FI900463A0 - Karboxylsyra- och sulfonsyraamider. - Google Patents
Karboxylsyra- och sulfonsyraamider.Info
- Publication number
- FI900463A0 FI900463A0 FI900463A FI900463A FI900463A0 FI 900463 A0 FI900463 A0 FI 900463A0 FI 900463 A FI900463 A FI 900463A FI 900463 A FI900463 A FI 900463A FI 900463 A0 FI900463 A0 FI 900463A0
- Authority
- FI
- Finland
- Prior art keywords
- sulphonyraamider
- carboxylsyra
- och
- thromboses
- inflammations
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/17—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Detergent Compositions (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pyridine Compounds (AREA)
- Curing Cements, Concrete, And Artificial Stone (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH32689 | 1989-01-31 | ||
CH406989 | 1989-11-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
FI900463A0 true FI900463A0 (fi) | 1990-01-30 |
Family
ID=25684228
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI900463A FI900463A0 (fi) | 1989-01-31 | 1990-01-30 | Karboxylsyra- och sulfonsyraamider. |
Country Status (21)
Country | Link |
---|---|
US (1) | US5084466A (pt) |
EP (1) | EP0381033B1 (pt) |
JP (1) | JPH085848B2 (pt) |
AT (1) | ATE103273T1 (pt) |
AU (1) | AU632086B2 (pt) |
CA (1) | CA2008311A1 (pt) |
CZ (1) | CZ277999B6 (pt) |
DE (1) | DE59005041D1 (pt) |
DK (1) | DK0381033T3 (pt) |
ES (1) | ES2050851T3 (pt) |
FI (1) | FI900463A0 (pt) |
HU (1) | HU206193B (pt) |
IE (1) | IE64004B1 (pt) |
IL (1) | IL93170A (pt) |
MC (1) | MC2082A1 (pt) |
NO (1) | NO172536C (pt) |
NZ (1) | NZ232195A (pt) |
PH (1) | PH29926A (pt) |
PT (1) | PT93014B (pt) |
RU (1) | RU2072986C1 (pt) |
SK (1) | SK277762B6 (pt) |
Families Citing this family (125)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL99537A (en) * | 1990-09-27 | 1995-11-27 | Merck & Co Inc | Fibrinogen receptor antagonists and pharmaceutical preparations containing them |
US5264420A (en) * | 1990-09-27 | 1993-11-23 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
NZ239846A (en) * | 1990-09-27 | 1994-11-25 | Merck & Co Inc | Sulphonamide derivatives and pharmaceutical compositions thereof |
DE4102024A1 (de) * | 1991-01-24 | 1992-07-30 | Thomae Gmbh Dr K | Biphenylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
JP3258659B2 (ja) * | 1991-03-06 | 2002-02-18 | ジー.デイー.サール アンド カンパニー | 血小板凝集阻害剤として有用なフェニルアミジン誘導体類 |
RU2097378C1 (ru) * | 1991-03-26 | 1997-11-27 | Ф.Хоффманн-Ля Рош Аг | ПРОИЗВОДНЫЕ N-АЦИЛ- α -АМИНОКИСЛОТЫ ИЛИ ИХ ФИЗИОЛОГИЧЕСКИ ПРИЕМЛЕМЫЕ СОЛИ, ПРОСТЫЕ ИЛИ СЛОЖНЫЕ ЭФИРЫ, АМИДЫ ИЛИ ГИДРАТЫ И КОМПОЗИЦИЯ ИНГИБИРУЮЩАЯ СВЯЗЫВАНИЕ АДГЕЗИВНЫХ ПРОТЕИНОВ С ТРОМБОЦИТАМИ И АГРЕГАЦИЮ ТРОМБОЦИТОВ |
US5545658A (en) * | 1991-03-26 | 1996-08-13 | Hoffman-La Roche Inc. | Amino acid derivatives |
HUT68769A (en) * | 1991-05-07 | 1995-07-28 | Merck & Co Inc | FIBRINOGéN RECEPTOR ANTAGONIST COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AS EFFECTIVE SUBSTANCE |
US5220050A (en) * | 1991-05-17 | 1993-06-15 | G. D. Searle & Co. | Peptide mimetic compounds useful as platelet aggregation inhibitors |
US5939412A (en) * | 1992-06-26 | 1999-08-17 | Smithkline Beecham Corporation | Bicyclic fibrinogen antagonists |
AU666318B2 (en) * | 1991-06-28 | 1996-02-08 | Smithkline Beecham Corporation | Bicyclic fibrinogen antagonists |
DE4127404A1 (de) * | 1991-08-19 | 1993-02-25 | Thomae Gmbh Dr K | Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
US5294713A (en) * | 1991-08-23 | 1994-03-15 | Takeda Chemical Industries, Ltd. | 2-piperazinone compounds and their use |
IL103252A (en) | 1991-09-30 | 1997-03-18 | Du Pont Merck Pharma | CYCLIC COMPOUNDS USEFUL AS INHIBITORS OF PLATELET GLYCOPROTEIN IIb/IIIa AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
US5239113A (en) * | 1991-10-15 | 1993-08-24 | Monsanto Company | Substituted β-amino acid derivatives useful as platelet aggregation inhibitors and intermediates thereof |
US5625093A (en) * | 1991-10-15 | 1997-04-29 | G. D. Searle & Co. | Substituted β-amino acid derivatives useful as platelet aggregation inhibitors |
DK0630366T3 (da) * | 1991-10-15 | 2003-04-22 | Searle & Co | Substituerede heterocycliske derivater, der er nyttige som blodpladeaggregeringsinhibitorer |
US5674863A (en) * | 1991-10-18 | 1997-10-07 | Genentech, Inc. | Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa receptor |
US5250679A (en) * | 1991-10-18 | 1993-10-05 | Genentech, Inc. | Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor |
US5272158A (en) * | 1991-10-29 | 1993-12-21 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
US5389631A (en) * | 1991-10-29 | 1995-02-14 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
AU3241693A (en) * | 1991-12-13 | 1993-07-19 | G.D. Searle & Co. | Phenyl amidines lactones useful as platelet aggregation inhibitors |
US5424334A (en) * | 1991-12-19 | 1995-06-13 | G. D. Searle & Co. | Peptide mimetic compounds useful as platelet aggregation inhibitors |
US5227490A (en) * | 1992-02-21 | 1993-07-13 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
US5206373A (en) * | 1992-02-28 | 1993-04-27 | Merck & Co., Inc. | Process for preparing fibrinogen receptor antagonists |
TW223629B (pt) * | 1992-03-06 | 1994-05-11 | Hoffmann La Roche | |
WO1993018058A1 (en) * | 1992-03-06 | 1993-09-16 | G.D. Searle & Co. | Peptides mimics useful as platelet aggregation inhibitors |
DE4212304A1 (de) * | 1992-04-13 | 1993-10-14 | Cassella Ag | Asparaginsäurederivate, ihre Herstellung und Verwendung |
GB9208740D0 (en) * | 1992-04-23 | 1992-06-10 | Glaxo Group Ltd | Chemical compounds |
KR940005271A (ko) * | 1992-04-28 | 1994-03-21 | 디터 라우딘, 게르하르트 후버 | 표지된 피브리노겐 수용체 길항제, 이의 용도 및 이의 제조방법 |
DE4219158A1 (de) * | 1992-06-11 | 1993-12-16 | Thomae Gmbh Dr K | Biphenylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
WO1994000424A1 (en) * | 1992-06-25 | 1994-01-06 | G.D. Searle & Co. | Phenyl amidine alkanoic acids and lactones useful as platelet aggregation inhibitors |
US5272162A (en) * | 1992-07-02 | 1993-12-21 | G. D. Searle & Co. | Platelet aggregation inhibitors |
US5354738A (en) * | 1992-09-04 | 1994-10-11 | G. D. Searle & Co. | Platelet aggregation inhibitors |
DE4234295A1 (de) * | 1992-10-12 | 1994-04-14 | Thomae Gmbh Dr K | Carbonsäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
US5340798A (en) * | 1992-10-14 | 1994-08-23 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
EP0667773A4 (en) * | 1992-10-14 | 1996-09-25 | Merck & Co Inc | FIBRINOGEN RECEPTOR ANTAGONISTS. |
US5358956A (en) * | 1992-10-14 | 1994-10-25 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
EP0664792B1 (en) * | 1992-10-14 | 2000-01-05 | Merck & Co. Inc. | Fibrinogen receptor antagonists |
GB9225141D0 (en) * | 1992-12-01 | 1993-01-20 | Smithkline Beecham Corp | Chemical compounds |
CA2150550A1 (en) * | 1992-12-01 | 1994-06-09 | Melissa S. Egbertson | Fibrinogen receptor antagonists |
EP0677043A1 (en) * | 1992-12-29 | 1995-10-18 | Smithkline Beecham Corporation | Platelet aggregation inhibiting compounds |
US5314902A (en) * | 1993-01-27 | 1994-05-24 | Monsanto Company | Urea derivatives useful as platelet aggregation inhibitors |
DE4302485A1 (de) * | 1993-01-29 | 1994-08-04 | Merck Patent Gmbh | Piperazinderivate |
US5409939A (en) * | 1993-02-12 | 1995-04-25 | G. D. Searle & Co. | Phenyl amidine thio derivatives useful as platelet aggregation inhibitors |
DE4304650A1 (de) * | 1993-02-16 | 1994-08-18 | Thomae Gmbh Dr K | Kondensierte 5-gliedrige Heterocyclen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
EP0684823A4 (en) * | 1993-02-22 | 1997-07-09 | Merck & Co Inc | FIBRINOGEN RECEPTOR ANTAGONISTS. |
DE69410193T2 (de) * | 1993-03-17 | 1998-09-03 | Meiji Seika K.K., Tokio/Tokyo | Neue verbindungen mit blutplättchenaggregationshemmender aktivität |
US5753659A (en) * | 1993-03-29 | 1998-05-19 | Zeneca Limited | Heterocyclic compouds |
US5652242A (en) * | 1993-03-29 | 1997-07-29 | Zeneca Limited | Heterocyclic derivatives |
SK120895A3 (en) * | 1993-03-29 | 1996-06-05 | Zeneca Ltd | Pyridine derivatives, process for preparing the same and intermediate products in this process and pharmaceutical compositions containing them |
NZ262942A (en) * | 1993-03-29 | 1997-07-27 | Zeneca Ltd | Pyridyl substituted piperazine and various other derivatives of azaheteroaryl substituted piperazines; pharmaceutical compositions |
US5750754A (en) * | 1993-03-29 | 1998-05-12 | Zeneca Limited | Heterocyclic compounds |
US5441952A (en) * | 1993-04-05 | 1995-08-15 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
ES2134870T3 (es) * | 1993-05-01 | 1999-10-16 | Merck Patent Gmbh | Antagonistas del receptor de adhesion. |
US5334596A (en) * | 1993-05-11 | 1994-08-02 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
US5612355A (en) * | 1993-06-23 | 1997-03-18 | G. D. Searle & Co. | Phenyl amidine lactones useful as platelet aggregation inhibitors |
US5463011A (en) * | 1993-06-28 | 1995-10-31 | Zeneca Limited | Acid derivatives |
GB9313285D0 (en) * | 1993-06-28 | 1993-08-11 | Zeneca Ltd | Acid derivatives |
GB9313268D0 (en) * | 1993-06-28 | 1993-08-11 | Zeneca Ltd | Chemical compounds |
US5397791A (en) * | 1993-08-09 | 1995-03-14 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
US5430043A (en) * | 1993-08-24 | 1995-07-04 | G. D. Searle & Co. | Platelet aggregation inhibitors |
TW394760B (en) * | 1993-09-07 | 2000-06-21 | Hoffmann La Roche | Novel Carboxamides, process for their preparation and pharmaceutical composition containing the same |
DE4332384A1 (de) * | 1993-09-23 | 1995-03-30 | Merck Patent Gmbh | Adhäsionsrezeptor-Antagonisten III |
US5523302A (en) * | 1993-11-24 | 1996-06-04 | The Du Pont Merck Pharmaceutical Company | Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists |
US5446056A (en) * | 1993-11-24 | 1995-08-29 | The Du Pont Merck Pharmaceutical Company | Isoxazoline compounds useful as fibrinogen receptor antagonists |
US5849736A (en) * | 1993-11-24 | 1998-12-15 | The Dupont Merck Pharmaceutical Company | Isoxazoline and isoxazole fibrinogen receptor antagonists |
EP0656348B1 (de) * | 1993-12-03 | 2000-05-03 | F. Hoffmann-La Roche Ag | Essigsäurederivate als Arzneimittel |
US5563158A (en) * | 1993-12-28 | 1996-10-08 | The Dupont Merck Pharmaceutical Company | Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists |
MA23420A1 (fr) * | 1994-01-07 | 1995-10-01 | Smithkline Beecham Corp | Antagonistes bicycliques de fibrinogene. |
DE4405378A1 (de) * | 1994-02-19 | 1995-08-24 | Merck Patent Gmbh | Adhäsionsrezeptor-Antagonisten |
US5821241A (en) * | 1994-02-22 | 1998-10-13 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
US6458784B1 (en) | 1994-06-29 | 2002-10-01 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
DE4429461A1 (de) * | 1994-08-19 | 1996-02-22 | Merck Patent Gmbh | Adhäsionsrezeptor-Antagonisten |
US6387880B1 (en) | 1994-10-24 | 2002-05-14 | G.D. Searle & Co. | Transdermal N-[N-[5-[4-(aminoiminomethly)phenyl]-1-oxopentyl]-L-α-aspartyl]-L-phenylalainine or its esters and their pharmaceutically acceptable salts |
DK0710657T3 (da) | 1994-11-02 | 1999-05-25 | Merck Patent Gmbh | Adhæsionsreceptor-antagonister |
DE4439846A1 (de) * | 1994-11-08 | 1996-05-09 | Merck Patent Gmbh | Adhäsionsrezeptor-Antagonisten |
EP0799189A4 (en) * | 1994-12-13 | 1999-03-17 | Smithkline Beecham Corp | BICYCLIC FIBRINOGENIC ANTAGONISTS |
US6037343A (en) * | 1994-12-22 | 2000-03-14 | Smithkline Beecham Corporation | Fibrinogen receptor antagonists |
DE19504954A1 (de) * | 1995-02-15 | 1996-08-22 | Merck Patent Gmbh | Adhäsionsrezeptor-Antagonisten |
US5719144A (en) * | 1995-02-22 | 1998-02-17 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
DE19515500A1 (de) * | 1995-04-27 | 1996-10-31 | Thomae Gmbh Dr K | Substituierte Phenylamidine, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
DE19516483A1 (de) | 1995-05-05 | 1996-11-07 | Merck Patent Gmbh | Adhäsionsrezeptor-Antagonisten |
US5674894A (en) * | 1995-05-15 | 1997-10-07 | G.D. Searle & Co. | Amidine derivatives useful as platelet aggregation inhibitors and vasodilators |
ZA963391B (en) * | 1995-05-24 | 1997-10-29 | Du Pont Merck Pharma | Isoxazoline fibrinogen receptor antagonists. |
US5977101A (en) * | 1995-06-29 | 1999-11-02 | Smithkline Beecham Corporation | Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity |
US5789421A (en) * | 1995-10-26 | 1998-08-04 | Merck & Co., Inc. | Fibrinogen receptor antagonist |
US5952306A (en) * | 1996-01-16 | 1999-09-14 | Merck & Co., Inc. | Integrin receptor antagonists |
US5780480A (en) * | 1996-02-28 | 1998-07-14 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
DE69706407T2 (de) * | 1996-03-29 | 2002-05-29 | G.D. Searle & Co., Chicago | META-SUBSTITUIERTE PHENYLENDERIVATE UND IHRE VERWENDUNG ALS ALPHAvBETA3 INTERGRIN-ANTAGONISTEN ODER INHIBITOREN |
US5889023A (en) * | 1996-05-10 | 1999-03-30 | Merck & Co., Inc. | Fibrinogen receptor antagonist |
ATE339196T1 (de) * | 1996-07-25 | 2006-10-15 | Biogen Idec Inc | Zelladhäsionsinhibitoren |
US5872138A (en) * | 1996-09-13 | 1999-02-16 | Merck & Co., Inc. | Thrombin inhibitors |
JP2001500864A (ja) * | 1996-09-13 | 2001-01-23 | メルク エンド カンパニー インコーポレーテッド | トロンビン阻害物質 |
UA59384C2 (uk) * | 1996-12-20 | 2003-09-15 | Пфайзер, Інк. | Похідні сульфонамідів та амідів як агоністи простагландину, фармацевтична композиція та способи лікування на їх основі |
US6294549B1 (en) | 1997-07-23 | 2001-09-25 | Merck & Co., Inc. | Method for eliciting an αvβ5 or dual αvβ3/αvβ5 antagonizing effect |
US6133297A (en) * | 1997-09-30 | 2000-10-17 | Merck & Co., Inc. | Thrombin inhibitors |
UA67754C2 (uk) * | 1997-10-10 | 2004-07-15 | Пфайзер, Інк. | Агоністи простагландину, фармацевтична композиція на їх основі (варіанти), спосіб нарощення та збереження кісткової маси у хребетних та спосіб лікування (варіанти) |
US5872122A (en) * | 1997-10-16 | 1999-02-16 | Monsanto Company | Pyrimidinylamidino β-amino acid derivatives useful as inhibitors of platelet aggregation |
US6028087A (en) * | 1998-01-21 | 2000-02-22 | Smithkline Beecham Corporation | Platelet aggregation inhibiting compounds |
US6291514B1 (en) | 1998-02-09 | 2001-09-18 | 3-Dimensional Pharmaceuticals, Inc. | Heteroaryl amidines, methylamidines and guanidines, preparation thereof, and use thereof as protease inhibitors |
JP4523153B2 (ja) | 1998-03-19 | 2010-08-11 | ブリストル−マイヤーズ スクイブ カンパニー | 易溶性薬物の二層性放出制御送達システムおよび方法 |
JP2003504301A (ja) | 1998-04-01 | 2003-02-04 | ブリストル−マイヤーズ スクイブ ファーマ カンパニー | インテグリンアンタゴニスト |
US6037365A (en) * | 1998-09-25 | 2000-03-14 | G.D. Searle & Co. | Aminobenzamidinosuccinyl lactone derivatives useful as inhibitors of platelet aggregation |
US6204282B1 (en) | 1998-11-30 | 2001-03-20 | Schering Corporation | Benzimidazole compounds that are vitronectin receptor antagonists |
CN1346282A (zh) | 1998-12-23 | 2002-04-24 | G.D.西尔公司 | 在肿瘤的治疗中使用环加氧酶-2-抑制剂与一种或多种抗肿瘤剂作为联合治疗的方法 |
US6335459B1 (en) | 1998-12-23 | 2002-01-01 | Syntex (U.S.A.) Llc | Aryl carboxylic acid and aryl tetrazole derivatives as IP receptor modulators |
EP1150979A1 (en) * | 1999-02-09 | 2001-11-07 | 3-Dimensional Pharmaceuticals, Inc. | Heteroaryl amidines, methylamidines and guanidines as protease inhibitors |
WO2000059876A1 (fr) * | 1999-03-31 | 2000-10-12 | Kissei Pharmaceutical Co., Ltd. | Derives de 3-amidinobenzenesulfonamide, compositions medicales qui les contiennent, et produits intermediaires pour leur elaboration |
JP5278983B2 (ja) * | 1999-11-17 | 2013-09-04 | 塩野義製薬株式会社 | アミド化合物の新規用途 |
AU1733701A (en) * | 1999-12-16 | 2001-06-25 | Sumitomo Pharmaceuticals Company, Limited | Substituted guanidine derivatives |
UA75093C2 (en) | 2000-10-06 | 2006-03-15 | Dimensional Pharm Inc | Aminopyridinyl-,aminoguanidinyl-, and alkoxyguanidinesubstituted phenylsubstituted phenylacetamides as protease inhibitors |
US6610701B2 (en) | 2001-02-09 | 2003-08-26 | Merck & Co., Inc. | Thrombin inhibitors |
MXPA03007284A (es) * | 2001-02-15 | 2003-12-04 | Pfizer Prod Inc | Agonistas de receptor activador del proliferador de peroxisomas. |
US7429593B2 (en) | 2001-09-14 | 2008-09-30 | Shionogi & Co., Ltd. | Utilities of amide compounds |
DE602004010889T2 (de) * | 2003-02-14 | 2008-12-11 | Eli Lilly And Co., Indianapolis | Sulfonamid-derivate als ppar-modulatoren |
WO2004093806A2 (en) * | 2003-04-22 | 2004-11-04 | Wellstat Therapeutics Corporation | Compounds for the treatment of metabolic disorders |
US7056932B2 (en) * | 2003-12-19 | 2006-06-06 | Hoffman-La Roche Inc. | Heterocyclyl substituted 1-alkoxy acetic acid amides |
EP2404899A1 (en) * | 2004-02-25 | 2012-01-11 | Astellas Pharma Inc. | Contrast medium for thrombus detection |
US7914705B2 (en) * | 2005-01-10 | 2011-03-29 | Robert Eliot Sisson | Flowable electrical conductive liquid |
CA2696995C (en) * | 2007-08-21 | 2017-11-21 | Senomyx, Inc. | Identification of human t2r receptors that respond to bitter compounds that elicit the bitter taste in compositions, and the use thereof in assays to identify compounds that inhibit (block) bitter taste in compositions and use thereof |
RU2016125229A (ru) | 2010-07-09 | 2018-12-04 | БиЭйчВи ФАРМА, ИНК. | Комбинированная система доставки с немедленным/замедленным высвобождением для лекарственных средств с коротким периодом полувыведения, в том числе для ремоглифлозина |
BR112013011188B1 (pt) | 2010-11-05 | 2022-01-04 | Senomyx, Inc | Método não-médico para modular canal potencial de receptor transiente de melastina 8 (trpm8), método não-médico para modular a sensação de resfriamento de uma composição, método não-médico para induzir uma sensação de resfriamento em um humano ou animal e composto |
RU2745616C1 (ru) | 2015-10-01 | 2021-03-29 | Сеномикс, Инк. | Соединения, используемые в качестве модуляторов trpm8 |
CN116283648B (zh) * | 2023-03-07 | 2024-03-19 | 中国医学科学院药用植物研究所 | 一种取代的苯丙烯酰基或苯丙酰基苯乙胺类化合物及其制备方法和应用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT22882B (de) * | 1904-11-28 | 1906-01-25 | Woldemar Greiner | Heizkörper für Vakuumapparate u. dgl. |
GB1047245A (pt) * | 1963-02-15 | |||
DD142804A3 (de) * | 1977-11-07 | 1980-07-16 | Wagner Guenter | Verfahren zur herstellung von na-alkyl-bzw.na-aryl-sulfonylierten omega-amidinophenyl-alpha-aminoalkylcarbonsaeureamiden |
SE8004088L (sv) * | 1980-06-02 | 1981-12-03 | Haessle Ab | Nya substituerade 3-fenoxi-l-alkoxikarbonylalkylamino-propanol-2-er med beta-receptorblockerande egenskaper samt forfarande for deras framstellning, farmaceutiska beredningar innehallande desamma och metod att ... |
SE8203887D0 (sv) * | 1982-06-23 | 1982-06-23 | Kabivitrum Ab | Nya trombininhiberande foreningar |
US4746737A (en) * | 1985-07-26 | 1988-05-24 | Kowa Co., Ltd. | Phenyl guanidinobenzoate derivatives which have protease inhibitory activity |
DE3610643A1 (de) * | 1986-03-29 | 1987-10-01 | Boehringer Mannheim Gmbh | Neue phenoxyalkylcarbonsaeure-derivate, verfahren zu ihrer herstellung sowie diese verbindungen enthaltende arzneimittel |
IL83230A (en) * | 1986-08-06 | 1992-06-21 | Tanabe Seiyaku Co | Phenoxyacetic acid derivatives,their preparation and pharmaceutical compositions containing them |
EP0325245B1 (en) * | 1988-01-19 | 1993-10-20 | Tanabe Seiyaku Co., Ltd. | Phenoxyacetic acid derivatives, preparation thereof, pharmaceutical compositions comprising them and use |
-
1990
- 1990-01-16 US US07/465,858 patent/US5084466A/en not_active Expired - Fee Related
- 1990-01-22 HU HU90218A patent/HU206193B/hu not_active IP Right Cessation
- 1990-01-23 NZ NZ232195A patent/NZ232195A/en unknown
- 1990-01-23 CA CA002008311A patent/CA2008311A1/en not_active Abandoned
- 1990-01-24 AT AT90101404T patent/ATE103273T1/de not_active IP Right Cessation
- 1990-01-24 DK DK90101404.3T patent/DK0381033T3/da not_active Application Discontinuation
- 1990-01-24 DE DE90101404T patent/DE59005041D1/de not_active Expired - Fee Related
- 1990-01-24 ES ES90101404T patent/ES2050851T3/es not_active Expired - Lifetime
- 1990-01-24 EP EP90101404A patent/EP0381033B1/de not_active Expired - Lifetime
- 1990-01-25 AU AU48817/90A patent/AU632086B2/en not_active Ceased
- 1990-01-25 PH PH39933A patent/PH29926A/en unknown
- 1990-01-25 CZ CS90354A patent/CZ277999B6/cs unknown
- 1990-01-25 IL IL9317090A patent/IL93170A/en not_active IP Right Cessation
- 1990-01-25 SK SK354-90A patent/SK277762B6/sk unknown
- 1990-01-29 MC MC902101A patent/MC2082A1/xx unknown
- 1990-01-30 FI FI900463A patent/FI900463A0/fi not_active IP Right Cessation
- 1990-01-30 NO NO900418A patent/NO172536C/no unknown
- 1990-01-30 IE IE34490A patent/IE64004B1/en not_active IP Right Cessation
- 1990-01-30 RU SU904742946A patent/RU2072986C1/ru active
- 1990-01-30 PT PT93014A patent/PT93014B/pt not_active IP Right Cessation
- 1990-01-31 JP JP2019361A patent/JPH085848B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
PT93014A (pt) | 1990-07-31 |
JPH085848B2 (ja) | 1996-01-24 |
ATE103273T1 (de) | 1994-04-15 |
NO172536C (no) | 1993-08-04 |
US5084466A (en) | 1992-01-28 |
CA2008311A1 (en) | 1990-07-31 |
IL93170A (en) | 1994-05-30 |
HU206193B (en) | 1992-09-28 |
ES2050851T3 (es) | 1994-06-01 |
AU4881790A (en) | 1990-08-09 |
PH29926A (en) | 1996-09-16 |
PT93014B (pt) | 1995-12-29 |
DK0381033T3 (da) | 1994-07-18 |
CZ35490A3 (en) | 1993-03-17 |
JPH02235853A (ja) | 1990-09-18 |
EP0381033B1 (de) | 1994-03-23 |
IL93170A0 (en) | 1990-11-05 |
SK35490A3 (en) | 1994-12-07 |
EP0381033A1 (de) | 1990-08-08 |
IE64004B1 (en) | 1995-06-28 |
MC2082A1 (fr) | 1991-01-07 |
RU2072986C1 (ru) | 1997-02-10 |
DE59005041D1 (de) | 1994-04-28 |
IE900344L (en) | 1990-07-31 |
HUT53070A (en) | 1990-09-28 |
SK277762B6 (en) | 1994-12-07 |
NO900418D0 (no) | 1990-01-30 |
NZ232195A (en) | 1992-05-26 |
NO172536B (no) | 1993-04-26 |
AU632086B2 (en) | 1992-12-17 |
NO900418L (no) | 1990-08-01 |
CZ277999B6 (en) | 1993-07-14 |
HU900218D0 (en) | 1990-03-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FI900463A0 (fi) | Karboxylsyra- och sulfonsyraamider. | |
NO941592L (no) | Adhesjonsreseptorantagonister | |
RO77508A (ro) | 796cedeu 7e5t9u 6bti5e9ea u5ui fi3a4e5t 7e5t9u sutu9i chi9u9gica3e | |
IT1202698B (it) | Apparecchiatura bombardatrice di stampi per piegatrice | |
ITMI910909A1 (it) | Procedimento per l'ottenimento di politereftalato di etilene modificato | |
ATE85607T1 (de) | Arylhydrazone. | |
CO4410181A1 (es) | Derivado de 2-(2-amino-1,6-dihidro-6-oxo-purin-9-il) metoxi-1,3-propandiol | |
DK0608759T3 (da) | Piperazinderivater | |
FR2525100B1 (fr) | Extracteur d'agrafes chirugicales | |
KR910700089A (ko) | 히드로클로로플루오로프로판의 공비 조성물 또는 공비형 조성물 | |
IT1274997B (it) | Procedimento per la produzione di spazzole nonche' macchina per la produzione di spazzole per l'esecuzione del procedimento | |
DE3770130D1 (de) | Polymerisierbare zusammensetzungen. | |
IT1162893B (it) | Procedimento per l'esecuzione di una prova di mutageneita | |
DK248484A (da) | Isoquinolinderivater | |
ITMI930630A0 (it) | Procedimento per la copolimerizzazione dell'etilene | |
IT1270850B (it) | Apparecchiatura di tipo perfezionato per trattamenti di emodiafiltrazione | |
TH9003EX (th) | ซัลโฟนิลอมิดิโนไฮดราโซนที่ถูกแทนที่ | |
IT8603600A0 (it) | Apparecchiatura per l'essicazione del legname | |
RU94011275A (ru) | Линейные пептиды, способ их получения, фармацевтическая композиция и способ ее получения | |
IT9003334A0 (it) | Apparecchiatura di tipo perfezionato per trattamenti di dialisi | |
IT9084147A0 (it) | Apparecchiatura per l'attrezzamento di macchine profilatrici | |
IT8967298A0 (it) | Perfezionamenti all ansa di elettroresezione endoscopica |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM | Patent lapsed |
Owner name: F. HOFFMANN - LA ROCHE AG |