FI91763C - Menetelmä terapeuttisesti käyttökelpoisen 2',3'-dideoksi-3'-fluoripyrimidiini- tai -puriininukleosidin valmistamiseksi - Google Patents

Menetelmä terapeuttisesti käyttökelpoisen 2',3'-dideoksi-3'-fluoripyrimidiini- tai -puriininukleosidin valmistamiseksi

Info

Publication number
FI91763C
FI91763C FI885094A FI885094A FI91763C FI 91763 C FI91763 C FI 91763C FI 885094 A FI885094 A FI 885094A FI 885094 A FI885094 A FI 885094A FI 91763 C FI91763 C FI 91763C
Authority
FI
Finland
Prior art keywords
fluoropyrimidine
dideoxy
preparing
therapeutically useful
purine nucleoside
Prior art date
Application number
FI885094A
Other languages
English (en)
Swedish (sv)
Other versions
FI885094A0 (fi
FI91763B (fi
FI885094A (fi
Inventor
Charlene Louise Burns
Susan Mary Daluge
George Walter Koszalka
Thomas Anthony Krenitsky
Tuttle Joel Van
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of FI885094A0 publication Critical patent/FI885094A0/fi
Publication of FI885094A publication Critical patent/FI885094A/fi
Publication of FI91763B publication Critical patent/FI91763B/fi
Application granted granted Critical
Publication of FI91763C publication Critical patent/FI91763C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
FI885094A 1987-11-07 1988-11-04 Menetelmä terapeuttisesti käyttökelpoisen 2',3'-dideoksi-3'-fluoripyrimidiini- tai -puriininukleosidin valmistamiseksi FI91763C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB878726136A GB8726136D0 (en) 1987-11-07 1987-11-07 Therapeutic nucleosides
GB8726136 1987-11-07

Publications (4)

Publication Number Publication Date
FI885094A0 FI885094A0 (fi) 1988-11-04
FI885094A FI885094A (fi) 1989-05-08
FI91763B FI91763B (fi) 1994-04-29
FI91763C true FI91763C (fi) 1994-08-10

Family

ID=10626612

Family Applications (1)

Application Number Title Priority Date Filing Date
FI885094A FI91763C (fi) 1987-11-07 1988-11-04 Menetelmä terapeuttisesti käyttökelpoisen 2',3'-dideoksi-3'-fluoripyrimidiini- tai -puriininukleosidin valmistamiseksi

Country Status (17)

Country Link
US (1) US5574149A (fi)
EP (3) EP0317128B1 (fi)
JP (1) JP2731551B2 (fi)
KR (1) KR890008160A (fi)
AT (1) ATE131826T1 (fi)
AU (1) AU616914B2 (fi)
CA (1) CA1333391C (fi)
DE (1) DE3854811T2 (fi)
DK (1) DK615788A (fi)
ES (1) ES2081286T3 (fi)
FI (1) FI91763C (fi)
GB (1) GB8726136D0 (fi)
GR (1) GR3019379T3 (fi)
HU (2) HU204839B (fi)
MX (1) MX9203217A (fi)
PT (1) PT88948B (fi)
ZA (1) ZA888289B (fi)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5506215A (en) * 1987-11-03 1996-04-09 Medivir Ab 1-(3'-fluoro-2',3'-dideoxy-β-D-ribofuranosyl)-5-substituted pyrimidine nucleosides
US5157114A (en) * 1988-08-19 1992-10-20 Burroughs Wellcome Co. 2',3'-dideoxy-3'-fluoro-5-ethyngluridine
WO1990003978A1 (en) * 1988-10-03 1990-04-19 Stichting Rega Vzw 5-halogeno-3'-fluoro-2',3'-dideoxyuridine compounds and their therapeutic application
WO1991006554A1 (en) * 1989-11-06 1991-05-16 Nycomed As Nucleoside derivatives
FR2668153B1 (fr) * 1990-10-22 1995-03-31 Pasteur Merieux Serums Vacc Nouveaux composes ribonucleosides, leur procede de preparation et les medicaments les contenant.
AU3170193A (en) * 1992-01-06 1993-08-03 Wellcome Foundation Limited, The Therapeutic nucleosides
GB9200150D0 (en) * 1992-01-06 1992-02-26 Wellcome Found Therapeutic nucleosides
HU9501978D0 (en) * 1993-03-31 1995-09-28 Sterling Winthorp Inc Bifunctional nucleosides, oligomers thereof, and methods of making and using the same
AU6686394A (en) * 1993-05-12 1994-12-12 Rhone-Poulenc Chemicals Limited Preparation of fluoro-nucleosides and intermediates for use therein
PT917879E (pt) * 1997-11-22 2002-12-31 Roche Diagnostics Gmbh Processo melhorado para estabilizacao de proteinas
US6156349A (en) * 1998-12-14 2000-12-05 Steinbach, Pylant And Herman, L.L.C. Method of treating HIV infection with suppository containing mammalian liver extract
US6514979B1 (en) 1999-03-03 2003-02-04 University Of Maryland Biotechnology Institute Synergistic combinations of guanosine analog reverse transcriptase inhibitors and inosine monophosphate dehydrogenese inhibitors and uses therefor
WO2003000200A2 (en) * 2001-06-22 2003-01-03 Pharmasset Ltd. β-2'-OR 3'-HALONUCLEOSIDES

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3328388A (en) * 1964-09-02 1967-06-27 Merck & Co Inc Arabinofuranosyl pyrimidines and methods of preparing same
US3775397A (en) * 1969-11-12 1973-11-27 Akad Wissenschaften Ddr Novel cytostatic 2',3'-dideoxy-3'-fluoropyrimidine-nucleosides
SE8602981D0 (sv) * 1986-07-04 1986-07-04 Astra Laekemedel Ab Novel medicinal use
DD279407A1 (de) * 1986-07-24 1990-06-06 Akad Wissenschaften Ddr Verfahren zur herstellung eines mittels gegen aids
US5153180A (en) * 1986-07-24 1992-10-06 Eckart Matthes Fluorinated nucleosides and process for treating retrovirus infections therewith
GB8719877D0 (en) * 1987-08-22 1987-09-30 Wellcome Found Antiviral compounds
SE8704298D0 (sv) * 1987-11-03 1987-11-03 Astra Ab Compounds for use in therapy

Also Published As

Publication number Publication date
DK615788A (da) 1989-05-08
ATE131826T1 (de) 1996-01-15
EP0317128B1 (en) 1995-12-20
DK615788D0 (da) 1988-11-04
ES2081286T3 (es) 1996-03-01
FI885094A0 (fi) 1988-11-04
ZA888289B (en) 1990-07-25
JPH01153697A (ja) 1989-06-15
EP0669341A1 (en) 1995-08-30
AU2476388A (en) 1989-05-25
US5574149A (en) 1996-11-12
MX9203217A (es) 1992-07-01
PT88948A (pt) 1988-12-01
HU200931B (en) 1990-09-28
EP0670328A1 (en) 1995-09-06
GB8726136D0 (en) 1987-12-09
FI91763B (fi) 1994-04-29
HU902123D0 (en) 1990-07-28
DE3854811T2 (de) 1996-08-01
DE3854811D1 (de) 1996-02-01
HUT48466A (en) 1989-06-28
HU204839B (en) 1992-02-28
GR3019379T3 (en) 1996-06-30
EP0317128A3 (en) 1991-10-02
AU616914B2 (en) 1991-11-14
FI885094A (fi) 1989-05-08
PT88948B (pt) 1993-02-26
KR890008160A (ko) 1989-07-10
JP2731551B2 (ja) 1998-03-25
EP0317128A2 (en) 1989-05-24
CA1333391C (en) 1994-12-06

Similar Documents

Publication Publication Date Title
MY102693A (en) Antiviral nucleosides
MY121839A (en) Antiviral purine derivatives
FI101793B1 (fi) Menetelmä uusien, terapeuttisesti käyttökelpoisten 9-purinyylifosfonihappojohdannaisten valmistamiseksi
FI91763C (fi) Menetelmä terapeuttisesti käyttökelpoisen 2',3'-dideoksi-3'-fluoripyrimidiini- tai -puriininukleosidin valmistamiseksi
DE3854297T2 (de) Nucleoside und nucleotide mit antiviraler, antitumoraler, antimetastatischer sowie immunstimulierender wirkung.
CA2215190A1 (en) Aryl-ester phosphoramidate derivatives of nucleosides
AU4690989A (en) Antiviral cytosine and guanine derivatives
FI885153A0 (fi) Menetelmä terapeuttisesti aktiivisten 2',3'-dideoksi-2'-fluorinukleosidien valmistamiseksi
WO1993017651A3 (de) Antivirale nucleosidanaloge, ihre herstellung und ihre verwendung
TW371662B (en) Antiviral acyclic phosphonomethoxyalkyl substituted alkenyl purine and pyrimidine derivatives
ES8707971A1 (es) Un metodo para producir un nucleosido de citosina
NO932287D0 (no) 2'-deoksy-2',2'-difluor(2,6,8-substituerte) purine nukleosider med antiviral- og anticanceraktivitet, og mellomprodukter
ZA892284B (en) Novel fluorophosphonate nucleotide derivatives
EP0340778A3 (en) Prodrugs of 2',3'- didehydro-2',3'-dideoxynucleosides
EP0335770A3 (en) Novel fluorophosphonate nucleotide derivatives
JPS6422853A (en) Nucleoside analog
HK1009451A1 (en) Process for the synthesis of nucleoside analogues
FI970666A (fi) Välituotteita ja menetelmiä niiden valmistamiseksi
EP0353268A4 (en) ANTI-TUMOR PURINES OF 6-SULFENAMIDE, 6-SULFINAMIDE AND 6-SULFONAMIDE, PURINE NUCLEOSIDES, PURINE NUCLEOTIDES AND RELATED COMPOUNDS.
GEP20002030B (en) Diastereoselective Synthesis of Nucleosides
JPS6426594A (en) Nucleotides and antitumor agent
ES2002342A6 (es) Procedimiento para la preparacion de 3'-azido-nucleosidos
FR2406446A1 (fr) Application therapeutique de la (s) et (rs)-9-(2,3-dihydroxypropyl)adenine

Legal Events

Date Code Title Description
BB Publication of examined application
MM Patent lapsed
MM Patent lapsed

Owner name: THE WELLCOME FOUNDATION LIMITED