FI943326A - Entsymaattisia menetelmiä taksaanien valmistuksessa välituotteina käyttökelpoisten yhdisteiden enantiomeeristen seosten resoluutiota varten - Google Patents
Entsymaattisia menetelmiä taksaanien valmistuksessa välituotteina käyttökelpoisten yhdisteiden enantiomeeristen seosten resoluutiota varten Download PDFInfo
- Publication number
- FI943326A FI943326A FI943326A FI943326A FI943326A FI 943326 A FI943326 A FI 943326A FI 943326 A FI943326 A FI 943326A FI 943326 A FI943326 A FI 943326A FI 943326 A FI943326 A FI 943326A
- Authority
- FI
- Finland
- Prior art keywords
- taxanes
- intermediates
- resolution
- preparation
- compounds useful
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/874—Pseudomonas
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/921—Candida
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/939—Rhizopus
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9217093A | 1993-07-14 | 1993-07-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FI943326A0 FI943326A0 (fi) | 1994-07-12 |
| FI943326A true FI943326A (fi) | 1995-01-15 |
Family
ID=22231980
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI943326A FI943326A (fi) | 1993-07-14 | 1994-07-12 | Entsymaattisia menetelmiä taksaanien valmistuksessa välituotteina käyttökelpoisten yhdisteiden enantiomeeristen seosten resoluutiota varten |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US5879929A (ja) |
| EP (1) | EP0634492A1 (ja) |
| JP (1) | JPH0775595A (ja) |
| KR (1) | KR960014352A (ja) |
| CN (1) | CN1100144A (ja) |
| AU (1) | AU688766B2 (ja) |
| CA (1) | CA2127972A1 (ja) |
| FI (1) | FI943326A (ja) |
| HU (1) | HU217790B (ja) |
| IL (1) | IL110278A (ja) |
| SG (1) | SG54231A1 (ja) |
| TW (1) | TW397866B (ja) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR8407009A (pt) * | 1983-08-11 | 1985-07-02 | Noel Carroll | Processo e aparelho para separar liquidos |
| US5602272A (en) * | 1994-06-21 | 1997-02-11 | Bristol-Myers Squibb Company | Reduction and resolution methods for the preparation of compounds useful as intemediates for preparing taxanes |
| US5635531A (en) * | 1996-07-08 | 1997-06-03 | Bristol-Myers Squibb Company | 3'-aminocarbonyloxy paclitaxels |
| EP0855446B1 (en) * | 1997-01-24 | 2003-04-09 | Sumitomo Chemical Company, Limited | Process for producing optically active azetidine-2-carboxylic acid derivative |
| GB9714877D0 (en) * | 1997-07-15 | 1997-09-17 | Chiroscience Ltd | Microorganism and its use |
| JP2003517266A (ja) | 1998-02-17 | 2003-05-27 | ジー・ディー・サール・アンド・カンパニー | ラクタムの酵素分割方法 |
| JP3757629B2 (ja) * | 1998-07-17 | 2006-03-22 | 住友化学株式会社 | 光学活性ｎ−置換アゼチジン−２−カルボン酸化合物の製造方法 |
| WO2001007438A1 (en) * | 1999-07-23 | 2001-02-01 | Eli Lilly And Company | Enantioselective acylation of cis racemic azetidinones |
| AU775373B2 (en) | 1999-10-01 | 2004-07-29 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| US6548293B1 (en) * | 1999-10-18 | 2003-04-15 | Fsu Research Foundation, Inc. | Enzymatic process for the resolution of enantiomeric mixtures of β-lactams |
| BR0104350A (pt) | 2000-02-02 | 2002-01-02 | Univ Florida State Res Found | Taxanos de c10 acetato heterossubstituìdo como agentes antitumor |
| US6649632B2 (en) | 2000-02-02 | 2003-11-18 | Fsu Research Foundation, Inc. | C10 ester substituted taxanes |
| CO5280224A1 (es) | 2000-02-02 | 2003-05-30 | Univ Florida State Res Found | Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen |
| PL350315A1 (en) | 2000-02-02 | 2002-12-02 | Univ Florida State Res Found | C7 carbonate substituted taxanes as antitumor agents |
| ATE392422T1 (de) | 2000-02-02 | 2008-05-15 | Univ Florida State Res Found | C7-carbamoyloxysubstituierte taxane als antitumormittel |
| PL350328A1 (en) * | 2000-02-02 | 2002-12-02 | Univ Florida State Res Found | C7 heterosubstituted acetate taxanes as antitumor agents |
| CA2368151A1 (en) | 2000-02-02 | 2001-08-09 | Florida State University Research Foundation, Inc. | C10 carbonate substituted taxanes as antitumor agents |
| JP2003522173A (ja) * | 2000-02-02 | 2003-07-22 | フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド | 抗腫瘍剤としてのｃ１０カルバモイルオキシ置換タキサン |
| WO2002036795A2 (en) * | 2000-11-02 | 2002-05-10 | Csir | Process for preparing (-)- menthol and similar compounds |
| JP4142444B2 (ja) * | 2001-03-07 | 2008-09-03 | 第一三共株式会社 | ２−アゼチジノン誘導体の製造方法 |
| US7064980B2 (en) * | 2003-09-17 | 2006-06-20 | Sandisk Corporation | Non-volatile memory and method with bit line coupled compensation |
| HN2005000054A (es) * | 2004-02-13 | 2009-02-18 | Florida State University Foundation Inc | Taxanos sustituidos con esteres de ciclopentilo en c10 |
| CN1960721A (zh) | 2004-03-05 | 2007-05-09 | 佛罗里达州立大学研究基金有限公司 | C7乳酰氧基取代的紫杉烷类 |
| MX2007009748A (es) * | 2005-02-14 | 2007-09-26 | Univ Florida State Res Found | Composiciones de taxano sustituidas con esteres ciclopropilicos en c10. |
| JP2011517455A (ja) * | 2008-03-31 | 2011-06-09 | フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド | Ｃ（１０）エチルエステルおよびｃ（１０）シクロプロピルエステル置換タキサン |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4492757A (en) * | 1981-12-28 | 1985-01-08 | Denki Kagaku Kogyo Kabushiki Kaisha | Process for preparing L-threonine |
| JPS60248192A (ja) * | 1984-05-23 | 1985-12-07 | Sumitomo Chem Co Ltd | 光学活性なスレオ−３−フエニルセリン誘導体の製造方法 |
| FR2629819B1 (fr) * | 1988-04-06 | 1990-11-16 | Rhone Poulenc Sante | Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii |
| US4943528A (en) * | 1988-11-22 | 1990-07-24 | Nitto Chemical Industry Co., Ltd. | Process for the production of optically active (R)-(-)-3-halo-1,2-propanediol |
| JPH02190195A (ja) | 1989-01-19 | 1990-07-26 | Rikagaku Kenkyusho | 光学活性プロピオン酸エステル類化合物の製法 |
| JPH02273196A (ja) | 1989-03-08 | 1990-11-07 | Wisconsin Alumni Res Found | ラセミ化合物の生体触媒分割のエナンチオ選択性の改良法 |
| WO1990014434A1 (en) * | 1989-05-15 | 1990-11-29 | Schering Corporation | Process for preparing antibacterial compounds and intermediates thereto |
| US5175315A (en) * | 1989-05-31 | 1992-12-29 | Florida State University | Method for preparation of taxol using β-lactam |
| EP0404586A3 (en) * | 1989-06-21 | 1991-12-11 | Merck & Co. Inc. | Nitrogen deprotected 4-acyloxyazetidin-2-ones |
| EP0407190A3 (en) * | 1989-07-07 | 1991-03-13 | Schering Corporation | Process for producing antibacterial intermediates via enzyme hydrolysis of racemic substrates |
| IL95436A (en) * | 1989-08-23 | 1996-07-23 | Centre Nat Rech Scient | Process for preparing the history of phenylisosarine |
| US5241064A (en) * | 1989-10-02 | 1993-08-31 | Fujisawa Pharmaceutical Co., Ltd. | Enzymatic process for preparing optically active 3-substituted azetidinones |
| US5015744A (en) * | 1989-11-14 | 1991-05-14 | Florida State University | Method for preparation of taxol using an oxazinone |
| US5136060A (en) * | 1989-11-14 | 1992-08-04 | Florida State University | Method for preparation of taxol using an oxazinone |
| EP0451668B1 (en) | 1990-04-12 | 1997-08-13 | Chisso Corporation | Process for the production of optically active alkyl 3-aryl-3-hydroxypropionates |
| JPH04258297A (ja) | 1991-02-07 | 1992-09-14 | Ajinomoto Co Inc | 光学活性１−フェニル−１、３−プロパンジオールおよびその誘導体の製造法 |
| US5346828A (en) | 1991-03-27 | 1994-09-13 | Celgene Corporation | Stereoisomeric enrichment of 2-amino-3-hydroxy-3-phenylpropionic acids using d-threonine aldolase |
| CA2071160A1 (en) * | 1991-07-31 | 1993-02-01 | Vittorio Farina | Asymmetric synthesis of taxol side chain |
| EP0529483B1 (de) * | 1991-08-22 | 1996-02-28 | Lonza Ag | Verfahren zur Herstellung von optisch aktiven 4-Amino-3-hydroxycarbonsäuren |
| US5250683A (en) * | 1991-09-23 | 1993-10-05 | Florida State University | Certain substituted taxanes and pharmaceutical compositions containing them |
| US5227400A (en) * | 1991-09-23 | 1993-07-13 | Florida State University | Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them |
| US5243045A (en) * | 1991-09-23 | 1993-09-07 | Florida State University | Certain alkoxy substituted taxanes and pharmaceutical compositions containing them |
| CA2434312A1 (en) | 1992-01-15 | 1993-07-16 | Ramesh N. Patel | Enzymatic processes for resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes |
| US5272171A (en) * | 1992-02-13 | 1993-12-21 | Bristol-Myers Squibb Company | Phosphonooxy and carbonate derivatives of taxol |
| US5294737A (en) * | 1992-02-27 | 1994-03-15 | The Research Foundation State University Of New York | Process for the production of chiral hydroxy-β-lactams and hydroxyamino acids derived therefrom |
| US5294637A (en) * | 1992-07-01 | 1994-03-15 | Bristol-Myers Squibb Company | Fluoro taxols |
| US5254580A (en) * | 1993-01-19 | 1993-10-19 | Bristol-Myers Squibb Company | 7,8-cyclopropataxanes |
| EP0582469A2 (en) * | 1992-08-06 | 1994-02-09 | Wisconsin Alumni Research Foundation | Process for preparing taxol-type compound from beta-lactam precursors |
| CA2111527C (en) * | 1992-12-24 | 2000-07-18 | Jerzy Golik | Phosphonooxymethyl ethers of taxane derivatives |
-
1994
- 1994-05-16 TW TW083104413A patent/TW397866B/zh not_active IP Right Cessation
- 1994-07-11 IL IL110278A patent/IL110278A/en not_active IP Right Cessation
- 1994-07-12 EP EP94305095A patent/EP0634492A1/en not_active Withdrawn
- 1994-07-12 FI FI943326A patent/FI943326A/fi unknown
- 1994-07-12 SG SG1996005278A patent/SG54231A1/en unknown
- 1994-07-13 CA CA002127972A patent/CA2127972A1/en not_active Abandoned
- 1994-07-13 AU AU67433/94A patent/AU688766B2/en not_active Ceased
- 1994-07-13 KR KR1019940016815A patent/KR960014352A/ko not_active Application Discontinuation
- 1994-07-13 HU HU9402096A patent/HU217790B/hu not_active IP Right Cessation
- 1994-07-14 JP JP6162145A patent/JPH0775595A/ja active Pending
- 1994-07-14 CN CN94108597A patent/CN1100144A/zh active Pending
-
1995
- 1995-06-05 US US08/461,236 patent/US5879929A/en not_active Expired - Fee Related
-
1998
- 1998-11-16 US US09/193,105 patent/US6541242B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0634492A1 (en) | 1995-01-18 |
| IL110278A (en) | 1998-06-15 |
| FI943326A0 (fi) | 1994-07-12 |
| US5879929A (en) | 1999-03-09 |
| KR960014352A (ko) | 1996-05-22 |
| HU217790B (hu) | 2000-04-28 |
| CA2127972A1 (en) | 1995-01-15 |
| HUT69958A (en) | 1995-09-28 |
| AU6743394A (en) | 1995-01-27 |
| HU9402096D0 (en) | 1994-09-28 |
| CN1100144A (zh) | 1995-03-15 |
| AU688766B2 (en) | 1998-03-19 |
| IL110278A0 (en) | 1994-10-21 |
| TW397866B (en) | 2000-07-11 |
| SG54231A1 (en) | 1998-11-16 |
| JPH0775595A (ja) | 1995-03-20 |
| US6541242B1 (en) | 2003-04-01 |
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