FI925894A0 - Neuromuskulaera blockeringsmedel - Google Patents

Neuromuskulaera blockeringsmedel

Info

Publication number
FI925894A0
FI925894A0 FI925894A FI925894A FI925894A0 FI 925894 A0 FI925894 A0 FI 925894A0 FI 925894 A FI925894 A FI 925894A FI 925894 A FI925894 A FI 925894A FI 925894 A0 FI925894 A0 FI 925894A0
Authority
FI
Finland
Prior art keywords
cis
geometrical
isomer
optical isomers
potency
Prior art date
Application number
FI925894A
Other languages
English (en)
Other versions
FI103507B1 (fi
FI103507B (fi
FI925894A (fi
Inventor
Derek Anthony Hill
Geoffrey Lloyd Turner
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of FI925894A0 publication Critical patent/FI925894A0/fi
Publication of FI925894A publication Critical patent/FI925894A/fi
Application granted granted Critical
Publication of FI103507B1 publication Critical patent/FI103507B1/fi
Publication of FI103507B publication Critical patent/FI103507B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Semiconductor Lasers (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Led Devices (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Paper (AREA)
FI925894A 1990-07-13 1992-12-28 Menetelmä terapeuttisesti käyttökelpoisen 1R-cis,1'R-cis-2,2'-(3,11-di okso-4,10-dioksatridekametyleeni)-bis(1,2,3,4-tetrahydro-6,7-dimetoksi -2-metyyli-1-veratryyli-isokinolinium)suolan valmistamiseksi FI103507B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909015473A GB9015473D0 (en) 1990-07-13 1990-07-13 Neuromuscular blocking agents
PCT/GB1991/001150 WO1992000965A1 (en) 1990-07-13 1991-07-12 Neuromuscular blocking agents

Publications (4)

Publication Number Publication Date
FI925894A0 true FI925894A0 (fi) 1992-12-28
FI925894A FI925894A (fi) 1992-12-28
FI103507B1 FI103507B1 (fi) 1999-07-15
FI103507B FI103507B (fi) 1999-07-15

Family

ID=10679071

Family Applications (2)

Application Number Title Priority Date Filing Date
FI925894A FI103507B (fi) 1990-07-13 1992-12-28 Menetelmä terapeuttisesti käyttökelpoisen 1R-cis,1'R-cis-2,2'-(3,11-di okso-4,10-dioksatridekametyleeni)-bis(1,2,3,4-tetrahydro-6,7-dimetoksi -2-metyyli-1-veratryyli-isokinolinium)suolan valmistamiseksi
FI982342A FI982342A0 (fi) 1990-07-13 1998-10-28 Neuromuskulaarisia salpausaineita

Family Applications After (1)

Application Number Title Priority Date Filing Date
FI982342A FI982342A0 (fi) 1990-07-13 1998-10-28 Neuromuskulaarisia salpausaineita

Country Status (40)

Country Link
EP (1) EP0539470B1 (fi)
JP (3) JP2823356B2 (fi)
KR (1) KR0174284B1 (fi)
AT (1) ATE138369T1 (fi)
AU (2) AU8190491A (fi)
BE (1) BE1003407A3 (fi)
CA (1) CA2087104C (fi)
CH (1) CH683427A5 (fi)
CY (1) CY1985A (fi)
CZ (1) CZ284645B6 (fi)
DE (2) DE69119768T2 (fi)
DK (2) DK0539470T3 (fi)
ES (2) ES2088009T3 (fi)
FI (2) FI103507B (fi)
FR (1) FR2665701B1 (fi)
GB (2) GB9015473D0 (fi)
GE (1) GEP19981163B (fi)
GR (1) GR3020792T3 (fi)
HK (1) HK80196A (fi)
HU (2) HU218766B (fi)
IE (1) IE912440A1 (fi)
IL (1) IL98814A (fi)
IT (1) IT1249677B (fi)
LT (1) LT3317B (fi)
LU (1) LU88198A1 (fi)
LV (1) LV10432B (fi)
MX (1) MX9203220A (fi)
MY (1) MY113017A (fi)
NL (1) NL9120017A (fi)
NZ (1) NZ238964A (fi)
PA (1) PA8401801A1 (fi)
PL (1) PL167302B1 (fi)
PT (1) PT98306B (fi)
RU (1) RU2104005C1 (fi)
SA (1) SA91120073B1 (fi)
SE (1) SE9300052L (fi)
SK (1) SK279907B6 (fi)
UA (1) UA32536C2 (fi)
WO (1) WO1992000965A1 (fi)
ZA (1) ZA915468B (fi)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5453510A (en) * 1990-07-13 1995-09-26 Burroughs Wellcome Co. Neuromuscular blocking agents
DE19535762A1 (de) * 1995-09-26 1997-03-27 Basf Ag Verfahren zur Racematspaltung
US5684154A (en) * 1996-02-16 1997-11-04 Abbott Laboratories Process for the preparation and isolation of atracurium besylate
PT971898E (pt) 1997-03-25 2005-07-29 Avera Pharmaceuticals Inc Isoquinolinas substituidas como bloqueadores neuromusculares de accao ultra-rapida
EP2125742A2 (en) 2007-03-08 2009-12-02 Chemagis Ltd. (1r,1'r)-atracurium salts separation process
BRPI0808581A2 (pt) * 2007-03-26 2014-09-16 Chemagis Ltd "método para separar cisatracúrio com alta pureza de uma mistura de isômeros de (1r, 1'r) - atracúrio"
US8293912B2 (en) 2007-05-01 2012-10-23 Chemagis Ltd. Process for producing cisatracurium compounds and associated intermediates
WO2008132746A1 (en) 2007-05-01 2008-11-06 Chemagis Ltd. Novel isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates
BRPI0811687A2 (pt) * 2007-06-18 2015-02-18 Chemagis Ltd MÉTODO PARA SEPARAR O ISÔMETRO 1R-CIS, 1'R-CIS (cisatracúrio) DE UMA MISTURA DE ISÔMEROS DE SAIS DE (1R, 1'R) - ATRACÚRIO
CN101337935B (zh) * 2007-07-06 2011-01-12 江苏恒瑞医药股份有限公司 一种用两相萃取法纯化苯磺酸阿曲库铵的方法
CN101337936B (zh) * 2007-07-06 2011-03-23 江苏恒瑞医药股份有限公司 一种用柱色谱法纯化苯磺酸阿曲库铵的方法
BRPI0816519A2 (pt) 2007-10-29 2015-03-24 Chemagis Ltd Processo para preparar um sal de r, r'-atracúrio isomericamente enriquecido e sal de r, r'-atracúrio
IT1396543B1 (it) 2008-07-16 2012-12-14 Farmabios Spa Processo per la purificazione di bloccanti neuromuscolari
WO2010128518A2 (en) * 2009-05-04 2010-11-11 Gland Pharma Limited Novel process for the preparation of cisatracurium besylate
CN107056700A (zh) * 2017-04-18 2017-08-18 哈尔滨医科大学 一种四氢异喹啉类化合物外消旋体的半量拆分法
CN112939862B (zh) * 2021-02-03 2023-01-10 江苏诚信药业有限公司 一种苯磺顺阿曲库铵杂质h的分离制备方法及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3004031A (en) * 1958-07-03 1961-10-10 Allen & Hauburys Ltd Diquaternary salts of papaverino esters
AU506657B2 (en) 1975-12-10 1980-01-17 Wellcome Foundation Limited, The Isoquinoline derivatives
GB1579822A (en) * 1976-10-29 1980-11-26 Wellcome Found Tetrahydroisoquinolinium muscle relaxants
ES454090A1 (es) * 1976-12-09 1978-01-16 Wellcome Found Un metodo para preparar compuestos heterociclicos.
DE3328664A1 (de) * 1983-08-09 1985-02-21 Robert Bosch Gmbh, 7000 Stuttgart Zuckerziehmaschine
BG41897A1 (en) * 1985-07-19 1987-09-15 Ivanov Dichlormethylate of n, n'- 4, 10- dioxa- 3, 11- bis- tetrahydropapaverine and method for its preparation

Also Published As

Publication number Publication date
GB2260763A (en) 1993-04-28
JPH05508648A (ja) 1993-12-02
FR2665701A1 (fr) 1992-02-14
HU218766B (hu) 2000-11-28
IL98814A0 (en) 1992-07-15
JP2823356B2 (ja) 1998-11-11
SE9300052D0 (sv) 1993-01-12
EP0539470B1 (en) 1996-05-22
FR2665701B1 (fr) 1995-03-03
BE1003407A3 (fr) 1992-03-17
PA8401801A1 (es) 1997-01-03
IE912440A1 (en) 1992-01-15
ITRM910518A1 (it) 1992-01-14
GR3020792T3 (en) 1996-11-30
SK383392A3 (en) 1999-05-07
AU687481B2 (en) 1998-02-26
PL167302B1 (en) 1995-08-31
DE4191541T1 (de) 1993-05-13
GEP19981163B (en) 1998-07-06
UA32536C2 (uk) 2001-02-15
DE69119768D1 (de) 1996-06-27
GB2260763B (en) 1994-01-05
IL98814A (en) 1995-12-08
LU88198A1 (fr) 1993-05-17
DK149692D0 (da) 1992-12-14
SE9300052L (sv) 1993-01-12
AU8190491A (en) 1992-02-04
MY113017A (en) 2001-11-30
ZA915468B (en) 1993-03-31
EP0539470A1 (en) 1993-05-05
ES2088009T3 (es) 1996-08-01
JP2001058981A (ja) 2001-03-06
FI103507B1 (fi) 1999-07-15
LV10432A (lv) 1995-02-20
JPH10139763A (ja) 1998-05-26
PL297606A1 (fi) 1992-07-13
NZ238964A (en) 1992-06-25
GB9015473D0 (en) 1990-08-29
CH683427A5 (fr) 1994-03-15
KR0174284B1 (ko) 1999-02-18
PT98306A (pt) 1992-06-30
SK279907B6 (sk) 1999-05-07
PT98306B (pt) 1999-01-29
GB9224764D0 (en) 1993-02-03
DK149692A (da) 1992-12-14
ES2083315B1 (es) 1997-11-16
DK0539470T3 (da) 1996-08-05
IT1249677B (it) 1995-03-09
DE69119768T2 (de) 1996-10-02
CY1985A (en) 1997-09-05
CZ383392A3 (en) 1994-02-16
WO1992000965A1 (en) 1992-01-23
HUT67613A (en) 1995-04-28
SA91120073B1 (ar) 2002-10-26
RU2104005C1 (ru) 1998-02-10
NL9120017A (nl) 1993-04-01
MX9203220A (es) 1992-07-01
HU211169A9 (en) 1995-11-28
CZ284645B6 (cs) 1999-01-13
JP3462165B2 (ja) 2003-11-05
FI982342A (fi) 1998-10-28
FI103507B (fi) 1999-07-15
LT3317B (en) 1995-06-26
AU1134695A (en) 1995-03-30
CA2087104A1 (en) 1992-01-14
ITRM910518A0 (it) 1991-07-12
FI982342A0 (fi) 1998-10-28
FI925894A (fi) 1992-12-28
CA2087104C (en) 1998-08-18
HK80196A (en) 1996-05-17
ES2083315A1 (es) 1996-04-01
LV10432B (en) 1995-08-20
HU9300052D0 (en) 1993-04-28
LTIP274A (en) 1994-10-25
ATE138369T1 (de) 1996-06-15

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MA Patent expired