KR960701058A - 2-벤질-폴리사이클릭 구아닌 유도체 및 이의 제조방법(2-Benzyl-polycyslic guanine derivative and process for preparing them) - Google Patents
2-벤질-폴리사이클릭 구아닌 유도체 및 이의 제조방법(2-Benzyl-polycyslic guanine derivative and process for preparing them)Info
- Publication number
- KR960701058A KR960701058A KR1019950703596A KR19950703596A KR960701058A KR 960701058 A KR960701058 A KR 960701058A KR 1019950703596 A KR1019950703596 A KR 1019950703596A KR 19950703596 A KR19950703596 A KR 19950703596A KR 960701058 A KR960701058 A KR 960701058A
- Authority
- KR
- South Korea
- Prior art keywords
- polycyslic
- benzyl
- preparing
- guanine derivative
- guanine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in position 2 or 6
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2354993A | 1993-02-26 | 1993-02-26 | |
US2459993A | 1993-02-26 | 1993-02-26 | |
PCT/US1994/001728 WO1994019351A1 (en) | 1993-02-26 | 1994-02-24 | 2-benzyl-polycyclic guanine derivatives and process for preparing them |
Publications (1)
Publication Number | Publication Date |
---|---|
KR960701058A true KR960701058A (ko) | 1996-02-24 |
Family
ID=26697306
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019950703596A KR960701058A (ko) | 1993-02-26 | 1995-08-25 | 2-벤질-폴리사이클릭 구아닌 유도체 및 이의 제조방법(2-Benzyl-polycyslic guanine derivative and process for preparing them) |
Country Status (14)
Country | Link |
---|---|
US (1) | US5939419A (ko) |
EP (1) | EP0686157A1 (ko) |
JP (1) | JPH08507068A (ko) |
KR (1) | KR960701058A (ko) |
CN (1) | CN1118600A (ko) |
AU (1) | AU681875B2 (ko) |
CA (1) | CA2156918A1 (ko) |
FI (1) | FI953981A0 (ko) |
HU (1) | HUT72640A (ko) |
IL (1) | IL108754A0 (ko) |
NZ (1) | NZ262797A (ko) |
SG (1) | SG43809A1 (ko) |
TW (1) | TW270118B (ko) |
WO (1) | WO1994019351A1 (ko) |
Families Citing this family (76)
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US5631365A (en) | 1993-09-21 | 1997-05-20 | Schering Corporation | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
US5824683A (en) * | 1995-11-28 | 1998-10-20 | Schering Corporation | 2'- 4'-halo- 1,1'-biphenyl!-4-yl!methyl!-5'-methyl-spiro cyclopentane-1,7' (8'H)- 3H! imidazo 2,1-b!purin!-4' (5'H)-ones |
ZA969888B (en) * | 1995-11-28 | 1997-05-26 | Schering Corp | 2'-[[4'-halo-[1,1-biphenyl]-4-yl]methyl]-5'-methyl-spiro[cyclopentane-1,7'(8'H)-[3H]imidazo[2,1-b]purin]-4'(5'H)-ones |
US6410584B1 (en) | 1998-01-14 | 2002-06-25 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells with indole derivatives |
US6200771B1 (en) | 1998-10-15 | 2001-03-13 | Cell Pathways, Inc. | Method of using a novel phosphodiesterase in pharmaceutical screeing to identify compounds for treatment of neoplasia |
US6133271A (en) * | 1998-11-19 | 2000-10-17 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells and related conditions by exposure thienopyrimidine derivatives |
US6187779B1 (en) | 1998-11-20 | 2001-02-13 | Cell Pathways, Inc. | Method for inhibiting neoplastic cells and related conditions by exposure to 2,8-disubstituted quinazoline derivatives |
US6369092B1 (en) | 1998-11-23 | 2002-04-09 | Cell Pathways, Inc. | Method for treating neoplasia by exposure to substituted benzimidazole derivatives |
US6077842A (en) * | 1998-11-24 | 2000-06-20 | Cell Pathways, Inc. | Method of inhibiting neoplastic cells with pyrazolopyridylpyridazinone derivatives |
US6486155B1 (en) | 1998-11-24 | 2002-11-26 | Cell Pathways Inc | Method of inhibiting neoplastic cells with isoquinoline derivatives |
US6034099A (en) * | 1998-11-24 | 2000-03-07 | Cell Pathways, Inc. | Method for inhibiting neoplastic lesions by administering 4-(arylmethylene)- 2, 3- dihydro-pyrazol-3-ones |
US6025394A (en) | 1999-01-29 | 2000-02-15 | Cell Pathways, Inc. | Method for treating patients with acne by administering substituted sulfonyl indenyl acetic acids, amides and alcohols |
US6020379A (en) * | 1999-02-19 | 2000-02-01 | Cell Pathways, Inc. | Position 7 substituted indenyl-3-acetic acid derivatives and amides thereof for the treatment of neoplasia |
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WO2006104870A2 (en) * | 2005-03-25 | 2006-10-05 | Schering Corporation | Methods of treating benign prostatic hyperplasia or lower urinary track symptoms by using pde 5 inhibitors |
JP5084725B2 (ja) | 2005-06-06 | 2012-11-28 | 武田薬品工業株式会社 | 有機化合物 |
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AU2006327317B2 (en) | 2005-12-23 | 2010-11-25 | Astrazeneca Ab | GABA-B receptor modulators |
US7745474B2 (en) | 2005-12-23 | 2010-06-29 | Astrazeneca Ab | Imidazole derivatives for the treatment of gastrointestinal disorders |
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US7901872B2 (en) | 2007-05-21 | 2011-03-08 | Macronix International Co., Ltd. | Exposure process and photomask set used therein |
WO2009002423A2 (en) * | 2007-06-21 | 2008-12-31 | Schering Corporation | Polycyclic guanine derivatives and use thereof |
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CN104370920A (zh) | 2007-12-06 | 2015-02-25 | 武田药品工业株式会社 | 有机化合物 |
WO2009144548A1 (en) * | 2008-05-28 | 2009-12-03 | Glenmark Pharmaceuticals S.A. | Imidazo [2,1-b] purine derivatives as trpa1 modulators |
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KR20110095881A (ko) | 2008-12-06 | 2011-08-25 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 유기 화합물 |
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US9801882B2 (en) | 2013-02-17 | 2017-10-31 | Intra-Cellular Therapies, Inc. | Phosphodiesterase-1 inhibitors and their use in treatment of cardiovascular diseases |
RU2679142C2 (ru) | 2013-03-15 | 2019-02-06 | Интра-Селлулар Терапиз, Инк. | Органические соединения |
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WO2017172795A1 (en) | 2016-03-28 | 2017-10-05 | Intra-Cellular Therapies, Inc. | Novel compositions and methods |
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MX2019007803A (es) | 2016-12-28 | 2019-08-29 | Dart Neuroscience Llc | Compuestos de pirazolopirimidinona sustituida como inhibidores de fosfodiesterasas 2 (pde2). |
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WO2019152697A1 (en) | 2018-01-31 | 2019-08-08 | Intra-Cellular Therapies, Inc. | Novel uses |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE7810946L (sv) * | 1978-10-20 | 1980-04-21 | Draco Ab | Metod att behandla kronisk obstruktiv luftvegssjukdom |
CH643260A5 (fr) * | 1980-05-02 | 1984-05-30 | Nestle Sa | 1-allyl-3-butyl-8-methylxanthine, procede de preparation et utilisation dans un medicament. |
US4663446A (en) * | 1983-06-27 | 1987-05-05 | Trustees Of The Univ. Of Massachusetts | N2 (phenyl substituted) deoxy guanosine containing compounds |
DE3324115A1 (de) * | 1983-07-05 | 1985-01-17 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue imidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel |
DE3347290A1 (de) * | 1983-12-28 | 1985-07-11 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue 2-phenyl-imidazole, ihre herstellung und diese verbindungen enthaltende arzneimittel |
DE3445299A1 (de) * | 1984-12-12 | 1986-06-19 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue imidazoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
US5270316A (en) * | 1989-10-20 | 1993-12-14 | Kyowa Hakko Kogyo Co., Ltd. | Condensed purine derivatives |
ZA914727B (en) * | 1990-06-21 | 1992-03-25 | Schering Corp | Polycyclic guanine derivatives |
DE4022314A1 (de) * | 1990-07-13 | 1992-01-16 | Boehringer Ingelheim Kg | Verfahren zur herstellung von 2-chlor-1,7-dihydropurin-6-on und verfahren zu dessen reinigung |
DE4035599A1 (de) * | 1990-11-06 | 1992-05-07 | Dresden Arzneimittel | Neue 5-(phenoxyalkanoylamino)-uracile, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
JP3260037B2 (ja) * | 1994-06-17 | 2002-02-25 | 松下電器産業株式会社 | 超音波ドプラ血流計 |
-
1994
- 1994-02-24 CN CN94191306A patent/CN1118600A/zh active Pending
- 1994-02-24 EP EP94910124A patent/EP0686157A1/en not_active Withdrawn
- 1994-02-24 IL IL10875494A patent/IL108754A0/xx unknown
- 1994-02-24 SG SG1996001116A patent/SG43809A1/en unknown
- 1994-02-24 WO PCT/US1994/001728 patent/WO1994019351A1/en not_active Application Discontinuation
- 1994-02-24 AU AU62687/94A patent/AU681875B2/en not_active Expired - Fee Related
- 1994-02-24 NZ NZ262797A patent/NZ262797A/xx unknown
- 1994-02-24 TW TW083101584A patent/TW270118B/zh active
- 1994-02-24 US US08/507,508 patent/US5939419A/en not_active Expired - Fee Related
- 1994-02-24 HU HU9502464A patent/HUT72640A/hu unknown
- 1994-02-24 JP JP6519139A patent/JPH08507068A/ja active Pending
- 1994-02-24 CA CA002156918A patent/CA2156918A1/en not_active Abandoned
-
1995
- 1995-08-24 FI FI953981A patent/FI953981A0/fi not_active Application Discontinuation
- 1995-08-25 KR KR1019950703596A patent/KR960701058A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO1994019351A1 (en) | 1994-09-01 |
IL108754A0 (en) | 1994-06-24 |
SG43809A1 (en) | 1997-11-14 |
HUT72640A (en) | 1996-05-28 |
TW270118B (ko) | 1996-02-11 |
FI953981A (fi) | 1995-08-24 |
HU9502464D0 (en) | 1995-10-30 |
AU681875B2 (en) | 1997-09-11 |
CA2156918A1 (en) | 1994-09-01 |
CN1118600A (zh) | 1996-03-13 |
AU6268794A (en) | 1994-09-14 |
JPH08507068A (ja) | 1996-07-30 |
US5939419A (en) | 1999-08-17 |
NZ262797A (en) | 1997-08-22 |
FI953981A0 (fi) | 1995-08-24 |
EP0686157A1 (en) | 1995-12-13 |
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WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |