI953981 A FI 953981A FI 953981 A FI953981 A FI 953981A FI 953981 A FI953981 A FI 953981A FI 953981 A FI953981 A FI 953981A
- Authority
- FI
- Finland
- Prior art keywords
- benzyl
- preparation
- guanine derivatives
- polycyclic guanine
- polycyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2354993A | 1993-02-26 | 1993-02-26 | |
US2459993A | 1993-02-26 | 1993-02-26 | |
PCT/US1994/001728 WO1994019351A1 (en) | 1993-02-26 | 1994-02-24 | 2-benzyl-polycyclic guanine derivatives and process for preparing them |
Publications (2)
Publication Number | Publication Date |
---|---|
FI953981A0 FI953981A0 (fi) | 1995-08-24 |
FI953981A true FI953981A (fi) | 1995-08-24 |
Family
ID=26697306
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI953981A FI953981A (fi) | 1993-02-26 | 1995-08-24 | 2-Bentsyyli-polysykliset guaniinijohdannaiset ja menetelmä niiden valmistamiseksi |
Country Status (14)
Country | Link |
---|---|
US (1) | US5939419A (xx) |
EP (1) | EP0686157A1 (xx) |
JP (1) | JPH08507068A (xx) |
KR (1) | KR960701058A (xx) |
CN (1) | CN1118600A (xx) |
AU (1) | AU681875B2 (xx) |
CA (1) | CA2156918A1 (xx) |
FI (1) | FI953981A (xx) |
HU (1) | HUT72640A (xx) |
IL (1) | IL108754A0 (xx) |
NZ (1) | NZ262797A (xx) |
SG (1) | SG43809A1 (xx) |
TW (1) | TW270118B (xx) |
WO (1) | WO1994019351A1 (xx) |
Families Citing this family (76)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5631365A (en) | 1993-09-21 | 1997-05-20 | Schering Corporation | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
AR004752A1 (es) * | 1995-11-28 | 1999-03-10 | Schering Corp | 2'-[[4'-halo-[1,1'-bifenil]-4-il]metil]-5'-metil-espiro[ciclopentano-1,7' (8'h)-[3h imidazo[2,1-b]purin]-4'(5'h)-onas, uso del mismo para la preparacionde un medicamento, composicion farmaceutica y un proceso para su preparacion. |
US5824683A (en) * | 1995-11-28 | 1998-10-20 | Schering Corporation | 2'- 4'-halo- 1,1'-biphenyl!-4-yl!methyl!-5'-methyl-spiro cyclopentane-1,7' (8'H)- 3H! imidazo 2,1-b!purin!-4' (5'H)-ones |
US6410584B1 (en) | 1998-01-14 | 2002-06-25 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells with indole derivatives |
US6200771B1 (en) | 1998-10-15 | 2001-03-13 | Cell Pathways, Inc. | Method of using a novel phosphodiesterase in pharmaceutical screeing to identify compounds for treatment of neoplasia |
US6133271A (en) * | 1998-11-19 | 2000-10-17 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells and related conditions by exposure thienopyrimidine derivatives |
US6187779B1 (en) | 1998-11-20 | 2001-02-13 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells and related conditions by exposure to 2,8-disubstituted quinazoline derivatives |
US6369092B1 (en) | 1998-11-23 | 2002-04-09 | Cell Pathways, Inc. | Method for treating neoplasia by exposure to substituted benzimidazole derivatives |
US6034099A (en) * | 1998-11-24 | 2000-03-07 | Cell Pathways, Inc. | Method for inhibiting neoplastic lesions by administering 4-(arylmethylene)- 2, 3- dihydro-pyrazol-3-ones |
US6077842A (en) * | 1998-11-24 | 2000-06-20 | Cell Pathways, Inc. | Method of inhibiting neoplastic cells with pyrazolopyridylpyridazinone derivatives |
US6486155B1 (en) | 1998-11-24 | 2002-11-26 | Cell Pathways Inc | Method of inhibiting neoplastic cells with isoquinoline derivatives |
US6025394A (en) | 1999-01-29 | 2000-02-15 | Cell Pathways, Inc. | Method for treating patients with acne by administering substituted sulfonyl indenyl acetic acids, amides and alcohols |
US6020379A (en) * | 1999-02-19 | 2000-02-01 | Cell Pathways, Inc. | Position 7 substituted indenyl-3-acetic acid derivatives and amides thereof for the treatment of neoplasia |
US6403799B1 (en) * | 1999-10-21 | 2002-06-11 | Agouron Pharmaceuticals, Inc. | Methods for the preparation of intermediates in the synthesis of HIV-protease inhibitors |
US6821978B2 (en) | 2000-09-19 | 2004-11-23 | Schering Corporation | Xanthine phosphodiesterase V inhibitors |
ES2302835T3 (es) | 2001-08-28 | 2008-08-01 | Schering Corporation | Inhibidores de fosfodiesterasa v policiclicos de guanina. |
EP1790652A1 (en) * | 2001-08-28 | 2007-05-30 | Schering Corporation | Polycyclic guanine phosphodiesterase V inhibitors |
ES2429132T3 (es) | 2001-08-31 | 2013-11-13 | The Rockefeller University | Atividad de fosfodiesterasa y regulación de la señalización mediada por fosfodiesterasa 1-B en el cerebro |
WO2003042216A1 (en) * | 2001-11-09 | 2003-05-22 | Schering Corporation | Polycyclic guanine derivative phosphodiesterase v inhibitors |
EP1719772A1 (en) | 2002-05-31 | 2006-11-08 | Schering Corporation | Process for preparing xanthine phosphodiesterase v inhibitors and precursors thereof |
US7312223B2 (en) * | 2003-07-31 | 2007-12-25 | Schering Corporation | Metabolite of xanthine Phosphodiesterase 5 inhibitor and derivatives thereof useful for treatment of erectile dysfunction |
KR20060101762A (ko) * | 2003-11-21 | 2006-09-26 | 쉐링 코포레이션 | 포스포디에스테라제 v 억제제 제형 |
SE0401653D0 (sv) | 2004-06-24 | 2004-06-24 | Astrazeneca Ab | New compounds |
US20070004745A1 (en) * | 2005-03-25 | 2007-01-04 | Schering-Plough Corporation | Methods of treating benign prostatic hyperplasia or lower urinary tract symptoms by using PDE 5 inhibitors |
WO2006133261A2 (en) * | 2005-06-06 | 2006-12-14 | Intra-Cellular Therapies, Inc. | Organic compounds |
EP1919287A4 (en) * | 2005-08-23 | 2010-04-28 | Intra Cellular Therapies Inc | ORGANIC COMPOUNDS FOR TREATING A REDUCED DOPAMINE RECEPTOR SIGNALING ACTIVITY |
CA2632021A1 (en) | 2005-12-23 | 2007-06-28 | Astrazeneca Ab | Gaba-b receptor modulators |
CN101341130A (zh) | 2005-12-23 | 2009-01-07 | 阿斯利康(瑞典)有限公司 | 用于治疗胃肠障碍的咪唑衍生物 |
GB0601951D0 (en) | 2006-01-31 | 2006-03-15 | Novartis Ag | Organic compounds |
CA2651519A1 (en) * | 2006-06-06 | 2007-12-13 | Intra-Cellular Therapies, Inc. | Organic compounds |
ES2411604T3 (es) * | 2006-11-13 | 2013-07-05 | Intra-Cellular Therapies, Inc. | Compuestos orgánicos |
WO2008070095A1 (en) | 2006-12-05 | 2008-06-12 | Intra-Cellular Therapies, Inc. | Novel uses |
US7901872B2 (en) | 2007-05-21 | 2011-03-08 | Macronix International Co., Ltd. | Exposure process and photomask set used therein |
EP2170896A2 (en) * | 2007-06-21 | 2010-04-07 | Schering Corporation | Polycyclic guanine derivatives and use thereof |
AU2008335811B2 (en) | 2007-12-06 | 2012-05-17 | Intra-Cellular Therapies, Inc. | Organic compounds |
MX2010006208A (es) * | 2007-12-06 | 2010-12-21 | Intra Cellular Therapies Inc | Compuestos organicos. |
WO2009144548A1 (en) * | 2008-05-28 | 2009-12-03 | Glenmark Pharmaceuticals S.A. | Imidazo [2,1-b] purine derivatives as trpa1 modulators |
KR20110017431A (ko) | 2008-06-10 | 2011-02-21 | 아보트 러보러터리즈 | 신규한 트리사이클릭 화합물 |
BRPI0922808A2 (pt) | 2008-12-06 | 2018-05-29 | Intracellular Therapies Inc | compostos orgânicos |
KR20110098732A (ko) | 2008-12-06 | 2011-09-01 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 유기 화합물 |
JP5710492B2 (ja) | 2008-12-06 | 2015-04-30 | イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. | 有機化合物 |
JP5813511B2 (ja) | 2008-12-06 | 2015-11-17 | イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. | 有機化合物 |
US8536159B2 (en) | 2008-12-06 | 2013-09-17 | Intra-Cellular Therapies, Inc. | Organic compounds |
BRPI0922131A2 (pt) * | 2008-12-06 | 2015-08-18 | Intracellular Therapies Inc | Compostos orgânicos |
JP2012518685A (ja) | 2009-02-25 | 2012-08-16 | イントラ−セルラー・セラピーズ・インコーポレイテッド | 眼障害のためのpde1阻害剤 |
JP2012526810A (ja) | 2009-05-13 | 2012-11-01 | イントラ−セルラー・セラピーズ・インコーポレイテッド | 有機化合物 |
WO2011016861A2 (en) | 2009-08-05 | 2011-02-10 | Intra-Cellular Therapies, Inc. | Novel regulatory proteins and inhibitors |
SG181147A1 (en) | 2009-12-01 | 2012-07-30 | Abbott Lab | Novel tricyclic compounds |
CR20170159A (es) | 2009-12-01 | 2017-06-26 | Abbvie Inc | Nuevos compuestos tricíclicos |
WO2011153135A1 (en) | 2010-05-31 | 2011-12-08 | Intra-Cellular Therapies, Inc. | Organic compounds |
EP2575817A4 (en) | 2010-05-31 | 2014-01-08 | Intra Cellular Therapies Inc | ORGANIC CONNECTIONS |
TW201206937A (en) | 2010-05-31 | 2012-02-16 | Intra Cellular Therapies Inc | Organic compounds |
US9763948B2 (en) | 2010-05-31 | 2017-09-19 | Intra-Cellular Therapies, Inc. | PDE1 inhibitory compounds and methods |
WO2012171016A1 (en) | 2011-06-10 | 2012-12-13 | Intra-Cellular Therapies, Inc. | Organic compounds |
EP2956141A4 (en) | 2013-02-17 | 2016-10-26 | Intra Cellular Therapies Inc | NEW USES |
US9545406B2 (en) | 2013-03-15 | 2017-01-17 | Intra-Cellular Therapies, Inc. | Method of treating a CNS injury with a PDE1 inhibitor |
PL2970279T3 (pl) | 2013-03-15 | 2021-05-31 | Intra-Cellular Therapies, Inc. | Związki organiczne |
EP3091983B1 (en) | 2014-01-08 | 2019-10-02 | Intra-Cellular Therapies, Inc. | Pharmaceutical compositions comprising a pde-1 inhibitor and a pde-2 inhibitor |
EP3157926B1 (en) | 2014-06-20 | 2019-05-15 | Intra-Cellular Therapies, Inc. | Organic compounds |
US9546175B2 (en) | 2014-08-07 | 2017-01-17 | Intra-Cellular Therapies, Inc. | Organic compounds |
US10285992B2 (en) | 2014-08-07 | 2019-05-14 | Intra-Cellular Therapies, Inc. | Combinations of PDE1 inhibitors and NEP inhibitors and associated methods |
ES2745819T3 (es) | 2014-08-07 | 2020-03-03 | Intra Cellular Therapies Inc | Derivados de imidazo[1,2-a]-pirazolo[4,3-e]-pirimidin-4-ona con actividad inhibidora de la PDE1 |
CN107106563B (zh) | 2014-09-17 | 2021-05-25 | 细胞内治疗公司 | 化合物和方法 |
BR112017012005B1 (pt) | 2014-12-06 | 2023-04-04 | Intra-Cellular Therapies, Inc | Compostos orgânicos inibidores de pde2, composições farmacêuticas compreendendo os ditos compostos e uso dos mesmos no tratamento de um distúrbio mediado por pde2 |
EP3226870B1 (en) | 2014-12-06 | 2019-09-25 | Intra-Cellular Therapies, Inc. | Organic compounds |
US11512092B2 (en) | 2015-10-16 | 2022-11-29 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
EP3362455A1 (en) | 2015-10-16 | 2018-08-22 | AbbVie Inc. | PROCESSES FOR THE PREPARATION OF (3S,4R)-3-ETHYL-4-(3H-IMIDAZO[1,2-a]PYRROLO[2,3-e]-PYRAZIN-8-YL)-N-(2,2,2-TRIFLUOROETHYL)PYRROLIDINE-1-CARBOXAMIDE AND SOLID STATE FORMS THEREOF |
US11365198B2 (en) | 2015-10-16 | 2022-06-21 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
US11524964B2 (en) | 2015-10-16 | 2022-12-13 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
US10550126B2 (en) | 2015-10-16 | 2020-02-04 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-A]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
US11780848B2 (en) | 2015-10-16 | 2023-10-10 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1- carboxamide and solid state forms thereof |
EP3436083A4 (en) | 2016-03-28 | 2019-11-27 | Intra-Cellular Therapies, Inc. | NEW COMPOSITIONS AND METHODS |
US11291666B2 (en) | 2016-09-12 | 2022-04-05 | Intra-Cellular Therapies, Inc. | Uses |
CN110337437B (zh) | 2016-12-28 | 2023-02-03 | 达特神经科学有限公司 | 作为pde2抑制剂的取代的吡唑并嘧啶酮化合物 |
CA3120971A1 (en) | 2017-11-27 | 2019-05-31 | Dart Neuroscience, Llc | Substituted furanopyrimidine compounds as pde1 inhibitors |
JP7401442B2 (ja) | 2018-01-31 | 2023-12-19 | イントラ-セルラー・セラピーズ・インコーポレイテッド | 新規使用 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE7810946L (sv) * | 1978-10-20 | 1980-04-21 | Draco Ab | Metod att behandla kronisk obstruktiv luftvegssjukdom |
CH643260A5 (fr) * | 1980-05-02 | 1984-05-30 | Nestle Sa | 1-allyl-3-butyl-8-methylxanthine, procede de preparation et utilisation dans un medicament. |
US4663446A (en) * | 1983-06-27 | 1987-05-05 | Trustees Of The Univ. Of Massachusetts | N2 (phenyl substituted) deoxy guanosine containing compounds |
DE3324115A1 (de) * | 1983-07-05 | 1985-01-17 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue imidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel |
DE3347290A1 (de) * | 1983-12-28 | 1985-07-11 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue 2-phenyl-imidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel |
DE3445299A1 (de) * | 1984-12-12 | 1986-06-19 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue imidazoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
CA2028235C (en) * | 1989-10-20 | 1997-01-21 | Fumio Suzuki | Condensed purine derivatives |
IL98559A0 (en) * | 1990-06-21 | 1992-07-15 | Schering Corp | Polycyclic guanine derivatives |
DE4022314A1 (de) * | 1990-07-13 | 1992-01-16 | Boehringer Ingelheim Kg | Verfahren zur herstellung von 2-chlor-1,7-dihydropurin-6-on und verfahren zu dessen reinigung |
DE4035599A1 (de) * | 1990-11-06 | 1992-05-07 | Dresden Arzneimittel | Neue 5-(phenoxyalkanoylamino)-uracile, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
JP3260037B2 (ja) * | 1994-06-17 | 2002-02-25 | 松下電器産業株式会社 | 超音波ドプラ血流計 |
-
1994
- 1994-02-24 CA CA002156918A patent/CA2156918A1/en not_active Abandoned
- 1994-02-24 WO PCT/US1994/001728 patent/WO1994019351A1/en not_active Application Discontinuation
- 1994-02-24 SG SG1996001116A patent/SG43809A1/en unknown
- 1994-02-24 EP EP94910124A patent/EP0686157A1/en not_active Withdrawn
- 1994-02-24 HU HU9502464A patent/HUT72640A/hu unknown
- 1994-02-24 CN CN94191306A patent/CN1118600A/zh active Pending
- 1994-02-24 IL IL10875494A patent/IL108754A0/xx unknown
- 1994-02-24 TW TW083101584A patent/TW270118B/zh active
- 1994-02-24 JP JP6519139A patent/JPH08507068A/ja active Pending
- 1994-02-24 NZ NZ262797A patent/NZ262797A/xx unknown
- 1994-02-24 US US08/507,508 patent/US5939419A/en not_active Expired - Fee Related
- 1994-02-24 AU AU62687/94A patent/AU681875B2/en not_active Expired - Fee Related
-
1995
- 1995-08-24 FI FI953981A patent/FI953981A/fi not_active Application Discontinuation
- 1995-08-25 KR KR1019950703596A patent/KR960701058A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
TW270118B (xx) | 1996-02-11 |
EP0686157A1 (en) | 1995-12-13 |
HU9502464D0 (en) | 1995-10-30 |
CA2156918A1 (en) | 1994-09-01 |
WO1994019351A1 (en) | 1994-09-01 |
AU681875B2 (en) | 1997-09-11 |
JPH08507068A (ja) | 1996-07-30 |
HUT72640A (en) | 1996-05-28 |
FI953981A0 (fi) | 1995-08-24 |
SG43809A1 (en) | 1997-11-14 |
AU6268794A (en) | 1994-09-14 |
NZ262797A (en) | 1997-08-22 |
IL108754A0 (en) | 1994-06-24 |
US5939419A (en) | 1999-08-17 |
KR960701058A (ko) | 1996-02-24 |
CN1118600A (zh) | 1996-03-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application lapsed |