FI943574A - Trisubstituoidut pyrimido/5,4-d/pyrimidiinit monilääkevastuksen moduloimiseksi, näitä yhdisteitä sisältävät lääkeaineet ja menetelmä niiden valmistamiseksi - Google Patents
Trisubstituoidut pyrimido/5,4-d/pyrimidiinit monilääkevastuksen moduloimiseksi, näitä yhdisteitä sisältävät lääkeaineet ja menetelmä niiden valmistamiseksi Download PDFInfo
- Publication number
- FI943574A FI943574A FI943574A FI943574A FI943574A FI 943574 A FI943574 A FI 943574A FI 943574 A FI943574 A FI 943574A FI 943574 A FI943574 A FI 943574A FI 943574 A FI943574 A FI 943574A
- Authority
- FI
- Finland
- Prior art keywords
- pyrimidines
- preparation
- compounds containing
- drug resistance
- containing drugs
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 230000036457 multidrug resistance Effects 0.000 title 1
- 150000003230 pyrimidines Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4325900A DE4325900A1 (de) | 1993-08-02 | 1993-08-02 | Trisubstituierte Pyrimido [5,4-d] pyrimidine zur Modulation der Multidrugresistenz, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FI943574A0 FI943574A0 (fi) | 1994-08-01 |
| FI943574A true FI943574A (fi) | 1995-02-03 |
Family
ID=6494272
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI943574A FI943574A (fi) | 1993-08-02 | 1994-08-01 | Trisubstituoidut pyrimido/5,4-d/pyrimidiinit monilääkevastuksen moduloimiseksi, näitä yhdisteitä sisältävät lääkeaineet ja menetelmä niiden valmistamiseksi |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5618814A (cs) |
| EP (1) | EP0645390A1 (cs) |
| JP (1) | JPH0789963A (cs) |
| KR (1) | KR950005828A (cs) |
| CN (1) | CN1041091C (cs) |
| AU (1) | AU683888B2 (cs) |
| BG (1) | BG98931A (cs) |
| CA (1) | CA2129179A1 (cs) |
| CZ (1) | CZ184594A3 (cs) |
| DE (1) | DE4325900A1 (cs) |
| EE (1) | EE9400255A (cs) |
| FI (1) | FI943574A (cs) |
| HU (1) | HUT70957A (cs) |
| IL (1) | IL110509A (cs) |
| NO (1) | NO301479B1 (cs) |
| NZ (1) | NZ264133A (cs) |
| PL (1) | PL304512A1 (cs) |
| RO (1) | RO113557B1 (cs) |
| RU (1) | RU94028278A (cs) |
| SK (1) | SK91594A3 (cs) |
| TW (1) | TW251286B (cs) |
| ZA (1) | ZA945689B (cs) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW414798B (en) * | 1994-09-07 | 2000-12-11 | Thomae Gmbh Dr K | Pyrimido (5,4-d) pyrimidines, medicaments comprising these compounds, their use and processes for their preparation |
| DE19608653A1 (de) * | 1996-03-06 | 1997-09-11 | Thomae Gmbh Dr K | Pyrimido[5,4-d]pyrimidine, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| US6331543B1 (en) * | 1996-11-01 | 2001-12-18 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use |
| USRE37234E1 (en) * | 1996-11-01 | 2001-06-19 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiestrase inhibitor compounds, compositions and their uses |
| US5958926A (en) | 1996-11-01 | 1999-09-28 | Nitromed, Inc. | Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses |
| US6472425B1 (en) | 1997-10-31 | 2002-10-29 | Nitromed, Inc. | Methods for treating female sexual dysfunctions |
| US8309562B2 (en) * | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
| CN1984660B (zh) | 2003-07-03 | 2010-12-15 | 美瑞德生物工程公司 | 作为天冬氨酸特异性半胱氨酸蛋白酶活化剂和细胞程序死亡诱导剂的4-芳基氨基-喹唑啉 |
| DE102004002557A1 (de) * | 2004-01-17 | 2005-08-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von substituierten Pyrimido(5,4-d)pyrimidinen zur Behandlung von Atemwegserkrankungen |
| CA2592900A1 (en) | 2005-01-03 | 2006-07-13 | Myriad Genetics Inc. | Nitrogen containing bicyclic compounds and therapeutical use thereof |
| US8258145B2 (en) * | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
| CN115650827B (zh) * | 2022-10-27 | 2024-03-15 | 戊言医药科技（上海）有限公司 | 用于一类蒽环类毒素衍生物的制备方法、中间体化合物及合成方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0023559B1 (de) * | 1979-07-03 | 1984-09-19 | Dr. Karl Thomae GmbH | 2-(Perhydro-1,4-diazino)-pyrimido(5,4-d)pyrimidine, ihre Herstellung und diese Verbindungen enthaltenden Arzneimittel |
| DE2931573A1 (de) * | 1979-08-03 | 1981-02-26 | Thomae Gmbh Dr K | Mittel zur bekaempfung des wachstums von krebszellen und dessen herstellung |
| DE3049207A1 (de) * | 1980-12-27 | 1982-07-29 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue trisubstituierte pyrimido (5,4-d) pyrimidine, ihre herstellung und ihre verwendung als arzneimittel |
| DE3423092A1 (de) * | 1984-06-22 | 1986-01-02 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue 8-alkylthio-2-piperazino-pyrimido(5,4-d) pyrimidine, ihre herstellung und diese verbindungen enthaltende arzneimittel |
| DE3833392A1 (de) * | 1988-10-01 | 1990-04-05 | Thomae Gmbh Dr K | Verwendung von pyrimido(5,4-d)pyrimidinen zur verhinderung der primaeren und sekundaeren resistenz bei der chemotherapie und diese verbindungen enthaltende arzneimittel |
-
1993
- 1993-08-02 DE DE4325900A patent/DE4325900A1/de not_active Withdrawn
-
1994
- 1994-07-07 TW TW083106205A patent/TW251286B/zh active
- 1994-07-26 EP EP94111739A patent/EP0645390A1/de not_active Withdrawn
- 1994-07-27 RO RO94-01270A patent/RO113557B1/ro unknown
- 1994-07-28 BG BG98931A patent/BG98931A/bg unknown
- 1994-07-29 IL IL110509A patent/IL110509A/en not_active IP Right Cessation
- 1994-07-29 CA CA002129179A patent/CA2129179A1/en not_active Abandoned
- 1994-07-29 NZ NZ264133A patent/NZ264133A/en unknown
- 1994-07-29 SK SK915-94A patent/SK91594A3/sk unknown
- 1994-08-01 PL PL94304512A patent/PL304512A1/xx unknown
- 1994-08-01 ZA ZA945689A patent/ZA945689B/xx unknown
- 1994-08-01 CN CN94114910A patent/CN1041091C/zh not_active Expired - Fee Related
- 1994-08-01 KR KR1019940018961A patent/KR950005828A/ko not_active Application Discontinuation
- 1994-08-01 HU HU9402253A patent/HUT70957A/hu unknown
- 1994-08-01 FI FI943574A patent/FI943574A/fi unknown
- 1994-08-01 JP JP6179359A patent/JPH0789963A/ja active Pending
- 1994-08-01 RU RU94028278/04A patent/RU94028278A/ru unknown
- 1994-08-01 AU AU68813/94A patent/AU683888B2/en not_active Ceased
- 1994-08-01 NO NO942853A patent/NO301479B1/no unknown
- 1994-08-02 US US08/284,325 patent/US5618814A/en not_active Expired - Fee Related
- 1994-08-02 CZ CZ941845A patent/CZ184594A3/cs unknown
- 1994-11-23 EE EE9400255A patent/EE9400255A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1041091C (zh) | 1998-12-09 |
| HU9402253D0 (en) | 1994-09-28 |
| US5618814A (en) | 1997-04-08 |
| IL110509A (en) | 1998-01-04 |
| CN1106405A (zh) | 1995-08-09 |
| AU683888B2 (en) | 1997-11-27 |
| FI943574A0 (fi) | 1994-08-01 |
| SK91594A3 (en) | 1995-04-12 |
| AU6881394A (en) | 1995-02-09 |
| CA2129179A1 (en) | 1995-02-03 |
| DE4325900A1 (de) | 1995-02-09 |
| BG98931A (en) | 1995-09-29 |
| ZA945689B (en) | 1996-02-01 |
| CZ184594A3 (en) | 1995-02-15 |
| EP0645390A1 (de) | 1995-03-29 |
| NO942853D0 (cs) | 1994-08-01 |
| PL304512A1 (en) | 1995-02-06 |
| IL110509A0 (en) | 1994-10-21 |
| RO113557B1 (ro) | 1998-08-28 |
| NZ264133A (en) | 1996-05-28 |
| NO942853L (no) | 1995-02-03 |
| KR950005828A (ko) | 1995-03-20 |
| HUT70957A (en) | 1995-11-28 |
| EE9400255A (et) | 1996-02-15 |
| TW251286B (cs) | 1995-07-11 |
| NO301479B1 (no) | 1997-11-03 |
| JPH0789963A (ja) | 1995-04-04 |
| RU94028278A (ru) | 1996-08-27 |
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