FI940115A - Nanokapslar innehållande farmaceutiska kompositioner - Google Patents

Nanokapslar innehållande farmaceutiska kompositioner Download PDF

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Publication number
FI940115A
FI940115A FI940115A FI940115A FI940115A FI 940115 A FI940115 A FI 940115A FI 940115 A FI940115 A FI 940115A FI 940115 A FI940115 A FI 940115A FI 940115 A FI940115 A FI 940115A
Authority
FI
Finland
Prior art keywords
nanocapsules
suspension
composition
pharmaceutical compositions
compositions containing
Prior art date
Application number
FI940115A
Other languages
English (en)
Finnish (fi)
Other versions
FI940115A0 (sv
FI111441B (sv
Inventor
Henri Vranckx
Martine Demoustier
Michel Deleers
Original Assignee
Ucb Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Sa filed Critical Ucb Sa
Publication of FI940115A0 publication Critical patent/FI940115A0/sv
Publication of FI940115A publication Critical patent/FI940115A/sv
Application granted granted Critical
Publication of FI111441B publication Critical patent/FI111441B/sv

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5169—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/14—Polymerisation; cross-linking
    • B01J13/18—In situ polymerisation with all reactants being present in the same phase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cosmetics (AREA)
FI940115A 1993-01-18 1994-01-11 Förfarande för framställning av farmaceutisk komposition innehållande nanokapslar FI111441B (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9300875 1993-01-18
GB939300875A GB9300875D0 (en) 1993-01-18 1993-01-18 Nanocapsule containing pharmaceutical compositions

Publications (3)

Publication Number Publication Date
FI940115A0 FI940115A0 (sv) 1994-01-11
FI940115A true FI940115A (sv) 1994-07-19
FI111441B FI111441B (sv) 2003-07-31

Family

ID=10728864

Family Applications (1)

Application Number Title Priority Date Filing Date
FI940115A FI111441B (sv) 1993-01-18 1994-01-11 Förfarande för framställning av farmaceutisk komposition innehållande nanokapslar

Country Status (21)

Country Link
US (1) US5500224A (sv)
EP (1) EP0608207B1 (sv)
JP (1) JP3688731B2 (sv)
KR (1) KR100311056B1 (sv)
AT (1) ATE172111T1 (sv)
AU (1) AU670840B2 (sv)
CA (1) CA2113243C (sv)
CY (1) CY2132B1 (sv)
DE (1) DE69413857T2 (sv)
DK (1) DK0608207T3 (sv)
ES (1) ES2122217T3 (sv)
FI (1) FI111441B (sv)
GB (1) GB9300875D0 (sv)
HU (1) HUT67213A (sv)
NO (1) NO307445B1 (sv)
NZ (1) NZ250673A (sv)
PL (1) PL173254B1 (sv)
RU (1) RU2145498C1 (sv)
SG (1) SG43682A1 (sv)
TW (1) TW336174B (sv)
ZA (1) ZA94205B (sv)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2721510B1 (fr) * 1994-06-22 1996-07-26 Rhone Poulenc Rorer Sa Nanoparticules filtrables dans des conditions stériles.
WO1996024332A1 (en) * 1995-02-06 1996-08-15 Nanosystems L.L.C. Formulations of compounds as nanoparticulate dispersions in digestible oils or fatty acids
JP3759986B2 (ja) * 1995-12-07 2006-03-29 フロイント産業株式会社 シームレスカプセルおよびその製造方法
FR2766368B1 (fr) * 1997-07-24 2000-03-31 Univ Claude Bernard Lyon Procede de preparation de nanocapsules de type vesiculaire, utilisables notamment comme vecteurs colloidaux de principes actifs pharmaceutiques ou autres
US6248363B1 (en) * 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US6761903B2 (en) 1999-06-30 2004-07-13 Lipocine, Inc. Clear oil-containing pharmaceutical compositions containing a therapeutic agent
US6982281B1 (en) * 2000-11-17 2006-01-03 Lipocine Inc Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
US6458383B2 (en) 1999-08-17 2002-10-01 Lipocine, Inc. Pharmaceutical dosage form for oral administration of hydrophilic drugs, particularly low molecular weight heparin
US20030236236A1 (en) * 1999-06-30 2003-12-25 Feng-Jing Chen Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
AU4724401A (en) * 2000-02-28 2001-09-12 Genesegues Inc Nanocapsule encapsulation system and method
FR2806005B1 (fr) * 2000-03-10 2002-06-14 Univ Claude Bernard Lyon Procede de preparation de particules colloidales sous forme de nanocapsules
US7153525B1 (en) 2000-03-22 2006-12-26 The University Of Kentucky Research Foundation Microemulsions as precursors to solid nanoparticles
CN1531436A (zh) * 2001-05-09 2004-09-22 (株)美大富历寿 用于增强粘膜吸收的两亲肝素衍生物制剂
US20030095928A1 (en) * 2001-09-19 2003-05-22 Elan Pharma International Limited Nanoparticulate insulin
ATE424815T1 (de) * 2001-12-03 2009-03-15 Dor Biopharma Inc Stabilisierte umkehr-mizellen-zusammensetzungen und ihre verwendung
US20040038303A1 (en) * 2002-04-08 2004-02-26 Unger Gretchen M. Biologic modulations with nanoparticles
PT1530482E (pt) 2002-07-18 2014-01-15 Helix Biopharma Corp Utilização de urease para inibição de crescimento de células cancerigenas
WO2004053056A2 (en) * 2002-09-24 2004-06-24 University Of Kentucky Research Foundation Nanoparticle-based vaccine delivery system containing adjuvant
JP2006521366A (ja) * 2003-03-28 2006-09-21 シグモイド・バイオテクノロジーズ・リミテッド シームレスマイクロカプセルを含む固形経口剤形
US20060003002A1 (en) * 2003-11-03 2006-01-05 Lipocine, Inc. Pharmaceutical compositions with synchronized solubilizer release
CA2581816A1 (en) * 2004-09-27 2006-04-06 Sigmoid Biotechnologies Limited Microcapsules comprising a methylxanthine and a corticosteroid
FR2899797A1 (fr) * 2006-04-13 2007-10-19 Oreal Emulsion eau dans l'huile pour le traitement des fibres keratiniques comprenant un monomere cyanoacrylate et de l'ammoniaque
FR2899800B1 (fr) * 2006-04-13 2008-10-10 Oreal Emulsion eau dans l'huile pour le traitement des fibres keratiniques comprenant un monomere cyanoacrylate
CA2683409A1 (en) 2007-04-04 2008-10-16 Sigmoid Pharma Limited A pharmaceutical composition of tacrolimus
ES2963291T3 (es) * 2007-04-26 2024-03-26 Sublimity Therapeutics Ltd Fabricación de múltiples minicápsulas
US20100239665A1 (en) * 2007-05-01 2010-09-23 Ivan Coulter Pharmaceutical nimodipine compositions
EP2257220B1 (en) * 2008-03-13 2017-06-14 Liebel-Flarsheim Company LLC Multi-function, foot-activated controller for imaging system
CN102215830A (zh) * 2008-05-06 2011-10-12 葛兰素集团有限公司 生物活性剂的囊封方法
US11304960B2 (en) 2009-01-08 2022-04-19 Chandrashekar Giliyar Steroidal compositions
EP2432455B1 (en) 2009-05-18 2014-11-12 Sigmoid Pharma Limited Composition comprising oil drops
CA2770570A1 (en) 2009-08-12 2011-02-17 Sigmoid Pharma Limited Immunomodulatory compositions comprising a polymer matrix and an oil phase
GB201020032D0 (en) 2010-11-25 2011-01-12 Sigmoid Pharma Ltd Composition
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US20180153904A1 (en) 2010-11-30 2018-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US20120148675A1 (en) 2010-12-10 2012-06-14 Basawaraj Chickmath Testosterone undecanoate compositions
GB201212010D0 (en) 2012-07-05 2012-08-22 Sigmoid Pharma Ltd Formulations
RU2566069C2 (ru) * 2013-05-31 2015-10-20 Общество с ограниченной ответственностью "Изварино Фарма" Система доставки вещества белковой природы в виде наночастиц и способ ее получения
GB201319791D0 (en) 2013-11-08 2013-12-25 Sigmoid Pharma Ltd Formulations
JP6612333B2 (ja) * 2014-05-30 2019-11-27 アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー 高薬物負荷ポリ（アルキル２−シアノアクリレート）ナノカプセル
WO2016033549A2 (en) 2014-08-28 2016-03-03 Lipocine Inc. (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
WO2016033556A1 (en) 2014-08-28 2016-03-03 Lipocine Inc. BIOAVAILABLE SOLID STATE (17-β)-HYDROXY-4-ANDROSTEN-3-ONE ESTERS
EP3188716B1 (en) 2014-09-03 2022-10-26 GeneSegues, Inc. Therapeutic nanoparticles and related compositions, methods and systems
PL3215127T3 (pl) 2014-11-07 2021-05-17 Sublimity Therapeutics Limited Kompozycje zawierające cyklosporynę
PL238187B1 (pl) 2015-01-23 2021-07-19 Helix Biopharma Corp Koniugaty przeciwciało-ureaza dla celów terapeutycznych
RU2590651C1 (ru) * 2015-03-30 2016-07-10 Александр Александрович Кролевец Способ получения нанокапсул рибофлавина в геллановой камеди
US20180147215A1 (en) 2016-11-28 2018-05-31 Lipocine Inc. Oral testosterone undecanoate therapy
WO2023089240A1 (en) * 2021-11-19 2023-05-25 Nanoform Finland Oyj A composition comprising nanosized active pharmaceutical ingredient

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2515960A1 (fr) * 1981-11-06 1983-05-13 Alkhouri Fallouh Nazir Nanocapsules ou nanoparticules biodegradables contenant une substance biologiquement active, leur preparation et leur application
JPS6061521A (ja) * 1983-09-16 1985-04-09 Kyowa Hakko Kogyo Co Ltd マイクロカプセル化製剤
DE3341001A1 (de) * 1983-11-12 1985-05-23 Krause, Hans Jürgen Nanopartikel aus bioabbaubarem, synthetischem material, verfahren zu deren herstellung und ihre anwendung
FR2659554B1 (fr) * 1990-03-16 1994-09-30 Oreal Composition pour le traitement cosmetique et/ou pharmaceutique des couches superieures de l'epiderme par application topique sur la peau et procede de preparation correspondant.

Also Published As

Publication number Publication date
EP0608207B1 (fr) 1998-10-14
PL173254B1 (pl) 1998-02-27
NO307445B1 (no) 2000-04-10
JP3688731B2 (ja) 2005-08-31
HU9400107D0 (en) 1994-05-30
KR940018086A (ko) 1994-08-16
RU94002474A (ru) 1996-11-10
US5500224A (en) 1996-03-19
FI940115A0 (sv) 1994-01-11
RU2145498C1 (ru) 2000-02-20
HUT67213A (en) 1995-03-28
CY2132B1 (en) 2002-06-21
JPH06256172A (ja) 1994-09-13
KR100311056B1 (ko) 2002-03-21
TW336174B (en) 1998-07-11
EP0608207A1 (fr) 1994-07-27
NO940111D0 (no) 1994-01-12
NZ250673A (en) 1994-11-25
DE69413857T2 (de) 1999-04-15
ATE172111T1 (de) 1998-10-15
ZA94205B (en) 1994-08-22
NO940111L (no) 1994-07-19
ES2122217T3 (es) 1998-12-16
DE69413857D1 (de) 1998-11-19
DK0608207T3 (da) 1999-06-23
CA2113243A1 (en) 1994-07-19
SG43682A1 (en) 1997-11-14
CA2113243C (en) 2008-08-05
AU5309794A (en) 1994-07-21
GB9300875D0 (en) 1993-03-10
AU670840B2 (en) 1996-08-01
PL301841A1 (en) 1994-07-25
FI111441B (sv) 2003-07-31

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