FI89916B - Foerfarande foer framstaellning av terapeutiskt anvaendbara 3-/4-(1-substituerade-4-piperazinyl)butyl/-4-tiazolidinoner - Google Patents

Foerfarande foer framstaellning av terapeutiskt anvaendbara 3-/4-(1-substituerade-4-piperazinyl)butyl/-4-tiazolidinoner Download PDF

Info

Publication number
FI89916B
FI89916B FI885332A FI885332A FI89916B FI 89916 B FI89916 B FI 89916B FI 885332 A FI885332 A FI 885332A FI 885332 A FI885332 A FI 885332A FI 89916 B FI89916 B FI 89916B
Authority
FI
Finland
Prior art keywords
thiazolidinone
butyl
piperazinyl
mixture
etoac
Prior art date
Application number
FI885332A
Other languages
English (en)
Finnish (fi)
Other versions
FI89916C (sv
FI885332A0 (fi
FI885332A (fi
Inventor
Nicholas J Hrib
John Gerard Jurcak
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of FI885332A0 publication Critical patent/FI885332A0/fi
Publication of FI885332A publication Critical patent/FI885332A/fi
Application granted granted Critical
Publication of FI89916B publication Critical patent/FI89916B/fi
Publication of FI89916C publication Critical patent/FI89916C/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Claims (9)

1. Förfarande för framställning av terapeutiskt användbara 3-[4-(l-substituerade-4-piperazinyl)butyl]-4-5 tiazolidinoner med formeln I (°) _ \ I R
10. V 3 / ,4 I A--N _ ° X(C»2’ väri n är 0 eller 1; A är * V Xl·™. xx> . 20 “li—N— (S,ra eller Π4-(Τ)π> , väri X, Y, Z, U, V, W, Q, S och T var och en betecknar väte, halogen, lägre alkyl, hydroxi, nitro, lägre alkoxi, amino, cyan eller 25 tr if luonne tyl, m är 1 eller
2; R3 och R2 betecknar bäda s- jälvständigt väte, lägre alkyl eller aryl eller alterna-tivt bildar Rx + R2 tillsanunans med den koi atom till vilken de är bundna en cyklopentan-, cyklohexan-, cykloheptan-, pyran-, tiopyran-, pyrrolidin- eller piperidinring; R3 och 30 R4 betecknar bäda självständigt väte eller lägre alkyl eller alternativt bildar R3 + R4 tillsanunans med den kolatom tili vilken de är bundna en cyklopentan-, cyklohexan-, cykloheptan-, pyran-, tiopyran-, pyrrolidin- eller piperi-dinring, varvid termen aryl betecknar en osubstituerad 35 fenylgrupp eller en fenylgrupp som är substituerad med en, tvä eller tre substituenter varav var och en särskilt be- 54 399U tecknar lägre alkyl, lägre alkoxi, hydroxi, halogen, läg-re alkyltlo, cyan, amino eller trifluormetyl, eller dess farmaceutiskt godtagbara salter, kännetecknat därav, att 5 a) en förening med formeln III ·, ?“ . o^~NW\Br väri n, R2, R2, R3 och R4 är som definierade, fAr reagera 15 med en förening med formeln IV ^ H K“—λ ΤΗ W 20 väri A är som definierad, eller b) eventuellt fAr en förening med formeln I, väri n är 0, reagera sAlunda, att man erhAller en förening med formeln I, väri n är 1. y. 25 2. Förfarande enligt patentkravet 1, känne tecknat därav, att n är 0.
3. Förfarande enligt patentkravet 2, kännetecknat därav, att Rlf R2, r3 ja R4 var och en sär-skilt betecknar väte, lägre alkyl eller aryl och A är en -30 radikal ”' ττΟ- ts>” eiiar XiOm" väri X, S och T är som definierade. 35
4. Förfarande enligt patentkravet 3, känne tecknat därav, att Rx, R2, R3 och R4 var och en sär- II 8991 6 55 skilt betecknar väte, metyl eller fenyl och A är en radi-kal 130 eller , väri X är metyl, 5 ~ metoxl, Cl, F eller CF3.
5. Förfarande enligt patentkravet 1, känne- t e c k n a t därav, att man framställer 2-metyl-3-[4-[1-(4-fluorfenyl)-4-piperazinyl]butyl]-4-tiazolidinon el-10 ler dess £armaceutiskt godtagbara syraadditionssalt.
6. Förfarande enligt patentkravet 1, känne- t e c k n a t därav, att man framställer 3-[4-[l-(3-me-tylfenyl)-4-piperazinyl]butyl]-4-tiazolidinon eller dess farmaceutiskt godtagbara syraadditionssalt. 15
7. Förfarande enligt patentkravet 1, känne- t e c k n a t därav, att man framställer 3-[4-[1-(2,3-dimetylfenyl)-4-piperazinyl]butyl]-4-tiazolidinon eller dess farmaceutiskt godtagbara syraadditionssalt.
8. Förfarande enligt patentkravet 1, känne-20 tecknat därav, att man framställer 3-[4-[l-(4-klor- fenyl)-4-piperazinyl]butyl]-4-tiazolidinon eller dess farmaceutiskt godtagbara syraadditionssalt.
9. Förfarande enligt patentkravet 1, känne- : tecknat därav, att man framställer 3-[4-[1-( 1,2- 25 benzisotiazol-3-yl)-4-piperazinyl] butyl] - 5,5-dimetyl-4- tiazolidinon eller dess farmaceutiskt godtagbara syraadditionssalt.
FI885332A 1987-11-20 1988-11-17 Förfarande för framställning av terapeutiskt användbara 3-/4-(1-substi tuerade-4-piperazinyl)butyl/-4-tiazolidinoner FI89916C (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12362287A 1987-11-20 1987-11-20
US12362287 1987-11-20

Publications (4)

Publication Number Publication Date
FI885332A0 FI885332A0 (fi) 1988-11-17
FI885332A FI885332A (fi) 1989-05-21
FI89916B true FI89916B (fi) 1993-08-31
FI89916C FI89916C (sv) 1993-12-10

Family

ID=22409774

Family Applications (1)

Application Number Title Priority Date Filing Date
FI885332A FI89916C (sv) 1987-11-20 1988-11-17 Förfarande för framställning av terapeutiskt användbara 3-/4-(1-substi tuerade-4-piperazinyl)butyl/-4-tiazolidinoner

Country Status (20)

Country Link
US (5) US4933453A (sv)
EP (1) EP0316723B1 (sv)
JP (1) JP2617546B2 (sv)
KR (1) KR0130976B1 (sv)
AT (1) ATE81123T1 (sv)
AU (1) AU624092B2 (sv)
CA (1) CA1317955C (sv)
DE (1) DE3875073T2 (sv)
DK (1) DK645688A (sv)
ES (1) ES2052675T3 (sv)
FI (1) FI89916C (sv)
GR (1) GR3006698T3 (sv)
HU (1) HU206709B (sv)
IE (1) IE62229B1 (sv)
IL (1) IL88414A (sv)
NO (1) NO176143C (sv)
NZ (1) NZ226999A (sv)
PH (1) PH27330A (sv)
PT (1) PT89020B (sv)
ZA (1) ZA888651B (sv)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0316723B1 (en) * 1987-11-20 1992-09-30 Hoechst-Roussel Pharmaceuticals Incorporated 3-[4(1-Substituted-4-piperazinyl)butyl]-4-thiazolidinones a process for their preparation and their use as medicaments
US5801186A (en) 1987-11-20 1998-09-01 Hoechst Marion Roussel, Inc. 3- 4-(1-substituted-4-piperazinyl)butyl!-4-thiazolidinone and related compounds
WO1991000863A1 (en) * 1989-07-07 1991-01-24 Pfizer Inc. Heteroaryl piperazine antipsychotic agents
HU205092B (en) * 1989-11-24 1992-03-30 Richter Gedeon Vegyeszet Process for producing new thiazolidinone derivatives and pharmaceutical compositions comprising same
US5216002A (en) * 1989-12-21 1993-06-01 Eli Lilly And Company Method of treating inflammatory bowel disease
US5034392A (en) * 1990-04-16 1991-07-23 Hoechst-Roussel Pharmaceuticals Incorporated 4-(3-(4-oxothiazolidinyl)butynylamines
US5041445A (en) * 1990-05-21 1991-08-20 Hoechst-Roussel Pharmaceuticals Incorporated 3-[1-thiazolidinylbutyl-4-piperazinyl]-1H-indazoles
US5045546A (en) * 1990-10-26 1991-09-03 Hoechst-Roussel Pharmaceuticals Inc. 8-azabicyclo[3.2.1]octylalkylthiazolidines
US5130315A (en) * 1991-01-10 1992-07-14 Raymond R. Wittekind 1-piperazinyl-2-butenes and -2-butynes
US5194436A (en) * 1991-01-10 1993-03-16 Hoechst-Roussel Pharmaceuticals Inc. 1-piperazinyl-2-butenes and -2-butynes
US5240927A (en) * 1992-05-19 1993-08-31 Hoechst-Roussel Pharmaceuticals Incorporated Benzo[β]thiophen-3-yl piperazines as antipsychotic agents
AU664084B2 (en) * 1992-06-03 1995-11-02 Ciba-Geigy Ag Novel thiosemicarbazonic acid esters
US5272148A (en) * 1992-09-09 1993-12-21 Hoechst-Roussel Pharmaceuticals Incorporated Heteroarenylpiperazines
EP0635506A4 (en) * 1993-02-04 1995-04-12 Meiji Seika Co CONNECTION WITH ANTIPSYCHOTIC EFFECT.
US5391570A (en) * 1993-10-14 1995-02-21 Bristol-Myers Squibb Aminomethyl-benzodioxane and benzopyran serotonergic agents
CA2157348A1 (en) * 1994-09-01 1996-03-02 Aventis Pharmaceuticals Inc. 3-¬4-(1-substituted-4-piperazinyl)butyl|-4-thiazolidinone and related compounds
KR960022486A (ko) * 1994-12-29 1996-07-18 김준웅 신규 티아졸리딘-4-온 유도체
ES2170177T3 (es) * 1995-03-17 2002-08-01 Aventis Pharma Inc Benzotienilpiperazinas sustituidas, su uso como medicamentos y procedimientos para su preparacion.
KR970032857A (ko) * 1995-12-29 1997-07-22 김준웅 약제 조성물
US5880121A (en) * 1996-01-05 1999-03-09 Hoechst Marion Roussel Inc. 4,5-dihydronaphth (1,2-c) isoxazoles and derivatives thereof
ZA9711376B (en) * 1996-12-20 1998-07-21 Lundbeck & Co As H Indole or dihydroindole derivatives
US6506751B1 (en) 1999-11-12 2003-01-14 Millennium Pharmaceuticals, Inc. Thiazolidinone compounds useful as chemokine inhibitors
US7049146B2 (en) * 2000-11-14 2006-05-23 Facet Analytical Services And Technology, Llc Calibration standards, methods, and kits for water determination
US7122376B2 (en) * 2001-11-01 2006-10-17 Facet Analytical Services And Technology, Llc Calibration standards, methods, and kits for water determination
CA2453633A1 (en) * 2001-07-16 2003-01-30 Euro-Celtique S.A. Aryl substituted thiazolidinones and the use thereof
WO2004027361A1 (en) * 2002-09-17 2004-04-01 University Of Virginia Patent Foundation Remote temperature sensing of small volume and related apparatus thereof
EA017351B1 (ru) * 2007-03-29 2012-11-30 Общество С Ограниченной Ответственностью "Фармвинг" Средство противогистаминного антиаллергического действия и способ его получения
EP2350002A1 (en) * 2008-10-02 2011-08-03 Abbott Laboratories Novel compounds as calcium channel blockers
WO2011115813A1 (en) * 2010-03-18 2011-09-22 Abbott Laboratories Lactam acetamides as calcium channel blockers

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2520179A (en) * 1949-02-02 1950-08-29 Sterling Drug Inc 4-thiazolidones and a method for preparation thereof
JPS51125389A (en) * 1975-04-09 1976-11-01 Yoshitomi Pharmaceut Ind Ltd A process for preparing heterocyclic compovnds
US4456756A (en) * 1981-08-03 1984-06-26 Mead Johnson & Company Spirothiazolidinyl piperazine derivatives
US4411901A (en) * 1981-12-23 1983-10-25 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4619930A (en) * 1985-01-16 1986-10-28 Bristol-Myers Company Antipsychotic cyclic imide derivatives of 2-(4-butylpiperazin-1-yl)pyridines, compositions and use
GB8512163D0 (en) * 1985-05-14 1985-06-19 Fujisawa Pharmaceutical Co Oxothiazolidine compound
EP0316723B1 (en) * 1987-11-20 1992-09-30 Hoechst-Roussel Pharmaceuticals Incorporated 3-[4(1-Substituted-4-piperazinyl)butyl]-4-thiazolidinones a process for their preparation and their use as medicaments
US5041445A (en) * 1990-05-21 1991-08-20 Hoechst-Roussel Pharmaceuticals Incorporated 3-[1-thiazolidinylbutyl-4-piperazinyl]-1H-indazoles

Also Published As

Publication number Publication date
IE883463L (en) 1989-05-20
ZA888651B (en) 1989-09-27
JPH01160975A (ja) 1989-06-23
FI89916C (sv) 1993-12-10
ATE81123T1 (de) 1992-10-15
PH27330A (en) 1993-06-08
AU2569488A (en) 1989-05-25
IL88414A (en) 1993-07-08
US4933453A (en) 1990-06-12
CA1317955C (en) 1993-05-18
KR0130976B1 (ko) 1998-04-16
DE3875073T2 (de) 1993-03-11
NO885152L (no) 1989-05-22
ES2052675T3 (es) 1994-07-16
FI885332A0 (fi) 1988-11-17
US5229388A (en) 1993-07-20
GR3006698T3 (sv) 1993-06-30
US5037984A (en) 1991-08-06
KR890008137A (ko) 1989-07-10
NZ226999A (en) 1991-05-28
HU206709B (en) 1992-12-28
DK645688A (da) 1989-05-21
IL88414A0 (en) 1989-06-30
PT89020A (pt) 1988-12-01
HUT54149A (en) 1991-01-28
NO885152D0 (no) 1988-11-18
AU624092B2 (en) 1992-06-04
NO176143C (no) 1995-02-08
US5371087A (en) 1994-12-06
PT89020B (pt) 1993-02-26
DK645688D0 (da) 1988-11-18
EP0316723B1 (en) 1992-09-30
DE3875073D1 (sv) 1992-11-05
IE62229B1 (en) 1995-01-11
EP0316723A1 (en) 1989-05-24
NO176143B (no) 1994-10-31
FI885332A (fi) 1989-05-21
JP2617546B2 (ja) 1997-06-04
US5136037A (en) 1992-08-04

Similar Documents

Publication Publication Date Title
FI89916B (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara 3-/4-(1-substituerade-4-piperazinyl)butyl/-4-tiazolidinoner
FR2569404A1 (fr) Nouveaux derives de 1,2-benzisothiazol-3-ylpiperazine, compositions pharmaceutiques contenant de tels composes et leurs procedes de preparation
HU214032B (en) Process for producing benzoisothiazole and benzoisoxazole-3-carboxamide derivatives and pharmaceutical compositions comprising such compounds as active ingredient
US4780466A (en) Arylpiperazinylalkoxy derivatives of cyclic imides
FI78103B (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara 11-substituerade 5h,11h-pyrrolo/2,1-c//1,4/ bensoxazepiner.
IE912976A1 (en) 6,7-Dihydro-3-phenyl-1,2-benzisoxazol-4(5H)-ones and -ols,¹a process for their preparation and their use as¹medicaments
EP0599240B1 (en) Indole-7-carboxamide derivatives as analgesics
FR2705346A1 (fr) Nouveaux dérivés de pipéridinyl thio indole, leurs procédés de préparation, compositions pharmaceutiques les contenant, utiles notamment comme antalgiques .
FI94757B (sv) Förfarande för framställning av terapeutiskt användbara 3-/1-tiazolidinylbutyl-4-piperazinyl/-1H-indazoler
HU195200B (en) Process for producing oxo-thiazolidine compounds and pharmaceutical preparations comprising the same
US5801186A (en) 3- 4-(1-substituted-4-piperazinyl)butyl!-4-thiazolidinone and related compounds
FI103970B (sv) Förfarande för framställning av 3-(1,2-bensisoxazol-3-yl)-4-pyridinamin och dess derivat, vilka är användbara för lindring av smärta och behandling av hudsjukdomer och funktionstörningar i minnet
US5053508A (en) Fused heterotricyclic imides with psychotropic activity and intermedrates thereof
US4826846A (en) Arylpiperazinylalkoxy derivatives of cyclic imides to treat anxiety
US5034392A (en) 4-(3-(4-oxothiazolidinyl)butynylamines
EP0699675A2 (en) 3-(4-(1-Substituted-4-piperazinyl)butyl)-4-thiazolidinone and related compounds
FR2640975A1 (sv)

Legal Events

Date Code Title Description
BB Publication of examined application
PC Transfer of assignment of patent

Owner name: HOECHST MARION ROUSSEL, INC.

MM Patent lapsed

Owner name: HOECHST MARION ROUSSEL INC., INC.