FI944734A0 - Kinoliinijohdannaiset leukotrieeniantagonisteina - Google Patents
Kinoliinijohdannaiset leukotrieeniantagonisteinaInfo
- Publication number
- FI944734A0 FI944734A0 FI944734A FI944734A FI944734A0 FI 944734 A0 FI944734 A0 FI 944734A0 FI 944734 A FI944734 A FI 944734A FI 944734 A FI944734 A FI 944734A FI 944734 A0 FI944734 A0 FI 944734A0
- Authority
- FI
- Finland
- Prior art keywords
- leukotriene antagonists
- quinoline derivatives
- compounds
- useful
- leukotriene
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Quinoline Compounds (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/866,690 US5270324A (en) | 1992-04-10 | 1992-04-10 | Fluorinated hydroxyalkylquinoline acids as leukotriene antagonists |
CN92105948A CN1080169A (zh) | 1992-04-10 | 1992-06-16 | 含有水溶性药物的控释片 |
PCT/CA1993/000156 WO1993021159A1 (en) | 1992-04-10 | 1993-04-08 | Quinoline derivatives as leukotriene antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
FI944734A0 true FI944734A0 (fi) | 1994-10-07 |
FI944734A FI944734A (fi) | 1994-10-07 |
Family
ID=25742768
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI944734A FI944734A (fi) | 1992-04-10 | 1994-10-07 | Kinoliinijohdannaiset leukotrieeniantagonisteina |
Country Status (21)
Country | Link |
---|---|
US (1) | US5270324A (zh) |
EP (1) | EP0565185B1 (zh) |
JP (1) | JP2504687B2 (zh) |
CN (2) | CN1080169A (zh) |
AT (1) | ATE168100T1 (zh) |
AU (1) | AU653476B2 (zh) |
BG (1) | BG62402B1 (zh) |
CA (1) | CA2092896C (zh) |
CZ (1) | CZ246394A3 (zh) |
DE (1) | DE69319482T2 (zh) |
ES (1) | ES2117691T3 (zh) |
FI (1) | FI944734A (zh) |
HR (1) | HRP930803A2 (zh) |
HU (1) | HU218917B (zh) |
IL (1) | IL105193A0 (zh) |
LV (1) | LV12290B (zh) |
MX (1) | MX9302033A (zh) |
NO (1) | NO943792L (zh) |
SI (1) | SI9300188A (zh) |
WO (1) | WO1993021159A1 (zh) |
ZA (1) | ZA932533B (zh) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5856322A (en) * | 1990-10-12 | 1999-01-05 | Merck Frosst Canada, Inc. | Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists |
GB9216768D0 (en) * | 1992-08-07 | 1992-09-23 | Leo Pharm Prod Ltd | Chemical compounds |
ES2080656B1 (es) * | 1993-07-19 | 1996-10-16 | Merck Frosst Canada Inc | Acidos de hidroxialquilquinolina fluorados como antagonistas del leucotrieno. |
CA2130723C (en) * | 1993-09-03 | 2006-01-31 | Wilhelm Quittmann | Process for preparing y-mercaptocarboxylic acid derivatives |
DE4339724C1 (de) * | 1993-11-22 | 1995-01-19 | Siemens Ag | Gasarmatur |
TW416948B (en) * | 1993-12-28 | 2001-01-01 | Merck & Co Inc | Process for the preparation of leukotriene antagonists |
US5427933A (en) * | 1994-07-20 | 1995-06-27 | Merck & Co., Inc. | Reduction of phenylalkyl ketones to the corresponding (S)-hydroxy derivatives using mucor hiemalis IFO 5834 |
US5491077A (en) * | 1994-07-20 | 1996-02-13 | Merck & Co., Inc. | Microbial method |
GB9415997D0 (en) * | 1994-08-08 | 1994-09-28 | Merck Sharp & Dohme | Therapeutic agents |
US5545758A (en) * | 1994-08-11 | 1996-08-13 | Merck & Co., Inc. | Process for the preparation of diisopinocampheylchloroborane |
US5523477A (en) * | 1995-01-23 | 1996-06-04 | Merck & Co., Inc. | Process for the preparation of 1-(thiomethyl)-cyclopropaneacetic acid |
US5558879A (en) * | 1995-04-28 | 1996-09-24 | Andrx Pharmaceuticals, Inc. | Controlled release formulation for water soluble drugs in which a passageway is formed in situ |
US5648448A (en) * | 1995-06-06 | 1997-07-15 | Hitachi Chemical Company, Ltd. | Method of preparation of polyquinolines |
US5750539A (en) * | 1995-06-07 | 1998-05-12 | Merck Frosst Canada | Heteroaryl diol acids as leukotriene antagonists |
TR199801511T2 (xx) * | 1996-02-08 | 1998-10-21 | Merck&Co.,Inc. | Farmas�tik bile�im. |
IL136461A0 (en) * | 1997-12-23 | 2001-06-14 | Schering Corp | Composition for treating respiratory and skin diseases, comprising at least one leukotriene antagonist and at least one antihistamine |
US6384038B1 (en) * | 1998-04-14 | 2002-05-07 | Sepracor Inc. | Methods and compositions using cetirizine in combination with leukotriene inhibitors or decongestants |
US6262066B1 (en) | 1998-07-27 | 2001-07-17 | Schering Corporation | High affinity ligands for nociceptin receptor ORL-1 |
US6696466B1 (en) * | 2000-09-07 | 2004-02-24 | Leslie Joe Dunaway | Methods of treating select neuronal inflammatory disorders using hydroxyalkylquinolines |
CA2371048C (en) | 2002-02-06 | 2011-01-04 | Delmar Chemicals Inc. | Process for the preparation of 1-(mercaptomethyl)-cyclopropaneacetic acid |
DE50307710D1 (de) * | 2003-08-15 | 2007-08-30 | Abb Turbo Systems Ag | Rotationsdichtung |
ES2371549T3 (es) * | 2003-10-10 | 2012-01-05 | Synthon B.V. | Montelukast en estado sólido. |
US7829716B2 (en) * | 2004-04-30 | 2010-11-09 | Synthon Pharmaceuticals, Inc. | Process for making montelukast and intermediates therefor |
US7501517B2 (en) * | 2004-04-30 | 2009-03-10 | Synthon Ip, Inc. | Process for making montelukast and intermediates therefor |
JP2008509143A (ja) * | 2004-08-04 | 2008-03-27 | シェーリング コーポレイション | 気道疾患の処置のためのプレコナリルを含む薬学的処方物 |
WO2006047427A1 (en) | 2004-10-25 | 2006-05-04 | Schering Corporation | M1 and/or m3 receptor antagonists in combination with other actives for treating respiratory disorders |
CA2625285A1 (en) * | 2005-11-16 | 2007-05-24 | Teva Pharmaceutical Industries Ltd. | Drying methods of montelukast sodium by azeotropic removal of the solvent |
AR057909A1 (es) * | 2005-11-18 | 2007-12-26 | Synthon Bv | Proceso para preparar montelukast y compuestos relacionados, que utiliza un compuesto intermediario derivado de un ester sulfonico. |
WO2007107297A1 (en) * | 2006-03-17 | 2007-09-27 | Synthon B.V. | Montelukast amantadine salt |
US20090326232A1 (en) * | 2006-06-26 | 2009-12-31 | Uttam Kumar Ray | Process for the Preparation of Leukotriene Receptor Antagonist (Montelukast Sodium) |
KR20090026217A (ko) * | 2006-07-11 | 2009-03-11 | 쉐링 코포레이션 | 치환된 5-옥사졸-2-일-퀴놀린 화합물의 크시나포에이트 염 |
US7271268B1 (en) | 2006-12-22 | 2007-09-18 | Formosa Laboratories Inc. | Process for preparation of [1-(mercaptomethyl)cyclopropyl]acetic acid and related derivatives |
PL205444B1 (pl) * | 2007-05-02 | 2010-04-30 | Zak & Lstrok Ady Farmaceutyczn | Sposób wytwarzania soli sodowej kwasu 1-(((1(R)-(3-(2-(7--chloro-2- chinolinylo)-etenylo)fenylo)-3-(2-(1-hydroksy-1- metyloetylo)fenylo)propylo)sulfanylo)metylo)-cyklopropanooctowego |
WO2009117381A2 (en) * | 2008-03-17 | 2009-09-24 | Dr. Reddy's Laboratories Ltd. | Preparation of montelukast and its salts |
WO2009130056A1 (en) * | 2008-04-25 | 2009-10-29 | Synthon B.V. | Process for making montelukast intermediates |
CN102834406A (zh) | 2009-06-16 | 2012-12-19 | 默沙东公司 | 作为糖皮质激素受体激动剂的新的[3.2-c]杂芳基甾体、其组合物和用途 |
JP6038914B2 (ja) * | 2011-07-26 | 2016-12-07 | スン プハルマ アドバンセド リサーチ カンパニー リミテド | キノリン−、キノキサリン、又はベンゾチアゾールベースのシステイニルロイコトリエンアンタゴニスト(ltc4) |
CN104069502B (zh) * | 2013-03-29 | 2018-02-16 | 北京罗诺强施医药技术研发中心有限公司 | 复合骨架材料及其药物组合物 |
CN105085391B (zh) | 2015-06-10 | 2017-08-22 | 广东默泰同创医药科技有限公司 | 用作白三烯受体拮抗剂的环丙基不饱和喹啉化合物及应用 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES8801209A1 (es) * | 1985-06-18 | 1988-01-01 | Merck Frosst Canada Inc | Un procedimiento para la preparacion de quinolinas 2-sustituidas. |
US4962203A (en) * | 1985-06-18 | 1990-10-09 | Merck Frost Canada, Inc. | 2-substituted quinolines useful as leukotriene antagonists |
US4851409A (en) * | 1986-02-14 | 1989-07-25 | Merck Frosst Canada Inc. | 2-substituted quinoline dioic acids and pharmaceutical compositions |
IE59889B1 (en) * | 1986-02-14 | 1994-04-20 | Merck Frosst Canada Inc | 2-substituted quinoline dioic acids |
EP0271287A3 (en) * | 1986-12-11 | 1990-06-13 | Merck Frosst Canada Inc. | Quinoline dioic acids and amides |
FR2617352B1 (fr) * | 1987-06-26 | 1989-12-01 | Eduvision Sa | Procede de codage de donnees informatiques pour transmission aux normes video, videodisque mettant en oeuvre ledit procede et interface d'exploitation d'un tel videodisque |
US4920132A (en) * | 1987-11-03 | 1990-04-24 | Rorer Pharmaceutical Corp. | Quinoline derivatives and use thereof as antagonists of leukotriene D4 |
IL88433A0 (en) * | 1987-11-25 | 1989-06-30 | Merck Frosst Canada Inc | Diarylstyrylquinoline diacids and pharmaceutical compositions containing them |
DE3814504A1 (de) * | 1988-04-29 | 1989-11-09 | Bayer Ag | (alpha)-substituierte 4-(chinolin-2-yl-methoxy)phenylessigsaeuren und -ester, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
DE3900261A1 (de) * | 1988-05-31 | 1989-12-07 | Bayer Ag | Substituierte 4-(chinolin-2-yl-methoxy) phenyl-essigsaeure-derivate |
US4918081A (en) * | 1988-06-20 | 1990-04-17 | Rorer Pharmaceutical Corp. | Quinoline derivatives and use thereof as antagonists of leukotriene d4 |
NZ233752A (en) * | 1989-05-24 | 1993-05-26 | Merck Frosst Canada Inc | Substituted quinoline derivatives, preparation and pharmaceutical compositions thereof |
DE69129257T2 (de) * | 1990-10-12 | 1998-11-05 | Merck Frosst Canada Inc | Ungesättigte Hydroxyalkylchinolinsäuren als Leukotrien-Antagonisten |
IE920499A1 (en) * | 1991-02-21 | 1992-08-26 | Merck Frosst Canada Inc | Quinoline-containing ketoacids as leukotriene antagonists |
-
1992
- 1992-04-10 US US07/866,690 patent/US5270324A/en not_active Expired - Lifetime
- 1992-06-16 CN CN92105948A patent/CN1080169A/zh active Pending
-
1993
- 1993-03-29 IL IL105193A patent/IL105193A0/xx unknown
- 1993-03-29 CA CA002092896A patent/CA2092896C/en not_active Expired - Fee Related
- 1993-04-02 EP EP93200973A patent/EP0565185B1/en not_active Expired - Lifetime
- 1993-04-02 DE DE69319482T patent/DE69319482T2/de not_active Expired - Fee Related
- 1993-04-02 AT AT93200973T patent/ATE168100T1/de not_active IP Right Cessation
- 1993-04-02 ES ES93200973T patent/ES2117691T3/es not_active Expired - Lifetime
- 1993-04-07 MX MX9302033A patent/MX9302033A/es unknown
- 1993-04-08 HU HU9402905A patent/HU218917B/hu not_active IP Right Cessation
- 1993-04-08 ZA ZA932533A patent/ZA932533B/xx unknown
- 1993-04-08 WO PCT/CA1993/000156 patent/WO1993021159A1/en not_active Application Discontinuation
- 1993-04-08 CZ CZ942463A patent/CZ246394A3/cs unknown
- 1993-04-08 AU AU36863/93A patent/AU653476B2/en not_active Ceased
- 1993-04-09 HR HR930803A patent/HRP930803A2/hr not_active Application Discontinuation
- 1993-04-09 SI SI9300188A patent/SI9300188A/sl unknown
- 1993-04-09 CN CN93105948A patent/CN1043761C/zh not_active Expired - Fee Related
- 1993-04-09 JP JP5083482A patent/JP2504687B2/ja not_active Expired - Fee Related
-
1994
- 1994-09-30 BG BG99085A patent/BG62402B1/bg not_active Expired - Lifetime
- 1994-10-07 NO NO943792A patent/NO943792L/no unknown
- 1994-10-07 FI FI944734A patent/FI944734A/fi unknown
-
1999
- 1999-04-26 LV LVP-99-68A patent/LV12290B/en unknown
Also Published As
Publication number | Publication date |
---|---|
DE69319482D1 (de) | 1998-08-13 |
HU218917B (hu) | 2000-12-28 |
NO943792D0 (no) | 1994-10-07 |
LV12290B (en) | 1999-11-20 |
ZA932533B (en) | 1993-11-04 |
CA2092896C (en) | 2005-12-20 |
JPH0625173A (ja) | 1994-02-01 |
US5270324A (en) | 1993-12-14 |
ATE168100T1 (de) | 1998-07-15 |
CN1080169A (zh) | 1994-01-05 |
HRP930803A2 (en) | 1994-12-31 |
AU653476B2 (en) | 1994-09-29 |
CZ246394A3 (en) | 1996-01-17 |
BG99085A (bg) | 1995-06-30 |
CN1083052A (zh) | 1994-03-02 |
SI9300188A (sl) | 1993-12-31 |
CA2092896A1 (en) | 1993-10-11 |
AU3686393A (en) | 1993-10-14 |
ES2117691T3 (es) | 1998-08-16 |
CN1043761C (zh) | 1999-06-23 |
NO943792L (no) | 1994-12-08 |
JP2504687B2 (ja) | 1996-06-05 |
LV12290A (lv) | 1999-06-20 |
MX9302033A (es) | 1994-07-29 |
HUT70399A (en) | 1995-10-30 |
FI944734A (fi) | 1994-10-07 |
IL105193A0 (en) | 1993-07-08 |
BG62402B1 (bg) | 1999-10-29 |
DE69319482T2 (de) | 1999-02-04 |
HU9402905D0 (en) | 1995-01-30 |
WO1993021159A1 (en) | 1993-10-28 |
EP0565185A1 (en) | 1993-10-13 |
EP0565185B1 (en) | 1998-07-08 |
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