LV10432A - Neiromuskularas parvades blokatori - Google Patents

Neiromuskularas parvades blokatori

Info

Publication number
LV10432A
LV10432A LV920334A LV920334A LV10432A LV 10432 A LV10432 A LV 10432A LV 920334 A LV920334 A LV 920334A LV 920334 A LV920334 A LV 920334A LV 10432 A LV10432 A LV 10432A
Authority
LV
Latvia
Prior art keywords
cis
neuromuscular
geometrical
isomer
optical isomers
Prior art date
Application number
LV920334A
Other languages
English (en)
Other versions
LV10432B (en
Inventor
Derek Anthony Hill
Geoffrey Lloyd Turner
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of LV10432A publication Critical patent/LV10432A/lv
Publication of LV10432B publication Critical patent/LV10432B/lv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pain & Pain Management (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Semiconductor Lasers (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Led Devices (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Paper (AREA)
LVP-92-334A 1990-07-13 1992-12-18 Neuromuscular transmission blocators LV10432B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909015473A GB9015473D0 (en) 1990-07-13 1990-07-13 Neuromuscular blocking agents
PCT/GB1991/001150 WO1992000965A1 (en) 1990-07-13 1991-07-12 Neuromuscular blocking agents

Publications (2)

Publication Number Publication Date
LV10432A true LV10432A (lv) 1995-02-20
LV10432B LV10432B (en) 1995-08-20

Family

ID=10679071

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-92-334A LV10432B (en) 1990-07-13 1992-12-18 Neuromuscular transmission blocators

Country Status (40)

Country Link
EP (1) EP0539470B1 (lv)
JP (3) JP2823356B2 (lv)
KR (1) KR0174284B1 (lv)
AT (1) ATE138369T1 (lv)
AU (2) AU8190491A (lv)
BE (1) BE1003407A3 (lv)
CA (1) CA2087104C (lv)
CH (1) CH683427A5 (lv)
CY (1) CY1985A (lv)
CZ (1) CZ284645B6 (lv)
DE (2) DE69119768T2 (lv)
DK (2) DK0539470T3 (lv)
ES (2) ES2083315B1 (lv)
FI (2) FI103507B (lv)
FR (1) FR2665701B1 (lv)
GB (2) GB9015473D0 (lv)
GE (1) GEP19981163B (lv)
GR (1) GR3020792T3 (lv)
HK (1) HK80196A (lv)
HU (2) HU218766B (lv)
IE (1) IE912440A1 (lv)
IL (1) IL98814A (lv)
IT (1) IT1249677B (lv)
LT (1) LT3317B (lv)
LU (1) LU88198A1 (lv)
LV (1) LV10432B (lv)
MX (1) MX9203220A (lv)
MY (1) MY113017A (lv)
NL (1) NL9120017A (lv)
NZ (1) NZ238964A (lv)
PA (1) PA8401801A1 (lv)
PL (1) PL167302B1 (lv)
PT (1) PT98306B (lv)
RU (1) RU2104005C1 (lv)
SA (1) SA91120073B1 (lv)
SE (1) SE9300052L (lv)
SK (1) SK383392A3 (lv)
UA (1) UA32536C2 (lv)
WO (1) WO1992000965A1 (lv)
ZA (1) ZA915468B (lv)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5453510A (en) * 1990-07-13 1995-09-26 Burroughs Wellcome Co. Neuromuscular blocking agents
DE19535762A1 (de) * 1995-09-26 1997-03-27 Basf Ag Verfahren zur Racematspaltung
US5684154A (en) * 1996-02-16 1997-11-04 Abbott Laboratories Process for the preparation and isolation of atracurium besylate
EP1526130A1 (en) * 1997-03-25 2005-04-27 Avera Pharmaceuticals, Inc. Substituted isoquinolines as ultra short acting neuromuscular blockers
EP2125742A2 (en) 2007-03-08 2009-12-02 Chemagis Ltd. (1r,1'r)-atracurium salts separation process
US20100087650A1 (en) * 2007-03-26 2010-04-08 Chemagis Ltd. (1r,1'r)-atracurium salts separation process
BRPI0809893A2 (pt) 2007-05-01 2014-09-30 Chemagis Ltd Processo para prepar um sal de (1r-cis) - [(3,4 - dimetoxifenil) metil] - 1, 2,3,4 - tetraidro - 6,7 - dimetoxi - 2 - metil - 2 - carboxietil - isoquinolínio"
AU2008273724B2 (en) 2007-05-01 2013-05-23 Chemagis Ltd. Process for Producing Cisatracurium and Associated Intermediates
CA2687157A1 (en) * 2007-06-18 2008-12-24 Chemagis Ltd. (1r,1'r)-atracurium salts separation process
CN101337935B (zh) * 2007-07-06 2011-01-12 江苏恒瑞医药股份有限公司 一种用两相萃取法纯化苯磺酸阿曲库铵的方法
CN101337936B (zh) * 2007-07-06 2011-03-23 江苏恒瑞医药股份有限公司 一种用柱色谱法纯化苯磺酸阿曲库铵的方法
AU2008320380A1 (en) 2007-10-29 2009-05-07 Chemagis Ltd. Novel R,R'-atracurium salts
IT1396543B1 (it) * 2008-07-16 2012-12-14 Farmabios Spa Processo per la purificazione di bloccanti neuromuscolari
WO2010128518A2 (en) * 2009-05-04 2010-11-11 Gland Pharma Limited Novel process for the preparation of cisatracurium besylate
CN107056700A (zh) * 2017-04-18 2017-08-18 哈尔滨医科大学 一种四氢异喹啉类化合物外消旋体的半量拆分法
CN112939862B (zh) * 2021-02-03 2023-01-10 江苏诚信药业有限公司 一种苯磺顺阿曲库铵杂质h的分离制备方法及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3004031A (en) * 1958-07-03 1961-10-10 Allen & Hauburys Ltd Diquaternary salts of papaverino esters
GB1579822A (en) * 1976-10-29 1980-11-26 Wellcome Found Tetrahydroisoquinolinium muscle relaxants
AU506657B2 (en) 1975-12-10 1980-01-17 Wellcome Foundation Limited, The Isoquinoline derivatives
ES454090A1 (es) * 1976-12-09 1978-01-16 Wellcome Found Un metodo para preparar compuestos heterociclicos.
DE3328664A1 (de) * 1983-08-09 1985-02-21 Robert Bosch Gmbh, 7000 Stuttgart Zuckerziehmaschine
BG41897A1 (en) * 1985-07-19 1987-09-15 Ivanov Dichlormethylate of n, n'- 4, 10- dioxa- 3, 11- bis- tetrahydropapaverine and method for its preparation

Also Published As

Publication number Publication date
PT98306A (pt) 1992-06-30
NZ238964A (en) 1992-06-25
ES2083315B1 (es) 1997-11-16
SE9300052D0 (sv) 1993-01-12
CH683427A5 (fr) 1994-03-15
AU687481B2 (en) 1998-02-26
GR3020792T3 (en) 1996-11-30
PL297606A1 (lv) 1992-07-13
CA2087104C (en) 1998-08-18
GB9015473D0 (en) 1990-08-29
ITRM910518A0 (it) 1991-07-12
RU2104005C1 (ru) 1998-02-10
JPH10139763A (ja) 1998-05-26
ES2088009T3 (es) 1996-08-01
IE912440A1 (en) 1992-01-15
MY113017A (en) 2001-11-30
DK0539470T3 (da) 1996-08-05
KR0174284B1 (ko) 1999-02-18
EP0539470A1 (en) 1993-05-05
FI103507B1 (fi) 1999-07-15
CY1985A (en) 1997-09-05
FI925894A0 (fi) 1992-12-28
LV10432B (en) 1995-08-20
WO1992000965A1 (en) 1992-01-23
DK149692A (da) 1992-12-14
FI925894A (fi) 1992-12-28
JP2001058981A (ja) 2001-03-06
GB9224764D0 (en) 1993-02-03
UA32536C2 (uk) 2001-02-15
AU8190491A (en) 1992-02-04
HUT67613A (en) 1995-04-28
FR2665701A1 (fr) 1992-02-14
FR2665701B1 (fr) 1995-03-03
SE9300052L (sv) 1993-01-12
JP2823356B2 (ja) 1998-11-11
SK279907B6 (sk) 1999-05-07
IT1249677B (it) 1995-03-09
LT3317B (en) 1995-06-26
GB2260763A (en) 1993-04-28
DE69119768D1 (de) 1996-06-27
PL167302B1 (en) 1995-08-31
FI982342A0 (fi) 1998-10-28
IL98814A (en) 1995-12-08
ZA915468B (en) 1993-03-31
FI103507B (fi) 1999-07-15
IL98814A0 (en) 1992-07-15
JPH05508648A (ja) 1993-12-02
CZ284645B6 (cs) 1999-01-13
HU9300052D0 (en) 1993-04-28
JP3462165B2 (ja) 2003-11-05
HU218766B (hu) 2000-11-28
HK80196A (en) 1996-05-17
CA2087104A1 (en) 1992-01-14
SA91120073B1 (ar) 2002-10-26
DE4191541T1 (de) 1993-05-13
MX9203220A (es) 1992-07-01
NL9120017A (nl) 1993-04-01
CZ383392A3 (en) 1994-02-16
DK149692D0 (da) 1992-12-14
AU1134695A (en) 1995-03-30
ATE138369T1 (de) 1996-06-15
BE1003407A3 (fr) 1992-03-17
PA8401801A1 (es) 1997-01-03
SK383392A3 (en) 1999-05-07
EP0539470B1 (en) 1996-05-22
LU88198A1 (fr) 1993-05-17
GB2260763B (en) 1994-01-05
ITRM910518A1 (it) 1992-01-14
GEP19981163B (en) 1998-07-06
HU211169A9 (en) 1995-11-28
PT98306B (pt) 1999-01-29
FI982342A (fi) 1998-10-28
LTIP274A (en) 1994-10-25
ES2083315A1 (es) 1996-04-01
DE69119768T2 (de) 1996-10-02

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