DK0587799T3 - Inhibitorer af cathepsin G og elastase til forebyggelse af bindevævsnedbrydning - Google Patents

Inhibitorer af cathepsin G og elastase til forebyggelse af bindevævsnedbrydning

Info

Publication number
DK0587799T3
DK0587799T3 DK92914209T DK92914209T DK0587799T3 DK 0587799 T3 DK0587799 T3 DK 0587799T3 DK 92914209 T DK92914209 T DK 92914209T DK 92914209 T DK92914209 T DK 92914209T DK 0587799 T3 DK0587799 T3 DK 0587799T3
Authority
DK
Denmark
Prior art keywords
cathepsin
connective tissue
elastase
inhibitors
tissue degradation
Prior art date
Application number
DK92914209T
Other languages
Danish (da)
English (en)
Inventor
Philippe Bey
Norton P Peet
Michael R Angelastro
Niall S Doherty
Michael J Janusz
Shujaath Mehdi
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Application granted granted Critical
Publication of DK0587799T3 publication Critical patent/DK0587799T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Transceivers (AREA)
  • Mobile Radio Communication Systems (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polymerisation Methods In General (AREA)
  • Vehicle Body Suspensions (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Dental Preparations (AREA)
DK92914209T 1991-05-23 1992-04-21 Inhibitorer af cathepsin G og elastase til forebyggelse af bindevævsnedbrydning DK0587799T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70449991A 1991-05-23 1991-05-23
PCT/US1992/003288 WO1992020357A1 (fr) 1991-05-23 1992-04-21 Inhibiteurs de la cathepsine g et de l'elastase empechant la degradation du tissu conjonctif

Publications (1)

Publication Number Publication Date
DK0587799T3 true DK0587799T3 (da) 1999-11-22

Family

ID=24829789

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92914209T DK0587799T3 (da) 1991-05-23 1992-04-21 Inhibitorer af cathepsin G og elastase til forebyggelse af bindevævsnedbrydning

Country Status (17)

Country Link
US (1) US5510333A (fr)
EP (1) EP0587799B1 (fr)
JP (1) JP3442075B2 (fr)
AT (1) ATE181925T1 (fr)
AU (1) AU655301B2 (fr)
DE (1) DE69229552T2 (fr)
DK (1) DK0587799T3 (fr)
ES (1) ES2136091T3 (fr)
FI (1) FI935172A0 (fr)
GR (1) GR3031005T3 (fr)
HU (1) HU217612B (fr)
IL (1) IL101925A (fr)
NO (1) NO934218D0 (fr)
NZ (1) NZ242807A (fr)
PT (1) PT100517B (fr)
WO (1) WO1992020357A1 (fr)
ZA (1) ZA923602B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5714470A (en) * 1991-08-22 1998-02-03 Merrell Pharmaceuticals, Inc. Orally-active elastase inhibitors
EP0635028B1 (fr) * 1992-04-10 2003-01-22 Abbott Laboratories Fragments proteiques tensio-actifs pulmonaires
CA2137832C (fr) * 1992-06-12 2000-09-26 Dennis J. Hoover Inhibiteurs de(s) chymase(s) de l'angiotensine i, y compris la chymase du coeur humain
US6008196A (en) * 1994-06-02 1999-12-28 Hoechst Marion Roussel, Inc. Perfluoroalkyl ketone inhibitors of elastase and processes for making the same
JP4221059B2 (ja) * 1994-06-02 2009-02-12 アベンティス・インコーポレイテッド エラスターゼインヒビターのプロドラッグとしてのアシル化エノール誘導体
US6017887A (en) * 1995-01-06 2000-01-25 Sibia Neurosciences, Inc. Peptide, peptide analog and amino acid analog protease inhibitors
US5804560A (en) * 1995-01-06 1998-09-08 Sibia Neurosciences, Inc. Peptide and peptide analog protease inhibitors
US5693515A (en) * 1995-04-28 1997-12-02 Arris Pharmaceutical Corporation Metal complexed serine protease inhibitors
DE19543750C2 (de) * 1995-11-24 1997-10-23 Crinos Industria Farmaco Cathepsin G inhibierende Aptamere
US6172044B1 (en) 1995-12-01 2001-01-09 Aventis Pharmaceuticals Inc. Acylated enol derivative of α-ketoesters and α-ketoamides
US5948886A (en) * 1996-11-20 1999-09-07 Hoechst Marion Roussel, Inc. Acylated enol derivatives of α-ketoesters and α-ketoamides
CA2251714A1 (fr) * 1996-04-22 1997-10-30 Massachusetts Institute Of Technology Suppression de reponse immunitaire par inhibition de cathepsine s
JP2002047256A (ja) * 2000-07-26 2002-02-12 Kanegafuchi Chem Ind Co Ltd α−アミノ−α´，α´，α´−トリハロケトン誘導体、α−アミノ−α´，α´，α´−トリハロアルコ−ル誘導体、及び、α−ヒドロキシ−β−アミノカルボン酸誘導体の製造法
WO2008054144A1 (fr) * 2006-11-03 2008-05-08 Amorepacific Corporation Composition à usage externe pour la peau contenant des inhibiteurs de la cathepsine g servant à prévenir le vieillissement de la peau et procédé de criblage pour le développement de substances antivieillissement
US8883857B2 (en) 2012-12-07 2014-11-11 Baylor College Of Medicine Small molecule xanthine oxidase inhibitors and methods of use
JP2023500182A (ja) 2019-09-17 2023-01-05 メレオ バイオファーマ ４ リミテッド 移植片拒絶反応、閉塞性細気管支炎症候群、及び移植片対宿主病の治療に使用するためのアルベレスタット
EP4106757B1 (fr) 2020-04-16 2023-08-23 Mereo Biopharma 4 Limited Procédés impliquant l'alvélestat inhibiteur de l'élastase neutrophile pour le traitement d'une maladie respiratoire induite par une déficience en alpha-1 antitrypsine
KR20230038457A (ko) 2020-06-10 2023-03-20 알리고스 테라퓨틱스 인코포레이티드 코로나바이러스, 피코르나바이러스 및 노로바이러스 감염을 치료하기 위한 항바이러스 화합물
AU2022306289A1 (en) 2021-07-09 2024-01-18 Aligos Therapeutics, Inc. Anti-viral compounds
US12065428B2 (en) 2021-09-17 2024-08-20 Aligos Therapeutics, Inc. Anti-viral compounds
TW202325294A (zh) 2021-10-20 2023-07-01 英商梅瑞奧生物製藥４有限公司 用於治療纖維化之嗜中性球彈性蛋白酶抑制劑

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3230275A1 (de) * 1982-08-14 1984-02-16 Bayer Ag, 5090 Leverkusen Elastaseinhibitoren, verfahren zu ihrer herstellung sowie diese enthaltende arzneimittel
DE3324534A1 (de) * 1983-07-07 1985-01-17 Ciba-Geigy Ag, Basel Modifizierte protease-inhibitoren, verfahren zu ihrer herstellung und daraus bereitete pharmazeutische mittel
US4629724A (en) * 1984-12-03 1986-12-16 E. R. Squibb & Sons, Inc. Amino acid ester and amide renin inhibitors
US4643991A (en) * 1984-12-18 1987-02-17 The University Of Kentucky Research Foundation Peptide elastase inhibitors and methods
US5055450A (en) * 1985-01-22 1991-10-08 Ici Americas Inc. Peptide derivatives
GB8600263D0 (en) * 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
ZA86746B (en) * 1985-02-04 1986-09-24 Merrell Dow Pharma Novel peptidase inhibitors
DE3683541D1 (de) * 1985-06-07 1992-03-05 Ici America Inc Selektionierte difluorverbindungen.
GB8613703D0 (en) * 1986-06-05 1986-07-09 Ici America Inc Difluoro peptide compounds
NZ223148A (en) * 1987-01-16 1989-10-27 Merrell Dow Pharma Peptide derivatives having peptidase inhibition activity
EP0307662A3 (fr) * 1987-08-24 1990-07-25 Kabushiki Kaisha Vitamin Kenkyusyo Analogues d'encéphalines
EP0356595A1 (fr) * 1988-09-01 1990-03-07 Merrell Dow Pharmaceuticals Inc. Inhibiteurs des peptidases
ZA897515B (en) * 1988-10-07 1990-06-27 Merrell Dow Pharma Novel peptidase inhibitors
CA2021660A1 (fr) * 1989-07-26 1991-01-27 Philippe Bey Inhibiteurs de la peptidose
DE3938971A1 (de) * 1989-11-24 1991-05-29 Biotechnolog Forschung Gmbh Leukozytenelastase und kathepsin g blockierendes peptid, dna, vektor, wirtsorganismus und verfahren zu seiner gewinnung sowie pharmazeutisches praeparat

Also Published As

Publication number Publication date
ZA923602B (en) 1993-02-24
NO934218L (no) 1993-11-22
FI935172A (fi) 1993-11-22
JP3442075B2 (ja) 2003-09-02
NZ242807A (en) 1994-07-26
AU655301B2 (en) 1994-12-15
HU9303314D0 (en) 1994-03-28
IL101925A0 (en) 1992-12-30
GR3031005T3 (en) 1999-12-31
ATE181925T1 (de) 1999-07-15
DE69229552D1 (de) 1999-08-12
US5510333A (en) 1996-04-23
JPH06508355A (ja) 1994-09-22
WO1992020357A1 (fr) 1992-11-26
EP0587799B1 (fr) 1999-07-07
AU2184192A (en) 1992-12-30
PT100517A (pt) 1993-09-30
FI935172A0 (fi) 1993-11-22
HU217612B (hu) 2000-03-28
NO934218D0 (no) 1993-11-22
EP0587799A1 (fr) 1994-03-23
IL101925A (en) 1996-03-31
ES2136091T3 (es) 1999-11-16
HUT65140A (en) 1994-04-28
PT100517B (pt) 1999-06-30
EP0587799A4 (fr) 1995-06-14
DE69229552T2 (de) 1999-12-23

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