ATE168100T1 - Chinolinderivate als leukotrien-antagoniste - Google Patents

Chinolinderivate als leukotrien-antagoniste

Info

Publication number
ATE168100T1
ATE168100T1 AT93200973T AT93200973T ATE168100T1 AT E168100 T1 ATE168100 T1 AT E168100T1 AT 93200973 T AT93200973 T AT 93200973T AT 93200973 T AT93200973 T AT 93200973T AT E168100 T1 ATE168100 T1 AT E168100T1
Authority
AT
Austria
Prior art keywords
antagonists
leucotrien
quinoline derivatives
compounds
useful
Prior art date
Application number
AT93200973T
Other languages
English (en)
Inventor
Robert Zamboni
Daniel Guay
Marc Labelle
Original Assignee
Merck Frosst Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Frosst Canada Inc filed Critical Merck Frosst Canada Inc
Application granted granted Critical
Publication of ATE168100T1 publication Critical patent/ATE168100T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Quinoline Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT93200973T 1992-04-10 1993-04-02 Chinolinderivate als leukotrien-antagoniste ATE168100T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/866,690 US5270324A (en) 1992-04-10 1992-04-10 Fluorinated hydroxyalkylquinoline acids as leukotriene antagonists
CN92105948A CN1080169A (zh) 1992-04-10 1992-06-16 含有水溶性药物的控释片

Publications (1)

Publication Number Publication Date
ATE168100T1 true ATE168100T1 (de) 1998-07-15

Family

ID=25742768

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93200973T ATE168100T1 (de) 1992-04-10 1993-04-02 Chinolinderivate als leukotrien-antagoniste

Country Status (21)

Country Link
US (1) US5270324A (de)
EP (1) EP0565185B1 (de)
JP (1) JP2504687B2 (de)
CN (2) CN1080169A (de)
AT (1) ATE168100T1 (de)
AU (1) AU653476B2 (de)
BG (1) BG62402B1 (de)
CA (1) CA2092896C (de)
CZ (1) CZ246394A3 (de)
DE (1) DE69319482T2 (de)
ES (1) ES2117691T3 (de)
FI (1) FI944734A0 (de)
HR (1) HRP930803A2 (de)
HU (1) HU218917B (de)
IL (1) IL105193A0 (de)
LV (1) LV12290B (de)
MX (1) MX9302033A (de)
NO (1) NO943792L (de)
SI (1) SI9300188A (de)
WO (1) WO1993021159A1 (de)
ZA (1) ZA932533B (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
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US5856322A (en) * 1990-10-12 1999-01-05 Merck Frosst Canada, Inc. Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists
GB9216768D0 (en) * 1992-08-07 1992-09-23 Leo Pharm Prod Ltd Chemical compounds
ES2080656B1 (es) * 1993-07-19 1996-10-16 Merck Frosst Canada Inc Acidos de hidroxialquilquinolina fluorados como antagonistas del leucotrieno.
CA2130723C (en) * 1993-09-03 2006-01-31 Wilhelm Quittmann Process for preparing y-mercaptocarboxylic acid derivatives
DE4339724C1 (de) * 1993-11-22 1995-01-19 Siemens Ag Gasarmatur
TW448160B (en) * 1993-12-28 2001-08-01 Merck & Co Inc Novel dicyclohexylamine salt and process for the preparation of leukotriene antagonists
US5427933A (en) * 1994-07-20 1995-06-27 Merck & Co., Inc. Reduction of phenylalkyl ketones to the corresponding (S)-hydroxy derivatives using mucor hiemalis IFO 5834
US5491077A (en) * 1994-07-20 1996-02-13 Merck & Co., Inc. Microbial method
GB9415997D0 (en) * 1994-08-08 1994-09-28 Merck Sharp & Dohme Therapeutic agents
US5545758A (en) * 1994-08-11 1996-08-13 Merck & Co., Inc. Process for the preparation of diisopinocampheylchloroborane
US5523477A (en) * 1995-01-23 1996-06-04 Merck & Co., Inc. Process for the preparation of 1-(thiomethyl)-cyclopropaneacetic acid
US5558879A (en) * 1995-04-28 1996-09-24 Andrx Pharmaceuticals, Inc. Controlled release formulation for water soluble drugs in which a passageway is formed in situ
US5648448A (en) * 1995-06-06 1997-07-15 Hitachi Chemical Company, Ltd. Method of preparation of polyquinolines
US5750539A (en) * 1995-06-07 1998-05-12 Merck Frosst Canada Heteroaryl diol acids as leukotriene antagonists
KR19990082367A (ko) * 1996-02-08 1999-11-25 폴락 돈나 엘. 치료 방법 및 약제학적 조성물
WO1999032125A1 (en) * 1997-12-23 1999-07-01 Schering Corporation Composition for treating respiratory and skin diseases, comprising at least one leukotriene antagonist and at least one antihistamine
US6384038B1 (en) * 1998-04-14 2002-05-07 Sepracor Inc. Methods and compositions using cetirizine in combination with leukotriene inhibitors or decongestants
US6262066B1 (en) 1998-07-27 2001-07-17 Schering Corporation High affinity ligands for nociceptin receptor ORL-1
US6696466B1 (en) * 2000-09-07 2004-02-24 Leslie Joe Dunaway Methods of treating select neuronal inflammatory disorders using hydroxyalkylquinolines
CA2371048C (en) 2002-02-06 2011-01-04 Delmar Chemicals Inc. Process for the preparation of 1-(mercaptomethyl)-cyclopropaneacetic acid
DE50307710D1 (de) * 2003-08-15 2007-08-30 Abb Turbo Systems Ag Rotationsdichtung
EP1678139B1 (de) * 2003-10-10 2011-08-31 Synhton B.V. Montelukast in fester phase
US7501517B2 (en) * 2004-04-30 2009-03-10 Synthon Ip, Inc. Process for making montelukast and intermediates therefor
US7829716B2 (en) * 2004-04-30 2010-11-09 Synthon Pharmaceuticals, Inc. Process for making montelukast and intermediates therefor
MX2007001561A (es) * 2004-08-04 2007-04-16 Schering Corp Formulacion farmaceutica que comprende pleconaril para tratamiento de enfermedades de vias aereas.
US20060110449A1 (en) 2004-10-25 2006-05-25 Lorber Richard R Pharmaceutical composition
US20070161796A1 (en) * 2005-11-16 2007-07-12 Ilan Kor-Sade Drying methods of montelukast sodium by azeotropic removal of the solvent
AR057908A1 (es) * 2005-11-18 2007-12-26 Synthon Bv Proceso para preparar montelukast e intermediarios del mismo
EP1996552A1 (de) * 2006-03-17 2008-12-03 Synthon B.V. Montelukast-amantadin-salz
WO2008001213A1 (en) * 2006-06-26 2008-01-03 Aurobindo Pharma Limited An improved process for the preparation of leukotriene receptor antagonist (montelukast sodium)
EP2038277A2 (de) * 2006-07-11 2009-03-25 Schering Corporation Xinafoat-salz auf einer substituierten 5-oxazol-2-yl-chinolin-verbindung
US7271268B1 (en) 2006-12-22 2007-09-18 Formosa Laboratories Inc. Process for preparation of [1-(mercaptomethyl)cyclopropyl]acetic acid and related derivatives
PL205444B1 (pl) * 2007-05-02 2010-04-30 Zak & Lstrok Ady Farmaceutyczn Sposób wytwarzania soli sodowej kwasu 1-(((1(R)-(3-(2-(7--chloro-2- chinolinylo)-etenylo)fenylo)-3-(2-(1-hydroksy-1- metyloetylo)fenylo)propylo)sulfanylo)metylo)-cyklopropanooctowego
EP2265586A4 (de) * 2008-03-17 2012-10-03 Reddys Lab Ltd Dr Herstellung von montelukast und seinen salzen
EP2276739A1 (de) * 2008-04-25 2011-01-26 Synthon B.V. Verfahren zur herstellung von montelukast-zwischenprodukten
AR077101A1 (es) 2009-06-16 2011-08-03 Schering Corp Esteroides de heteroarilo (3,2-c), como agonistas de receptor glucocorticoide, composiciones y usos de los mismos
AU2012320010B2 (en) * 2011-07-26 2017-03-30 Sun Pharma Advanced Research Company Ltd. Quinoline-, quinoxaline or benzothiazole based cysteinyl leukotriene antagonists (LTD4)
CN104069502B (zh) * 2013-03-29 2018-02-16 北京罗诺强施医药技术研发中心有限公司 复合骨架材料及其药物组合物
CN105085391B (zh) 2015-06-10 2017-08-22 广东默泰同创医药科技有限公司 用作白三烯受体拮抗剂的环丙基不饱和喹啉化合物及应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4962203A (en) * 1985-06-18 1990-10-09 Merck Frost Canada, Inc. 2-substituted quinolines useful as leukotriene antagonists
EP0206751A3 (de) * 1985-06-18 1988-05-25 Merck Frosst Canada Inc. 2-Substituierte Chinoline, ihre Herstellung und Verwendung
US4851409A (en) * 1986-02-14 1989-07-25 Merck Frosst Canada Inc. 2-substituted quinoline dioic acids and pharmaceutical compositions
IE59889B1 (en) * 1986-02-14 1994-04-20 Merck Frosst Canada Inc 2-substituted quinoline dioic acids
EP0271287A3 (de) * 1986-12-11 1990-06-13 Merck Frosst Canada Inc. Chinolindicarbonsäuren und ihre Amide
FR2617352B1 (fr) * 1987-06-26 1989-12-01 Eduvision Sa Procede de codage de donnees informatiques pour transmission aux normes video, videodisque mettant en oeuvre ledit procede et interface d'exploitation d'un tel videodisque
US4920132A (en) * 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
EP0318093A3 (de) * 1987-11-25 1990-12-05 Merck Frosst Canada Inc. Diarylchinolindicarbonsäure und ihre Verwendung als Arzneimittel
DE3814504A1 (de) * 1988-04-29 1989-11-09 Bayer Ag (alpha)-substituierte 4-(chinolin-2-yl-methoxy)phenylessigsaeuren und -ester, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
DE3900261A1 (de) * 1988-05-31 1989-12-07 Bayer Ag Substituierte 4-(chinolin-2-yl-methoxy) phenyl-essigsaeure-derivate
US4918081A (en) * 1988-06-20 1990-04-17 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene d4
NZ233752A (en) * 1989-05-24 1993-05-26 Merck Frosst Canada Inc Substituted quinoline derivatives, preparation and pharmaceutical compositions thereof
EP0480717B1 (de) * 1990-10-12 1998-04-15 Merck Frosst Canada Inc. Ungesättigte Hydroxyalkylchinolinsäuren als Leukotrien-Antagonisten
IE920499A1 (en) * 1991-02-21 1992-08-26 Merck Frosst Canada Inc Quinoline-containing ketoacids as leukotriene antagonists

Also Published As

Publication number Publication date
BG99085A (bg) 1995-06-30
CN1083052A (zh) 1994-03-02
LV12290A (lv) 1999-06-20
JP2504687B2 (ja) 1996-06-05
MX9302033A (es) 1994-07-29
HU9402905D0 (en) 1995-01-30
NO943792D0 (no) 1994-10-07
FI944734A (fi) 1994-10-07
HUT70399A (en) 1995-10-30
AU653476B2 (en) 1994-09-29
AU3686393A (en) 1993-10-14
CN1080169A (zh) 1994-01-05
SI9300188A (sl) 1993-12-31
CZ246394A3 (en) 1996-01-17
DE69319482T2 (de) 1999-02-04
CN1043761C (zh) 1999-06-23
US5270324A (en) 1993-12-14
DE69319482D1 (de) 1998-08-13
FI944734A0 (fi) 1994-10-07
IL105193A0 (en) 1993-07-08
WO1993021159A1 (en) 1993-10-28
LV12290B (en) 1999-11-20
CA2092896A1 (en) 1993-10-11
EP0565185A1 (de) 1993-10-13
ES2117691T3 (es) 1998-08-16
NO943792L (no) 1994-12-08
ZA932533B (en) 1993-11-04
JPH0625173A (ja) 1994-02-01
HU218917B (hu) 2000-12-28
HRP930803A2 (en) 1994-12-31
BG62402B1 (bg) 1999-10-29
CA2092896C (en) 2005-12-20
EP0565185B1 (de) 1998-07-08

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
REN Ceased due to non-payment of the annual fee