FI94638B - Förfarande för framställning av terapeutiskt användbara 1-acyl-3-/4-(2-pyrimidinyl)-1-piperazinyl/propaner - Google Patents

Förfarande för framställning av terapeutiskt användbara 1-acyl-3-/4-(2-pyrimidinyl)-1-piperazinyl/propaner Download PDF

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Publication number
FI94638B
FI94638B FI902070A FI902070A FI94638B FI 94638 B FI94638 B FI 94638B FI 902070 A FI902070 A FI 902070A FI 902070 A FI902070 A FI 902070A FI 94638 B FI94638 B FI 94638B
Authority
FI
Finland
Prior art keywords
formula
pyrimidinyl
preparation
piperazinyl
reaction
Prior art date
Application number
FI902070A
Other languages
English (en)
Finnish (fi)
Other versions
FI94638C (sv
FI902070A0 (sv
Inventor
Jr Willard Mckowan Welch
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of FI902070A0 publication Critical patent/FI902070A0/sv
Application granted granted Critical
Publication of FI94638B publication Critical patent/FI94638B/sv
Publication of FI94638C publication Critical patent/FI94638C/sv

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32One oxygen, sulfur or nitrogen atom
    • C07D239/42One nitrogen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08Bridged systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Graft Or Block Polymers (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)

Claims (4)

1. Förfarande för framställning av en terapeutiskt användbar förening med formeln (I) 5 R-S- (Cll2) 3-/ )1^^) ΙΠ 10 väri R är c§o- :;o- (a) <*» - CO- · <2>0- · (O <d>
25 Cy- ' O" (e. <f' 30 -n- co-· c»3-^y Cll-J 35 (g) 0,1 3i 94638 GO- · ÖO 5 αι <J> „ do ο> (k) O) 15 Ö3- °r CX}' CH3 (m) 20 eller med formeln (II) '{“'•-OÖ väri R1 är " :x> oo- - (a) (b) 30 “ν"Λ. . .-Λ-Ο- 35 (O 32 94638 . <p>o · GO- · 5 . . (£> (e) GO- eller <g) kännetecknat därav, att 5 för framställning av en förening med formeln (I) kopplas 4-[4-(2-pyrimidinyl)-l-piperazinyl]smörsyra genora dehydratisering med en amin med formeln RNH, väri R är som ovan definierad, i ett reaktionsinert lösningsmedel, och för framställning av en förening med formeln (II) 10 bringas l-(2-pyrimidyl)piperazin att reagera med en 3-klorpropylsulfonamid med formeln C1(CH2)3-S02-R1. 15 2. Förfarande enligt patentkrav 1, känne tecknat därav, att R är en grupp (1).
3. Förfarande enligt patentkrav 1, kännetecknat därav, att R är en grupp (m).
4. Förfarande enligt patentkrav 1, k ä n n e -20 tecknat därav, att R är en grupp (n). *« ' 1 • 9 ·
FI902070A 1987-10-26 1990-04-25 Förfarande för framställning av terapeutiskt användbara 1-acyl-3-/4-(2-pyrimidinyl)-1-piperazinyl/propaner FI94638C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8702855 1987-10-26
PCT/US1987/002855 WO1989003831A1 (en) 1987-10-26 1987-10-26 Anti-anxiety agents

Publications (3)

Publication Number Publication Date
FI902070A0 FI902070A0 (sv) 1990-04-25
FI94638B true FI94638B (sv) 1995-06-30
FI94638C FI94638C (sv) 1995-10-10

Family

ID=22202642

Family Applications (1)

Application Number Title Priority Date Filing Date
FI902070A FI94638C (sv) 1987-10-26 1990-04-25 Förfarande för framställning av terapeutiskt användbara 1-acyl-3-/4-(2-pyrimidinyl)-1-piperazinyl/propaner

Country Status (28)

Country Link
US (1) US4994455A (sv)
EP (1) EP0314363B1 (sv)
JP (1) JPH0643406B2 (sv)
KR (1) KR900006722B1 (sv)
CN (1) CN1022246C (sv)
AT (1) ATE87919T1 (sv)
AU (1) AU598161B2 (sv)
CA (1) CA1314881C (sv)
CS (2) CS274441B2 (sv)
DD (2) DD298397A5 (sv)
DE (1) DE3880077T2 (sv)
DK (1) DK171788B1 (sv)
ES (1) ES2054823T3 (sv)
FI (1) FI94638C (sv)
HU (2) HU208690B (sv)
IE (1) IE63285B1 (sv)
IL (1) IL88085A (sv)
MX (1) MX173180B (sv)
MY (1) MY103435A (sv)
NO (2) NO901652L (sv)
NZ (1) NZ226691A (sv)
PH (1) PH25106A (sv)
PL (2) PL153184B1 (sv)
PT (1) PT88835B (sv)
RU (1) RU2029768C1 (sv)
WO (1) WO1989003831A1 (sv)
YU (1) YU46592B (sv)
ZA (1) ZA887925B (sv)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR242678A1 (es) * 1986-03-05 1993-04-30 Gonzalez Jorge Alberto Mejoras en instrumentos musicales de cuerda de arco.
US4797488A (en) * 1987-04-03 1989-01-10 American Home Products Corporation Psychotropic polycyclic imides
SE8803429D0 (sv) * 1988-09-28 1988-09-28 Pharmacia Ab Novel pyridyl- and pyrimidyl derivatives
US5071845A (en) * 1988-12-28 1991-12-10 Suntory Limited Benzoxazepine derivative
US5114936A (en) * 1990-08-23 1992-05-19 Hoechst-Roussel Pharmaceuticals Incorporated 6,7-dihydro-3-phenyl-1,2-benzisoxazol-4(5h)-ones and -ols, compositions and pharmaceutical use
UA77526C2 (en) * 2002-06-07 2006-12-15 Sanofi Aventis Substituted derivatives of 1-piperazineacylpiperidine, a method for the preparation thereof and their use in therapy
FR2862968B1 (fr) * 2003-12-01 2006-08-04 Sanofi Synthelabo Derives de 4-[(arylmethyl)aminomethyl]piperidine, leur preparation et leur application en therapeutique
FR2862967B1 (fr) * 2003-12-01 2006-08-04 Sanofi Synthelabo Derives de (4-phenylpiperazin-1-yl)acylpiperidine, leur preparation et leur application en therapeutique
WO2010027567A2 (en) * 2008-07-23 2010-03-11 Schering Corporation Tricyclic spirocycle derivatives and methods of use thereof
US8617801B2 (en) * 2009-06-03 2013-12-31 Carestream Health, Inc. Film with blue dye

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US466691A (en) * 1892-01-05 Egg-crate
US2672460A (en) * 1952-06-24 1954-03-16 American Cyanamid Co Disubstituted piperazines and methods of preparing the same
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
US4666911A (en) * 1981-07-14 1987-05-19 Taiho Pharmaceutical Company Limited Allophanoylpiperazine compound and analgesic composition containing same as active ingredient
DE3321969A1 (de) * 1983-06-18 1984-12-20 Troponwerke GmbH & Co KG, 5000 Köln 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US4605655A (en) * 1984-03-06 1986-08-12 Bristol-Myers Company Antipsychotic 1-fluorophenylbutyl-4-(2-pyrimidinyl)piperazine derivatives
JPS6175A (ja) * 1984-03-06 1986-01-06 ブリストル−マイア−ズ コムパニ− 神経弛緩剤、1‐フルオロフェニルブチル‐4‐(5‐ハロ‐2‐ピリミジニル)ピペラジン誘導体
US4562255A (en) * 1984-03-30 1985-12-31 American Home Products Corporation Substituted bi-alicyclic imides
US4668687A (en) * 1984-07-23 1987-05-26 Bristol-Myers Company Psychogeriatric 1-(2-pyrimidinyl)piperazinyl derivatives of 1-pyrrolidin-2-ones
AR242678A1 (es) * 1986-03-05 1993-04-30 Gonzalez Jorge Alberto Mejoras en instrumentos musicales de cuerda de arco.
US4797488A (en) * 1987-04-03 1989-01-10 American Home Products Corporation Psychotropic polycyclic imides

Also Published As

Publication number Publication date
RU2029768C1 (ru) 1995-02-27
EP0314363A3 (en) 1990-07-11
CS135189A2 (en) 1990-08-14
NO901652D0 (no) 1990-04-11
IE63285B1 (en) 1995-04-05
ZA887925B (en) 1990-06-27
MX13562A (es) 1993-04-01
PL152117B1 (en) 1990-11-30
IL88085A (en) 1993-02-21
NZ226691A (en) 1990-04-26
FI94638C (sv) 1995-10-10
ES2054823T3 (es) 1994-08-16
KR900006722B1 (ko) 1990-09-20
CS274446B2 (en) 1991-04-11
CN1022246C (zh) 1993-09-29
PT88835B (pt) 1993-01-29
AU2432788A (en) 1989-04-27
HU206109B (en) 1992-08-28
HUT59393A (en) 1992-05-28
WO1989003831A1 (en) 1989-05-05
AU598161B2 (en) 1990-06-14
YU198988A (en) 1990-06-30
HUT58724A (en) 1992-03-30
DK591488D0 (da) 1988-10-25
DD298397A5 (de) 1992-02-20
EP0314363B1 (en) 1993-04-07
MX173180B (es) 1994-02-07
PH25106A (en) 1991-02-19
DE3880077D1 (de) 1993-05-13
ATE87919T1 (de) 1993-04-15
MY103435A (en) 1993-06-30
CS274441B2 (en) 1991-04-11
IE883218L (en) 1989-04-26
DK591488A (da) 1989-04-27
PL279558A1 (en) 1990-01-08
CN1042148A (zh) 1990-05-16
DE3880077T2 (de) 1993-07-22
CA1314881C (en) 1993-03-23
HU913849D0 (en) 1992-03-30
YU46592B (sh) 1993-11-16
PL153184B1 (en) 1991-03-29
US4994455A (en) 1991-02-19
FI902070A0 (sv) 1990-04-25
EP0314363A2 (en) 1989-05-03
KR890006621A (ko) 1989-06-14
HU208690B (en) 1993-12-28
DD283388A5 (de) 1990-10-10
PL275476A1 (en) 1989-09-18
NO901826D0 (no) 1990-04-25
DK171788B1 (da) 1997-05-26
CS708088A2 (en) 1990-08-14
JPH01157979A (ja) 1989-06-21
JPH0643406B2 (ja) 1994-06-08
NO901652L (no) 1990-04-11

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Owner name: PFIZER INC.