FI942077A0 - Monomeriska gallsyraderivat, förfarande för framställning av dem och användning av dessa föreningar som läkemedel - Google Patents

Monomeriska gallsyraderivat, förfarande för framställning av dem och användning av dessa föreningar som läkemedel

Info

Publication number
FI942077A0
FI942077A0 FI942077A FI942077A FI942077A0 FI 942077 A0 FI942077 A0 FI 942077A0 FI 942077 A FI942077 A FI 942077A FI 942077 A FI942077 A FI 942077A FI 942077 A0 FI942077 A0 FI 942077A0
Authority
FI
Finland
Prior art keywords
compounds
preparation
acid derivatives
bile acid
medicaments
Prior art date
Application number
FI942077A
Other languages
English (en)
Finnish (fi)
Other versions
FI942077A (sv
Inventor
Heiner Glombik
Alfons Enhsen
Werner Kramer
Guenther Wess
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of FI942077A0 publication Critical patent/FI942077A0/sv
Publication of FI942077A publication Critical patent/FI942077A/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI942077A 1993-05-08 1994-05-05 Monomeriska gallsyraderivat, förfarande för framställning av dem och användning av dessa föreningar som läkemedel FI942077A (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4315439 1993-05-08

Publications (2)

Publication Number Publication Date
FI942077A0 true FI942077A0 (sv) 1994-05-05
FI942077A FI942077A (sv) 1994-11-09

Family

ID=6487634

Family Applications (1)

Application Number Title Priority Date Filing Date
FI942077A FI942077A (sv) 1993-05-08 1994-05-05 Monomeriska gallsyraderivat, förfarande för framställning av dem och användning av dessa föreningar som läkemedel

Country Status (18)

Country Link
US (1) US5610151A (sv)
EP (1) EP0624594B1 (sv)
JP (1) JP3424978B2 (sv)
KR (1) KR100333151B1 (sv)
AT (1) ATE183191T1 (sv)
AU (1) AU673419B2 (sv)
CA (1) CA2123052C (sv)
CZ (1) CZ289209B6 (sv)
DE (1) DE59408602D1 (sv)
DK (1) DK0624594T3 (sv)
ES (1) ES2136677T3 (sv)
FI (1) FI942077A (sv)
GR (1) GR3031541T3 (sv)
HU (1) HUT67574A (sv)
IL (1) IL109580A (sv)
NO (1) NO304794B1 (sv)
NZ (1) NZ260471A (sv)
TW (1) TW289021B (sv)

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US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
US6268392B1 (en) 1994-09-13 2001-07-31 G. D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
US6262277B1 (en) 1994-09-13 2001-07-17 G.D. Searle And Company Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6107494A (en) * 1994-09-13 2000-08-22 G.D. Searle And Company Substituted 5-aryl-benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
DE19845403B4 (de) * 1998-10-02 2005-02-10 Aventis Pharma Deutschland Gmbh Mit Gallensäuren verknüpfte Propanolaminderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
DE19849722A1 (de) * 1998-10-28 2000-05-04 Aventis Pharma Gmbh Substituierte Phenyl-alkenoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
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EE200200143A (et) * 1999-09-22 2003-04-15 Aventis Pharma Deutschland Gmbh 4-bensüülaminokinoliini konjugaadid sapphappega ja nende heteroanaloogid, nende valmistamismeetod ning neid ühendeid sisaldavad ravimid ja nende kasutamine
WO2001068096A2 (en) * 2000-03-10 2001-09-20 Pharmacia Corporation Combination therapy for the prophylaxis and treatment of hyperlipidemic conditions and disorders
US6586434B2 (en) 2000-03-10 2003-07-01 G.D. Searle, Llc Method for the preparation of tetrahydrobenzothiepines
US6624155B2 (en) * 2001-05-01 2003-09-23 Board Of Trustees Of The University Of Arkansas Hybrid cholinergic agents and compositions
US20040077625A1 (en) * 2001-07-25 2004-04-22 Tremont Samuel J. Novel 1,4-benzothiazepine and 1,5-benzothiazepine compounds as inhibitors of apical sodium codependent bile acid transport abd taurocholate uptake
MXPA04003524A (es) * 2001-11-02 2004-07-23 Searle Llc Compuestos de benzotiepina monofluorados y difluorados novedosos como inhibidores de transporte de acido biliar co-dependiente de sodio apical (asbt) y captacion de taurocolato.
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JP2023504644A (ja) 2019-12-04 2023-02-06 アルビレオ・アクチボラグ ベンゾチアジアゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用
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TW202134220A (zh) 2019-12-04 2021-09-16 瑞典商艾爾比瑞歐公司 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途
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JP7078687B2 (ja) 2020-10-09 2022-05-31 ポリプラスチックス株式会社 ポリアセタール樹脂組成物及び自動車部品
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TW202313579A (zh) 2021-06-03 2023-04-01 瑞典商艾爾比瑞歐公司 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途
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Also Published As

Publication number Publication date
DK0624594T3 (da) 1999-12-13
JPH072891A (ja) 1995-01-06
CZ289209B6 (cs) 2001-12-12
US5610151A (en) 1997-03-11
NO941680D0 (no) 1994-05-06
KR100333151B1 (ko) 2002-09-04
AU673419B2 (en) 1996-11-07
DE59408602D1 (de) 1999-09-16
EP0624594B1 (de) 1999-08-11
TW289021B (sv) 1996-10-21
CZ113794A3 (en) 1994-11-16
ES2136677T3 (es) 1999-12-01
EP0624594A2 (de) 1994-11-17
HU9401408D0 (en) 1994-08-29
FI942077A (sv) 1994-11-09
CA2123052A1 (en) 1994-11-09
GR3031541T3 (en) 2000-01-31
NO304794B1 (no) 1999-02-15
CA2123052C (en) 2005-04-26
JP3424978B2 (ja) 2003-07-07
EP0624594A3 (de) 1996-05-01
HUT67574A (en) 1995-04-28
ATE183191T1 (de) 1999-08-15
NZ260471A (en) 1995-04-27
IL109580A (en) 1999-03-12
AU6194994A (en) 1994-11-10
IL109580A0 (en) 1994-08-26
NO941680L (no) 1994-11-09

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