FR2614890B1 - Compose resultant du couplage d'une molecule a structure chimiosensibilisante et d'une molecule a structure cytotoxique, procede de preparation, application a titre de medicament et compositions pharmaceutiques le contenant - Google Patents

Compose resultant du couplage d'une molecule a structure chimiosensibilisante et d'une molecule a structure cytotoxique, procede de preparation, application a titre de medicament et compositions pharmaceutiques le contenant

Info

Publication number
FR2614890B1
FR2614890B1 FR8706241A FR8706241A FR2614890B1 FR 2614890 B1 FR2614890 B1 FR 2614890B1 FR 8706241 A FR8706241 A FR 8706241A FR 8706241 A FR8706241 A FR 8706241A FR 2614890 B1 FR2614890 B1 FR 2614890B1
Authority
FR
France
Prior art keywords
structure molecule
chemosensitizing
coupling
preparation
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8706241A
Other languages
English (en)
Other versions
FR2614890A1 (fr
Inventor
Jean Louis Imbach
Alain Jean Joseph Carminati
Jean Louis Paul Phili Barascut
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS filed Critical Centre National de la Recherche Scientifique CNRS
Priority to FR8706241A priority Critical patent/FR2614890B1/fr
Priority to EP19880904232 priority patent/EP0358684A1/fr
Priority to PCT/FR1988/000213 priority patent/WO1988008840A1/fr
Publication of FR2614890A1 publication Critical patent/FR2614890A1/fr
Application granted granted Critical
Publication of FR2614890B1 publication Critical patent/FR2614890B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C07D233/92—Nitro radicals attached in position 4 or 5
    • C07D233/94—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to other ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C07D233/92—Nitro radicals attached in position 4 or 5
    • C07D233/95—Nitro radicals attached in position 4 or 5 with hydrocarbon radicals, substituted by nitrogen atoms, attached to other ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR8706241A 1987-05-04 1987-05-04 Compose resultant du couplage d'une molecule a structure chimiosensibilisante et d'une molecule a structure cytotoxique, procede de preparation, application a titre de medicament et compositions pharmaceutiques le contenant Expired FR2614890B1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
FR8706241A FR2614890B1 (fr) 1987-05-04 1987-05-04 Compose resultant du couplage d'une molecule a structure chimiosensibilisante et d'une molecule a structure cytotoxique, procede de preparation, application a titre de medicament et compositions pharmaceutiques le contenant
EP19880904232 EP0358684A1 (fr) 1987-05-04 1988-05-03 Agents de ciblage antitumoraux, leur préparation et applications
PCT/FR1988/000213 WO1988008840A1 (fr) 1987-05-04 1988-05-03 Agents de ciblage antitumoraux, leur preparation et applications

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8706241A FR2614890B1 (fr) 1987-05-04 1987-05-04 Compose resultant du couplage d'une molecule a structure chimiosensibilisante et d'une molecule a structure cytotoxique, procede de preparation, application a titre de medicament et compositions pharmaceutiques le contenant

Publications (2)

Publication Number Publication Date
FR2614890A1 FR2614890A1 (fr) 1988-11-10
FR2614890B1 true FR2614890B1 (fr) 1989-08-11

Family

ID=9350728

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8706241A Expired FR2614890B1 (fr) 1987-05-04 1987-05-04 Compose resultant du couplage d'une molecule a structure chimiosensibilisante et d'une molecule a structure cytotoxique, procede de preparation, application a titre de medicament et compositions pharmaceutiques le contenant

Country Status (3)

Country Link
EP (1) EP0358684A1 (fr)
FR (1) FR2614890B1 (fr)
WO (1) WO1988008840A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5691371A (en) * 1993-05-25 1997-11-25 Auckland Uniservices Limited Nitrobenzyl mustard quaternary salts and their use as hypoxia-selective cytotoxic agents
CN1270062A (zh) * 1999-04-08 2000-10-18 广州山河药业股份有限公司 一种放射、化学治疗增效剂—甘氨双唑金属盐及其制法和用途
US9056136B2 (en) * 2006-10-06 2015-06-16 Natural Pharmacia International, Inc. Weakly basic 2-nitroimidazoles for the non-invasive detection of tissue hypoxia
JPWO2022210189A1 (fr) * 2021-03-30 2022-10-06
WO2022210190A1 (fr) * 2021-03-30 2022-10-06 ナミックス株式会社 Dérivé d'amine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58188892A (ja) * 1982-04-26 1983-11-04 Tetsuo Suami 新規なニトロソウレア化合物
FR2540491A1 (fr) * 1983-02-08 1984-08-10 Centre Nat Rech Scient Nouvelles nitrosourees, leur procede de preparation et leur application therapeutique

Also Published As

Publication number Publication date
FR2614890A1 (fr) 1988-11-10
EP0358684A1 (fr) 1990-03-21
WO1988008840A1 (fr) 1988-11-17

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Legal Events

Date Code Title Description
ST Notification of lapse