FI90994B - Förfarande för framställning av penem - Google Patents

Förfarande för framställning av penem Download PDF

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Publication number
FI90994B
FI90994B FI874469A FI874469A FI90994B FI 90994 B FI90994 B FI 90994B FI 874469 A FI874469 A FI 874469A FI 874469 A FI874469 A FI 874469A FI 90994 B FI90994 B FI 90994B
Authority
FI
Finland
Prior art keywords
formula
enzyme
compound
reaction
penem
Prior art date
Application number
FI874469A
Other languages
English (en)
Finnish (fi)
Other versions
FI874469A (sv
FI90994C (sv
FI874469A0 (sv
Inventor
Maria Altamura
Pietro Cesti
Franco Francalanci
Marcello Marchi
Marco Foa
Stefano Cambiaghi
Franco Dallatomasina
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of FI874469A0 publication Critical patent/FI874469A0/sv
Publication of FI874469A publication Critical patent/FI874469A/sv
Application granted granted Critical
Publication of FI90994B publication Critical patent/FI90994B/sv
Publication of FI90994C publication Critical patent/FI90994C/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/883—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with a substituted hydrocarbon radical attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C12N1/18—Baker's yeast; Brewer's yeast
    • C12N1/185—Saccharomyces isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/85—Saccharomyces
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Botany (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pens And Brushes (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Claims (5)

1. Förfarande för framställning av en förening med for-meln (I) 20 ORj ySv^CH20H (I) l_J o ^-N \ CCXK^^. 25 i vilken Rj betecknar en trialkylsilyl- eller tetrahydro-pyranylgrupp, väri man hydrolyserar en förening med for-meln (II) 30 ORI CH20C0R I II (ii) I_m _M x ' 35 0* li 90994 i vilken R, betecknar detsamma soin ovan och R en alkyl-grupp med 1-18 kolatomer, kännetecknat därav, att hydro-lysen utförs med hjälp av ett lipas-, pankreatin- eller proteasenzym. 5
2. Förfarande enligt patentkravet 1, kännetecknat därav, att det nämnda enzymet isoleras och därefter an-vänds det för hydrolysering av föreningen med formeln (II). 10
3. Förfarande enligt patentkravet 2, kännetecknat därav, att det isolerade enzymet antingen immobiliseras i en inert bärare eller görs olösligt genom tvärbindning. 15
4. Förfarande enligt patentkravet 3, kännetecknat därav, att den slutliga föreningen med formeln (I) adsorberas i en inert bärare och tillvaratas därefter i ren form genom att enkelt tvätta bäraren med ett lämpligt lösningsmedel. 20
5. Förfarande enligt n&got av de föregäende patentkraven, kännetecknat därav, att den enzymatiska hydrolysen utförs i en vattenhaltig lösning, varvid koncentrationen av föreningen med formeln (II) är 1 - 100 g/1, eventuellt i närvaro av en liten mängd av kolväten, buffrad tili pH- 25 värde 5-9, i en temperatur av 10 °C - 50 °C, för en period av 0,5 - 48 timmar.
FI874469A 1986-10-15 1987-10-12 Förfarande för framställning av penem FI90994C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8624686 1986-10-15
GB868624686A GB8624686D0 (en) 1986-10-15 1986-10-15 Preparing penems

Publications (4)

Publication Number Publication Date
FI874469A0 FI874469A0 (sv) 1987-10-12
FI874469A FI874469A (sv) 1988-04-16
FI90994B true FI90994B (sv) 1994-01-14
FI90994C FI90994C (sv) 1994-04-25

Family

ID=10605770

Family Applications (1)

Application Number Title Priority Date Filing Date
FI874469A FI90994C (sv) 1986-10-15 1987-10-12 Förfarande för framställning av penem

Country Status (18)

Country Link
EP (1) EP0265166B1 (sv)
JP (1) JP2688053B2 (sv)
KR (1) KR950012694B1 (sv)
AT (1) ATE66961T1 (sv)
AU (1) AU590455B2 (sv)
CA (1) CA1300539C (sv)
DE (1) DE3772703D1 (sv)
ES (1) ES2026548T3 (sv)
FI (1) FI90994C (sv)
GB (1) GB8624686D0 (sv)
GR (1) GR3003059T3 (sv)
HU (1) HU198098B (sv)
IE (1) IE60493B1 (sv)
IL (1) IL84148A (sv)
NZ (1) NZ222141A (sv)
PT (1) PT85915B (sv)
SU (1) SU1625333A3 (sv)
ZA (1) ZA877682B (sv)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8713515D0 (en) * 1987-06-10 1987-07-15 Erba Farmitalia Methoxymethyl compounds
GB2206578B (en) * 1987-07-07 1991-07-03 Erba Carlo Spa Process for the preparation of penems

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES436565A1 (es) * 1974-06-05 1977-04-01 Bristol Myers Co Un procedimiento para la preparacion de acidos acetamidope- nicilanicos.
US4414328A (en) * 1980-07-21 1983-11-08 Fujisawa Pharmaceutical Co., Ltd. Process for the preparation of deacetylcephalosporin C

Also Published As

Publication number Publication date
IL84148A (en) 1992-05-25
ZA877682B (en) 1988-04-19
HUT45262A (en) 1988-06-28
AU590455B2 (en) 1989-11-02
IE60493B1 (en) 1994-07-27
PT85915B (pt) 1990-07-31
NZ222141A (en) 1989-03-29
ES2026548T3 (es) 1992-05-01
IE872721L (en) 1988-04-15
FI874469A (sv) 1988-04-16
JPS63105696A (ja) 1988-05-10
FI90994C (sv) 1994-04-25
KR950012694B1 (ko) 1995-10-20
FI874469A0 (sv) 1987-10-12
KR880005139A (ko) 1988-06-28
GR3003059T3 (en) 1993-02-17
PT85915A (en) 1987-11-01
GB8624686D0 (en) 1986-11-19
EP0265166A1 (en) 1988-04-27
IL84148A0 (en) 1988-03-31
SU1625333A3 (ru) 1991-01-30
HU198098B (en) 1989-07-28
JP2688053B2 (ja) 1997-12-08
CA1300539C (en) 1992-05-12
AU7957587A (en) 1988-04-21
EP0265166B1 (en) 1991-09-04
ATE66961T1 (de) 1991-09-15
DE3772703D1 (de) 1991-10-10

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Owner name: FARMITALIA CARLO ERBA S.R.L