FI935172A0 - Inhibitorer av katepsin G och elastas foer foerhindrande degeneration avbindvaevnad - Google Patents

Inhibitorer av katepsin G och elastas foer foerhindrande degeneration avbindvaevnad

Info

Publication number
FI935172A0
FI935172A0 FI935172A FI935172A FI935172A0 FI 935172 A0 FI935172 A0 FI 935172A0 FI 935172 A FI935172 A FI 935172A FI 935172 A FI935172 A FI 935172A FI 935172 A0 FI935172 A0 FI 935172A0
Authority
FI
Finland
Prior art keywords
avbindvaevnad
cathepsins
degeneration
inhibitor
elastic
Prior art date
Application number
FI935172A
Other languages
English (en)
Finnish (fi)
Other versions
FI935172A (fi
Inventor
Michael R Angelastro
Philippe Bey
Niall S Doherty
Michael Janusz
Shujaath Mehdi
Norton P Peet
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of FI935172A publication Critical patent/FI935172A/fi
Publication of FI935172A0 publication Critical patent/FI935172A0/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Transceivers (AREA)
  • Mobile Radio Communication Systems (AREA)
  • Vehicle Body Suspensions (AREA)
  • Polymerisation Methods In General (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Dental Preparations (AREA)
FI935172A 1991-05-23 1993-11-22 Inhibitorer av katepsin G och elastas foer foerhindrande degeneration avbindvaevnad FI935172A0 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70449991A 1991-05-23 1991-05-23
PCT/US1992/003288 WO1992020357A1 (fr) 1991-05-23 1992-04-21 Inhibiteurs de la cathepsine g et de l'elastase empechant la degradation du tissu conjonctif

Publications (2)

Publication Number Publication Date
FI935172A FI935172A (fi) 1993-11-22
FI935172A0 true FI935172A0 (fi) 1993-11-22

Family

ID=24829789

Family Applications (1)

Application Number Title Priority Date Filing Date
FI935172A FI935172A0 (fi) 1991-05-23 1993-11-22 Inhibitorer av katepsin G och elastas foer foerhindrande degeneration avbindvaevnad

Country Status (17)

Country Link
US (1) US5510333A (fr)
EP (1) EP0587799B1 (fr)
JP (1) JP3442075B2 (fr)
AT (1) ATE181925T1 (fr)
AU (1) AU655301B2 (fr)
DE (1) DE69229552T2 (fr)
DK (1) DK0587799T3 (fr)
ES (1) ES2136091T3 (fr)
FI (1) FI935172A0 (fr)
GR (1) GR3031005T3 (fr)
HU (1) HU217612B (fr)
IL (1) IL101925A (fr)
NO (1) NO934218L (fr)
NZ (1) NZ242807A (fr)
PT (1) PT100517B (fr)
WO (1) WO1992020357A1 (fr)
ZA (1) ZA923602B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5714470A (en) * 1991-08-22 1998-02-03 Merrell Pharmaceuticals, Inc. Orally-active elastase inhibitors
EP0635028B1 (fr) * 1992-04-10 2003-01-22 Abbott Laboratories Fragments proteiques tensio-actifs pulmonaires
CA2137832C (fr) * 1992-06-12 2000-09-26 Dennis J. Hoover Inhibiteurs de(s) chymase(s) de l'angiotensine i, y compris la chymase du coeur humain
JP3721538B2 (ja) * 1994-06-02 2005-11-30 メレル ファーマスーティカルズ インコーポレイテッド エラスターゼのパーフルオロアルキルケトン阻害剤およびそれらを製造する方法
HU221310B1 (en) * 1994-06-02 2002-09-28 Merrell Pharma Inc Acylated enol di and tripeptide derivatives, their use and pharmaceutical compositions comprising thereof
US5804560A (en) * 1995-01-06 1998-09-08 Sibia Neurosciences, Inc. Peptide and peptide analog protease inhibitors
US6017887A (en) * 1995-01-06 2000-01-25 Sibia Neurosciences, Inc. Peptide, peptide analog and amino acid analog protease inhibitors
US5693515A (en) * 1995-04-28 1997-12-02 Arris Pharmaceutical Corporation Metal complexed serine protease inhibitors
DE19543750C2 (de) * 1995-11-24 1997-10-23 Crinos Industria Farmaco Cathepsin G inhibierende Aptamere
US6172044B1 (en) 1995-12-01 2001-01-09 Aventis Pharmaceuticals Inc. Acylated enol derivative of α-ketoesters and α-ketoamides
US5948886A (en) * 1996-11-20 1999-09-07 Hoechst Marion Roussel, Inc. Acylated enol derivatives of α-ketoesters and α-ketoamides
US6608030B1 (en) * 1996-04-22 2003-08-19 Brigham & Women's Hospital, Inc. Suppression of immune response via inhibition of cathepsin S
JP2002047256A (ja) * 2000-07-26 2002-02-12 Kanegafuchi Chem Ind Co Ltd α−アミノ−α´，α´，α´−トリハロケトン誘導体、α−アミノ−α´，α´，α´−トリハロアルコ−ル誘導体、及び、α−ヒドロキシ−β−アミノカルボン酸誘導体の製造法
WO2008054144A1 (fr) * 2006-11-03 2008-05-08 Amorepacific Corporation Composition à usage externe pour la peau contenant des inhibiteurs de la cathepsine g servant à prévenir le vieillissement de la peau et procédé de criblage pour le développement de substances antivieillissement
US8883857B2 (en) 2012-12-07 2014-11-11 Baylor College Of Medicine Small molecule xanthine oxidase inhibitors and methods of use
JP2023500182A (ja) 2019-09-17 2023-01-05 メレオ バイオファーマ ４ リミテッド 移植片拒絶反応、閉塞性細気管支炎症候群、及び移植片対宿主病の治療に使用するためのアルベレスタット
DK4106757T3 (da) 2020-04-16 2023-10-23 Mereo Biopharma 4 Ltd Fremgangsmåder der involverer neutrofil elastase-inhibitor alvelestat til behandling af luftvejssygdom medieret af alpha-1-antitrypsin-mangel
EP4165037A4 (fr) 2020-06-10 2024-07-03 Aligos Therapeutics Inc Composés antiviraux pour le traitement d'infections à coronavirus, picornavirus et norovirus
IL309732A (en) 2021-07-09 2024-02-01 Aligos Therapeutics Inc Antiviral compounds
CA3234399A1 (fr) 2021-10-20 2023-04-27 Mereo Biopharma 4 Limited Inhibiteurs de l'elastase neutrophile utilises dans le traitement de la fibrose

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3230275A1 (de) * 1982-08-14 1984-02-16 Bayer Ag, 5090 Leverkusen Elastaseinhibitoren, verfahren zu ihrer herstellung sowie diese enthaltende arzneimittel
DE3324534A1 (de) * 1983-07-07 1985-01-17 Ciba-Geigy Ag, Basel Modifizierte protease-inhibitoren, verfahren zu ihrer herstellung und daraus bereitete pharmazeutische mittel
US4629724A (en) * 1984-12-03 1986-12-16 E. R. Squibb & Sons, Inc. Amino acid ester and amide renin inhibitors
US4643991A (en) * 1984-12-18 1987-02-17 The University Of Kentucky Research Foundation Peptide elastase inhibitors and methods
US5055450A (en) * 1985-01-22 1991-10-08 Ici Americas Inc. Peptide derivatives
GB8600263D0 (en) * 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
CA1341029C (fr) * 1985-02-04 2000-06-20 Michael Kolb Inhibiteurs de la peptidase
DE3683541D1 (de) * 1985-06-07 1992-03-05 Ici America Inc Selektionierte difluorverbindungen.
GB8613703D0 (en) * 1986-06-05 1986-07-09 Ici America Inc Difluoro peptide compounds
NZ223148A (en) * 1987-01-16 1989-10-27 Merrell Dow Pharma Peptide derivatives having peptidase inhibition activity
EP0307662A3 (fr) * 1987-08-24 1990-07-25 Kabushiki Kaisha Vitamin Kenkyusyo Analogues d'encéphalines
EP0356595A1 (fr) * 1988-09-01 1990-03-07 Merrell Dow Pharmaceuticals Inc. Inhibiteurs des peptidases
ZA897515B (en) * 1988-10-07 1990-06-27 Merrell Dow Pharma Novel peptidase inhibitors
ZA905737B (en) * 1989-07-26 1991-05-29 Merrell Dow Pharma Novel peptidase inhibitors
DE3938971A1 (de) * 1989-11-24 1991-05-29 Biotechnolog Forschung Gmbh Leukozytenelastase und kathepsin g blockierendes peptid, dna, vektor, wirtsorganismus und verfahren zu seiner gewinnung sowie pharmazeutisches praeparat

Also Published As

Publication number Publication date
ES2136091T3 (es) 1999-11-16
EP0587799B1 (fr) 1999-07-07
PT100517B (pt) 1999-06-30
IL101925A (en) 1996-03-31
FI935172A (fi) 1993-11-22
DK0587799T3 (da) 1999-11-22
GR3031005T3 (en) 1999-12-31
AU2184192A (en) 1992-12-30
HU217612B (hu) 2000-03-28
HUT65140A (en) 1994-04-28
JPH06508355A (ja) 1994-09-22
NO934218D0 (no) 1993-11-22
EP0587799A4 (fr) 1995-06-14
DE69229552T2 (de) 1999-12-23
NO934218L (no) 1993-11-22
AU655301B2 (en) 1994-12-15
JP3442075B2 (ja) 2003-09-02
EP0587799A1 (fr) 1994-03-23
NZ242807A (en) 1994-07-26
US5510333A (en) 1996-04-23
HU9303314D0 (en) 1994-03-28
IL101925A0 (en) 1992-12-30
PT100517A (pt) 1993-09-30
WO1992020357A1 (fr) 1992-11-26
ZA923602B (en) 1993-02-24
DE69229552D1 (de) 1999-08-12
ATE181925T1 (de) 1999-07-15

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