FI952022A0 - Biologiska faktorer och neurala stamceller - Google Patents

Biologiska faktorer och neurala stamceller

Info

Publication number
FI952022A0
FI952022A0 FI952022A FI952022A FI952022A0 FI 952022 A0 FI952022 A0 FI 952022A0 FI 952022 A FI952022 A FI 952022A FI 952022 A FI952022 A FI 952022A FI 952022 A0 FI952022 A0 FI 952022A0
Authority
FI
Finland
Prior art keywords
stem cells
neural stem
biological factors
oligodendrocytes
astrocytes
Prior art date
Application number
FI952022A
Other languages
English (en)
Finnish (fi)
Other versions
FI952022A (sv
Inventor
Samuel Weiss
Brent A Reynolds
Joseph P Hammang
Edward E Baetge
Original Assignee
Neurospheres Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25513066&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI952022(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Neurospheres Ltd filed Critical Neurospheres Ltd
Publication of FI952022A0 publication Critical patent/FI952022A0/sv
Publication of FI952022A publication Critical patent/FI952022A/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0065—Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/01—Hydro-lyases (4.2.1)
    • C12Y402/01011—Phosphopyruvate hydratase (4.2.1.11), i.e. enolase
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/46—Amines, e.g. putrescine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/148—Transforming growth factor alpha [TGF-a]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones
    • C12N2501/392—Sexual steroids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
FI952022A 1992-10-28 1995-04-27 Biologiska faktorer och neurala stamceller FI952022A (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96762292A 1992-10-28 1992-10-28
PCT/CA1993/000456 WO1994010292A1 (en) 1992-10-28 1993-10-27 Biological factors and neural stem cells

Publications (2)

Publication Number Publication Date
FI952022A0 true FI952022A0 (sv) 1995-04-27
FI952022A FI952022A (sv) 1995-04-27

Family

ID=25513066

Family Applications (1)

Application Number Title Priority Date Filing Date
FI952022A FI952022A (sv) 1992-10-28 1995-04-27 Biologiska faktorer och neurala stamceller

Country Status (14)

Country Link
EP (2) EP0669973B9 (sv)
JP (2) JPH08502652A (sv)
KR (1) KR950704476A (sv)
AT (2) ATE483795T1 (sv)
AU (2) AU5367694A (sv)
CA (1) CA2148138C (sv)
DE (2) DE69332759T3 (sv)
DK (1) DK0669973T4 (sv)
ES (1) ES2194016T5 (sv)
FI (1) FI952022A (sv)
NO (1) NO324412B1 (sv)
PT (1) PT669973E (sv)
RU (1) RU95115822A (sv)
WO (1) WO1994010292A1 (sv)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5981165A (en) * 1991-07-08 1999-11-09 Neurospheres Holdings Ltd. In vitro induction of dopaminergic cells
US5849553A (en) * 1992-07-27 1998-12-15 California Institute Of Technology Mammalian multipotent neural stem cells
US5672499A (en) * 1992-07-27 1997-09-30 California Institute Of Technology Immoralized neural crest stem cells and methods of making
US6872699B2 (en) 1992-11-13 2005-03-29 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften, E.V. Truncated Flk-1 receptor protein, methods of use and a recombinant vector containing a nucleotide encoding the truncated Flk-1 protein
US6001654A (en) * 1994-01-28 1999-12-14 California Institute Of Technology Methods for differentiating neural stem cells to neurons or smooth muscle cells using TGT-β super family growth factors
WO1996004368A1 (en) * 1994-07-29 1996-02-15 Dalhousie University Propagation and inducible differentiation of human fetal central nervous system progenitor cells
AU714837B2 (en) * 1994-09-23 2000-01-13 Neurospheres Holdings Ltd In vitro models of CNS function and dysfunction
KR970707272A (ko) * 1994-11-14 1997-12-01 스코트 디. 코르맥 신경 간세포 증식 조절 방법(regulation of neural stem cell proliferation)
WO1996037601A1 (en) * 1995-05-24 1996-11-28 Cellfactors Plc Cell differentiation agents
FR2746109B1 (fr) 1996-03-12 1998-04-17 Rhone Poulenc Rorer Sa Milieu pour la conservation de materiel biologique
US7544511B2 (en) 1996-09-25 2009-06-09 Neuralstem Biopharmaceuticals Ltd. Stable neural stem cell line methods
US5753506A (en) * 1996-05-23 1998-05-19 Cns Stem Cell Technology, Inc. Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals
US6969608B1 (en) 1996-08-26 2005-11-29 Mcgill University Pharmaceuticals containing multipotential precursor cells from tissues containing sensory receptors
US6787355B1 (en) 1996-08-26 2004-09-07 Mcgill University Multipotent neural stem cells from peripheral tissues and uses thereof
US6713247B1 (en) 1996-09-03 2004-03-30 Signal Pharmaceuticials, Inc. Human CNS cell lines and methods of use therefor
CA2216439A1 (en) * 1996-09-25 1998-03-25 Derek Van Der Kooy Pharmaceuticals containing retinal stem cells
KR20060002033A (ko) * 1997-07-04 2006-01-06 유니버시티 오브 유타 리서치 파운데이션 계통이 예정된 신경세포 전구체
US20020123143A1 (en) 1997-08-22 2002-09-05 Jean Toma Multipotent stem cells from peripheral tissues and uses thereof
US5968829A (en) 1997-09-05 1999-10-19 Cytotherapeutics, Inc. Human CNS neural stem cells
US6165783A (en) 1997-10-24 2000-12-26 Neuro Spheres Holdings Ltd. Erythropoietin-mediated neurogenesis
JP3291698B2 (ja) * 1998-07-24 2002-06-10 スティーブン・カーティン 可変眼鏡用レンズ
US6787356B1 (en) 1998-07-24 2004-09-07 The United States Of America As Represented By The Department Of Health And Human Services Cell expansion system for use in neural transplantation
EP1109887A4 (en) * 1998-07-29 2003-05-21 Layton Bioscience Inc PRODUCTION AND USE OF DOPAMINERGIC CELLS TO TREAT DOPAMINERGIC DEFICIENCIES
SE9804064D0 (sv) 1998-11-25 1998-11-25 A & Science Invest Ab Medicinal product and method for treatment of conditions affecting neural stem cells or progenitor cells
US6291516B1 (en) 1999-01-13 2001-09-18 Curis, Inc. Regulators of the hedgehog pathway, compositions and uses related thereto
EP1220681A2 (en) * 1999-09-16 2002-07-10 Prescient Neuropharma Inc. Opaminergic neuronal survival-promoting factors and uses thereof
WO2001029206A1 (en) 1999-10-15 2001-04-26 Advanced Cell Technology, Inc. Methods of producing differentiated progenitor cells and lineage-defective embryonic stem cells
US7544509B2 (en) 2000-01-24 2009-06-09 Mcgill University Method for preparing stem cell preparations
US7514259B2 (en) 2000-02-11 2009-04-07 Schepens Eye Research Institute Isolation and transplantation of retinal stem cells
US8852937B2 (en) 2000-03-30 2014-10-07 Curis, Inc. Small organic molecule regulators of cell proliferation
US6613798B1 (en) 2000-03-30 2003-09-02 Curis, Inc. Small organic molecule regulators of cell proliferation
US7115653B2 (en) 2000-03-30 2006-10-03 Curis, Inc. Small organic molecule regulators of cell proliferation
US6683108B1 (en) 2000-03-30 2004-01-27 Curis, Inc. Agonists of hedgehog signaling pathways and uses related thereto
US20020114788A1 (en) * 2000-07-27 2002-08-22 Ole Isacson Cell implantation therapy for neurological diseases or disorders
US6908732B2 (en) 2000-10-13 2005-06-21 President & Fellows Of Harvard College Compounds and methods for regulating cell differentiation
AU2002325712C1 (en) 2001-08-30 2008-07-31 Stem Cell Therapeutics Inc. Differentiation of neural stem cells and therapeutic use theeof
JP4906231B2 (ja) 2001-09-14 2012-03-28 ステム セル セラピューティクス インコーポレイテッド プロラクチン誘導性の神経幹細胞数の増加ならびにその治療用途
EP2266396A3 (en) 2001-09-24 2011-06-15 Sangamo BioSciences, Inc. Modulation of stem cells using zinc finger proteins
WO2003050273A1 (fr) * 2001-12-13 2003-06-19 Japan Science And Technology Agency Milieu de culture pour des cellules humaines et methode de culture
US7635467B2 (en) 2002-01-14 2009-12-22 The Board Of Trustees Of The University Of Illinois Mammalian multipotent stem cells and compositions, methods of preparation and methods of administration thereof
JP2005517717A (ja) * 2002-02-15 2005-06-16 コーネル リサーチ ファンデーション， インコーポレーティッド 希突起膠細胞前駆細胞を用いた先天性髄鞘発育不全の前脳の有髄化
EP1496905B1 (en) 2002-04-22 2008-08-13 Johns Hopkins University School of Medicine Modulators of hedgehog signaling pathways, compositions and uses related thereto
EP1549740A2 (en) * 2002-07-30 2005-07-06 Stem Cell Therapeutics Inc. Oligodendrocyte production from multipotent neural stem cells
CA2492442A1 (en) 2002-07-31 2004-02-05 Stem Cell Therapeutics Inc. Method of enhancing neural stem cell proliferation, differentiation, and survival using pituitary adenylate cyclase activating polypeptide (pacap)
US8293488B2 (en) 2002-12-09 2012-10-23 Neuralstem, Inc. Method for screening neurogenic agents
EP1576134B1 (en) 2002-12-09 2013-03-06 Judith Kelleher-Andersson Method for discovering neurogenic agents
WO2004053084A2 (en) 2002-12-09 2004-06-24 The Mclean Hospital Corporation Dopaminergic neurons differentiated from embryonic cells for treating neurodegenerative diseases
US7459152B2 (en) 2003-04-23 2008-12-02 Rush University Medical Center Erythropoietin administration to improve graft survival
ATE493504T1 (de) 2003-09-12 2011-01-15 Stemcell Technologies Inc Test für neurale koloniebildung
US20070269412A1 (en) 2003-12-02 2007-11-22 Celavie Biosciences, Llc Pluripotent cells
CN101065478B (zh) * 2003-12-02 2012-07-04 塞拉维生物科学公司 用于繁殖神经祖细胞的组合物和方法
AU2005211847B2 (en) 2004-02-13 2011-02-24 Stem Cell Therapeutics Corp. Use of luteinizing hormone (LH) and chorionic gonadotropin (hCG) for proliferation of neural stem cells and neurogenesis
US7691629B2 (en) 2004-11-17 2010-04-06 Neuralstem, Inc. Transplantation of human neural cells for treatment of neurodegenerative conditions
JP2009509943A (ja) 2005-09-27 2009-03-12 ステム セル セラピューティクス コーポレイション プロラクチンにより制御される乏突起膠細胞前駆体細胞の増殖
WO2007106987A1 (en) 2006-03-17 2007-09-27 Stem Cell Therapeutics Corp. Continuous dosing regimens for neural stem cell proliferating agents and neural stem cell differentiating agents
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
JP2008220205A (ja) * 2007-03-09 2008-09-25 Sumitomo Bakelite Co Ltd 神経幹細胞凝集塊形成用容器、その製造方法、及び神経幹細胞凝集塊の作成方法。
CN101801396B (zh) * 2007-08-15 2013-10-30 桑比欧公司 治疗神经变性的方法和组合物
WO2009137674A2 (en) 2008-05-08 2009-11-12 University Of Rochester Treating myelin diseases with optimized cell preparations
WO2010075500A1 (en) 2008-12-23 2010-07-01 Stemcells California, Inc Target populations of oligodendrocyte precursor cells and methods of making and using same
EP2380972B1 (en) 2010-04-19 2012-09-19 Technische Universität Dresden Methods and compositions for the expansion of somatic stem cells and progenitor cells
US9540611B2 (en) 2010-07-28 2017-01-10 Neuralstem, Inc. Methods for treating and/or reversing neurodegenerative diseases and/or disorders
JP5867797B2 (ja) * 2011-05-27 2016-02-24 国立大学法人京都大学 ドーパミン産生神経の分化誘導用の細胞培養基材
US10865383B2 (en) 2011-07-12 2020-12-15 Lineage Cell Therapeutics, Inc. Methods and formulations for orthopedic cell therapy
EP3492586B1 (en) 2012-02-17 2024-04-17 Schepens Eye Research Institute Phenotype profile of human retinal progenitor cells
EP2954046A4 (en) 2013-02-06 2016-07-20 Univ Rochester Oligodendrocyte precursor cells derived from isolated pluripotent cells to treat myelin disease
MX2017005186A (es) 2014-10-20 2017-07-26 Neuralstem Inc Celulas madre neurales estables que comprenden un polinucleótido exógeno que codifica un factor de crecimiento y métodos de uso de las mismas.
US9724432B2 (en) 2015-04-30 2017-08-08 University Of Rochester Non-human mammal model of human degenerative disorder, uses thereof, and method of treating human degenerative disorder
US20180306780A1 (en) * 2015-10-29 2018-10-25 The Regents Of The University Of California Astrocyte differentiation protocol
CN110913689A (zh) 2017-05-10 2020-03-24 罗切斯特大学 治疗神经精神病症的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ226750A (en) * 1987-10-29 1990-09-26 Amrad Corp Ltd Immortalisation of neural precursor cells by introducing a retrovirus vector containing a myc-oncogene
AU6174490A (en) * 1989-08-04 1991-03-11 Board Of Regents, The University Of Texas System Methods and compositions; purified preparation of neural progenitor regulatory factor
JP4416837B2 (ja) * 1991-07-08 2010-02-17 ニューロスフィアーズ ホウルディングス リミテッド 試験管内で増殖し得る新規な成長因子応答性の前駆細胞

Also Published As

Publication number Publication date
DK0669973T3 (da) 2003-07-14
AU5367694A (en) 1994-05-24
ATE234353T1 (de) 2003-03-15
ES2194016T3 (es) 2003-11-16
CA2148138C (en) 2002-01-08
WO1994010292A1 (en) 1994-05-11
ATE483795T1 (de) 2010-10-15
AU703729B2 (en) 1999-04-01
EP0669973B9 (en) 2007-10-10
PT669973E (pt) 2003-06-30
NO951617L (no) 1995-04-27
EP0669973B1 (en) 2003-03-12
JPH08502652A (ja) 1996-03-26
EP0669973B2 (en) 2007-04-18
EP1298202A3 (en) 2003-12-03
CA2148138A1 (en) 1994-05-11
AU4924197A (en) 1998-03-12
FI952022A (sv) 1995-04-27
DK0669973T4 (da) 2007-08-27
DE69334344D1 (de) 2010-11-18
KR950704476A (ko) 1995-11-20
DE69332759D1 (de) 2003-04-17
EP1298202A2 (en) 2003-04-02
DE69332759T2 (de) 2003-10-16
EP0669973A1 (en) 1995-09-06
ES2194016T5 (es) 2007-11-16
JP2007014352A (ja) 2007-01-25
DE69332759T3 (de) 2008-01-24
RU95115822A (ru) 1997-03-20
EP1298202B1 (en) 2010-10-06
NO951617D0 (no) 1995-04-27
NO324412B1 (no) 2007-10-08

Similar Documents

Publication Publication Date Title
FI952022A0 (sv) Biologiska faktorer och neurala stamceller
FI951677A0 (sv) Remyelination genom användning av neutrala stamceller
DE69433661D1 (de) Genetische modifikation von neuralen stammzellen
DE59813404D1 (de) Neurale vorläuferzellen, verfahren zu ihrer herstellung und ihre verwendung zur therapie von neuralen defekten
CA2018228A1 (en) Cell culture systems and media
DE3777536D1 (de) Behaelter, bestimmt zur aufnahme eines oder mehrerer mikroorganismenkulturmedien.
FI971168A (sv) In vitro-modeller för funktion av och störning i det centrala nervsystemet
HUT39773A (en) Process for conserving and reproducing virusgenomes and derivatives
DE3871530D1 (de) Vorrichtung zum kultivieren von ruhenden zellen in einem bioreaktor.
IT1220516B (it) Impianto perfezionato per la coltura in strato laminare sottile dei microrganismi fotosintetici
GR3005343T3 (sv)