FI942976A - 5-amino-8-metyyli-7-pyrrolidinyylikinoliini-3-karboksyylihappojohdannaiset - Google Patents

5-amino-8-metyyli-7-pyrrolidinyylikinoliini-3-karboksyylihappojohdannaiset Download PDF

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Publication number
FI942976A
FI942976A FI942976A FI942976A FI942976A FI 942976 A FI942976 A FI 942976A FI 942976 A FI942976 A FI 942976A FI 942976 A FI942976 A FI 942976A FI 942976 A FI942976 A FI 942976A
Authority
FI
Finland
Prior art keywords
compounds
hydrogen atom
alkyl group
lower alkyl
carboxylic acid
Prior art date
Application number
FI942976A
Other languages
English (en)
Swedish (sv)
Other versions
FI942976A0 (fi
FI113174B (fi
Inventor
Yasuo Ito
Hideo Kato
Singo Yasuda
Noriyaki Kado
Toshihiko Yoshida
Yoichi Yamamoto
Original Assignee
Hokuriku Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hokuriku Pharmaceutical filed Critical Hokuriku Pharmaceutical
Publication of FI942976A0 publication Critical patent/FI942976A0/fi
Publication of FI942976A publication Critical patent/FI942976A/fi
Application granted granted Critical
Publication of FI113174B publication Critical patent/FI113174B/fi

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epoxy Resins (AREA)
  • Medicinal Preparation (AREA)
  • Pyrrole Compounds (AREA)
FI942976A 1993-08-27 1994-06-21 Menetelmä ja välituote 5-amino-8-metyyli-7-pyrrolidinyylikinoliini-3-karboksyylihappojohdannaisten valmistamiseksi FI113174B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP23431093 1993-08-27
JP23431093 1993-08-27
JP28627293 1993-10-22
JP28627293 1993-10-22
JP7631894 1994-03-24
JP7631894 1994-03-24

Publications (3)

Publication Number Publication Date
FI942976A0 FI942976A0 (fi) 1994-06-21
FI942976A true FI942976A (fi) 1995-02-28
FI113174B FI113174B (fi) 2004-03-15

Family

ID=27302121

Family Applications (1)

Application Number Title Priority Date Filing Date
FI942976A FI113174B (fi) 1993-08-27 1994-06-21 Menetelmä ja välituote 5-amino-8-metyyli-7-pyrrolidinyylikinoliini-3-karboksyylihappojohdannaisten valmistamiseksi

Country Status (23)

Country Link
US (1) US5547962A (fi)
EP (1) EP0641793B1 (fi)
JP (1) JP2673937B2 (fi)
KR (1) KR100218807B1 (fi)
CN (1) CN1048242C (fi)
AT (1) ATE144508T1 (fi)
AU (1) AU676729B2 (fi)
CA (1) CA2126118C (fi)
CZ (1) CZ286524B6 (fi)
DE (1) DE69400791T2 (fi)
DK (1) DK0641793T3 (fi)
ES (1) ES2096413T3 (fi)
FI (1) FI113174B (fi)
GR (1) GR3021715T3 (fi)
HU (1) HU221952B1 (fi)
IL (1) IL110060A (fi)
MY (1) MY111702A (fi)
NO (1) NO305515B1 (fi)
NZ (1) NZ260851A (fi)
PL (1) PL175870B1 (fi)
SG (1) SG52147A1 (fi)
TW (1) TW252107B (fi)
UA (1) UA39859C2 (fi)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0806421A4 (en) * 1995-01-24 1998-04-15 Hokuriku Pharmaceutical DERIVATIVES OF CHINOLINE CARBONIC ACID
US6121285A (en) * 1995-11-22 2000-09-19 Daiichi Pharmaceutical Co., Ltd. Substituted aminocycloalkylpyrrolidine derivatives and cis-substituted aminocycloalkylpyrrolidine derivatives
TR200001435T2 (tr) 1997-09-15 2000-08-21 The Procter & Gamble Company Antimikrobiyal kuinolonlar, bunların bileşimleri ve kullanımları
US6387928B1 (en) 1997-09-15 2002-05-14 The Procter & Gamble Co. Antimicrobial quinolones, their compositions and uses
EP1132375B1 (en) 1998-11-18 2003-07-16 Asahi Glass Company Ltd. Aminoacrylic acid derivatives and process for producing the same
CN1343128B (zh) 1999-03-17 2010-04-21 第一制药株式会社 药物组合物
US7176313B2 (en) 2000-02-09 2007-02-13 Daiichi Pharmaceutical Co., Ltd. Anti acid-fast bacterial agent containing pyridonecarboxylic acids as active ingredient
WO2001062734A1 (fr) * 2000-02-25 2001-08-30 Daiichi Pharmaceutical Co., Ltd. Procede de production d'acides quinolonecarboxyliques et de leurs intermediaires
US6825353B2 (en) 2000-02-25 2004-11-30 Daiichi Pharmaceutical Co., Ltd. Process for producing quinolonecarboxylic acids and intermediates thereof
KR20010044286A (ko) * 2001-02-01 2001-06-05 남근수 알킬-3-(2,6-디할로겐-5-플루오로)-옥소-3-피리딘프로피오네이트의 제조방법
US7928232B2 (en) * 2005-05-20 2011-04-19 Daiichi Sankyo Company, Limited Method for producing asymmetric tetrasubstituted carbon atom-containing compound
WO2007037303A1 (ja) * 2005-09-28 2007-04-05 Daiichi Sankyo Company, Limited テトラ置換-5-アザスピロ[2.4]へプタン誘導体の製法およびその光学活性中間体
US7528264B2 (en) * 2006-03-28 2009-05-05 The Procter & Gamble Company Hydride reduction process for preparing quinolone intermediates
JP5097967B2 (ja) * 2006-03-28 2012-12-12 タイゲン バイオテクノロジー カンパニー,リミテッド リンゴ酸塩類、及び(3s,5s)−7−[3−アミノ−5−メチルーピペリジニル]−1−シクロプロピル−1,4−ジヒドロ−8−メトキシ−4−オキソ−3−キノリンカルボン酸の多形体類
KR20110082635A (ko) * 2006-03-28 2011-07-19 워너 칠콧 컴퍼니 엘엘씨 퀴놀론 중간체를 제조하기 위한 커플링 방법
TWI362386B (en) * 2007-03-30 2012-04-21 Daiichi Sankyo Co Ltd A production method for the qunolon-carboxylic acid derivative
FR2928150A1 (fr) * 2008-02-29 2009-09-04 Vetoquinol Sa Sa Nouveaux derives 7-substitues de 3-carboxy-oxadiazino-quinolones, leur preparation et leur application comme anti-bacteriens

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US4665079A (en) * 1984-02-17 1987-05-12 Warner-Lambert Company Antibacterial agents
IE58742B1 (en) * 1984-07-20 1993-11-05 Warner Lambert Co Substituted-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7h-pyrido[1,2,3-de] [1,4]benzoxauine-6-carboxylic acids; sibstituted-5-amino-6-6fluoro-4-oxo.1,4-dihydroquinoline-3 carboxylic acids; substituted-5-amino-6-fluoro-1,4-dihydro-4-oxo-1.8-naphthyridine-3-carboxylic acids; derivatives thereof; pharmaceutical compositions comprising the compounds; and processes for producing the compounds
JPH0635457B2 (ja) * 1985-06-28 1994-05-11 杏林製薬株式会社 ピリドンカルボン酸誘導体およびその製造方法
DE3608745A1 (de) * 1985-07-24 1987-01-29 Bayer Ag Bakterizide zubereitungen zur anwendung auf dem gebiet der veterinaermedizin
JPH0637489B2 (ja) * 1985-09-21 1994-05-18 杏林製薬株式会社 キノロンカルボン酸誘導体およびその製造方法
JPH089597B2 (ja) * 1986-01-21 1996-01-31 杏林製薬株式会社 選択毒性に優れた8‐アルコキシキノロンカルボン酸およびその塩並びにその製造方法
JPS62215572A (ja) 1986-03-17 1987-09-22 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
EP0242789A3 (en) * 1986-04-25 1990-09-05 Dainippon Pharmaceutical Co., Ltd. Novel quinoline derivates and processes for preparation thereof
FI88506C (fi) * 1986-07-04 1993-05-25 Chemie Linz Gmbh Foerfarande foer framstaellning av farmaceutiskt anvaendbar 7-diazabicykloalkyl-6-fluor-1-(2,4-difluorfenyl)-1,4-dihydro-4-oxo-kinolin-3-karboxylsyra eller karboxylsyraester
US4771055A (en) * 1986-07-28 1988-09-13 Warner-Lambert Company 7-[[3-(aminomethyl)-3-alkyl]-1-pyrrolidinyl]-quinoline-carboxylic acids
JPS63152318A (ja) * 1986-08-07 1988-06-24 Dainippon Pharmaceut Co Ltd 抗マイコプラズマ剤
DE3702393A1 (de) * 1987-01-28 1988-08-11 Bayer Ag 8-cyano-1-cyclopropyl-1,4-dihydro-4-oxo- 3-chinolincarbonsaeuren, verfahren zu ihrer herstellung und diese enthaltende antibakterielle mittel
US5190955A (en) * 1987-01-28 1993-03-02 Bayer Aktiengesellschaft Antibacterial 8-cyano-1-cyclopropyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids
DE3711193A1 (de) * 1987-04-02 1988-10-13 Bayer Ag 5-substituierte chinolon- und naphthyridoncarbonsaeure-derivate
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JP2844079B2 (ja) * 1988-05-23 1999-01-06 塩野義製薬株式会社 ピリドンカルボン酸系抗菌剤
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DE3906365A1 (de) * 1988-07-15 1990-01-18 Bayer Ag 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe
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DE3910920A1 (de) * 1989-04-05 1990-10-11 Bayer Ag Enantiomerenreine 7-(3-amino-1-pyrrolidinyl)-chinolon- und -naphthyridoncarbonsaeuren
DE4032560A1 (de) * 1990-10-13 1992-04-16 Bayer Ag 7-(2,7-diazabicyclo(3.3.0)octyl)-3-chinolon- und -naphtyridoncarbonsaeure-derivate
DE69132314T2 (de) * 1990-12-05 2000-12-14 Naeja Pharmaceutical Inc 7-substituierte-6-fluor-1,4-dihydro-4-oxo-chinolin-3-carbonsäurederivate als antibakterielle wirkstoffe
US5137892A (en) * 1990-12-12 1992-08-11 Abbott Laboratories Quinoline, naphthyridine and pyridobenzoxazine derivatives
KR950014567B1 (ko) * 1991-08-01 1995-12-08 주식회사대웅제약 신규한 퀴놀론 카르복실산 유도체

Also Published As

Publication number Publication date
CN1048242C (zh) 2000-01-12
HUT67259A (en) 1995-03-28
CZ286524B6 (cs) 2000-05-17
TW252107B (fi) 1995-07-21
EP0641793A1 (en) 1995-03-08
AU676729B2 (en) 1997-03-20
PL175870B1 (pl) 1999-02-26
EP0641793B1 (en) 1996-10-23
AU6487094A (en) 1995-03-09
SG52147A1 (en) 1998-09-28
ATE144508T1 (de) 1996-11-15
NO942309D0 (no) 1994-06-17
KR950005823A (ko) 1995-03-20
MY111702A (en) 2000-11-30
GR3021715T3 (en) 1997-02-28
CA2126118A1 (en) 1995-02-28
ES2096413T3 (es) 1997-03-01
IL110060A0 (en) 1994-10-07
NZ260851A (en) 1996-03-26
FI942976A0 (fi) 1994-06-21
KR100218807B1 (ko) 1999-09-01
PL304063A1 (en) 1995-03-06
DK0641793T3 (da) 1996-11-25
CN1117491A (zh) 1996-02-28
US5547962A (en) 1996-08-20
NO942309L (no) 1995-02-28
JP2673937B2 (ja) 1997-11-05
DE69400791D1 (de) 1996-11-28
HU9401954D0 (en) 1994-09-28
FI113174B (fi) 2004-03-15
DE69400791T2 (de) 1997-03-06
CZ157494A3 (en) 1995-10-18
UA39859C2 (uk) 2001-07-16
CA2126118C (en) 2001-02-06
IL110060A (en) 1999-10-28
NO305515B1 (no) 1999-06-14
JPH07309864A (ja) 1995-11-28
HU221952B1 (hu) 2003-03-28

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