FI95250B - Förfarande för framställning av nya, terapeutiskt användbara kromanderivat - Google Patents

Förfarande för framställning av nya, terapeutiskt användbara kromanderivat Download PDF

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Publication number
FI95250B
FI95250B FI903704A FI903704A FI95250B FI 95250 B FI95250 B FI 95250B FI 903704 A FI903704 A FI 903704A FI 903704 A FI903704 A FI 903704A FI 95250 B FI95250 B FI 95250B
Authority
FI
Finland
Prior art keywords
chromene
dimethyl
formula
oxo
dihydro
Prior art date
Application number
FI903704A
Other languages
English (en)
Finnish (fi)
Other versions
FI903704A0 (sv
FI95250C (sv
Inventor
Rolf Gericke
Manfred Baumgarth
Ingeborg Lues
Rolf Bergmann
Peyer Jacques De
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of FI903704A0 publication Critical patent/FI903704A0/sv
Application granted granted Critical
Publication of FI95250B publication Critical patent/FI95250B/sv
Publication of FI95250C publication Critical patent/FI95250C/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyridine Compounds (AREA)

Claims (2)

1. Förfarande för framställning av nya, terapeu-tiskt användbara kromanderivat med formeln I 5 e R4"Z
10 R” R väri R1 Mr alkyl med 1-6 kolatomer, R2 är alkyl med 1-6 kolatomer,
15 R3 är CHO eller CH20H, R4 är en oxodihydropyridyl- eller oxodihydropyridä-zinylgrupp, R5 är H eller CN, R6 är H, och
20 Z är O eller en bindning, samt salter därav, kännetecknat därav, att en förening med formeln II " >6? Rb 30 väri E är Cl, Br, I eller en reaktionsduglig, förestrad OH-grupp och R1, R2, R3, R5 och R6 betecknar samma som i samband med formeln I, omsätts med en förening med formeln III
35 R4-Z-H III • · 20 95250 väri R4 och Z betecknar sanuna som i samband med formeln I, eller för framställning av en förening med formeln I, väri R3 är CH2OH, behandlas en förening med formeln I, väri 5 R3 är CHO, med ett reduktionsmedel och/eller, ifall önskvärt, överförs en eller flera av grupperna R4 och R5 i en förening med formeln I tili andra grupper R4 och/eller R5 och/eller en basisk eller sur förening med formeln I överförs tili ett sait därav genom 10 behandling med en syra eller bas.
2. Förfarande enligt patentkrav 1, k ä n n e -t e c k n a t därav, att man framställer (a) 2,2-dimetyl-3-formyl-4-(1,2-dihydro-2-oxo-l-pyridyl)-6-cyan-3-kromen, 15 (b) 2,2-dimetyl-3-hyrdoximetyl-4-(1,2-dihydro-2- oxo-l-pyridyl)-6-cyan-3-kromen eller (c) 2,2-dimetyl-3-formyl-4-(6-oxo-l,6-dihydro-3-py r i da z i ny 1 ox i) - 6 - cy an - 3 - k r omen. m
FI903704A 1989-07-24 1990-07-23 Förfarande för framställning av nya, terapeutiskt användbara kromanderivat FI95250C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3924417 1989-07-24
DE3924417A DE3924417A1 (de) 1989-07-24 1989-07-24 Chromanderivate

Publications (3)

Publication Number Publication Date
FI903704A0 FI903704A0 (sv) 1990-07-23
FI95250B true FI95250B (sv) 1995-09-29
FI95250C FI95250C (sv) 1996-01-10

Family

ID=6385695

Family Applications (1)

Application Number Title Priority Date Filing Date
FI903704A FI95250C (sv) 1989-07-24 1990-07-23 Förfarande för framställning av nya, terapeutiskt användbara kromanderivat

Country Status (20)

Country Link
US (1) US5143924A (sv)
EP (1) EP0410208B1 (sv)
JP (1) JPH0358983A (sv)
KR (1) KR910002845A (sv)
AR (1) AR245938A1 (sv)
AT (1) ATE107640T1 (sv)
AU (1) AU623544B2 (sv)
CA (1) CA2021684A1 (sv)
DE (2) DE3924417A1 (sv)
DK (1) DK0410208T3 (sv)
ES (1) ES2055830T3 (sv)
FI (1) FI95250C (sv)
HU (1) HU206707B (sv)
IE (1) IE63917B1 (sv)
IL (1) IL95167A (sv)
NO (1) NO176100C (sv)
NZ (1) NZ234609A (sv)
PT (1) PT94792B (sv)
TW (1) TW210337B (sv)
ZA (1) ZA905773B (sv)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5387587A (en) * 1986-12-23 1995-02-07 Merck Patent Gesellschaft Mit Beschrankter Haftung Chroman derivatives
US5284838A (en) * 1987-06-23 1994-02-08 Elf Sanofi Use of 2,2-dimethylchroman-3-ol derivatives in the treatment of asthma
DE3922392A1 (de) * 1989-07-07 1991-01-17 Merck Patent Gmbh Chromanderivate
TW257762B (sv) * 1991-06-14 1995-09-21 Nippon Chemicals Pharmaceutical Co Ltd
US5250547A (en) * 1991-08-29 1993-10-05 Syntex (U.S.A.) Inc. Benzopyran derivatives
US5837702A (en) * 1993-10-07 1998-11-17 Bristol-Myers Squibb Co. 4-arylamino-benzopyran and related compounds
CA2153498A1 (en) * 1993-11-10 1995-05-18 Hidetsura Cho Chroman derivative and medicinal use thereof
US5482942A (en) * 1994-06-28 1996-01-09 American Home Products Corporation (3,4-dioxocyclobuten-1-yl)chromene, indene, and dihydronaphthalenone derivatives as smooth muscle relaxants
US5470861A (en) * 1994-08-04 1995-11-28 Hoffmann-La Roche Inc. Method of promoting hair growth
US5612370A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phenylglycine and phenylalaninen amido benzopyran derivatives
US5612323A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phosphinic ester substituted benzopyran derivatives
US5629429A (en) * 1995-06-07 1997-05-13 Bristol-Myers Squibb Company Process for preparing 4-arylamino-benzopyran and related compounds
US5869478A (en) * 1995-06-07 1999-02-09 Bristol-Myers Squibb Company Sulfonamido substituted benzopyran derivatives

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1770171C3 (de) * 1967-04-14 1979-08-30 Beecham Group Ltd., Brentford, Mddlesex (Grossbritannien) 2,2-Dimethyl-7-alkyl-4-(4-pyridyl)-2H-chromen-5-ole, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneipräparate
US3973023A (en) * 1972-01-26 1976-08-03 Beecham Group Limited Anti-hypertensive polycyclic compounds for treating hypertension
GB1417745A (en) * 1973-07-07 1975-12-17 Beecham Group Ltd Chromene compounds
US3947462A (en) * 1974-05-22 1976-03-30 Abbott Laboratories 2,4,7-substituted 5-hydroxy benzopyrans and esters
DE2745305A1 (de) * 1977-10-07 1979-04-19 Bayer Ag Insektizide und akarizide mittel
US4486428A (en) * 1982-03-16 1984-12-04 Pfizer Inc. Bicyclic benzo fused compounds
DE3579390D1 (de) * 1984-06-22 1990-10-04 Beecham Group Plc Wirksame benzopyranverbindungen.
GB8521857D0 (en) * 1985-09-03 1985-10-09 Beecham Group Plc Active compounds
DE3726261A1 (de) * 1986-12-23 1988-07-07 Merck Patent Gmbh Chromanderivate
DE3835011A1 (de) * 1988-10-14 1990-04-19 Merck Patent Gmbh Chromanderivate
FR2615191B1 (fr) * 1987-05-16 1991-01-11 Sandoz Sa Nouveaux benzo(b)pyrannes et pyrannopyridines, leur preparation et leur utilisation comme medicaments
IL86798A (en) * 1987-06-23 1992-12-01 Sanofi Sa 2,2-dimethylchroman-3-ol derivatives, their preparation and pharmaceutical compositions containing them
US4971982A (en) * 1987-07-06 1990-11-20 Hoffmann-La Roche Inc. Benzopyran derivatives
JPH0753725B2 (ja) * 1987-10-08 1995-06-07 富山化学工業株式会社 ４ｈ―１―ベンゾピラン―４―オン誘導体およびその塩、それらの製造法並びにそれらを含有する抗炎症剤
FR2621587B1 (fr) * 1987-10-12 1990-02-09 Sanofi Sa Derives du dimethyl-2,2 chromene, procede pour leur preparation et composition pharmaceutiques les contenant
DE3811017A1 (de) * 1988-03-31 1989-10-19 Hoechst Ag Ungesaettigte n-benzopyranyllactame
AU628331B2 (en) * 1988-05-06 1992-09-17 Merck Patent Gesellschaft Mit Beschrankter Haftung Chroman derivatives
DE3918041A1 (de) * 1989-06-02 1990-12-06 Merck Patent Gmbh Chromanderivate

Also Published As

Publication number Publication date
NO176100B (no) 1994-10-24
CA2021684A1 (en) 1991-01-25
ES2055830T3 (es) 1994-09-01
IL95167A0 (en) 1991-06-10
AU623544B2 (en) 1992-05-14
FI903704A0 (sv) 1990-07-23
AR245938A1 (es) 1994-03-30
DE3924417A1 (de) 1991-01-31
PT94792B (pt) 1997-03-31
EP0410208A1 (de) 1991-01-30
HU904594D0 (en) 1990-12-28
IE63917B1 (en) 1995-06-14
US5143924A (en) 1992-09-01
ATE107640T1 (de) 1994-07-15
FI95250C (sv) 1996-01-10
AU5975190A (en) 1991-01-24
PT94792A (pt) 1991-03-20
NO903275D0 (no) 1990-07-23
KR910002845A (ko) 1991-02-26
NO176100C (no) 1995-02-01
JPH0358983A (ja) 1991-03-14
ZA905773B (en) 1991-05-29
HUT59130A (en) 1992-04-28
NO903275L (no) 1991-01-25
HU206707B (en) 1992-12-28
EP0410208B1 (de) 1994-06-22
IL95167A (en) 1995-11-27
IE902676A1 (en) 1991-02-27
DK0410208T3 (da) 1994-07-25
TW210337B (sv) 1993-08-01
NZ234609A (en) 1991-04-26
DE59006189D1 (de) 1994-07-28

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Owner name: MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUN