FI94638B - Förfarande för framställning av terapeutiskt användbara 1-acyl-3-/4-(2-pyrimidinyl)-1-piperazinyl/propaner - Google Patents
Förfarande för framställning av terapeutiskt användbara 1-acyl-3-/4-(2-pyrimidinyl)-1-piperazinyl/propaner Download PDFInfo
- Publication number
- FI94638B FI94638B FI902070A FI902070A FI94638B FI 94638 B FI94638 B FI 94638B FI 902070 A FI902070 A FI 902070A FI 902070 A FI902070 A FI 902070A FI 94638 B FI94638 B FI 94638B
- Authority
- FI
- Finland
- Prior art keywords
- formula
- pyrimidinyl
- preparation
- piperazinyl
- reaction
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Graft Or Block Polymers (AREA)
- Silicates, Zeolites, And Molecular Sieves (AREA)
Claims (4)
1. Förfarande för framställning av en terapeutiskt användbar förening med formeln (I) 5 R-S- (Cll2) 3-/ )1^^) ΙΠ 10 väri R är c§o- :;o- (a) <*» - CO- · <2>0- · (O <d>
25 Cy- ' O" (e. <f' 30 -n- co-· c»3-^y Cll-J 35 (g) 0,1 3i 94638 GO- · ÖO 5 αι <J> „ do ο> (k) O) 15 Ö3- °r CX}' CH3 (m) 20 eller med formeln (II) '{“'•-OÖ väri R1 är " :x> oo- - (a) (b) 30 “ν"Λ. . .-Λ-Ο- 35 (O 32 94638 . <p>o · GO- · 5 . . (£> (e) GO- eller <g) kännetecknat därav, att 5 för framställning av en förening med formeln (I) kopplas 4-[4-(2-pyrimidinyl)-l-piperazinyl]smörsyra genora dehydratisering med en amin med formeln RNH, väri R är som ovan definierad, i ett reaktionsinert lösningsmedel, och för framställning av en förening med formeln (II) 10 bringas l-(2-pyrimidyl)piperazin att reagera med en 3-klorpropylsulfonamid med formeln C1(CH2)3-S02-R1. 15 2. Förfarande enligt patentkrav 1, känne tecknat därav, att R är en grupp (1).
3. Förfarande enligt patentkrav 1, kännetecknat därav, att R är en grupp (m).
4. Förfarande enligt patentkrav 1, k ä n n e -20 tecknat därav, att R är en grupp (n). *« ' 1 • 9 ·
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8702855 | 1987-10-26 | ||
| PCT/US1987/002855 WO1989003831A1 (en) | 1987-10-26 | 1987-10-26 | Anti-anxiety agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI902070A0 FI902070A0 (sv) | 1990-04-25 |
| FI94638B true FI94638B (sv) | 1995-06-30 |
| FI94638C FI94638C (sv) | 1995-10-10 |
Family
ID=22202642
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI902070A FI94638C (sv) | 1987-10-26 | 1990-04-25 | Förfarande för framställning av terapeutiskt användbara 1-acyl-3-/4-(2-pyrimidinyl)-1-piperazinyl/propaner |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US4994455A (sv) |
| EP (1) | EP0314363B1 (sv) |
| JP (1) | JPH0643406B2 (sv) |
| KR (1) | KR900006722B1 (sv) |
| CN (1) | CN1022246C (sv) |
| AT (1) | ATE87919T1 (sv) |
| AU (1) | AU598161B2 (sv) |
| CA (1) | CA1314881C (sv) |
| CS (2) | CS274441B2 (sv) |
| DD (2) | DD298397A5 (sv) |
| DE (1) | DE3880077T2 (sv) |
| DK (1) | DK171788B1 (sv) |
| ES (1) | ES2054823T3 (sv) |
| FI (1) | FI94638C (sv) |
| HU (2) | HU208690B (sv) |
| IE (1) | IE63285B1 (sv) |
| IL (1) | IL88085A (sv) |
| MX (1) | MX173180B (sv) |
| MY (1) | MY103435A (sv) |
| NO (2) | NO901652L (sv) |
| NZ (1) | NZ226691A (sv) |
| PH (1) | PH25106A (sv) |
| PL (2) | PL153184B1 (sv) |
| PT (1) | PT88835B (sv) |
| RU (1) | RU2029768C1 (sv) |
| WO (1) | WO1989003831A1 (sv) |
| YU (1) | YU46592B (sv) |
| ZA (1) | ZA887925B (sv) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR242678A1 (es) * | 1986-03-05 | 1993-04-30 | Gonzalez Jorge Alberto | Mejoras en instrumentos musicales de cuerda de arco. |
| US4797488A (en) * | 1987-04-03 | 1989-01-10 | American Home Products Corporation | Psychotropic polycyclic imides |
| SE8803429D0 (sv) * | 1988-09-28 | 1988-09-28 | Pharmacia Ab | Novel pyridyl- and pyrimidyl derivatives |
| US5071845A (en) * | 1988-12-28 | 1991-12-10 | Suntory Limited | Benzoxazepine derivative |
| US5114936A (en) * | 1990-08-23 | 1992-05-19 | Hoechst-Roussel Pharmaceuticals Incorporated | 6,7-dihydro-3-phenyl-1,2-benzisoxazol-4(5h)-ones and -ols, compositions and pharmaceutical use |
| UA77526C2 (en) * | 2002-06-07 | 2006-12-15 | Sanofi Aventis | Substituted derivatives of 1-piperazineacylpiperidine, a method for the preparation thereof and their use in therapy |
| FR2862968B1 (fr) * | 2003-12-01 | 2006-08-04 | Sanofi Synthelabo | Derives de 4-[(arylmethyl)aminomethyl]piperidine, leur preparation et leur application en therapeutique |
| FR2862967B1 (fr) * | 2003-12-01 | 2006-08-04 | Sanofi Synthelabo | Derives de (4-phenylpiperazin-1-yl)acylpiperidine, leur preparation et leur application en therapeutique |
| WO2010027567A2 (en) * | 2008-07-23 | 2010-03-11 | Schering Corporation | Tricyclic spirocycle derivatives and methods of use thereof |
| US8617801B2 (en) * | 2009-06-03 | 2013-12-31 | Carestream Health, Inc. | Film with blue dye |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US466691A (en) * | 1892-01-05 | Egg-crate | ||
| US2672460A (en) * | 1952-06-24 | 1954-03-16 | American Cyanamid Co | Disubstituted piperazines and methods of preparing the same |
| BE759371A (fr) * | 1969-11-24 | 1971-05-24 | Bristol Myers Co | Azaspirodecanediones heterocycliques et procedes pour leur preparation |
| US4666911A (en) * | 1981-07-14 | 1987-05-19 | Taiho Pharmaceutical Company Limited | Allophanoylpiperazine compound and analgesic composition containing same as active ingredient |
| DE3321969A1 (de) * | 1983-06-18 | 1984-12-20 | Troponwerke GmbH & Co KG, 5000 Köln | 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
| US4605655A (en) * | 1984-03-06 | 1986-08-12 | Bristol-Myers Company | Antipsychotic 1-fluorophenylbutyl-4-(2-pyrimidinyl)piperazine derivatives |
| JPS6175A (ja) * | 1984-03-06 | 1986-01-06 | ブリストル−マイア−ズ コムパニ− | 神経弛緩剤、１‐フルオロフェニルブチル‐４‐（５‐ハロ‐２‐ピリミジニル）ピペラジン誘導体 |
| US4562255A (en) * | 1984-03-30 | 1985-12-31 | American Home Products Corporation | Substituted bi-alicyclic imides |
| US4668687A (en) * | 1984-07-23 | 1987-05-26 | Bristol-Myers Company | Psychogeriatric 1-(2-pyrimidinyl)piperazinyl derivatives of 1-pyrrolidin-2-ones |
| AR242678A1 (es) * | 1986-03-05 | 1993-04-30 | Gonzalez Jorge Alberto | Mejoras en instrumentos musicales de cuerda de arco. |
| US4797488A (en) * | 1987-04-03 | 1989-01-10 | American Home Products Corporation | Psychotropic polycyclic imides |
-
1987
- 1987-10-26 HU HU913849A patent/HU208690B/hu not_active IP Right Cessation
- 1987-10-26 US US07/477,835 patent/US4994455A/en not_active Expired - Lifetime
- 1987-10-26 MX MX013562A patent/MX173180B/es unknown
- 1987-10-26 HU HU876036A patent/HU206109B/hu not_active IP Right Cessation
- 1987-10-26 WO PCT/US1987/002855 patent/WO1989003831A1/en active IP Right Grant
-
1988
- 1988-10-17 ES ES88309725T patent/ES2054823T3/es not_active Expired - Lifetime
- 1988-10-17 AT AT88309725T patent/ATE87919T1/de not_active IP Right Cessation
- 1988-10-17 DE DE8888309725T patent/DE3880077T2/de not_active Expired - Fee Related
- 1988-10-17 EP EP88309725A patent/EP0314363B1/en not_active Expired - Lifetime
- 1988-10-19 IL IL88085A patent/IL88085A/xx not_active IP Right Cessation
- 1988-10-21 MY MYPI88001197A patent/MY103435A/en unknown
- 1988-10-24 ZA ZA887925A patent/ZA887925B/xx unknown
- 1988-10-24 DD DD88337989A patent/DD298397A5/de not_active IP Right Cessation
- 1988-10-24 DD DD88321032A patent/DD283388A5/de not_active IP Right Cessation
- 1988-10-24 CA CA000581091A patent/CA1314881C/en not_active Expired - Fee Related
- 1988-10-24 CN CN88107386A patent/CN1022246C/zh not_active Expired - Fee Related
- 1988-10-24 PT PT88835A patent/PT88835B/pt not_active IP Right Cessation
- 1988-10-24 JP JP63268008A patent/JPH0643406B2/ja not_active Expired - Lifetime
- 1988-10-25 PL PL1988279558A patent/PL153184B1/pl unknown
- 1988-10-25 PL PL1988275476A patent/PL152117B1/pl unknown
- 1988-10-25 DK DK591488A patent/DK171788B1/da active
- 1988-10-25 KR KR1019880013911A patent/KR900006722B1/ko not_active IP Right Cessation
- 1988-10-25 NZ NZ226691A patent/NZ226691A/en unknown
- 1988-10-25 AU AU24327/88A patent/AU598161B2/en not_active Ceased
- 1988-10-25 YU YU198988A patent/YU46592B/sh unknown
- 1988-10-25 IE IE321888A patent/IE63285B1/en not_active IP Right Cessation
- 1988-10-26 PH PH37726A patent/PH25106A/en unknown
- 1988-10-26 CS CS708088A patent/CS274441B2/cs not_active IP Right Cessation
-
1989
- 1989-03-02 CS CS135189A patent/CS274446B2/cs not_active IP Right Cessation
-
1990
- 1990-04-11 NO NO90901652A patent/NO901652L/no unknown
- 1990-04-25 NO NO1990901826A patent/NO901826D0/no unknown
- 1990-04-25 RU SU904743942A patent/RU2029768C1/ru active
- 1990-04-25 FI FI902070A patent/FI94638C/sv not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB | Publication of examined application | ||
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: PFIZER INC. |