GEP20002030B - Diastereoselective Synthesis of Nucleosides
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Diastereoselective Synthesis of Nucleosides
Info
Publication number
GEP20002030B
GEP20002030BGEAP19922642AGEAP1992002642AGEP20002030BGE P20002030 BGEP20002030 BGE P20002030BGE AP19922642 AGEAP19922642 AGE AP19922642AGE AP1992002642 AGEAP1992002642 AGE AP1992002642AGE P20002030 BGEP20002030 BGE P20002030B
Authority
GE
Georgia
Prior art keywords
nucleosides
glycosylating
diastereoselective synthesis
base
chemistry
Prior art date
Application number
GEAP19922642A
Inventor
Allan H L Mse
Tarek Mansour
M Arshad Siddiqui
Haolun Jin
Original Assignee
Biochem Pharma Inc Ca
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biochem Pharma Inc CafiledCriticalBiochem Pharma Inc Ca
Priority to GEAP19922642ApriorityCriticalpatent/GEP20002030B/en
Publication of GEP20002030BpublicationCriticalpatent/GEP20002030B/en
1. Technical Result Simplification of the technological process and intensification of antiviral activity. 2. Essence A method for preparing optically active cis-nucleosides (1,3-oxathiolanes, 2,4-dioxolanes and 1,3-dithiolanes), nucleoside analogues and derivatives of the formula (I) (where R1, R2 W and X are presented in the description) comprising glycosylating the desired base with sugar and glycosylating the desired purine or pyrimidine base or derivative thereof with an intermediate. 3. Field of Application Chemistry, in particular organic chemistry. 5 ind. cl., and 28 dep. cl.
GEAP19922642A1992-05-211992-05-21Diastereoselective Synthesis of Nucleosides
GEP20002030B
(en)
METHOD AND COMPOSITIONS FOR THE SYNTHESIS OF DIOXOLANE NUCLEOSIDES WITH β-CONFIGURATION the invention relates to methods and compositions for preparing biologically important nucleoside analogues containing 1,3-dioxolane sugar rings.
Diastereoselective processes for production of optically active cis-nucleosides, analogues and derivative nucleosides, intermediates and processes for production thereof The present invention relates to highly diastereoselective processes for production of optically active cis-nucleosides, nucleoside analogues and derivatives and intermediates useful in thos The technical result consists in increasing the yield of highly pure and optically active cis-nucleosides. Claims: 34