GR3019379T3 - Anti-HIV Pyrimidine Nucleosides - Google Patents

Anti-HIV Pyrimidine Nucleosides

Info

Publication number
GR3019379T3
GR3019379T3 GR960400779T GR960400779T GR3019379T3 GR 3019379 T3 GR3019379 T3 GR 3019379T3 GR 960400779 T GR960400779 T GR 960400779T GR 960400779 T GR960400779 T GR 960400779T GR 3019379 T3 GR3019379 T3 GR 3019379T3
Authority
GR
Greece
Prior art keywords
hiv
pyrimidine nucleosides
nucleosides
pyrimidine
found
Prior art date
Application number
GR960400779T
Other languages
English (en)
Inventor
Charlene Louise Burns
Susan Mary Daluge
George Walter Koszalka
Thomas Anthony Krenitsky
Joel Van Tuttle
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of GR3019379T3 publication Critical patent/GR3019379T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
GR960400779T 1987-11-07 1996-03-20 Anti-HIV Pyrimidine Nucleosides GR3019379T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878726136A GB8726136D0 (en) 1987-11-07 1987-11-07 Therapeutic nucleosides

Publications (1)

Publication Number Publication Date
GR3019379T3 true GR3019379T3 (en) 1996-06-30

Family

ID=10626612

Family Applications (1)

Application Number Title Priority Date Filing Date
GR960400779T GR3019379T3 (en) 1987-11-07 1996-03-20 Anti-HIV Pyrimidine Nucleosides

Country Status (17)

Country Link
US (1) US5574149A (el)
EP (3) EP0317128B1 (el)
JP (1) JP2731551B2 (el)
KR (1) KR890008160A (el)
AT (1) ATE131826T1 (el)
AU (1) AU616914B2 (el)
CA (1) CA1333391C (el)
DE (1) DE3854811T2 (el)
DK (1) DK615788A (el)
ES (1) ES2081286T3 (el)
FI (1) FI91763C (el)
GB (1) GB8726136D0 (el)
GR (1) GR3019379T3 (el)
HU (2) HU200931B (el)
MX (1) MX9203217A (el)
PT (1) PT88948B (el)
ZA (1) ZA888289B (el)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5506215A (en) * 1987-11-03 1996-04-09 Medivir Ab 1-(3'-fluoro-2',3'-dideoxy-β-D-ribofuranosyl)-5-substituted pyrimidine nucleosides
US5157114A (en) * 1988-08-19 1992-10-20 Burroughs Wellcome Co. 2',3'-dideoxy-3'-fluoro-5-ethyngluridine
WO1990003978A1 (en) * 1988-10-03 1990-04-19 Stichting Rega Vzw 5-halogeno-3'-fluoro-2',3'-dideoxyuridine compounds and their therapeutic application
EP0500610A1 (en) * 1989-11-06 1992-09-02 Nycomed Imaging As Nucleoside derivatives
FR2668153B1 (fr) * 1990-10-22 1995-03-31 Pasteur Merieux Serums Vacc Nouveaux composes ribonucleosides, leur procede de preparation et les medicaments les contenant.
GB9200150D0 (en) * 1992-01-06 1992-02-26 Wellcome Found Therapeutic nucleosides
DE69324244T2 (de) * 1992-01-06 1999-09-30 Wellcome Found Therapeutische nukleoside der 2',3'-dideoxy-3'-fluor -purin reihe
EP0701564A1 (en) * 1993-03-31 1996-03-20 Sanofi Bifunctional nucleosides, oligomers thereof, and methods of making and using the same
DE69412090T2 (de) * 1993-05-12 1999-01-07 Rhodia Ltd Herstellung von fluoro-nukleosiden und dafür geeignete zwischenprodukte
PT917879E (pt) * 1997-11-22 2002-12-31 Roche Diagnostics Gmbh Processo melhorado para estabilizacao de proteinas
US6156349A (en) * 1998-12-14 2000-12-05 Steinbach, Pylant And Herman, L.L.C. Method of treating HIV infection with suppository containing mammalian liver extract
US6514979B1 (en) 1999-03-03 2003-02-04 University Of Maryland Biotechnology Institute Synergistic combinations of guanosine analog reverse transcriptase inhibitors and inosine monophosphate dehydrogenese inhibitors and uses therefor
US6949522B2 (en) * 2001-06-22 2005-09-27 Pharmasset, Inc. β-2′- or 3′-halonucleosides

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3328388A (en) * 1964-09-02 1967-06-27 Merck & Co Inc Arabinofuranosyl pyrimidines and methods of preparing same
US3775397A (en) * 1969-11-12 1973-11-27 Akad Wissenschaften Ddr Novel cytostatic 2',3'-dideoxy-3'-fluoropyrimidine-nucleosides
SE8602981D0 (sv) * 1986-07-04 1986-07-04 Astra Laekemedel Ab Novel medicinal use
US5153180A (en) * 1986-07-24 1992-10-06 Eckart Matthes Fluorinated nucleosides and process for treating retrovirus infections therewith
DD279407A1 (de) * 1986-07-24 1990-06-06 Akad Wissenschaften Ddr Verfahren zur herstellung eines mittels gegen aids
GB8719877D0 (en) * 1987-08-22 1987-09-30 Wellcome Found Antiviral compounds
SE8704298D0 (sv) * 1987-11-03 1987-11-03 Astra Ab Compounds for use in therapy

Also Published As

Publication number Publication date
DK615788A (da) 1989-05-08
HU204839B (en) 1992-02-28
FI885094A (fi) 1989-05-08
EP0317128A3 (en) 1991-10-02
FI91763C (fi) 1994-08-10
HUT48466A (en) 1989-06-28
EP0670328A1 (en) 1995-09-06
ES2081286T3 (es) 1996-03-01
AU616914B2 (en) 1991-11-14
PT88948A (pt) 1988-12-01
EP0317128B1 (en) 1995-12-20
EP0669341A1 (en) 1995-08-30
ATE131826T1 (de) 1996-01-15
HU200931B (en) 1990-09-28
CA1333391C (en) 1994-12-06
HU902123D0 (en) 1990-07-28
US5574149A (en) 1996-11-12
EP0317128A2 (en) 1989-05-24
DE3854811D1 (de) 1996-02-01
ZA888289B (en) 1990-07-25
MX9203217A (es) 1992-07-01
GB8726136D0 (en) 1987-12-09
DE3854811T2 (de) 1996-08-01
FI91763B (fi) 1994-04-29
JP2731551B2 (ja) 1998-03-25
DK615788D0 (da) 1988-11-04
KR890008160A (ko) 1989-07-10
AU2476388A (en) 1989-05-25
JPH01153697A (ja) 1989-06-15
FI885094A0 (fi) 1988-11-04
PT88948B (pt) 1993-02-26

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